检索结果-南通市图书馆

Bio-analysis of Saliva Using Paper Devices and Colorimetric Assays

在线全文

学校读者我要写书评

暂无评论

Journal of Analysis and Testing 2024年第1期8卷 114-132页

作者： Adhan Narasimhan Harshil Jain Kowshika Muniandy Raja Chinnappan Naresh Kumar Mani Microfluidics Sensors and Diagnostics(μSenD)LaboratoryCentre for MicrofluidicsBiomarkersPhotoceutics&Sensors(μBioPS)Department of BiotechnologyManipal Institute of TechnologyManipal Academy of Higher EducationManipalKarnataka 576104India College of Medicine Alfaisal UniversityRiyadh 11533SaudiArabia Tissue/Organ Bioengineering&BioMEMS Lab Organ Transplant Centre of ExcellenceTransplant Research&Innovation DepartmentKing Faisal Specialist Hospital and Research CentreRiyadhSaudi Arabia

In light of the evolving nature of various diseases,time becomes a crucial factor in diagnosis and identifying the underlying causes.A point-of-care device provides a rapid diagnosis of a disease without using complex and advanced instruments,which are costly and difficult to transport.A paper-based device is a relatively frugal solution wherein the paper is used as a substratum in which the reactions are carried out.These methods are non-invasive,and the sample collection is relatively easy.Saliva is one such body fluid in which various biomarkers are present for numerous diseases.Bioanalysis of saliva has attracted more attention recently due to its non-invasiveness and robustness.Exploiting the discovery of clinical biomarkers from salivary analysis has the potential to revolutionize the healthcare sector by providing crucial information to monitor the health status of individuals and disease progression which enables personalized treatment.This review provides the limitation of the traditional methods in clinical applications and highlights the significance of saliva as a non-invasive biological fluid that is a source of multiple biomarkers associated with various diseases.It also provides insights into the different paper-based colorimetric microfluidic devices developed against salivary biomarkers in the past decade.The major challenges in the point-of-care application and the future prospects have been discussed as well.Further,we also emphasize the importance of this approach in dental disease diagnosis which is least explored and holds potential applications.

关键词： Paper-based assay Salivary analysis Non-invasive Point-of-care Body fluids Biomarkers Qualitative detection

Left bundle branch pacing set to outshine biventricular pacing for cardiac resynchronization therapy?

在线全文

学校读者我要写书评

暂无评论

World Journal of Cardiology 2024年第4期16卷 186-190页

作者： Akash Batta Juniali Hatwal Department of Cardiology Dayanand Medical College and HospitalLudhiana 141001India Department of Internal Medicine Advanced Cardiac CentrePost Graduate Institute of Medical Education&ResearchChandigarh 160012India

The deleterious effects of long-term right ventricular pacing necessitated the search for alternative pacing sites which could prevent or alleviate pacinginduced cardiomyopathy.Until recently,biventricular pacing(BiVP)was the only modality which could mitigate or prevent pacing induced dysfunction.Further,BiVP could resynchronize the baseline electromechanical dssynchrony in heart failure and improve outcomes.However,the high non-response rate of around 20%-30%remains a major limitation.This non-response has been largely attributable to the direct non-physiological stimulation of the left ventricular myocardium bypassing the conduction system.To overcome this limitation,the concept of conduction system pacing(CSP)came up.Despite initial success of the first CSP via His bundle pacing(HBP),certain drawbacks including lead instability and dislodgements,steep learning curve and rapid battery depletion on many occasions prevented its widespread use for cardiac resynchronization therapy(CRT).Subsequently,CSP via left bundle branch-area pacing(LBBP)was developed in 2018,which over the last few years has shown efficacy comparable to BiVP-CRT in small observational studies.Further,its safety has also been well established and is largely free of the pitfalls of the HBP-CRT.In the recent metanalysis by Yasmin et al,comprising of 6 studies with 389 participants,LBBPCRT was superior to BiVP-CRT in terms of QRS duration,left ventricular ejection fraction,cardiac chamber dimensions,lead thresholds,and functional status amongst heart failure patients with left bundle branch block.However,there are important limitations of the study including the small overall numbers,inclusion of only a single small randomized controlled trial(RCT)and a small follow-up duration.Further,the entire study population analyzed was from China which makes generalizability a concern.Despite the concerns,the meta-analysis adds to the growing body of evidence demonstrating the efficacy of LBBP-CRT.At this stage,one must acknowledge that the fact that stil

关键词： Biventricular pacing Cardiac resynchronization therapy Conduction system pacing Left bundle branch-area pacing Left bundle branch block Electromechanical dssynchrony

