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Comparison of acute pneumonia caused by SARS-CoV-2 and other respiratory viruses in children:a retrospective multi-center cohort study during COVID-19 outbreak

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Military Medical Research 2021年第4期8卷 468-480页

作者： Guang-Li Ren Xian-Feng Wang Jun Xu Jun Li Qiong Meng Guo-Qiang Xie Bo Huang Wei-Chun Zhu Jing Lin Cheng-He Tang Sheng Ye Zhuo Li Jie Zhu Zhen Tang Ming-Xin Ma Cong Xie Ying-Wen Wu Chen-Xi Liu Fang Yang Yu-Zong Zhou Ying Zheng Shu-Ling Lan Jian-Feng Chen Feng Ye Yu He BenQing Wu Long Chen Si-Mao Fu Cheng-Zhong Zheng Yuan Shi department of pediatrics General Hospital of Southern Theater Command of PLA111 Liuhua RoadYuexiu DistrictGuangzhou 510010GuangdongChina. department of pediatrics the Third People’s Hospital of ShenzhenShenzhen 518100GuangdongChina. Pediatric Intensive Care Unit Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430010China. Pediatric Intensive Care Unit Maternal and Child Health Hospital of HuangshiHuangshi 435000HubeiChina. department of pediatrics the Second People’s Hospital of Guangdong ProvinceGuangzhou 510317China. department of pediatrics the Third Affiliated Hospital of Zunyi Medical University(the First People’s Hospital of Zunyi)Guizhou 563000China. department of pediatrics the Eighth People’s Hospital of GuangzhouGuangzhou 510440China. department of pediatrics the First Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453100HenanChina. Pediatric Intensive Care Unit the Children’s Hospital Zhejiang University School of MedicineHangzhou 310000China. department of Emergency/Critical Medicine Children’s Hospital of Nanjing Medical UniversityNanjing 210008China. department of pediatrics the Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510260China. department of Medical information date room General Hospital of Southern Theater Command of PLAGuangzhou 510010China. department of pediatrics the First Affiliated Hospital of Jinan UniversityGuangzhou 510632China. department of pediatrics Maternal and Child Health Hospital of YangjiangYangjiang 529500GuangdongChina. department of pediatrics Shenzhen Hospital Affiliated to the University of Chinese Academy of SciencesShenzhen 518107GuangdongChina. department of pediatrics Nanfang Hospital of Southern Medical UniversityGuangzhou 510515China. department of pediatrics Zhujiang Hospital of Southern Medical UniversityGuangzhou 510280China. department of pediatrics Military Hospital of 74 Group of PLAGuangzhou 510318China. department of Neonatology

Background:Until January 18,2021,coronavirus disease-2019(COVID-19)has infected more than 93 million individuals and has caused a certain degree of *** pneumonia caused by common viruses such as respiratory syncytial virus,rhinovirus,human metapneumovirus,human bocavirus,and parainfluenza viruses have been more common in ***,the incidence of COVID-19 in children was significantly lower than that in *** purpose of this study was to describe the clinical manifestations,treatment and outcomes of COVID-19 in children compared with those of other sources of viral pneumonia diagnosed during the COVID-19 ***:Children with COVID-19 and viral pneumonia admitted to 20 hospitals were enrolled in this retrospective multi-center cohort study.A total of 64 children with COVID-19 were defined as the COVID-19 cohort,of which 40 children who developed pneumonia were defined as the COVID-19 pneumonia *** 284 children with pneumonia caused by other viruses were defined as the viral pneumonia *** epidemiologic,clinical,and laboratory findings were compared by Kolmogorov-Smirnov test,t-test,Mann-Whitney U test and Contingency table *** usage,immunotherapy,blood transfusion,and need for oxygen support were collected as the treatment ***,intensive care needs and symptomatic duration were collected as the outcome ***:Compared with the viral pneumonia cohort,children in the COVID-19 cohort were mostly exposed to family members confirmed to have COVID-19(53/64 vs.23/284),were of older median age(6.3 years vs.3.2 years),and had a higher proportion of ground-glass opacity(GGO)on computed tomography(18/40 vs.0/38,P<0.001).Children in the COVID-19 pneumonia cohort had a lower proportion of severe cases(1/40 vs.38/284,P=0.048),and lower cases with high fever(3/40 vs.167/284,P<0.001),requiring intensive care(1/40 vs.32/284,P<0.047)and with shorter symptomatic duration(median 5d vs.8d,P<0.001).The propor

