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Mechanisms underlying the role of endoplasmic reticulum stress in the placental injury and fetal growth restriction in an ovine gestation model

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Journal of Animal Science and Biotechnology 2024年第1期15卷 201-217页

作者： Hao Zhang Xia Zha Yi Zheng Xiaoyun Liu Mabrouk Elsabagh Hongrong Wang Honghua Jiang Mengzhi Wang Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition College of Animal Science and TechnologyYangzhou UniversityYangzhou 225009P.R.China Joint International Research Laboratory of Agriculture and Agri‑Product Safety Ministry of Education of ChinaYangzhou UniversityYangzhou 225009P.R.China Department of Animal Production and Technology Faculty of Agricultural Sciences and TechnologiesNiğde Omer Halisdemir UniversityNigde 51240Turkey Department of Nutrition and Clinical Nutrition Faculty of Veterinary MedicineKafrelsheikh UniversityKafrelSheikhEgypt Department of Pediatrics Northern Jiangsu People’s HospitalClinical Medical CollegeYangzhou UniversityYangzhou 225001China State Key Laboratory of Sheep Genetic Improvement and Healthy Production Xinjiang Academy of Agricultural Reclamation ScienceShihezi 832000China

Background Exposure to bisphenol A(BPA),an environmental pollutant known for its endocrine-disrupting properties,during gestation has been reported to increase the risk of fetal growth restriction(FGR)in an ovine model of *** hypothesized that the FGR results from the BPA-induced insufficiency and barrier dysfunction of the placenta,oxidative stress,inflammatory responses,autophagy and endoplasmic reticulum stress(ERS).However,precise mechanisms underlying the BPA-induced placental dysfunction,and subsequently,FGR,as well as the potential involvement of placental ERS in these complications,remain to be *** In vivo experiment,16 twin-pregnant(from d 40 to 130 of gestation)Hu ewes were randomly distributed into two groups(8 ewes each).One group served as a control and received corn oil once a day,whereas the other group received BPA(5 mg/kg/d as a subcutaneous injection).In vitro study,ovine trophoblast cells(OTCs)were exposed to 4 treatments,6 replicates *** OTCs were treated with 400μmol/L BPA,400μmol/L BPA+0.5μg/m L tunicamycin(Tm;ERS activator),400μmol/L BPA+1μmol/L 4-phenyl butyric acid(4-PBA;ERS antagonist)and DMEM/F12 complete medium(control),for 24 *** In vivo experiments,pregnant Hu ewes receiving the BPA from 40 to 130 days of pregnancy experienced a decrease in placental efficiency,progesterone(P4)level and fetal weight,and an increase in placental estrogen(E2)level,together with barrier dysfunctions,OS,inflammatory responses,autophagy and ERS in type A *** vitro experiment,the OTCs exposed to BPA for 24 h showed an increase in the E2 level and related protein and gene expressions of autophagy,ERS,pro-apoptosis and inflammatory response,and a decrease in the P4 level and the related protein and gene expressions of antioxidant,anti-apoptosis and barrier ***,treating the OTCs with Tm aggravated BPA-induced dysfunction of barrier and endocrine(the increased E2 level and decreased P4 level),OS,inflamm

关键词： Autophagy Bisphenol A Endoplasmic reticulum stress Fetal growth restriction Inflammatory responses Sheep

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Speculative bubbles and herding in cryptocurrencies

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Financial Innovation 2022年第1期8卷 2137-2169页

作者： Ozkan Haykir Ibrahim Yag Finance and Banking Department Nigde Omer Halisdemir UniversityNigdeTurkey Accounting and Finance Department Nevsehir HacıBektas Veli UniversityNevsehirTurkey

This study investigates speculative bubbles in the cryptocurrency market and factors affecting bubbles during the COVID-19 *** results indicate that each cryptocurrency covered in the study presented ***,we found that explosive behavior in one currency leads to explosivity in other *** the pandemic,herd behavior was evident among investors;however,this diminishes during bubbles,indicating that bubbles are not explained by herd *** cryptocurrency and market-specific factors,we found that Google Trends and volume are positively associated with predicting speculative bubbles in time-series and panel probit ***,investors should exercise caution when investing in cryptocurrencies and follow both crypto currency and market-related factors to estimate *** liquidity,volatility,and Google Trends measures are used for robustness analysis and yield similar ***,our results suggest that bubble behavior is common in the cryptocurrency market,contradicting the efficient market hypothesis.

