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Phase-contrast imaging Simulation Based on a Micro-cT System

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chinese Journal of biomedical Engineering(English Edition) 2016年第2期25卷 87-92页

作者： GUI Jian-bao ZOU Jing RONG Jun-yan HU Zhan-li ZHANG Qi-yang ZHENG Hai-rong XIA Dan Paul C.Lauterbur Research Center for Biomedical Imaging Institute of Biomedical and Health EngineeringShenzhen Institutes of Advanced TechnologyChinese Academy of Sciences

Propagation-based phase-contrast imaging was simulated based on paraxial Fresnel-Kirchoff diffraction integral and spherical wave illumination. Under a developed micro-cT system parameters, the effects of focal-spot size and imaging geometry on phase-contrast imaging have been investigated using a 2-mm-thickness polystyrene edge phantom. An equivalent mono-energy was used to substitute the polychromatic spectrum of the micro-focus X-ray source. To consider effects of focal-spot size and detector resolution, the obtained phase-contrast image with an ideal point source was convolved with source intensity distribution and point spread function of detector. Simulations show reasonable influences of the two parameters which are in good agreement with experimental results.

关键词： micro-cT phase-contrast imaging X-ray micro-focus source simulation

近红外二区荧光可视化超声联合吲哚菁绿微泡开放血脑屏障增强脑胶质瘤光热治疗

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Science Bulletin 2022年第22期67卷 2316-2326页

作者：梁思敏胡德红黎国锋高笃阳李飞郑海荣潘敏盛宗海 Department of Ultrasonography Shenzhen Hospital(Futian)of Guangzhou University of Chinese MedicineShenzhen 518034China Paul C.Lauterbur Research Center for Biomedical Imaging CAS Key Laboratory of Health InformaticsShenzhen Key Laboratory of Ultrasound Imaging and TherapyInstitute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China School of biomedical Engineering Guangdong Medical UniversityDongguan 523808China

聚焦超声开放血脑屏障是增强胶质母细胞瘤治疗的关键,然而,缺乏一种高时空分辨率的体内成像方法用于原位同步监测血脑屏障开放过程.本文报道了使用吲哚菁绿掺杂的微泡(MBs-IcG)可视化聚焦超声开放血脑屏障和增强对抗胶质母细胞瘤的光热... 详细信息

聚焦超声开放血脑屏障是增强胶质母细胞瘤治疗的关键,然而,缺乏一种高时空分辨率的体内成像方法用于原位同步监测血脑屏障开放过程.本文报道了使用吲哚菁绿掺杂的微泡(MBs-IcG)可视化聚焦超声开放血脑屏障和增强对抗胶质母细胞瘤的光热治疗方法.结果显示, MBs-IcG具有明亮的近红外二区荧光,超声造影成像和超声响应特性.利用其互补的成像特性, MBs-IcG可实现脑血管的高分辨率(~168.9μm)近红外二区荧光成像、大穿透深度(~7 mm)超声造影成像.通过近红外二区荧光成像, MBs-IcG联合聚焦超声可原位同步可视化血脑屏障开放,信噪比为6.2±1.2.此外,在聚焦超声辐照下, MBs-IcG转化为脂质IcG纳米颗粒,并在10 min内迅速进入肿瘤组织,成功用于增强原位胶质母细胞瘤小鼠的光热治疗.多功能MBs-IcG为监测血脑屏障开放和增强胶质母细胞瘤治疗提供了一种新的范式.