关键词： Children Severe acute respiratory syndrome Coronavirus disease-2019 Viral pneumonia

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Best practice for infection prevention in pediatric respiratory clinics during the COVID‑19 epidemic

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World Journal of pediatrics 2020年第4期16卷 326-332页

作者： Jing Zhang Lei Zhang Yong Yin Quan Lu Jian‑Guo Hong Xiao‑Bo Zhang Xiao‑Jian Zhou Li‑Bo Wang Jian‑Hua Zhang Min Lu Xiao‑Yan Dong Jie Shao Yan‑Ming Lu Jun Yu Li Gu Respiratory Disease Group,Pediatric Committee of Shanghai Medical Association,Shanghai,China department of Respiratory Medicine Shanghai Children’s Medical CenterShanghai Jiao Tong University School of MedicineNo.1678 Dongfang RoadShanghaiChina department of Respiratory Medicine Children’s Hospital of Shanghai Jiao Tong UniversityShanghaiChina department of pediatrics Shanghai General HospitalShanghai Jiao Tong UniversityShanghaiChina department of Respiratory Medicine Children’s Hospital of Fudan UniversityShanghaiChina department of Respiratory Medicine XinHua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina department of pediatrics Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina department of pediatrics Renji HospitalShanghai Jiao Tong University School of MedicineShanghaiChina department of pediatrics Shanghai FengXian District Central HospitalShanghaiChina department of pediatrics Shanghai Tenth People’s HospitalTong Ji UniversityShanghaiChina 不详

During the COVID-19 epidemic,it is important for ensuring infection prevention and control in the pediatric respiratory ***,we introduced the practice of infection prevention and control in pediatric respiratory clinics in *** measures for patients who visit respiratory clinics,quality control for pediatric respiratory clinics and other preventive measures for related examinations and treatment have been introduced in this review article.

关键词： prevention pediatric respiratory

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Efficacy of thalidomide therapy in pediatric Crohn's disease with evidence of tuberculosis

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World Journal of Gastroenterology 2017年第43期23卷 7727-7734页

作者： Lin Wang Yan Hong Jie Wu Ying-Kit Leung Ying Huang department of Gastroenterology Pediatric Inflammatory Bowel Disease Research CenterChildren’s Hospital of Fudan University department of pediatrics Taizhou Women’s and Children’s Hospital of Wenzhou Medical University

AIM To evaluate the efficacy of thalidomide for treating troublesome cases of pediatric Crohn's disease(CD) with tuberculosis *** A retrospective study of clinical outcome among children treated with thalidomide was conducted. All patients had evidence of tuberculosis infection with a failure of anti-tuberculosis treatment for more than one year,and were subsequently diagnosed with CD. All the patients received thalidomide treatment with a starting dose of 1.2-2.5 mg/kg per day. Remission was defined as pediatric CD activity index less than or equal to *** Ten patients with CD were treated with thalidomide at an average age of 7.2 years and followed up for a median of 22.2 mo. Clinical remission rate was 60% after 9-12 mo of thalidomide treatment. One patient with no response had an interleukin-10 receptor alpha gene mutation. Erythrocyte sedimentation rate,C-reactive protein and platelet count showed a dramatic decrease; hemoglobin level and weight improved significantly after thalidomide treatment when compared with the baseline *** Thalidomide is an effective and safe drug for remission of CD in pediatric patients who have been treated for tuberculosis.

关键词： Inflammatory bowel disease Intestinal tuberculosis Anti-tubercular treatment Thalidomide Children

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Problem of Obstetrical Evacuations: About 630 Cases Collected at the Maternity of bouake university hospital

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Open Journal of Obstetrics and Gynecology 2018年第3期8卷 253-262页

作者： Lydie Estelle Djanhan Jean Marc Dia Messou Michelle Menin Yaya Samaké Claussen M’broh Kouadio Narcisse Kouadio Kouamé Privat Kouakou Yacouba Doumbia department of Gynecology and Obstetrics University and Hospital Center of Bouaké (CHUB) Bouaké Cote d’Ivoire department of Gynecology and Obstetrics University and Hospital Center of Treichville (CHUT) Abidjan Cote d’Ivoire

