检索结果-南通市图书馆

The emerging tumor microbe microenvironment: From delineation to multidisciplinary approach-based interventions

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第4期14卷 1560-1591页

作者： Yu Fu Jia Li Wenyun Cai Yulan Huang Xinlong Liu Zhongyi Ma Zhongjie Tang Xufei Bian Ji Zheng Jiayun Jiang Chong Li Medical research Institute College of Pharmaceutical SciencesSouthwest UniversityChongqing 400715China Institute of Hepatobiliary Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Department of Urology Urologic Surgery CenterXinqiao HospitalThird Military Medical University(Army Medical University)Chongqing 400037China

Intratumoral microbiota has become research hotspots,and emerges as a non-negligent new component of tumor microenvironments(TME),due to its powerful infuence on tumor initiation,metas-tasis,immunosurveillance and prognosis despite in *** accumulations of microbes,and their related components and metabolites within tumor tissues,endow TME with additional pluralistic features which are distinct from the conventional ***,it's definitely necessary to comprehen-sively delineate the sophisticated landscapes of tumor microbe microenvironment,as well as their func-tions and related underlying ***,in this review,we focused on the fields of tumor microbe microenvironment,including the heterogeneity of intratumor microbiota in different types of tu-mors,the controversial roles of intratumoral microbiota,the basic features of tumor microbe microenvi-ronment(i.e.,pathogen-associated molecular patterns(PAMPs),typical microbial metabolites,autophagy,infammation,multi-faceted immunomodulation and chemoresistance),as well as the multi-disciplinary approach-based intervention of tumor microbiome for cancer therapy by applying wild-type or engineered live microbes,microbiota metabolites,antibiotics,synthetic biology and rationally de-signed *** hope our work will provide valuable insight to deeply understand the interplay of cancer-immune-microbial,and facilitate the development of microbes-based tumor-specific treatments.

关键词： Tumor microbe microenvironment Microbiota metabolites Immunomodulation Chemoresistance Multidisciplinary approach Genetically engineered microbiota Autophagy Outer membrane vesicles

Quantifying freeze-melt dynamics of lakes on the Tibetan Plateau using Sentinel-1 synthetic aperture radar imagery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mountain Science 2024年第3期21卷 805-819页

作者： JIN Lu CHEN Jun CAI Yu KONG Yecheng WANG Yongfeng DUAN Zheng School of Environment and Energy Engineering Anhui Jianzhu UniversityHefei 230601China Anhui Engineering and Technology research center for Smart City Anhui Jianzhu UniversityHefei 230601China School of Geographic and Oceanographic Sciences Nanjing UniversityNanjing 210023China Department of Physical Geography and Ecosystem Science Lund UniversityLund 22362Sweden

The ice phenology of alpine lakes on the Tibetan Plateau(TP)is a rapid and direct responder to climate changes,and the variations in lake ice exhibit high temporal frequency *** and passive microwave data are widely used to monitor lake ice changes with high temporal ***,the low spatial resolutions make it difficult to effectively quantify the freeze-melt dynamics of *** work used Sentinel-1 synthetic aperture radar(SAR)data to derive high-resolution ice maps(about 6 days),then with the aid of Sentinel-2 optical images to quantify freeze-melt processes in three typical lakes on the TP(*** Co,Ayakekumu Lake,and Nam Co).The results showed that three lakes had an average annual ice period of 125-157 days and a complete ice cover period of 72-115 days,from 2018 to *** exhibit different ice phenology *** Co is characterized by repeated episodes of freezing,melting,and refreezing,resulting in a prolonged freeze-up ***,the break-up period of Nam Co lasts for a longer duration(about 19 days),and the break-up exhibits a smooth ***,Ayakekumu Lake showed more significant inter-annual fluctuations in the freeze-up period,with deviations of up to 28 days observed among different *** to the other two lakes,Selin Co experienced a relatively short freeze-up and break-up *** short,Sentinel-1 SAR data can effectively monitor the weekly and seasonal variations in lake ice on the ***,this data facilitates quantification of the freeze-melt dynamics.

关键词： Lake ice Sentinel-1 SAR Tibetan Plateau Climate change

The Application and Effect Evaluation of Corpus Linguistics in English Teaching

在线全文

学校读者我要写书评

暂无评论

Journal of Contemporary educational research 2024年第7期8卷 290-296页

作者： Lei Yang Foreign Language Teaching and research center Department of BusinessHuanghe Science and Technology CollegeZhengzhou 450000Henan ProvinceChina

This paper explores the application and effect evaluation of corpus linguistics in English *** first introduces the basic concepts and development history of corpus linguistics,then analyzes its connection with language teaching theories,discussing the advantages and challenges of using corpora in language ***,it delves into the methods and technologies for building and utilizing corpora,as well as their role in developing teaching ***,within the framework and methods of teaching effect evaluation,specific application cases of corpus linguistics in teaching design are analyzed,and their effects are *** for teaching improvement and future development directions are also proposed.