关键词：吲哚菁绿光热治疗胶质母细胞瘤血脑屏障聚焦超声荧光成像近红外脑胶质瘤

Biomimetic nanoparticles directly remodel immunosuppressive microenvironment for boosting glioblastoma immunotherapy

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Bioactive Materials 2022年第10期7卷 418-432页

作者： Tingting Wang Hao Zhang Weibao Qiu Yaobao Han Hanghang Liu Zhen Li center for Molecular imaging and Nuclear Medicine State Key Laboratory of Radiation Medicine and ProtectionSchool for Radiological and Interdisciplinary Sciences(RAD-X)Soochow UniversityCollaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSuzhou215123PR China Paul C.Lauterbur Research Center for Biomedical Imaging Institute of Biomedical and Health EngineeringShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen518055PR China

Glioblastoma(GBM),as a very aggressive cancer of central nervous system,is very challenging to completely cure by the conventional combination of surgical resection with radiotherapy and chemotherapy.The success of emerging immunotherapy in hot tumors has attracted considerable interest for the treatment of GBM,but the unique tumor immunosuppressive microenvironment(TIME)of GBM leads to the failure of immunotherapy.Here,we show the significant improvement of the immunotherapy efficacy of GBM by modulating the TIME through novel all-in-one biomimetic nanoparticles(i.e.cS-I/J@cM NPs).The nanoparticles consist of utrasmall cu2-xSe nanoparticles(NPs)with outstanding intrinsic properties(e.g.,photo-responsive Fenton-like catalytic property for inducing immunogenic cell death(IcD)and alleviating the hypoxia of tumor),indoximod(IND,an inhibitor of indoleamine-2,3-dioxygenease in tumor),JQ1(an inhibitor for reducing the expression of PD-L1 by tumor cells),and tumor cell membrane for improving the targeting capability and accumulation of nanoparticles in tumor.We reveal that these smart cS-I/J@cM NPs could drastically activate the immune responses through remodeling TIME of GBM by multiple functions.They could(1)increase M1-phenotype macrophages at tumor site by promoting the polarization of tumor-associated macrophages through the reactive oxygen species(ROS)and oxygen generated from the Fenton-like reaction between nanoparticles and H2O2 within tumor under NIR II irradiation;(2)decrease the infiltration of Tregs cells at tumor site through the release of IND;(3)decrease the expression of PD-L1 on tumor cells through JQ1.The notable increments of anti-tumor cD8+T cells in the tumor and memory T cells(TEM)in the spleen show excellent therapy efficacy and effectively prevent the recurrence of GBM after modulation of the TIME.This work demonstrates the modulation of TIME could be a significant strategy to improve the immunotherapy of GBM and other cold tumors.

关键词： Glioblastoma Immunotherapy Ultrasmall copper selenide nanoparticles Tumor immune microenvironment Immune checkpoint blockade therapy

Molecular Engineering of NIR BODIPY Structure for Organic-Molecule-Based Nanoparticles with Enhanced Photothermal and Photoacoustic Efficiencies in cancer Theranostics

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Molecular Engineering of NIR BODIPY Structure for Organic-Mo...

Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics

第十一届全国化学生物学学术会议

作者： Gao Duyang Zhang Boyu Zhang Xuanjun Yuan Zhen Sheng Zonghai Paul C.Lauterbur Research Center for Biomedical Imaging Shenzhen Institutes of Advanced TechnologyCAS Faculty of Health Sciences University of Macau

Engineering a single organic-molecule-based nanoparticle integrating precise diagnosis and effective therapy is of great significance for cancer treatment and future clinical applications but remains a great challenge. In this study, Boca-BODIPY with strong NIR absorption is designed as a theranostic agent through simply molecular engineering. The Boca-BODIPY molecules are further encapsulated in reduced BSA through self-assembly, which exhibit excellent biocompatibility, extraordinary stability and high photothermal conversion efficiency up to 58.7%. The nanoparticles could dramatically enhance photoacoustic contrast of the tumor region, and the signal-to-noise ratio is increased about 14 times at 10 h post intravenous injection in 4 T1 tumor-bearing mice. In addition, the nanoassemblies can efficiently convert laser energy into hyperthermia for tumor ablation. Under the photoacoustic imaging-guided photothermal therapy（PTT）, the 4 T1 cancer cells are efficiently killed, no tumor recurrence and PTT-induced toxicity is observed. Overall, the as-designed organic-based theranostic agents show great promise for imaging-guided cancer precision therapy.