The interventional effect of Polygonatum cyrtonema Hua polysaccharide on atherosclerosis in mice of different sexes

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第1期13卷 370-380页

作者： Anjun Guo Xueying Li Lihua Pan Qiangming Li Jianping Luo Xueqiang Zha Engineering research centre of Bioprocess of Ministry of education Hefei University of TechnologyHefei 230009China School of Food and Biological Engineering Hefei University of TechnologyHefei 230009China Key Laboratory of Metabolism and Regulation for Major Disease of Anhui Higher education Institutes Hefei University of TechnologyHefei 230009China

In the present study,we investigated the intervention effects of a purified Polygonatum cyrtonema polysaccharide(PCP)on high-fat diet(HFD)-induced atherosclerosis in male and female LDLr-/-mice.Results showed that HFD caused severe dyslipidemia,atherosclerotic lesions,oxidative damages and inflammation in male and female mice,and these effects seemed to be more pronounced in males than in females.However,the above variations could be dose-dependently reversed by PCP treatment,and the intervention effects on males were greater than those on females.Nuclear factor kappa-B(NF-κB),mitogen-activated protein kinase(MAPKs)and protein kinase B(Akt)are 3 pivotal signaling pathways mediating the development of atherosclerosis.Consistently,PCP was also found to significantly decrease the phosphorylation of p65,p38,extracellular-regulated kinase 1/2(ERK1/2)and Akt,and increase the protein expression of inhibitor of NF-κB(IκB)in the aortas of male and female mice induced by HFD.Taken together,these findings indicated that PCP could be effective for the prevention of atherosclerosis,and the intervention effect of PCP on male mice was more obvious than that of female mice.

关键词： Polygonatum cyrtonema polysaccharide Anti-atherosclerosis Sex

Long COVID:From olfactory dysfunctions to viral Parkinsonism

在线全文

学校读者我要写书评

暂无评论

World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 137-147页

作者： Sanyukta Pandey Vibha Bapat Jancy Nixon Abraham Nixon M.Abraham Department of Biology Laboratory of Neural Circuits and Behaviour(LNCB)Indian Institute of Science Education and Research(IISER)PuneMaharashtraIndia Department of Life Sciences Centre of Excellence in EpigeneticsShiv Nadar Institution of EminenceGautam Buddha NagarUttar PradeshIndia

Neurological and psychiatric complications continue to be a public health concern in long coronavirus disease 2019(COVID-19).This varies from olfactory dysfunctions such as parosmia to cognitive and emotional challenges.Historically,the surge of neurological disorders followed the viral pandemics,for example,the emergence of Encephalitis Lethargica after the outbreak of Spanish Influenza.During and after COVID-19 infection,the problems associated with the sense of smell and the reports of affected olfactory and limbic brain areas are leading to a growing concern about the similarity with the symptoms and the pattern of degeneration observed at the onset of Parkinson's disease and Alzheimer's disease.These reports reveal the essentiality of long-term studies of olfactory and cognitive functions in the post-COVID era and the experiments using animal models to dissect the neural basis of these complications.In this manuscript,we summarize the research reporting the potential correlation between neurological disorders and viral pandemic outbreaks with a historical perspective.Further,we discuss the studies providing evidence of neurodegeneration due to severe acute respiratory syndrome coronavirus 2 infection by focusing on viral Parkinsonism.

关键词： long COVID neurodegeneration neurotropism olfactory dysfunctions viral parkinsonism

Leisure-time physical activity and all-cause mortality and cardiovascular disease in adults with type 2 diabetes:Cross-country comparison of cohort studies

在线全文

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第2期13卷 212-221页

作者： Jakob Tarp Mengyun Luo Miguel Adriano Sanchez-Lastra Knut Eirik Dalene Borja del Pozo Cruz Mathias Ried-Larsen Reimar Wernich Thomsen Ulf Ekelund Ding Ding Department of Clinical Epidemiology Aarhus University&Aarhus University HospitalAarhus 8200Denmark Prevention research Collaboration Sydney School of Public HealthThe University of SydneyCamperdownNSW 2006Australia Charles Perkins centre the University of SydneyCamperdownNSW 2050Australia Department of Sports Medicine Norwegian School of Sports SciencesOslo 0806Norway Department of Special Didactics Faculty of Education and Sports SciencesUniversity of VigoPontevedra 36005Spain Well-Move research Group Galicia Sur Health Research Institute(IIS Galicia Sur)SERGAS-UVIGOVigo 36213Spain Department of Chronic Diseases Norwegian Institute of Public HealthOslo 0473Norway centre for Active and Healthy Ageing Department of Sports Science and Clinical BiomechanicsUniversity of Southern DenmarkOdense 5230Denmark Faculty of education University of CadizCadiz 11519Spain Biomedical research and Innovation Institute of Cadiz(INiBICA)research Unit Puerta del Mar University HospitalUniversity of CadizCadiz 11009Spain The centre of Inflammation and Metabolism&the centre for Physical Activity research RigshospitaletUniversity of CopenhagenCopenhagen 2100Denmark Department of Sports Science and Clinical Biomechanics University of Southern DenmarkOdense 5230Denmark

