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Polymorphisms of the oxidant enzymes glutathione S-transferase and glutathione reductase and their association with resistance of Plasmodium falciparum isolates to antimalarial drugs

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Asian Pacific Journal of Tropical Medicine 2010年第9期3卷 673-677页

作者： Raewadee Wisedpanichkij Wanna Chaicharoenkul Poonuch Mahamad Prapichaya Prompradit Kesara Na-Bangchang Pharmacology and Toxicology Unit Graduate Program in Biomedical SciencesThammasat UniversityThailand

Objective:To investigate the association between amplification of the two regulatory genes controlling glutathione(GSH) levels,glutathione reductase(PfGR) and glutathione S-transferase (PfGST) genes and sensitivity of Plasmodium falciparum(***) isolates collected from different malaria endemic areas of Thailand to standard antimalarial ***:A total of 70 *** isolates were collected from endemic areas of multi-drug resistance (Tak,Chantaburi and Ranong Provinces) during the year *** in vitro assessment of antimalarial activity of *** clones(K1- and Dd2 chloroquine resistant and 3D7- chloroquine sensitive) and isolates to chloroquine,quinine,mefloquine and arteusnate was performed based on SYBR Green modified ***:68(97.14%),11(15.71%) and 28(40%) isolates respectively were classified as chloroquine-,quinine- and mefloquine-resistant isolates. With this limited number of *** isolates included in the analysis,no significant association between amplification of PfGST gene and sensitivity of the parasite to chloroquine, quinine,mefloquine and quinine was *** on PCR analysis,Dd2,Kl and 3D7 clones all contained only one copy of the PfGST *** isolates(70) also carried only one copy number of PfGST *** appears to be an association between amplification of PfGR gene and chloroquine *** 3D7 and Dd2 clones were found to carry only one PfGR gene copy, whereas the K1 clone carried two gene ***:Chloroquine resistance is likely to be a consequence of multi-factors and enzymes in the GSH system may be partly involved. Larger number of parasite isolates are required to increase power of the hypothesis testing in order to confirm the involvement of both genes as well as other genes implicated in glutathione metabolism in conferring chloroquine resistance.

关键词： Plasmodium falciparum Drug resistance Glutathione reductase(PfGR) Glutathione S-transferase(P/GST)

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Pramipexole, a dopamine D3/D2 receptor-preferring agonist, attenuates reserpine-induced fibromyalgia-like model in mice

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Neural Regeneration Research 2022年第2期17卷 450-458页

作者： Carlos Pereira Martins Rodrigo Sebben Paes Gabriela Mantovani Baldasso Eduarda Gomes Ferrarini Rahisa Scussel Rubya Pereira Zaccaron Ricardo Andrez Machado-de-Avila Paulo Cesar Lock Silveira Rafael Cypriano Dutra Laboratory of Autoimmunity and Immunopharmacology Department of Health SciencesCampus AraranguaUniversidade Federal de Santa CatarinaAraranguáSCBrazil post-graduate program of Neuroscience Center of Biological SciencesUniversidade Federal de Santa CatarinaFlorianópolisSCBrazil Laboratory of Experimental Physiopathology Program of Postgraduate in Science of HealthUniversidade do Extremo Sul CatarinenseCriciumaSCBrazil

Fibromyalgia(FM) is a complex pathology described as persistent hyperalgesia including somatic and mood dysfunctions, depression and anxiety. Although the etiology of FM is still unknown, a significant decrease in biogenic amines is a common characteristic in its pathogenesis. Here, our main objective was to investigate the role of dopamine D3/D2 receptor during the reserpine-induced pain in mice. Our results showed that pramipexole(PPX) – a dopaminergic D3/D2 receptor agonist – inhibited mechanical allodynia and thermal sensitivity induced by reserpine. Relevantly, PPX treatment decreased immobility time and increased the number of grooming in the forced swimming test and splash test, respectively. Animals that received PPX remained longer in the open arms than the reserpine group using elevated plusmaze apparatus. The repeated PPX administration, given daily for 4 days, significantly blocked the mechanical and thermal allodynia during FM model, similarly to pregabalin, although it failed to affect the reserpine-induced thermal nociception. Reserpine administration induced significant downregulation of dopamine concentration in the central nervous system, and repeated treatment with PPX restored dopamine levels in the frontal cortex and spinal cord tissues. Moreover, PPX treatment inhibited oxidants production such as DCFH(2′,7′-dichlorodihydrofluorescein) and nitrite, also decreased oxidative damage(carbonyl), and upregulated the activity of superoxide dismutase in the spinal cord. Together, our findings demonstrated the ability of dopamine D3/D2 receptor-preferring agonist in reducing pain and mood dysfunction allied to FM in mice. All experimental protocols were approved by the Universidade Federal de Santa Catarina(UFSC) Ethics Committee(approval No. 2572210218) on May 10, 2018.

