Genetic factors of reproductive disorders in female

作     者：Inna I.Mordovina Alina K.Chebanu Maksim Y.Donnikov Tatiana A.Sinyukova Lyudmila V.Kovalenko Larisa D.Belotserkovtseva 

作者机构：Department of ObstetricsGynecologyand PerinatologyMedical Institute of Surgut State UniversitySurgutRussian Federation Scientific and Educational CenterMedical Institute of Surgut State UniversitySurgutRussian Federation Department of Pathophysiology and General PathologyDirector of the Medical InstituteSurgut State UniversitySurgutRussian Federation Surgut Regional Clinical Center for Maternity and Childhood ProtectionSurgutRussian Federation 

出 版 物：《Reproductive and Developmental Medicine》 (生殖与发育医学（英文版）)

年 卷 期：2024年第8卷第3期

页      面：186-195页

核心收录：

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

基　　金：supported by Project No.15.BRK.21.008 Multicenter Research Bioresource Collection“Human Reproductive Health”(Agreement No.075-15-2021-1058 dated September 28,2021) funded by the Ministry of Science and Higher Education of the Russian Federation 

主　　题：Genetics Infertility Reproductive disorders Premature ovarian insufficiency 

摘      要：Successful reproduction in mammals requires gamete development,fertilization,and early embryonic *** in any of these processes can lead to infertility,recurrent miscarriages,and congenital *** clinical recognition of the genetic causes of female reproductive insufficiency using increasingly advanced genetic technologies poses a serious challenge for reproductive medicine in the 21st ***,the current literature on genetic factors involved in reproductive losses was summarized.A literature search was conducted using Web of Science,MEDLINE,and PubMed databases for articles written in English on the genetic causes of women’s reproductive health *** implementation of whole-exome and wholegenome sequencing is expected to identify numerous genetic factors responsible for oocyte *** will aid in increasing the likelihood of successful female reproductive function,improve the outcomes of assisted reproductive technologies,optimize treatment,and facilitate genetic diagnosis of patients.