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World Journal of Gastroenterology 2009年第14期15卷 1764-1768页

作者： Hirohito Kato Takamasa Ishii Tatsuo Akimoto Yoshihisa Urita Motonobu Sugimoto Department of General Medicine and Emergency Care Toho University School of Medicine Omori Hospital 6-11-1 Omori-Nishi Ota-Ku Tokyo 143-8541 Japan

AIM： To evaluate the association between gastroesophageal reflux diseases （GERD） and coronary heart diseases. METHODS： One thousand nine hundred and seventy consecutive patients who attended our hospital were enrolled. All of the patients who first attend our hospital were asked to respond to the F-scale questionnaire regardless of their chief complaints. All patients had a careful history taken, and resting echocardiography （ECG） was performed by physicians if the diagnostic necessity arose. Patients with ECG signs of coronary artery ischemia were defined as ST- segment depression based on the Minnesota code. RESULTS： Among 712 patients （36%） with GERD, ECG was performed in 171 （24%）, and ischemic changes were detected in eight （5%）. Four （50%） of these patients with abnormal findings upon ECG had no chest symptoms such as chest pain, chest oppression, or palpitations. These patients （0.6%; 4/712） were thought to have non-GERD heartburn, which may be related to ischemic heart disease. Of 281 patients who underwent ECG and did not have GERD symptoms, 20 （7%） had abnormal findings upon ECG. In patients with GERD symptoms and ECG signs of coronary artery ischemia, the prevalence of linked angina was considered to be 0.4% （8/1970 patients）.CONCLUSION： The present study suggested that ischemic heart disease might be found although a patient was referred to the hospital with a complaint of GERD symptoms. Physicians have to be concerned about missing clinically important coronary artery disease while evaluating patients for GERD symptoms.

关键词： Linked angina Epidemiology Generalpractice Electrocardiography Gastroesophageal reflexdisease

Comprehensive monitoring of chlorinated aromatic and heteroaromatic pollutants at sites contaminated by chlorine production processes to inform policy making

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Emerging Contaminants 2020年第1期6卷 133-142页

作者： Takumi Takasuga Hiroaki Takemori Teru Yamamoto Kazuo Higashino Yuko Sasaki Roland Weber Shimadzu Techno Research INC.1Nishinokyo Shimoaicho Nakagyo-kuKyoto604-8436Japan Tokyo Metropolitan Government 8-1 Nishi-Shinjuku 2-chomeShinjuku-kuTokyo163-8001Japan The Tokyo Metropolitan Research Institute for Environmental Protection 1-7-5 Shinsuna Koto-kuTokyo136-0075Japan POPs Environmental Consulting Lindenfirststr.2373527Schw€abisch GmündGermany

The production of chlorine by the chlor-alkali process using graphite electrodes was one of the largest sources of polychlorinated dibenzo-p-dioxins and dibenzofurans(PCDD/PCDFs)in history with estimates in the kg TEQ range for individual *** addition,the chlorine production predecessor processes in the former Leblanc soda factories generated large amounts of PCDD/PCDFs,also in kg TEQ range for individual *** both processes coal tar,used as pitch binder for electrodes in the chlor-alkali process or tars for sealing chlorine chambers,was the major source for PCDD/PCDFs *** complex PAH mixture in the tars which were chlorinated in the processes contained approx.1%*** in this study we screened the full range of chlorinated aromatic and heteroaromatic compounds in contaminated soils from former chlor-alkali plants in Germany and Japan as well as from a German Leblanc factory,using high resolution time-of-flight mass spectrometry *** all three sites the full range of unintentionally produced persistent organic pollutants(POPs)listed in the Stockholm Convention(PCDFs,PCDDs,PCBs,PCNs,HCB,HCBD and PeCBz)were present at high ppb levels and TEQ was up to several 100,000 ng/kg soil in hot spot ***,a wide range of other polychlorinated(PC-)PAHs(PC-phenanthrene/anthracene,PC-pyrene/fluoranthene,PC-benzo(a)anthracene/chrysene)were *** of these compound classes were present in one to two order of magnitude higher concentrations compared to ***,polychlorinated methyldibenzofurans,polychlorinated dimethyl-/ethyl-dibenzofurans,and polychlorinated carbazoles e the N-analogue of dibenzofuran-were detected at levels comparable to PCDFs at all three *** benzonitriles were detected in addition to chlorobenzenes as monoaromatic *** all three factories have stopped production 50e120 years ago,all detected chlorinated aromatics can be regarded as very *** tec

关键词： Unintentional POPs PCDD/PCDFs Polychlorinated carbazoles Chlorinated PAHs Complex mixtures Fingerprint

Inner-arm dynein subspecies c of Chlamydomonas is a single-headed processive motor

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Inner-arm dynein subspecies c of Chlamydomonas is a single-h...