关键词： dopamine dopaminergic system fibromyalgia hyperalgesia pain pramipexole reserpine

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Sports and Public Space: Volleyball Practice inCopacabana and Carcavelos/Cascais Beaches

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Journal of Civil Engineering and Architecture 2020年第2期14卷 92-99页

作者： Marcelo Tavares Lilian Vaz Madalena Cunha Matos post-graduate program in Urbanism Federal University of Rio de Janeiro—PROURB/UFRJRio de Janeiro 21941-901Brazil post-graduate program in Architecture University of Lisbon—CIAUD/ULLisbon 1349-063Portugal

The aim of this paper is to analyze volleyball practice in the beaches of Copacabana(Rio de Janeiro,Brazil)and Carcavelos and Cascais Bay(Cascais,Portugal)and to review the forms of appropriation of public space based on public policies and rules of the sport in *** methodology rests on bibliographic review and ethnographic research to map and distinguish the results in two spatial and cultural contexts that are considerably *** show that even with greater extension of Copacabana beach in comparison with Cascais,volleyball has a relevant impact in both *** installation of the necessary equipment for volleyball practice is also a form of impact in the landscape and establishment of territoriality,which is mainly activated when the game happens.

关键词： Contemporaneity urban history public space beach volleyball.

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Notch signaling regulates expression of Mcl-1 andapoptosis in PPD-treated macrophages

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Cellular & Molecular Immunology 2013年第5期10卷 444-452页

作者： Tanapat P alaga Siriluk Ratanabunyong Thitiporn Pattarakankul Naunpun Sangphech Wipawee Wongchana Yukihiro Hadae Patipark Kueanjinda Department of Microbiology Faculty of Science Chulalongkorn University Bangkok 10330 Thailand Interdisciplinary program in Medical Microbiology Graduate School Chulalongkorn University Bangkok 10330 Thailand graduate program in Industrial Microbiology Faculty of Science Chulalongkorn University Bangkok 10330 Thailand graduate program in Biotechnology Faculty of Science Chulalongkorn University Bangkok 10330 Thailand International Center for Biotechnology Osaka University Osaka 565-0871 Japan

Macrophages are cellular targets for infection by bacteria and viruses. The fate of infected macrophages plays a key role in determining the outcome of the host immune response. Apoptotic cell death of macrophages is considered to be a protective host defense that eliminates pathogens and infected cells. In this study, we investigated the involvement of Notch signaling in regulating apoptosis in macrophages treated with tuberculin purified protein derivative （PPD）. Murine bone marrow-derived macrophages （BMMs） treated with PPD or infected with Mycobacterium bovis Bacillus Calmette-Guerin （BCG） induced upregulation of Notch1. This upregulation correlated well with the upregulation of the anti-apoptotic gene mcl-1 both at the transcriptional and translational levels. Decreased levels of Notch I and Mcl- 1 were observed in BMM treated with PPD when a gamma secretase inhibitor （GSI）, which inhibits the processing of Notch receptors, was used. Moreover, silencing Notch1 in the macrophage-like cell line RAW264.7 decreased Mcl-1 protein expression, suggesting that Notch1 is critical for Mcl-1 expression in macrophages. A significant increase in apoptotic cells was observed upon treatment of BMM with PPD in the presence of GSI compared to the vehicle-control treated cells. Finally, analysis of the mcl-1 promoter in humans and mice revealed a conserved potential CSURBP-Jκ binding site. The association of Notch I with the mcl-1 promoter was confirmed by chromatin immunoprecipitation. Taken together, these results indicate that Notch I inhibits apoptosis of macrophages stimulated with PPD by directly controlling the mcl-1 promoter.

关键词： apoptosis BCG macrophage Mcl-1 Notch signaling PPD

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Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi Yu Faith Teo En Ning Chang Liu Yu-Chi Liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

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液晶弹性体单元协同驱动作为功能设计平台（英文）

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Science China Materials 2025年第1期 236-243页

作者：王瑾宇 Hari Krishna Bisoyi 黄银亮徐艺艺张新芳范奔杨涛刘志洋黄帅李全 Institute of Advanced Materials and School of Chemistry and Chemical Engineering Southeast University Materials Science graduate program Kent State University

未来软体机器人设备的复杂性远超当前标准,因而需要建立新的设计方法.该方法需整合多个系统,以同步软执行器的运动和信号响应,从而增强柔性设备的智能性.本文提出了一个基于液晶弹性体(LCE)单元的平台,该平台将单元整合成组,以创建可扩...

未来软体机器人设备的复杂性远超当前标准,因而需要建立新的设计方法.该方法需整合多个系统,以同步软执行器的运动和信号响应,从而增强柔性设备的智能性.本文提出了一个基于液晶弹性体(LCE)单元的平台,该平台将单元整合成组,以创建可扩展的功能.每个单元的行为都是一个柔性驱动模块,可以在特定、稳定和可控的模式下进行双轴膨胀.通过以不同的方式组织LCE单元,分别实现了自适应性的软夹持器、信息处理的半加器和可调的声子带隙.这表明通过精巧地重新组装这些单元,可以在结构和功能上具备高度的可重构性和可扩展性.这种设计策略有望整合传统软执行器无法具备的多种功能,为开发智能软机器人提供平台.