关键词： Corpus linguistics English teaching Teaching resource development Corpus language analysis Effect evaluation Teaching improvement

Identification and effective regulation of scarb1 gene involved in pigmentation change in autotetraploid Carassius auratus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Zoological research 2024年第2期45卷 381-397页

作者： Xi-Dan Xu Yue Zhou Chong-Qing Wang Xu Huang Kun Zhang Xiao-Wei Xu Li-Wen He Xin-Yue Zhang Xin-Zhu Fu Ming Ma Qin-Bo Qin Shao-Jun Liu State Key Laboratory of Developmental Biology of Freshwater Fish Engineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education MinistryCollege of Life SciencesHunan Normal UniversityChangshaHunan 410081China Nansha-South China Agricultural University Fishery research Institute GuangzhouGuangdong 511458China Hunan Yuelu Mountain Science and Technology Co.Ltd.for Aquatic Breeding ChangshaHunan 410081China College of Chemistry and Chemical Engineering Hunan Normal UniversityChangshaHunan 410081China

The autotetraploid Carassius auratus(4nRR,4n=200,RRRR)is derived from whole-genome duplication of Carassius auratus red var.(RCC,2n=100,RR).In the current study,we demonstrated that chromatophores and pigment changes directly caused the coloration and variation of 4nRR skin(red in RCC,brownish-yellow in4nRR).To further explore the molecular mechanisms underlying coloration formation and variation in 4nRR,we performed transcriptome profiling and molecular functional verification in RCC and *** revealed that scarb1,associated with carotenoid metabolism,underwent significant down-regulation in *** editing of this candidate pigment gene provided clear evidence of its significant role in RCC ***,we identified four divergent scarb1 homeologs in 4nRR:two original scarb1 homeologs from RCC and two duplicated ***,three of these homeologs possessed two highly conserved alleles,exhibiting biased and allelespecific expression in the ***,after precise editing of both the original and duplicated scarb1homeologs and/or alleles,4nRR individuals,whether singly or multiply mutated,displayed a transition from brownishyellow skin to a cyan-gray ***,the proportional areas of the cyan-gray regions displayed a gene-dose *** findings illustrate the subfunctionalization of duplicated scarb1,with all scarb1genes synergistically and equally contributing to the pigmentation of *** is the first report concerning the functional differentiation of duplicated homeologs in an autopolyploidfish,substantiallyenrichingour understanding of coloration formation and change within this group of organisms.

关键词： Autopolyploidization Coloration change scarb1 Functional differentiation Genetic changes

Elucidating elusive quaternary selenide EuCeCuSe3:Synthesis,crystal structure,properties and theoretical studies

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2024年第1期42卷 163-171,I0006页

作者： Maxim V.Grigoriev Anna V.Ruseikina Maxim S.Molokeev Vladimir A.Chernyshev Aleksandr S.Aleksandrovsky Alexander S.Krylov Svetlana N.Krylova Nikolai P.Shestakov Dmitriy A.Velikanov Alexander A.Garmonov Alexey V.Matigorov Evgeny A.Ostapchuk Thomas Schleid Damir A.Safin Laboratory of Theory and Optimization of Chemical and Technological Processes University of TyumenVolodarskogo Str.6625003TyumenRussian Federation Kirensky Institute of Physics Federal Research Center KSC SB RASAkademgorodok 50 Bld.38660036KrasnoyarskRussian Federation Department of Physics Far Eastern State Transport UniversitySerysheva Str.47680021KrasnoyarskRussian Federation Institute of Natural Sciences and Mathematics Ural Federal University Named After the First President of Russia B.N.YeltsinMira Str.19620002EkaterinburgRussian Federation Department of Photonics and Laser Technology Siberian Federal UniversitySvobodnii Ave.79660079KrasnoyarskRussian Federation Institute of Physics and Technology University of TyumenVolodarskogo Str.6625003 TyumenRussian Federation Institute for Inorganic Chemistry University of StuttgartPfaffenwaldring 55D-70569StuttgartGermany Scientific and educational and Innovation center for Chemical and Pharmaceutical Technologies Ural Federal University named after the First President of Russia B.N.YeltsinMira Str.19620002 EkaterinburgRussian Federation University of Tyumen Volodarskogo Str.6625003TyumenRussian Federation

