Comparison of acute pneumonia caused by SARS-CoV-2 and other respiratory viruses in children:a retrospective multi-center cohort study during COVID-19 outbreak

作     者：Guang-Li Ren Xian-Feng Wang Jun Xu Jun Li Qiong Meng Guo-Qiang Xie Bo Huang Wei-Chun Zhu Jing Lin Cheng-He Tang Sheng Ye Zhuo Li Jie Zhu Zhen Tang Ming-Xin Ma Cong Xie Ying-Wen Wu Chen-Xi Liu Fang Yang Yu-Zong Zhou Ying Zheng Shu-Ling Lan Jian-Feng Chen Feng Ye Yu He BenQing Wu Long Chen Si-Mao Fu Cheng-Zhong Zheng Yuan Shi Guang-Li Ren;Xian-Feng Wang;Jun Xu;Jun Li;Qiong Meng;Guo-Qiang Xie;Bo Huang;Wei-Chun Zhu;Jing Lin;Cheng-He Tang;Sheng Ye;Zhuo Li;Jie Zhu;Zhen Tang;Ming-Xin Ma;Cong Xie;Ying-Wen Wu;Chen-Xi Liu;Fang Yang;Yu-Zong Zhou;Ying Zheng;Shu-Ling Lan;Jian-Feng Chen;Feng Ye;Yu He;Ben-Qing Wu;Long Chen;Si-Mao Fu;Cheng-Zhong Zheng;Yuan Shi

作者机构：Department of PediatricsGeneral Hospital of Southern Theater Command of PLA111 Liuhua RoadYuexiu DistrictGuangzhou 510010GuangdongChina. Department of Pediatricsthe Third People’s Hospital of ShenzhenShenzhen 518100GuangdongChina. Pediatric Intensive Care UnitWuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430010China. Pediatric Intensive Care UnitMaternal and Child Health Hospital of HuangshiHuangshi 435000HubeiChina. Department of Pediatricsthe Second People’s Hospital of Guangdong ProvinceGuangzhou 510317China. Department of Pediatricsthe Third Affiliated Hospital of Zunyi Medical University(the First People’s Hospital of Zunyi)Guizhou 563000China. Department of Pediatricsthe Eighth People’s Hospital of GuangzhouGuangzhou 510440China. Department of Pediatricsthe First Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453100HenanChina. Pediatric Intensive Care Unitthe Children’s Hospital Zhejiang University School of MedicineHangzhou 310000China. Department of Emergency/Critical MedicineChildren’s Hospital of Nanjing Medical UniversityNanjing 210008China. Department of Pediatricsthe Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510260China. Department of Medical information date roomGeneral Hospital of Southern Theater Command of PLAGuangzhou 510010China. Department of Pediatricsthe First Affiliated Hospital of Jinan UniversityGuangzhou 510632China. Department of PediatricsMaternal and Child Health Hospital of YangjiangYangjiang 529500GuangdongChina. Department of PediatricsShenzhen Hospital Affiliated to the University of Chinese Academy of SciencesShenzhen 518107GuangdongChina. Department of PediatricsNanfang Hospital of Southern Medical UniversityGuangzhou 510515China. Department of PediatricsZhujiang Hospital of Southern Medical UniversityGuangzhou 510280China. Department of PediatricsMilitary Hospital of 74 Group of PLAGuangzhou 510318China. Department of NeonatologyChildren’s Hospital of Chongqing Medical University/Ministry of Education Key Laboratory of Child/Development and Disorders/National Clinical Research Center for Child Health and Disorders/Chongqing Key Laboratory of PediatricsChongqing 400014China. Department of PediatricsZhongshan Boai HospitalZhongshan 528403GuangdongChina. Department of PediatricsStrategic Support Force Medical Center of PLABeijing 100101China. 

出 版 物：《Military Medical Research》 (军事医学研究（英文版）)

年 卷 期：2021年第8卷第4期

页      面：468-480页

核心收录：

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

基　　金：Scientific Research Project of Military Logistics Department Grant Award Number:CLB20J032 

主　　题：Children Severe acute respiratory syndrome Coronavirus disease-2019 Viral pneumonia 

摘      要：Background:Until January 18,2021,coronavirus disease-2019(COVID-19)has infected more than 93 million individuals and has caused a certain degree of *** pneumonia caused by common viruses such as respiratory syncytial virus,rhinovirus,human metapneumovirus,human bocavirus,and parainfluenza viruses have been more common in ***,the incidence of COVID-19 in children was significantly lower than that in *** purpose of this study was to describe the clinical manifestations,treatment and outcomes of COVID-19 in children compared with those of other sources of viral pneumonia diagnosed during the COVID-19 ***:Children with COVID-19 and viral pneumonia admitted to 20 hospitals were enrolled in this retrospective multi-center cohort study.A total of 64 children with COVID-19 were defined as the COVID-19 cohort,of which 40 children who developed pneumonia were defined as the COVID-19 pneumonia *** 284 children with pneumonia caused by other viruses were defined as the viral pneumonia *** epidemiologic,clinical,and laboratory findings were compared by Kolmogorov-Smirnov test,t-test,Mann-Whitney U test and Contingency table *** usage,immunotherapy,blood transfusion,and need for oxygen support were collected as the treatment ***,intensive care needs and symptomatic duration were collected as the outcome ***:Compared with the viral pneumonia cohort,children in the COVID-19 cohort were mostly exposed to family members confirmed to have COVID-19(53/64 vs.23/284),were of older median age(6.3 years vs.3.2 years),and had a higher proportion of ground-glass opacity(GGO)on computed tomography(18/40 vs.0/38,P0.001).Children in the COVID-19 pneumonia cohort had a lower proportion of severe cases(1/40 vs.38/284,P=0.048),and lower cases with high fever(3/40 vs.167/284,P0.001),requiring intensive care(1/40 vs.32/284,P0.047)and with shorter symptomatic duration(median 5d vs.8d,P0.001).The propor