Actively-controlled Beds for Ambulances

Third Congress of the Asian-Pacific Organization for Cell Biology

作者： Sakakibara,H. Sakai,Y. Kojima,H. Oiwa,K. Kansai Advanced Research Center Communications Research Laboratory 588-2 IwaokaNishi-kuKobe 651-2401Japan

Inner-arm dynein subspecies c of Chlamydomonas is the single-headed dynein which is capable of generating force on microtubules [Goodenough et al. (1987),J. Mol. Biol. 194,481-494, Kagami & Kamiya(1992),J. Cell Sci., ...

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International Journal of Automation and computing 2009年第1期6卷 1-6页

作者： Takahiko Ono Hikaru Inooka Graduate School of Information Sciences Hiroshima City University Asaminami-ku Research House LOGOS Aoba-ku

During transportation by ambulance, a patient is exposed to inertial acceleration when an ambulance decelerates or turns a corner. Such acceleration often gives a patient physical stress such as blood pressure variation or body sway, which causes strong pain, feeling of discomfort or sometimes critical damage for seriously injured persons. To reduce this undesirable effect of the acceleration, the authors developed the actively-controlled bed （ACB） which controls the posture of a stretcher in real time to reduce foot-to-head and lateral acceleration acting on a supine person. This paper describes development of the ACB, including control system design and performance evaluation. The control system is designed by Zakian＇s framework, which comprises the principle of matching and the method of inequalities, so that the design specifications on the tracking error and the motor torque are satisfied. From the results of driving experiments and simulation, it is estimated that the ACB can reduce the acceleration acting on a patient by 65% in the foot-to-head direction and by 75% in the lateral direction.

关键词： Control systems mechanical systems motor control acceleration control position control.

一种基于互补投票的高效光流计算方法(英文)

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自动化学报 2013年第7期39卷 1080-1092页

作者： FANG Ming XU Jing TAKAUJI Hidenori KANEKO Shun-Ichi XU Hong-Hua Changchun University of Science and Technology Hokkaido University Kita 14Nishi 9Kita-kuSapporo 060-0814Japan Muroran Institute of Technology 27-1 Mizumoto-choMuroran 050-8585Japan

This paper describes an efficient complementary voting based estimation algorithm of optical flow with reliability measure,called *** estimate the optical flow of an interest region,we divide the region into subreferences,then compute the similarity profile for each subreference using a certain matching *** similarity profiles are employed to extract two kinds of voting roles-positive voting and negative ***,the two kinds of voting roles are carried out to obtain an optimal voting result which is used to estimate an optical flow and a reliability value under a control *** reduce the computational complexity of the CMV,we propose a PV-based negative voting *** results show that the CMV is effective for estimating optical flow in poor-quality image sequence,and that the new negative voting strategy greatly reduces the computation complexity without degradation of the performance.

关键词：估计算法光流估计投票互补可靠性度量巨细胞病毒配置文件计算复杂性

Baicalein and Salvia officinalis Extract Upregulate Transglutaminase 1 mRNA Expression via the Activation of Transient Receptor Potential Channel V4

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Journal of Cosmetics, Dermatological Sciences and Applications 2022年第1期12卷 1-9页

作者： Akihiro Aioi Ryuta Muromoto Tadashi Matsuda Septem-Soken 2-4-27 Dojima Kita-ku Osaka Japan Laboratory of Immunology Faculty of Pharmaceutical Sciences Hokkaido University Kita 12 Nishi 6 Kita-ku Sapporo Japan

Background: It is important to maintain skin homeostasis for cosmetic and medical reasons. Many ceramide-related ingredients and cosmetics have been developed to improve the skin barrier function and skin hydration. Similar to extracellular lipids, the cornified envelope, which is a structure formed beneath the plasma membrane, contributes to the skin barrier function as a scaffold for extracellular lipids. Therefore, in this study, we focused on transglutaminase 1 (TGM1) which is the key enzyme for formation of the cornified envelope Objective: The objectives of this study were to identify compounds that could upregulate the expression of TGM1 and evaluate their underlying action mechanisms. Methods: Expression of the transient receptor potential channel vanilloid subfamily member 4 (TRPV4) at the mRNA and protein levels was estimated by PCR and western blotting. Effects of baicalein and Salvia officinalis (SO) extract on TGM1 mRNA expression were measured by PCR. The involvement of TRPV4 in TGM1 mRNA expression was evaluated by the inhibition and silencing of TRPV4. Results: TRPV4 was expressed in both basal cell-like HaCaT cells and suprabasal cell-like HaCaT cells. Baicalein and SO extract upregulated TGM1 mRNA expression in basal cell-like HaCaT cells. However, inhibition and silencing of TRPV4 abrogated the effects of baicalein and SO extract. Conclusion: Baicalein and SO extract upregulated the expression of TGM1 mRNA via the activation of TRPV4, suggesting that it may improve the skin barrier function by enhancing cornified envelope formation.

关键词： Transient Receptor Potential Channels Transglutaminase 1 Salvia officinalis Skin Homeostasis

Interface Induced Functional Nano-materials and Their EM Analysis

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Interface Induced Functional Nano-materials and Their EM Ana...

