Metabolic landscape in cardiac aging:insights into molecular biology and therapeutic implications
作者机构：Department of CardiologyRenmin Hospital of Wuhan UniversityHubei Key Laboratory of Metabolic and Chronic DiseasesCardiovascular Research Institute of Wuhan UniversityWuhanPR China State Key Laboratory of Complex Severe and Rare DiseasesDepartment of CardiologyPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijingPR China Department of CardiologyRenmin Hospital of Wuhan UniversityDepartment of CardiologyThe Fifth Affiliated Hospital of Xinjiang Medical UniversityÜrümqiPR China
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2023年第8卷第4期
页 面：1610-1629页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 071008[理学-发育生物学]
基 金：the National Key R&D Program of China(2018YFC1311300) the National Natural Science Foundation of China(No:82170245,81860080,and 82070204) The Regional Innovation and Development Joint Fund of National Natural Science Foundation of China(No.U22A20269)
主 题：cardiac degeneration involvement
摘 要：Cardiac aging is evident by a reduction in function which subsequently contributes to heart *** metabolic microenvironment has been identified as a hallmark of malignancy,but recent studies have shed light on its role in cardiovascular diseases(CVDs).Various metabolic pathways in cardiomyocytes and noncardiomyocytes determine cellular senescence in the aging *** alteration is a common process throughout cardiac ***,the involvement of cellular senescence in cardiac injuries,including heart failure and myocardial ischemia and infarction,has been ***,metabolic complexity among human aging hearts hinders the development of strategies that targets metabolic *** over the past decade have linked cellular senescence and function with their metabolic reprogramming pathway in cardiac aging,including autophagy,oxidative stress,epigenetic modifications,chronic inflammation,and myocyte systolic phenotype *** addition,metabolic status is involved in crucial aspects of myocardial biology,from fibrosis to hypertrophy and chronic ***,further elucidation of the metabolism involvement in cardiac degeneration is still ***,deciphering the mechanisms underlying how metabolic reprogramming impacts cardiac aging is thought to contribute to the novel interventions to protect or even restore cardiac function in aging ***,we summarize emerging concepts about metabolic landscapes of cardiac aging,with specific focuses on why metabolic profile alters during cardiac degeneration and how we could utilize the current knowledge to improve the management of cardiac aging.
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