Objective: To improve the care of evacuees at the maternity of the university hospital center of bouaké (CHUB). Methodology: This is a cross-sectional and descriptive study over a period of three months that covered 630 cases collected at the Maternity of the university hospital of bouaké. Results: Obstetric evacuation accounted for 42.5% of admissions to the delivery room. Patients under 20 years and over 34 years of age respectively represented 21% and 13.5% of the total. 62.7% of evacuees were not educated and 84.9% had low economic level. Nulliparous and multiparous women accounted for 54.9% of the patients and 88% had mean prenatal follow up. The evacuations were decided by midwives (91.3%), without previous adapted treatment (79.4%), with a badly filled evacuation card (49.7%) and no partograph. The taxi was the most used means of transportation (75.2%) and most evacuees took less than one hour to access the referral center (61.4%). The reasons for evacuation are mainly dominated by mechanical obstructions (34.8%);on admission the evacuees with no real reference reason were 243 (38.6%) and the diagnosis was inconsistent in 43% of cases. The majority of evacuated women delivered vaginally (69.4%). Most newborns had a satisfactory state at the 5th minute of life (79.4%) and we noted 54 cases (08.3%) of neonatal deaths. 7.8% of evacuees had a complication dominated by postpartum anemia (51.1%);we had lamented 17 cases (2.7%) of maternal deaths among evacuees, attributable to delivery haemorrhage (47.1%) and eclampsia (23.5%). Conclusion: A better organization of the reference and an equipment of the peripheral health structures would improve the prognosis of the evacuees.

关键词： Obstetric Emergencies Evacuations Reference Maternal Mortality

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Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts' consensus statement

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World Journal of pediatrics 2020年第3期16卷 223-231页

作者： Kunling Shen Yonghong Yang Tianyou Wang Dongchi Zhao Yi Jiang Runming Jin Yuejie Zheng Baoping Xu Zhengde Xie Likai Lin Yunxiao Shang Xiaoxia Lu Sainan Shu Yan Bai Jikui Deng Min Lu Leping Ye Xuefeng Wang Yongyan Wang Liwei Gao Global Pediatric Pulmonology Alliance department of Respiratory Medicine Beijing Children's HospitalCapital Medical UniversityBeijingChina Beijing Pediatric Research Institute Beijing Children's HospitalCapital Medical UniversityBeijingChina center of Hematologic Oncology Beijing Children's HospitalCapital Medical UniversityBeijingChina department of pediatrics Zhongnan Hospital of Wuhan UniversityWuhanChina department of pediatrics Renmin Hospital of Wuhan UniversityWuhanChina department of pediatrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina department of Respiratory Medicine Shenzhen Children's HospitalShenzhenChina hospital Management Institute of Wuhan university Zhongnan Hospital of Wuhan UniversityWuhanChina department of Pediatric Respiratory Shengjing Hospital of China Medical UniversityShenyangChina department of Respiratory Medicine Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina department of pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina department of Infectious Disease Shenzhen Children's HospitalShenzhenChina department of Respiratory Medicine Children's Hospital of ShanghaiShanghaiChina department of pediatrics Peking University First HospitalBeijingChina department of pediatrics Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyangChina Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijingChina

Since the outbreak of 2019 novel coronavirus infection (2019-nCoV) in Wuhan City,China,by January 30,2020,a total of 9692 confirmed cases and 15,238 suspected cases have been reported around 31 provinces or cities in *** the confirmed cases,1527 were severe cases,171 had recovered and been discharged at home,and 213 *** among these cases,a total of 28 children aged from 1 month to 17 years have been reported in *** standardizing prevention and management of 2019-nCoV infections in children,we called up an experts' committee to formulate this experts' consensus *** statement is based on the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards (the fourth edition) (National Health Committee) and other previous diagnosis and treatment strategies for pediatric virus *** present consensus statement summarizes current strategies on diagnosis,treatment,and prevention of 2019-nCoV infection in children.

关键词： prevention diagnosis treatment

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Surgical Management of a Giant Hydrocele of the Vagina in Adult

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Surgical Science 2020年第9期11卷 274-280页

作者： Anzoua Kouakou Ibrahim Kouakou Kouame Bernadin Traore Mamadou Gnangoran Koffi Marcelin Leh Bi Kalou Ismael N’Dri Ahou Bernadette Ekra Amos Kouakou Amos Bamba Inza Avion Kouassi Patrick Assohoun Krahibouet Toussaint Lebeau Roger Diane Bamourou General and Digestive Surgery department Bouaké Hospital and University Center Bouaké C&ocirc te d’Ivoire General and Digestive Surgery department Yopougon Hospital and University Center Yopougon C&ocirc te d’Ivoire