Purpose:This study aimed to quantify the dose-response association and the minimal effective dose of leisure-time physical activity(PA)to prevent mortality and cardiovascular disease in adults with type 2 diabetes.Methods:Cross-country comparison of 2 prospective cohort studies including 14,913 and 17,457 population-based adults with type 2 diabetes from the UK and China.Baseline leisure-time PA was self-reported and categorized by metabolic equivalent hours per week(MET-h/week)according to World Health Organization recommendations:none,below recommendation(>0-7.49 MET-h/week);at recommended level(7.5-14.9 MET-h/week);above recommendation(>15 MET-h/week).Mortality and cardiovascular disease data were obtained from national registries.Results:During a median follow-up of 12.4 and 9.7 years,in the UK and China cohorts,repectively,higher levels of leisure-time PA were inversely associated with all-cause(1571 and 2351 events)and cardiovascular mortality(392 and 1060 events),mostly consistent with a linear dose-response relationship.PA below,at,and above recommendations,compared with no activity,yielded all-cause mortality hazard ratios of0.94(95%confidence interval(95%CI):0.79-1.12),0.90(95%CI:0.74-1.10),and 0.85(95%CI:0.70-1.02)in British adults and 0.87(95%CI:0.68-1.10),0.88(95%CI:0.74-1.03),and 0.77(95%CI:0.70-0.85)in Chinese adults.Associations with cardiovascular mortality were more pronounced in British adults(0.80(95%CI:0.58-1.11),0.75(95%CI:0.52-1.09),and 0.69(95%CI:0.48-0.97))but less pronounced in Chinese adults(1.06(95%CI:0.76-1.47),1.01(95%CI:0.80-1.28),and 0.79(95%CI:0.69-0.92)).PA at recommended levels was not associated with lower rates of major adverse cardiovascular events(2345 and 4458 events).Conclusion:Leisure-time PA at the recommended levels was not convincingly associated with lower mortality and had no association with risk of major adverse cardiovascular events in British or Chinese adults with type 2 diabetes.Leisure-time PA above current recommendations may be needed to prevent cardiovascul

关键词： Complications Epidemiology Exercise Prevention

Multi-Time-Scale Variational Mode Decomposition-Based Robust Fault Diagnosis of Railway Point Machines Under Multiple Noises

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Electronics 2024年第3期33卷 814-822页

作者： Junqi LIU Tao WEN Guo XIE Yuan CAO Clive Roberts Shaanxi Key Laboratory of Complex System Control and Intelligent Information Processing Xi'an University of Technology The School of Electronic and Information Engineering Beijing Jiaotong University Birmingham centre for Railway research and education University of Birmingham

The fault diagnosis of railway point machines(RPMs) has attracted the attention of engineers and researchers.Seldom have studies considered diverse noises along the track.To fulfill this aspect,a multi-time-scale variational mode decomposition(MTSVMD) is proposed in this paper to realize the accurate and robust fault diagnosis of RPMs under multiple noises.MTSVMD decomposes condition monitoring signals after coarse-grained processing in varying degrees.In this manner,the information contained in the signal components at multiple time scales can construct a more abundant feature space than at a single scale.In the experimental validation,a random position,random type,random number,and random length(4R) noise-adding algorithm helps to verify the robustness of the approach.The adequate experimental results demoristrate the superiority of the proposed MTSVMD-based fault diagnosis.

关键词： Fault diagnosis Condition monitoring Noise Signal processing algorithms Aerospace electronics Rail transportation Robustness

Understanding the role of transmembrane 9 superfamily member 1 in bladder cancer pathogenesis

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2024年第4期15卷 468-471页

作者： Venkata Krishna Vamsi Gade Budhi Singh Yadav Department of Radiotherapy&Oncology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Department of Radiotherapy&Oncology Regional Cancer CentrePostgraduate Institute of Medical Education and ResearchChandigarh 160012India

In this editorial we comment on the article by Wei et al,published in the recent issue of the World Journal of Clinical Oncology.The authors investigated the role of Transmembrane 9 superfamily member 1(TM9SF1)protein in bladder cancer(BC)carcinogenesis.Lentiviral vectors were used to achieve silencing or overexpression of TM9SF1 gene in three BC cell lines.These cell lines were then subject to cell counting kit 8,wound-healing assay,transwell assay,and flow cytometry.Proliferation,migration,and invasion of BC cells were increased in cell lines subjected to TM9SF1 overexpression.TM9SF1 silencing inhibited proliferation,migration and invasion of BC cells.The authors conclude that TM9SF1 may be an oncogene in bladder cancer pathogenesis.

