Interactions between long interpregnancy interval and advanced maternal age on neonatal outcomes

作     者：Yan Ma Hua Fu Yang li Zheng‑Rong Bao Wen‑Bin Dong Xiao‑Ping Lei Yan Ma;Hua Fu;Yang li;Zheng-Rong Bao;Wen-Bin Dong;Xiao-Ping Lei

作者机构：Division of NeonatologyDepartment of PediatricsThe Affiliated Hospital of Southwest Medical UniversityXiaoping Lei8 Kangcheng RoadLuzhou 646000China Department of PerinatologyThe Afliated Hospital of Southwest Medical UniversityLuzhouChina Sichuan Clinical Research Center for Birth DefectsLuzhouChina School of PediatricsSouthwest Medical UniversityLuzhouChina 

出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)

年 卷 期：2023年第19卷第12期

页      面：1155-1161页

核心收录：

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

基　　金：Funding for this project was provided by the Sichuan Science and Technology Program grant No.2019YJ0696 and the Science and Technology Strategic Cooperation Programs of Luzhou Municipal People’s Government and Southwest Medical University Grant No.2021LZXNYD-J21 to Xiaoping Lei 

主　　题：Interaction Interpregnancy interval Low birth weight Maternal age Preterm birth 

摘      要：Background After the implementation of the universal two-child policy in China,it was more frequent to have long interpregnancy intervals(IPIs)and advanced maternal ***,the interactions between long IPIs and advanced maternal age on neonatal outcomes are *** The study subjects of this historical cohort study were multiparas with singleton live births between October 1st,2015,and October 31st,*** was defned as the interval between delivery and conception of the subsequent *** regression models were used to calculate adjusted odds ratios(aORs)and 95%confdence intervals(CIs)of the risks of preterm birth(PTB),low birth weight(LBW),small for gestation age,and 1-min Apgar score≤7 in diferent IPI *** excess risk due to interaction(RERI)was used to evaluate the additive interaction between long IPIs and advanced maternal *** Compared with the 24≤IPI≤59 months group,the long IPI group(IPI≥60 months)was associated with a higher risk of PTB(aOR,1.27;95%CI:1.07–1.50),LBW(aOR,1.32;95%CI 1.08–1.61),and one-minute Apgar score≤7(aOR,1.46;95%CI 1.07–1.98).Negative additive interactions(all RERIs0)existed between long IPIs and advanced maternal age for these neonatal ***,IPI12 months was also associated with PTB(aOR,1.51;95%CI 1.13–2.01),LBW(aOR,1.50;95%CI 1.09–2.07),and 1-min Apgar score≤7(aOR,1.93;95%CI 1.23–3.04).Conclusions Both short and long IPIs are associated with an increased risk of adverse neonatal *** IPI should be recommended to women planning to become pregnant *** addition,better antenatal care might be taken to balance the inferiority of advanced maternal age and to improve neonatal outcomes.