关键词： BODIPY molecular engineering photoacoustic imaging photothermal therapy theragnostic nanoparticles

来源： cnki会议评论

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Bioactive Materials 2022年第4期7卷 515-525页

作者： Ting chen Weiwei Zeng changjun Tie Mian Yu Huisong Hao Yang Deng Qianqian Li Hairong Zheng Meiying Wu Lin Mei School of Pharmaceutical Sciences(Shenzhen) Sun Yat-sen UniversityShenzhen518107China Paul C.Lauterbur Research Center for Biomedical Imaging Institute of Biomedical and Health EngineeringShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen518055China Tianjin Key Laboratory of biomedical Materials Key Laboratory of Biomaterials and Nanotechnology for Cancer ImmunotherapyInstitute of Biomedical EngineeringChinese Academy of Medical SciencesPeking Union Medical CollegeTianjin300192China

The imbalance between oxidants and antioxidants in cancer cells would evoke oxidative stress-induced cell death,which has been demonstrated to be highly effective in treating malignant tumors.Sonodynamic therapy(SDT)adopts ultrasound(US)as the excitation source to induce the production of reactive oxygen species(ROS),which emerges as a noninvasive therapeutic strategy with deep tissue penetration depth and high clinical safety.Herein,we construct novel sonoactivated oxidative stress amplification nanoplatforms by coating MnO_(2) on Au nanoparticle-anchored black phosphorus nanosheets and decorating soybean phospholipid subsequently(Au/BP@MS).The Au/BP@MS exhibit increased ROS generation efficiency under US irradiation in tumor tissues due to Au/BP nanosensitizer-induced improvement of electron-hole separation as well as MnO_(2)-mediated O_(2) generation and GSH depletion,thus leading to notable inhibition effect on tumor growth.Moreover,tumor microenvironment-responsive biodegradability of Au/BP@MS endows them with enhanced magnetic resonance imaging guidance and clinical potential for cancer theranostics.

关键词： Black phosphorus Oxidative stress Tumor microenvironment Sonodynamic therapy Theranostic

Tumor Microenvironment-Specific chemical Internalization for Enhanced Gene Therapy of Metastatic Breast cancer

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research 2021年第1期2021卷 689-703页

作者： Yun Zhou Mian Yu changjun Tie Yang Deng Junqing Wang Yunfei Yi Fan Zhang chenyi Huang Hairong Zheng Lin Mei Meiying Wu School of Pharmaceutical Sciences(Shenzhen) Sun Yat-sen UniversityShenzhen 518107China Paul C.Lauterbur Research Center for Biomedical Imaging Institute of Biomedical and Health EngineeringShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Tianjin Key Laboratory of biomedical Materials Key Laboratory of Biomaterials and Nanotechnology for Cancer ImmunotherapyInstitute of Biomedical EngineeringChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300192China

Benefiting from treating diseases at the genetic level,gene therapy has been considered a new revolution in the biomedical field.However,the extracellular and intracellular barriers during gene transport such as enzymatic degradation and endo-/lysosomal sequestration significantly compromise the therapeutic efficacy.Though photochemical internalization(PcI)has emerged as a promising approach for causing endo-/lysosomal leakage with translocation of the internalized molecules into the cytosol,its effect is still unsatisfactory due to the insufficient light penetration depth.Here,we develop tumor microenvironment-specific enhanced gene delivery by means of ROS generated from the in situ cascaded catalytic reactions in tumors involving GOx-mediated redox reaction and Mn2+-mediated Fenton-like reaction.The efficient enzymatic protection and successful endo-/lysosomal escape of cargo gene complexes have been demonstrated.Moreover,anti-Twist siRNA-loaded G@MMSNs-P exhibit tumor-specific biodegradation,excellent T1-weighted MR imaging,and significant inhibitory effects against breast cancer growth and pulmonary metastasis.