关键词： Urinary bladder cancer Transmembrane 9 superfamily member 1 gene cell line Lentiviral vectors Wound healing assay Oncogene Proliferation Migration

Role of microbiota-gut-brain axis in neurodegenerative diseases and the potential of microbiome-targeted d ietary strategies: A review of current evidence and future perspective

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Shuqing Zhang Wenjing Chen Chen Ma Yinghua Luo Li Dong Xiaosong Hu Fang Chen Daotong Li College of Food Science and Nutritional Engineering National Engineering research centre for Fruit and Vegetable Processing Key Laboratory of Fruits and Vegetables Processing Ministry of Agriculture Engineering research centre for Fruits and Vegetables Processing Ministry of education China Agricultural University

Neurodegenerative diseases (NDs)， mainly including Alzheimer’s disease， Parkinson’s disease， and Multiple sclerosis， represent a major public health challenge with the steady increase of aging population worldwide. Emerging evidence has revealed the key role of the microbiota-gut-brain axis in the pathogenesis of NDs. Diet is one of the most important environmental factors shaping the structure and function of gut microbiota. Manipulating the gut microbiota through specific diet patterns may represent a promising approach for NDs prevention. In this review， we highlight gut microbiota variations in NDs， outline several crucial signaling pathways of the gut-brain communication， and discuss the interplay of nutrients-microbes and biological effect of diet-derived microbial metabolites on neural physiology. In particular， we summarized the current knowledge about the application of dietary patterns in NDs to prevent disease progression via the modulation of the gut microbiota. Our study provides novel insights on the diet-microbiota-gut-brain axis in neurodegenerative disorders and highlights the potential of developing microbiome-targeted personalized dietary intervention for NDs management.

关键词：

CD36 promotes tubular ferroptosis by regulating the ubiquitination of FSP1 in acute kidney injury

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第1期11卷 449-463页

作者： Yixin Ma Lili Huang Zheng Zhang Pengfei Yang Qingsong Chen Xujia Zeng Fangyan Tan Chunxia Wang Xiongzhong Ruan Xiaohui Liao Department of Nephrology The Second Affiliated HospitalChongqing Medical UniversityChongqing 400010China Department of Cell Biology and Genetics Chongqing Medical UniversityChongqing 400016China centre for Nephrology Royal Free and University College Medical SchoolUniversity College LondonRoyal Free CampusRowland Hill StreetLondon NW32PFUnited Kingdom centre for Lipid research Key Laboratory of Molecular Biology on Infectious DiseasesMinistry of EducationChongqing Medical UniversityChongqing 400016China Kuanren Laboratory of Translational Lipidology Centre for Lipid ResearchSecond Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China

Reactive oxidative species(ROos)production-driven ferroptosis plays a role in acute kidney injury(Akl).However,its exact molecular mechanism is poorly understood.Scavenger receptor CD36 has important roles in oxidizing lipids,lipid accumulation,metabolic syndrome,and insulin resistance in chronic kidney disease,but its roles remain unexplored in AKl.The present study investigated the role and mechanism of CD36 in regulating proximal tubular cell ferroptosis and AKl.The expression of CD36 was found to be significantly up-regulated in AKI renal tissues and correlated with renal function,which might serve as an independent biomarker for AKl patients.Moreover,in adult mice subjected to AKl,deletion of CD36(CD36-/-)induced tubular cell Ros accumulation,ferroptosis activation,and renal injury.Mechanistically,combining LC-MS/MS,co-IP,and ubiquitination analyses revealed that CD36 could specifically bind to ferroptosis suppressor protein 1(FSP1)and regulate its ubiquitination at sites K16 and K24,leading to FSP1 degradation and progression of ferroptosis in AKl.The present results emphasize a novel mechanism of CD36 in cisplatin-induced AKl.The discovery of the special CD36 roles in promoting ferroptosis and AKI development by regulating the ubiquitination of FSP1 in proximal tubular cells may be potential therapeutic targets for AKl.Moreover,CD36 may play a key role in the progression of AKl.Therefore,targeting CD36 may provide a promising treatment option for AKI.

关键词： Acute kidney injury CD36 Ferroptosis FSP1 Ubiquitin-dependent degradation