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A preliminary evaluation of throughfall sampling techniques in a mature coniferous forest

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Journal of Forestry Research 2014年第2期25卷 407-413页

作者： Darryl. E. Carlyle-Moses Chad. E. Lishman Adam. J. McKee Department of Geography & Environmental Studies Thompson Rivers University graduate program in Environmental Science Thompson Rivers University

Rainfall, throughfall and stemflow were measured and canopy interception loss was derived for 14 rainfall events from June 22 to August 30, 2008 within a mature declining hybrid white spruce （Picea glauca （Moench） Voss x p engelmannii Parry ex Engelm.） - subalpine fir （Abies lasiocarpa （Hook.） Nutt.） - lodgepole pine （Pinus contorta vat. latifolia Dougl. ex Loud.） stand in south-central British Columbia, Can- ada. Stemflow was negligible during the study period, while, respectively throughfall and canopy interception loss accounted for approximately 59.4% and 40.6% of the 50.1 mm of cumulative rainfall. Throughfall variability was assessed with three approaches involving roving and stationary wedge-type gauges, and stationary trough gauges. Throughfall exhibited large spatial variability with the coefficient of variability of study period throughfall sampled using 16 stationary trough gauges being 30.3%, while it was 38.0% and 28.7% for 32 stationary and 32 roving wedge gauges, respectively. Our analysis suggests that a roving gauge method is better than a stationary approach since the errors associated with event mean throughfalls are summed quadratically and a greater portion of the canopy area is sampled. Trough gauges were more efficient than wedge gauges; however, this efficiency was less than expected given their much larger sampling areas, suggesting that spatial autocorrelation lengths of throughfall may be longer than the trough systems. The spatial distribution of throughfall showed a high degree of temporal persistence throughout the study suggesting the existence of stable ＂wet＂ and ＂dry＂ inputs to the floors of these coniferous forests.

关键词： throughfall canopy interception loss stemflow spatial variability temporal persistence

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Epidemiology, demographic characteristics and prognostic predictors of ulcerative colitis

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World Journal of Gastroenterology 2014年第28期20卷 9458-9467页

作者： Bruno César da Silva Andre Castro Lyra Raquel Rocha Genoile Oliveira Santana post-graduate program in Medicine and Health Federal University of Bahia Gastroenterology Department of the University Hospital Professor Edgard Santos Federal University of Bahia Gastro-Hepatology Service of Hospital S?o Rafael Department of Sciences of Nutrition School of NutritionFederal University of Bahia

Ulcerative colitis(UC)is a chronic disease characterized by diffuse inflammation of the mucosa of the colon and *** hallmark clinical symptom of UC is bloody *** clinical course is marked by exacerbations and remissions,which may occur spontaneously or in response to treatment changes or intercurrent *** is most commonly diagnosed in late adolescence or early adulthood,but it can occur at any *** incidence of UC has increased worldwide over recent decades,especially in developing *** contrast,during this period,therapeutic advances have improved the life expectancy of patients,and there has been a decrease in the mortality rate over *** is important to emphasize that there is considerable variability in the phenotypic presentation of *** this context,certain clinical and demographic characteristics are useful in identifying patients who tend to have more severe evolution of the disease and a poor *** this group of patients,better clinical surveillance and more intensive therapy may change the natural course of the *** aim of this article was to review the epidemiology and demographic characteristics of UC and the factors that may be associated with its clinical prognosis.

关键词： Ulcerative colitis Incidence Prevalence Risk factors Predictive factors

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High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon Kim Jun Young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

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CAD and CAE Integration Through Scientific Visualization Techniques for Illumination Design

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Tsinghua Science and Technology 2008年第S1期13卷 26-33页

作者： Tiago Martinuzzi Buriol Sergio Scheer graduate program in Numerical Methods for Engineering Civil Engineering Research Center Federal University of Parana

Engineers tend to use different software to perform tasks such as geometry modeling, database management, numerical analysis, and visualization. This may cause decrease of productivity and loss of information during the conversion process between different data file formats. This paper presents a computer aided design (CAD) and computer aided engineering (CAE) system integration using scientific visualization tools and techniques. It deals with the development of a 3D CAD add-in for lighting analysis which uses the CAD model as 3D interface for creating a lighting scheme, processing, and visualizing 2D or 3D illuminance fields. Visualization features as color and contour mapping were developed using the visualization toolkit (VTK) toolkit. The application integrates all functionalities of the 3D CAD with tools for light sources database management, pre-processing, processing, and post-processing of illuminance fields in a single environment. This approach increases productivity and eliminates the need for different software.

关键词： illumination design scalar fields post-processing 3D computer aided design (CAD) visualization toolkit (VTK) systems integration

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