超小二维硅量子片:一种用于脑胶质瘤原位诊疗的脑部光热纳米制剂

作     者：缪昭华 胡德红 高笃阳 范林昕 马艳 马腾 刘新 郑海荣 查正宝 盛宗海 徐成彦 Zhaohua Miao;Dehong Hu;Duyang Gao;Linxin Fan;Yan Ma;Teng Ma;Xin Liu;Hairong Zheng;Zhengbao Zha;Zonghai Sheng;Cheng-Yan Xu

作者机构：School of Food and Biological EngineeringHefei University of TechnologyHefei 230009China Paul C.Lauterbur Research Center for Biomedical ImagingShenzhen Key Laboratory of Ultrasound Imaging and TherapyInstitute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Shenzhen Bay LaboratoryShenzhen 518107China School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China 

出 版 物：《Science Bulletin》 (科学通报（英文版）)

年 卷 期：2021年第66卷第2期

页      面：147-157,M0004页

核心收录：

学科分类：1002[医学-临床医学] 07[理学] 070205[理学-凝聚态物理] 100214[医学-肿瘤学] 10[医学] 0702[理学-物理学] 

基　　金：supported by the National Key Research and Development Program of China:Scientific and Technological Innovation Cooperation of Mainland and Macao(2017YFE0120000) the National Natural Science Foundation of China(31800834,81527901,81571745,91859117,81771906,81827807,81901812,and 52071120) the Open Foundation of Shenzhen Bay Laboratory(SZBL2019062801005) the Fundamental Research Funds for the Central Universities(JZ2020HGTB0031 and JZ2018HGPA0273) the Science and Technology Key Project of Shenzhen(JCYJ20160229200902680) the Shenzhen Key Laboratory of Ultrasound Imaging and Therapy(ZDSYS201802061806314) the Shenzhen Double Chain Grant(256) the Natural Science Foundation of Guangdong Province(2014A030312006) the China Postdoctoral Science Foundation(2019 M653129)。 

主　　题：脑胶质瘤 肿瘤区域 纳米制剂 生物医学应用 光声信号 质量消光系数 脑疾病 横向尺寸 

摘      要：提出了一种化学脱嵌和低温辅助剥离相结合的策略用于制备二维硅量子片(silicon quantum sheets,Si QSs),并证实了硅量子片能够用作高性能光热纳米制剂,在恶性程度极高的脑胶质瘤诊断和治疗上有很好的应用前景.本文制备的硅量子片横向尺寸约为14.0 nm,厚度约为1.6 nm,质量消光系数和光热转换效率分别为27.5 g^(-1)cm^(-1)和47.2%,光热性能优于目前所报道的其他单元素二维材料.经尾静脉注射后,硅量子片可穿透血脑肿瘤屏障,在脑胶质瘤组织中有效蓄积,显著增强肿瘤区域的光声信号,实现了近红外光驱动的脑肿瘤靶向治疗.经激光照射5 min后,实验组小鼠的脑胶质瘤能得到有效抑制,小鼠生存期延长了1倍.该项工作拓展了二维硅在脑疾病治疗中的生物医学应用.