关键词： Internal loaded emerged

超小二维硅量子片:一种用于脑胶质瘤原位诊疗的脑部光热纳米制剂

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Science Bulletin 2021年第2期66卷 147-157,M0004页

作者：缪昭华胡德红高笃阳范林昕马艳马腾刘新郑海荣查正宝盛宗海徐成彦 School of Food and Biological Engineering Hefei University of TechnologyHefei 230009China Paul C.Lauterbur Research Center for Biomedical Imaging Shenzhen Key Laboratory of Ultrasound Imaging and TherapyInstitute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Shenzhen Bay Laboratory Shenzhen 518107China School of Materials Science and Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China

提出了一种化学脱嵌和低温辅助剥离相结合的策略用于制备二维硅量子片(silicon quantum sheets,Si QSs),并证实了硅量子片能够用作高性能光热纳米制剂,在恶性程度极高的脑胶质瘤诊断和治疗上有很好的应用前景.本文制备的硅量子片横向尺... 详细信息

提出了一种化学脱嵌和低温辅助剥离相结合的策略用于制备二维硅量子片(silicon quantum sheets,Si QSs),并证实了硅量子片能够用作高性能光热纳米制剂,在恶性程度极高的脑胶质瘤诊断和治疗上有很好的应用前景.本文制备的硅量子片横向尺寸约为14.0 nm,厚度约为1.6 nm,质量消光系数和光热转换效率分别为27.5 g^(-1)cm^(-1)和47.2%,光热性能优于目前所报道的其他单元素二维材料.经尾静脉注射后,硅量子片可穿透血脑肿瘤屏障,在脑胶质瘤组织中有效蓄积,显著增强肿瘤区域的光声信号,实现了近红外光驱动的脑肿瘤靶向治疗.经激光照射5 min后,实验组小鼠的脑胶质瘤能得到有效抑制,小鼠生存期延长了1倍.该项工作拓展了二维硅在脑疾病治疗中的生物医学应用.

关键词：脑胶质瘤肿瘤区域纳米制剂生物医学应用光声信号质量消光系数脑疾病横向尺寸

X-ray phase-sensitive microscope imaging with a grating interferometer:Theory and simulation

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chinese Physics B 2022年第9期31卷 652-657页

作者：杨杰成朱佩平梁栋郑海荣葛永帅 research center for Medical Artificial Intelligence Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Platform of Advanced Photon Source Technology R&D Laboratory of X-ray Optics and TechnologyBeijing Synchrotron Radiation FacilityInstitute of High Energy PhysicsChinese Academy of SciencesBeijing100049China Beijing Advanced Innovation center for imaging Theory and Technology Capital Normal UniversityBeijing 100048China Paul C.Lauterbur Research Center for Biomedical Imaging Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China4.Paul C Lauterbur Research Center for Biomedical ImagingShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

A general theoretical framework is presented to explain the formation of the phase signal in an x-ray microscope integrated with a grating interferometer,which simultaneously enables the high spatial resolution imaging and the improved image contrast.By using this theory,several key parameters of phase contrast imaging can be predicted,for instance,the fringe visibility and period,and the conversion condition from the differential phase imaging(DPI)to the phase difference imaging(PDI).Additionally,numerical simulations are performed with certain x-ray optical components and imaging geometry.comparison with the available experimental measurement[Appl.Phys.Lett.113063105(2018)]demonstrates the accuracy of this developed quantitative analysis method of x-ray phase-sensitive microscope imaging.

关键词： x-ray phase contrast imaging x-ray microscope grating interferometer

肿瘤穿膜肽结合的多柔比星热敏感脂质体提高肝脏肿瘤射频消融疗效

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国际医学放射学杂志 2018年第1期 92-93页

作者： F.Yan S.Wang W.Yang S.N.Goldberg H.Wu W.Duan 张俊峰 paul c. lauterbur research center for biomedical imaging Institute of Biomedical and Health EngineeringShenzhen Institutes of Advanced TechnologyChinese Academy of Sciences

摘要目的采用动物模型探究肿瘤穿膜肽[内源化cRGDRGPDc(i RGD)]结合的多柔比星(DOX)热敏感脂质体(TSL)在肝脏肿瘤射频(RF)消融中的作用。材料与方法本实

关键词：肝脏肿瘤 DOX TSL 多柔比星热敏感脂质体穿膜肽