Nanodot array deposition via single shot laser interference pattern using laser-induced forward transfer

国际材料科学与工程学术研讨会

作者： Hideki Ichinose Center for Advanced Research of Energy Technology Hokkaido University Nishi-7 Kita-13 Kita-ku Sapporo 060-8628

＜正＞ Grain boundary chemical structure and electronic structure of those nano-devise materials which are silicon carbide, ZnO, GaN and diamond were investigated by atomic resolution high voltage transmission electron microscopy （ARHVTEM） and electron energy loss spectroscopy （EELS） in correlation with possible property by the aid of abinitio calculation. Super-high resolution of the ARHVTEM, being 0.1nm of point to point resolution, enabled the advanced study. Each atomic species and atomic position was identified one by one from a high resolution TEM picture in the grain boundary employing maximum entropy method. Localized electron structure of the each atom was calculated by abinitio calculation and was compared with the EELS.

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International Journal of Extreme Manufacturing 2020年第2期2卷 114-118页

作者： Yoshiki Nakata Eiki Hayashi Koji Tsubakimoto Noriaki Miyanaga Aiko Narazaki Tatsuya Shoji Yasuyuki Tsuboi Institute of Laser Engineering Osaka University2-6 YamadaokaSuitaOsaka 565-0871Japan Institute for Laser Technology 1-8-4 Utsubo-honmachiNishi-kuOsaka 550-0004Japan National Institute of Advanced Industrial Science and Technology Chuo 21-1-1 UmezonoTsukubaIbaraki 305-8568Japan Department of Chemistry Osaka City University3-3-138SugimotoSumiyoshi-kuOsaka 558-8585Japan

Laser-induced forward transfer(LIFT)is a direct-writing technique capable of depositing a single dot smaller than the laser wavelength at small shot energy through the laser-induced dot transfer(LIDT)*** deposit a single nanodot in a single shot of laser irradiation,a liquid nanodrop is transferred from donor to receiver and finally solidified via a solid–liquid–solid(SLS)*** conventional LIDT experiments,multi-shots with step scanning have been used to form array ***,interference laser processing can achieve an arrayed process and generate a periodic structure in a single *** this study,a femtosecond laser interference pattern was first applied to LIDT,and an array of nanodots was successfully deposited in a single shot,producing the following unit structures:a single dot,adjoining dots,and stacking *** diameter of the smallest nanodot was 355 nm,and the narrowest gap between two adjoining nanodots was 17.2 *** LIDT technique produces high-purity,catalyst-free that do not require post-cleaning or alignment *** these significant advantages,LIDT can expand the usability of nanodots in a wide range of fields.

关键词： interference laser processing laser-induced dot transfer nanodot array femtosecond laser solid-liquid-solid mechanism Au

Current Status of the KSTAR Engineering

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Plasma Science and Technology 2004年第1期6卷 2159-2165页

作者： J.S.Bak K.Kim C.H.Choi Y.K.Oh B.C.Kim N.I.Her H.L.Yang G.S.Lee the KSTAR Team Korea Basic Science Institute 52 Yeoeun-Dong Yusung-Ku Daejeon 305-333 KoreaKorea Basic Science Institute 52 Yeoeun-Dong Yusung-Ku Daejeon 305-333 KoreaKorea Basic Science Institute 52 Yeoeun-Dong Yusung-Ku Daejeon 305-333 KoreaKorea Basic Science Institute 52 Yeoeun-Dong Yusung-Ku Daejeon 305-333 KoreaKorea Basic Science Institute 52 Yeoeun-Dong Yusung-Ku Daejeon 305-333 KoreaKorea Basic Science Institute 52 Yeoeun-Dong Yusung-Ku Daejeon 305-333 KoreaKorea Basic Science Institute 52 Yeoeun-Dong Yusung-Ku Daejeon 305-333 KoreaKorea Basic Science Institute 52 Yeoeun-Dong Yusung-Ku Daejeon 305-333 KoreaKorea Basic Science Institute 52 Yeoeun-Dong Yusung-Ku Daejeon 305-333 Korea

As there is substantial progress in the KSTAR tokamak engineering, all themajor structures and sub-systems are under fabrication and in procurement phase. The vacuum vessel,port, cryostat cylinder, lid, and bellows are being rigorously fabricated in the factory. The lowerpart of the KSTAR such as cryostat base and gravity support has been almost finished in itsfabrication. There are also great progresses and significant results in manufacturing of thesuperconducting magnet, including four Toroidal Field (TF) coils, lower and upper PF7 coils whichare the largest Poloidal Field (PF) coils. The TFOO coil, which has been made for test and back-upof the TF magnet system, was successfully tested in the cool-down and current charging. As thefabrications and procurements of major structures have been actively proceeded, assembly works werealso launched from Aug. 2003. More detailed description on these status, results, and plans will bedescribed in this paper.

关键词： KSTAR tokamak vacuum vessel magnet cryostat tokamak assembly