Introduction: Vaginal hydrocele is an amber-colored, sterile collection found between the parietal and visceral testis. It is said to be giant when it is larger than the patient’s skull or when it contains more than two liters of liquid. Objective: To report our method and the result of the surgical treatment. Observation: The authors reported an observation of a 50-year-old patient who consulted for a painless large left bursa. Clinical and paraclinical investigations, in particular scrotal ultrasound, have made it possible to diagnose a giant hydrocele of the vagina. The patient had surgical treatment which consisted of resecting of the vagina with hemostatic suture of the resected vaginal slice. The post-operation effects were not complicated. After a six-month setup, we did not notice any recurrence. Conclusion: Resection of the vagina with hemostatic suture of the resected vaginal slice in case of giant hydrocele could certainly give good results.

关键词： Giant Hydrocele Surgical Treatment

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Interactions between long interpregnancy interval and advanced maternal age on neonatal outcomes

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World Journal of pediatrics 2023年第12期19卷 1155-1161页

作者： Yan Ma Hua Fu Yang li Zheng‑Rong Bao Wen‑Bin Dong Xiao‑Ping Lei Division of Neonatology Department of PediatricsThe Affiliated Hospital of Southwest Medical UniversityXiaoping Lei8 Kangcheng RoadLuzhou 646000China department of Perinatology The Afliated Hospital of Southwest Medical UniversityLuzhouChina Sichuan Clinical Research center for Birth Defects LuzhouChina School of pediatrics Southwest Medical UniversityLuzhouChina

Background After the implementation of the universal two-child policy in China,it was more frequent to have long interpregnancy intervals(IPIs)and advanced maternal ***,the interactions between long IPIs and advanced maternal age on neonatal outcomes are *** The study subjects of this historical cohort study were multiparas with singleton live births between October 1st,2015,and October 31st,*** was defned as the interval between delivery and conception of the subsequent *** regression models were used to calculate adjusted odds ratios(aORs)and 95%confdence intervals(CIs)of the risks of preterm birth(PTB),low birth weight(LBW),small for gestation age,and 1-min Apgar score≤7 in diferent IPI *** excess risk due to interaction(RERI)was used to evaluate the additive interaction between long IPIs and advanced maternal *** Compared with the 24≤IPI≤59 months group,the long IPI group(IPI≥60 months)was associated with a higher risk of PTB(aOR,1.27;95%CI:1.07–1.50),LBW(aOR,1.32;95%CI 1.08–1.61),and one-minute Apgar score≤7(aOR,1.46;95%CI 1.07–1.98).Negative additive interactions(all RERIs<0)existed between long IPIs and advanced maternal age for these neonatal ***,IPI<12 months was also associated with PTB(aOR,1.51;95%CI 1.13–2.01),LBW(aOR,1.50;95%CI 1.09–2.07),and 1-min Apgar score≤7(aOR,1.93;95%CI 1.23–3.04).Conclusions Both short and long IPIs are associated with an increased risk of adverse neonatal *** IPI should be recommended to women planning to become pregnant *** addition,better antenatal care might be taken to balance the inferiority of advanced maternal age and to improve neonatal outcomes.

关键词： Interaction Interpregnancy interval Low birth weight Maternal age Preterm birth

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Hedgehog signaling pathway gene variant influences bronchopulmonary dysplasia in extremely low birth weight infants

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World Journal of pediatrics 2021年第3期17卷 298-304页

作者： Shaili Amatya Sharina Rajbhandari Sandeep Pradhan Van Trinh Umesh Paudel Lance A.Parton Newborn Medicine Division The Regional Neonatal Intensive Care UnitMaria Fareri Children's Hospital At Westchester Medical CenterValhallaNYUSA department of pediatrics New York Medical CollegeValhallaNYUSA department of pediatrics Penn State Children’s HospitalHersheyPAUSA Novant Health Presbyterian Medical center CharlotteNCUSA department of Public Health Penn State UniversityHersheyPAUSA department of pediatrics Harlem Hospital-Columbia University Irving Medical CenterNew YorkNYUSA