We report on the novel heterometallic quaternary selenide EuCeCuSe3,the fabrication of which has been a challenge until this *** structure of the reported selenide was elucidated from the powder X-ray diffraction data,which revealed the formation of EuCeCuSe3with excellent yield(96.7%)accompanied with a minor fraction of CeSe2(3.3%),and was best solved in orthorhombic space group Pnma with the BaLaCuS3structural ***,the crystal structure of the title compound completes the row of the heterometallic quaternary selenides EuRECuSe3(RE=La,Pr,Nd,Sm,Eu,Gd,Tb,Dy,Ho,Er,Tm,Yb,Lu,Y),of which the cerium-based derivative exclusively belongs to the BaLaCuS3structural *** distortion of the CuSe4polyhedron was compared for the whole series of EuRECuSe3compounds using theτ4-descriptor for four coordinated ions,which revealed the highest degree of distortion for the Ce3+-containing selenide,followed by the La3+-based ***,the crystallographic and geometrical parameters of the reported selenide were discussed in comparison to the Ce3+-based sulfides SrCeCuS3and *** initio calculations of the crystal structure,a phonon spectrum and elastic constants for the crystal of EuCeCuSe3were also *** types and wavenumbers of fundame ntal modes were determined and the involvement of ions participating in the phonon modes was *** experimental IR spectrum of the reported selenide was interpreted and found to be in agreement with the calculated *** experimental direct band gap of EuCeCuSe3was measured to be 1.36 eV that is consistent with the concept of its origin due to interband transitions between orbitals emerging mainly from 4f(valence band)and 5d(conduction band)levels of the Eu2+*** dependence of the Young’s modulus on the direction demonstrates the anisotropy of the elastic properties,while the Vickers hardness for EuCeCuSe3was calculated to be 5.2 ***,the title compound is paramagnetic above 4 K.

关键词： Quaternary selenide Synthesis Crystal structure Ab initio calculations Magnetic measurements Spectroscopy

Non-coding RNA as future target for diagnose and treatment of perineural invasion in cancers

在线全文

学校读者我要写书评

暂无评论

BIOCELL 2024年第6期48卷 923-934页

作者： BINGJIE LI WENBO CAO JINJING XIAO YIXIAO CHEN QIYING WEI MINGJIN YUE SAIJUN MO Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhouChina Collaborative Innovation center of Henan Province for Cancer Chemoprevention ZhengzhouChina State Key Laboratory of Esophageal Cancer Prevention and Treatment ZhengzhouChina Department of research and Development Henan Tianxing Education and Media Company LimitedZhengzhouChina

Perineural invasion(PNI),a particularly insidious form of tumor metastasis distinct from hematogenous or lymphatic spread,has the capacity to extend well beyond the primary tumor site,inﬁltrating distant regions devoid of lymphatic or vascular *** often heralds a decrease in patient survival rates and is recognized as an indicator of an unfavorable prognosis across a variety of *** its clinical signiﬁcance,the underlying molecular mechanisms of PNI remain elusive,complicating the development of speciﬁc and efﬁcacious diagnostic and therapeutic *** the realm of cancer research,non-coding RNAs(ncRNAs)have attracted considerable attention due to their multifaceted roles and cancer-speciﬁc expression proﬁles,positioning them as promising candidates for applications in cancer diagnostics,prognostics,and *** the various types of ncRNAs,microRNAs(miRNAs),long non-coding RNAs(lncRNAs),and circular RNAs(circRNAs)have emerged as inﬂuential players in *** involvement is increasingly recognized as a contributing factor to tumor progression and therapeutic *** study synthesizes and explores the diverse functions and mechanisms of ncRNAs in relation to PNI in *** comprehensive review aims to shed light on cutting-edge perspectives that could pave the way for innovative diagnostic and therapeutic approaches to address the challenges posed by PNI in oncology.

关键词： Perineural invasion Non-coding RNA Diagnose and treatment Cancer Biomarker

Degradation of black tea theaflavin through C-ring cleavage by gut microbiota

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2022年第3期11卷 598-605页

作者： Shuwei Zhang Christina Ohland Christian Jobin Shengmin Sang Laboratory for Functional Foods and Human Health Center for Excellence in Post-Harvest TechnologiesNorth Carolina Agricultural and Technical State UniversityNorth Carolina Research CampusKannapolisNorth Carolina 28081USA Department of Medicine University of FloridaGainesvilleFlorida 32611USA Department of Infectious Diseases and Immunology University of FloridaGainesvilleFlorida 32611USA