关键词： Cryptocurrency Bubbles Co-explosivity Herding COVID-19 pandemic

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Parameters Calibration of the Combined Hardening Rule through Inverse Analysis for Nylock Nut Folding Simulation

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Computer Modeling in Engineering & Sciences 2021年第7期128卷 87-108页

作者： Ilyas Kacar Faculty of Engineering Department of Mechatronics EngineeringNigde Omer Halisdemir UniversityNigdeTurkey

Locking nuts are widely used in industry and any defects from their manufacturing may cause loosening of the connection during their service *** this study,simulations of the folding process of a nut’s flange made from AISI 1040 steel are *** the bilinear isotropic hardening rule,Chaboche’s nonlinear kinematic hardening rule is employed with associated flow rule and Hill48 yield criterion to set a plasticity *** bilinear isotropic hardening rule’s parameters are determined by means of a monotonic tensile *** Chaboche’s parameters are determined by using a low cycle tension/compression test by applying curve fitting methods on the low cycle fatigue ***,the parameter calibrations are performed in the finite element simulations by using an optimization approach based on the inverse *** accuracy for the nut is of primary concern due to the tolerance constraints of the nut *** diameter and height measurements of the folded locking nut are compared with those obtained from the optimized *** results reveal that the folding dimensions can be predicted more accurately when the model parameters are determined by using the combined hardening *** calibrated parameters are presented for the folding and cycling deformation processes.

关键词： Optimization Chaboche kinematic hardening bilinear isotropic hardening nylock nut folding genetic algorithm

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Exploitation of tolerance to drought stress in carrot(Daucus carota L.):an overview

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Stress Biology 2023年第1期3卷 598-609页

作者： Muhammad Daniyal Junaid Zahide Neslihan Ozturk Ali Fuat Gokce Department of Agricultural Genetic Engineering Ayhan Sahenk Faculty of Agricultural Sciences and TechnologiesNigde Omer Halisdemir UniversityNigdeTurkiye Department of Plant Breeding and Genetics Faculty of Agricultural SciencesUniversity of The PunjabLahorePakistan

Drought stress is a significant environmental factor that adversely affects the growth and development of car-rot(Daucus carota L.),resulting in reduced crop yields and *** stress induces a range of physiological and biochemical changes in carrots,including reduced germination,hindered cell elongation,wilting,and disrupted photosynthetic efficiency,ultimately leading to stunted growth and decreased root *** research has focused on understanding the molecular mechanisms underlying carrot’s response to drought stress,identifying key genes and transcription factors involved in drought *** and proteomic analyses have provided insights into the regulatory networks and signaling pathways involved in drought stress *** biochemical processes,water scarcity alters carrot antioxidant levels,osmolytes,and *** review provides an overview of the effects of drought stress on carrots and highlights recent advances in drought stress-related studies on this *** recent advances in understanding the effects of drought stress on carrots and developing strategies for drought stress mitigation are crucial for ensuring sustainable carrot production in the face of changing climate ***,understanding the mechanisms underlying the plant’s response to drought stress is essential for developing strategies to improve its tolerance to water scarcity and ensure food security in regions affected by drought.

关键词： Carrots Drought Hormonal regulation miRNAs Metabolites Quality

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Impact of Electric Vehicle Aggregator with Communication Time Delay on Stability Regions and Stability Delay Margins in Load Frequency Control System

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Journal of Modern Power Systems and Clean Energy 2021年第3期9卷 595-601页

作者： Ausnain Naveed Sahin Sonmez Saffet Ayasun the Department of Electrical and Electronic Engineering Nigde Omer Halisdemir UniversityNigdeTurkey the Department of Electrical and Electronic Engineering Gazi UniversityAnkaraTurkey

This paper investigates the impact of electric vehicle(EV)aggregator with communication time delay on stability regions and stability delay margins of a single-area load frequency control(LFC)***,a graphical method characterizing stability boundary locus is *** a given time delay,the method computes all the stabilizing proportional-integral(PI)controller gains,which constitutes a stability region in the parameter space of PI ***,in order to complement the stability regions,a frequency-domain exact method is used to calculate stability delay margins for various values of PI controller *** qualitative impact of EV aggregator on both stability regions and stability delay margins is thoroughly analyzed and the results are authenticated by time-domain simulations and quasi-polynomial mapping-based root finder(QPmR)algorithm.