Background Genome wide association study identified hedgehog interacting protein gene(HHIP)variants with chronic obstructive pulmonary disease and *** of HHIP,a key regulator of the hedgehog signaling pathway,leads to impaired lung morphogenesis and lethality in animal models,through unimpeded sonic hedgehog expression blocking mesenchymal-expressed fibroblast growth factor 10(FGF10).Since bronchopulmonary dysplasia(BPD)is also associated with altered lung development and worsens with stimuli including mechanical ventilation,reactive oxygen species,and inflammation,HHIP and FGF10 may be candidate *** This was an observational,cohort study including extremely low birth weight infants that who developed BPD and those who did *** was isolated from buccal swabs and subjected to allelic discrimination,using specific HHIP and FGF10 *** levels were measured in tracheal ***'s t test,Chi-square,Z test and logistic regression were *** Demographic characteristics did not differ except that birth weight(715±153 vs.835±132 g)and gestational age(25 vs.26 weeks)were less in babies with *** variant rs 13147758(GG genotype)was found to be independently protective for BPD(odds ratio 0.35,95%confidence interval 0.15-0.82,P=-0.02).Early airway HHIP protein levels were increased in infants with BPD compared to those without[median(interquartile range)130.6(55.6-297.0)and 41.2(22.1-145.6)pg/mL,respectively;P=0.05].The FGF10 single nucleotide polymorphisms were not associated with *** HHIP,as a regulator of lung bud formation,affects BPD susceptibility,and may be valuable in understanding the specific mechanisms for this disease as well as for identifying therapeutic targets in the era of personalized medicine.

关键词： Gene Infants Lung Preterm Single nucleotide polymorphism

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Genotypic and phenotypic spectra of NBEA-related neurodevelopmental disorder with epilepsy:a case series and literature review

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World Journal of pediatrics 2022年第9期18卷 636-641页

作者： Zou Pan Chen Chen Fei Yin Jing Peng department of pediatrics Xiangya Hospital of Central South UniversityChangsha410008China Clinical Research center for Children Neurodevelopmental Disabilities of Hunan Province Xiangya HospitalCentral South UniversityChangsha410008China

NBEA(MIM#604,889)is a novel disease causative gene that responds for neurodevelopment disorder with or without generalized epilepsy(NEDEGE,MIM#619,157).It encodes neurobeachin protein,a multi-domain neuro-specific scaf-folding protein that plays a vital role in vesicle trafficking and synaptic *** was initially observed in an idiopathic autism patient,and thus NBEA has been regarded as a candidate autism gene for nearly two decades[1-4].In 2018,Mulhern et *** 24 individuals with de novo heterozygous NBEA variants with neurodevelopmental delay with autism and early onset generalized epilepsy,which led the Online Mendian Inheritance in Man(OMIM)team to identify it as a disease-causing gene for NEDEGE[5].Since then,only a few NBEA-related cases with similar clinical phenotypes have been reported[6-8].

关键词： epilepsy structure.

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Endoscopic cyanoacrylate injection for the treatment of gastric varices in children

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World Journal of Gastroenterology 2015年第9期21卷 2719-2724页

作者： Seak Hee Oh Seung Jin Kim Kang Won Rhee Kyung Mo Kim department of pediatrics Asan Medical Center Children’s HospitalUniversity of Ulsan College of MedicineSeoul 138-736South Korea

AIM:To evaluate the efficacy and safety of N-butyl-2-cyanoacrylate in treating acute bleeding of gastric varices in ***:The retrospective study included 21 children with 47 episodes of active gastric variceal bleeding who were treated by endoscopic injection of N-butyl-2-cyanoacrylate at Asan Medical center Children's hospital between August 2004 and December *** reduce the risk of embolism,each injection consisted of 0.1-0.5 mL of 0.5 mL N-butyl-2-cyanoacrylate diluted with 0.5 or 0.8 mL *** primary outcome was incidence of hemostasis after variceal obliteration and the secondary outcome was complication of the ***:The 21 patients experienced 47 episodes of active gastric variceal bleeding,including rebleeding,for which they received a total of 52 cyanoacrylate *** 42 bleeding episodes,hemostasis was achieved after one injection and following five bleeding episodes it was achieved after two *** mean volume of each single aliquot of cyanoacrylate injected was 0.3 ± 0.1 mL(range:0.1-0.5 m L).Injection achieved hemostasis in 45 of 47(95.7%) episodes of acute gastric variceal *** patients(52.4%) developed rebleeding events,with the mean duration of hemostasis being 11.1 ± 11.6 mo(range:1.0-39.2 mo).No treatment-related complications such as distal embolism were noted with the exception of abdominal pain in one patient(4.8%).Among four mortalities,one patient died of variceal ***:Endoscopic variceal obliteration using a small volume of aliquots with repeated cyanoacrylate injection was an effective and safe option for the treatment of gastric varices in children.

关键词： Cyanoacrylate Gastric varix Children Endoscopic va

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