Increasing evidence has shown that gut microbiota plays important roles in metabolizing large molecular polyphenols to bioavailable and bioactive microbial ***(TF)is one of the major color compounds in black tea and has demonstrated anti-inflammation,antioxidant,and anticancer effects ***,little is known about the metabolism of TF by gut microbiota in *** this study,following the administration of TF to mice,the C-ring cleavage metabolites,dihydro-and tetrahydro-theaflavin(DH-TF and TH-TF)were detected in mouse feces by LC-MS and validated by authentic standards from in situ chemical *** observation of the C-ring cleavage metabolites in TF-treated conventionalized mice but not in germ-free(GF)mice confirmed the role of gut microbiota in cleaving the C-rings of *** detection of DH-TF from the anaerobic incubation of TF with catechin-converting gut bacteria,Eggerthella lenta(Eggerth),suggested that the microbes with the capacity to cleave the C-ring of catechins were able to metabolize TF following the same ***,three small phenolic metabolites were detected in mouse feces,and one of them was primarily detected in SPF mice not GF mice,which revealed that TF,subsequent to the cleaved C-ring,can be further metabolized into smaller phenolic metabolites by gut ***-dependent production of these metabolites were observed from the administration of 100 mg/kg to 400 mg/kg body weight of *** conclusion,gut microbiota can metabolize TF to the open-ring metabolites and the phenolic metabolites through the C-ring cleavage in mice.

关键词： Theaflavin Black tea C-ring cleavage Anaerobic incubation Germ-free mice

Navigating interdisciplinary research:Historical progression and contemporary challenges

在线全文

学校读者我要写书评

暂无评论

Journal of Data and Information Science 2024年第3期9卷 14-28页

作者： Xiaoqiang Li Fen Cai Jintao Bao Yuqing Jian Zehui Sun Xin Xie The Office of Science and Technology Development Peking UniversityBeijing 100871China National center for Health Professions Education Development Peking UniversityBeijing 100871China Graduate School of Education Peking UniversityBeijing 100871China The Office of Scientific research Peking UniversityBeijing 100871China

Interdisciplinary research plays a crucial role in addressing complex problems by integrating knowledge from multiple *** integration fosters innovative solutions and enhances understanding across various *** study explores the historical and sociological development of interdisciplinary research and maps its evolution through three distinct phases:pre-disciplinary,disciplinary,and *** identifies key internal dynamics,such as disciplinary diversification,reorganization,and innovation,as primary drivers of this ***,this study highlights how external factors,particularly the urgency of World War II and the subsequent political and economic changes,have accelerated its *** rise of interdisciplinary research has significantly reshaped traditional educational paradigms,promoting its integration across different educational ***,the inherent contradictions within interdisciplinary research present cognitive,emotional,and institutional challenges for ***,finding a balance between the breadth and depth of knowledge remains a critical challenge in interdisciplinary education.

关键词： Interdisciplinary research Historical sociology Development phases Interdisciplinary challenges

Mild closed head traumatic brain injury-induced changes in monoamine neurotransmitters in the trigeminal subnuclei of a rat model:mechanisms underlying orofacial allodynias and headache

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration research 2017年第6期12卷 981-986页

作者： Golam Mustafa Jiamei Hou Rachel Nelson Shigeharu Tsuda Mansura Jahan Naweed S.Mohammad Joseph V.Watts Floyd J.Thompson Prodip Bose Brain Rehabilitation research center of Excellence Malcom Randall VA Medical Center North Florida/South Georgia Veterans Health System Department of Physiological Sciences College of Veterinary Medicine University of Florida Department of Neuroscience McKnight Brain Institute College of Medicine University of Florida Department of Neurology McKnight Brain Institute College of Medicine University of Florida

Our recent findings have demonstrated that rodent models of closed head traumatic brain injury exhibit comprehensive evidence of progressive and enduring orofacial allodynias, a hypersensitive pain response induced by non-painful stimulation. These allodynias, tested using thermal hyperalgesia, correlated with changes in several known pain signaling receptors and molecules along the trigeminal pain pathway, especially in the trigeminal nucleus caudalis. This study focused to extend our previous work to investigate the changes in monoamine neurotransmitter immunoreactivity changes in spinal trigeminal nucleus oralis, pars interpolaris and nucleus tractus solitaries following mild to moderate closed head traumatic brain injury, which are related to tactile allodynia, touch-pressure sensitivity, and visceral pain. Our results exhibited significant alterations in the excitatory monoamine, serotonin, in spinal trigeminal nucleus oralis and pars interpolaris which usually modulate tactile and mechanical sensitivity in addition to the thermal sensitivity. Moreover, we also detected a robust alteration in the expression of serotonin, and inhibitory molecule norepinephrine in the nucleus tractus solitaries, which might indicate the possibility of an alteration in visceral pain, and existence of other morbidities related to solitary nucleus dysfunction in this rodent model of mild to moderate closed head traumatic brain injury. Collectively, widespread changes in monoamine neurotransmitter may be related to orofacial allodynhias and headache after traumatic brain injury.

关键词： traumatic trigeminal headache alteration visceral nucleus underlying moderate stimulation possibility