关键词： Communication time delay electric vehicle(EV)aggregator frequency regulation proportional-integral(PI)controller design stability delay margin stability region

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Comparative evaluation of different statistical tools for the prediction of uniaxial compressive strength of rocks

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International Journal of Mining Science and Technology 2020年第6期30卷 785-797页

作者： Ahmet Teymen Engin Cemal Mengüç Department of Mining Engineering Nigde Ömer Halisdemir University51240 NigdeTurkey Department of Electrical and Electronics Engineering Nigde Ömer Halisdemir University51240 NigdeTurkey

In this study,uniaxial compressive strength(UCS),unit weight(UW),Brazilian tensile strength(BTS),Schmidt hardness(SHH),Shore hardness(SSH),point load index(Is50)and P-wave velocity(Vp)properties were *** predict the UCS,simple regression(SRA),multiple regression(MRA),artificial neural network(ANN),adaptive neuro-fuzzy inference system(ANFIS)and genetic expression programming(GEP)have been *** obtained UCS values were compared with the actual UCS values with the help of various *** were modeled using different methods and compared with each *** the study where the performance indice PIat was used to determine the best performing method,MRA method is the most successful method with a small *** is concluded that the mean PIat equal to 2.46 for testing dataset suggests the superiority of the MRA,while these values are 2.44,2.33,and 2.22 for GEP,ANFIS,and ANN techniques,*** results pointed out that the MRA can be used for predicting UCS of rocks with higher capacity in comparison with *** to the performance index assessment,the weakest model among the nine model is P7,while the most successful models are P2,P9,and P8,respectively.

关键词： Uniaxial compressive strength Adaptive neuro-fuzzy inference system Multiple regression Artificial neural network Genetic expression programming

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Application of Markovian models for non-ergodic and non-stationary earthquake times series for the identification of seismic patterns and future projections

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Earthquake Science 2020年第2期33卷 98-106页

作者： Hakan Karaca Department of Architecture Omer Halisdemir UniversityNigde 51240Turkey

The current earthquake forecast algorithms are not free of shortcomings due to inherent ***,the requirement of stationarity in the evaluation of earthquake time series as a prerequisite,significantly limits the use of forecast algorithms to areas where stationary data is not *** shortcoming of forecast algorithms is the ergodicity assumption,which states that certain characteristics of seismicity are spatially *** this study,a new earthquake forecast approach is introduced for the locations where stationary data are not *** this purpose,the spatial activity rate density for each spatial unit is evaluated as a parameter of a Markov *** temporal pattern is identified by setting the states at certain spatial activity rate *** using the transition patterns between the states,1-and 5-year forecasts were *** method is suggested as an alternative and complementary to the existing methods by proposing a solution to the issues of ergodicity and stationarity assumptions at the same time.

关键词： spatial pattern Markov chain spatially smoothed seismicity seismic activity rate

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Injector of the Turkish light source facility TURKAY

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Nuclear Science and Techniques 2017年第11期28卷 210-216页

作者： Zafer Nergiz Avni Aksoy Department of Physics Faculty of Arts and Sciences Omer Halisdemir University 51200 Nigde Turkey Institute of Accelerator Technologies Ankara University06830 Golbasi Ankara Turkey

A synchrotron radiation source called TURKAY is proposed as a sub-project of the Turkish Accelerator Center Project. The storage ring of TURKAY is a low emittance synchrotron and the radiation ranges between 0.01 and 60 keV can be generated from the insertion devices and bending magnets placed on it. The injector system of the facility will mainly consist of a 150 MeV linac and full energy booster. In this study, we present design considerations and beam dynamics studies of the pre-injector linac and booster ring for TURKAY.

关键词： Booster ring Pre-injector linac Beam dynamics

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Search for decay modes of heavy and superheavy nuclei

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Chinese Physics C 2019年第7期43卷 37-47页

作者： A.Soylu Department of Physics Nigde ?mer Halisdemir University

Spontaneous fission(SF) with a new formula based on a liquid drop model is proposed and used in the calculation of the SF half-lives of heavy and superheavy nuclei(Z = 90–120). The predicted half-lives are in agreement with the experimental SF half-lives. The half-lives of decay(AD) for the same nuclei are obtained by using the Wentzel-Kramers-Brillouin(WKB) method together with Bohr-Sommerfeld(BS) quantization condition considering the isospin-dependent effects for the cosh potential. The decay modes and branching ratios of superheavy nuclei(Z =104-118) with experimental decay modes are obtained, and the modes are compared with the experimental ones and with the predictions found in the literature. Although some nuclei have predicted decay modes that are different from their experimental decay modes, decay modes same as the experimental ones are predicted for many nuclei. The SF and AD half-lives, branching ratios, and decay modes are obtained for superheavy nuclei(Z = 119–120) with unknown decay modes and compared with the predictions obtained in a previous study. The present results provide useful information for future experimental studies performed on both the AD and SF of superheavy nuclei.

关键词： alpha decay spontaneous fission superheavy Wentzel-Kramers-Brillouin(WKB) method

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Apprehending the potential of BABY BOOM transcription factors to mitigate cotton regeneration and transformation

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Journal of Cotton Research 2020年第4期3卷 297-310页

作者： YAVUZ Caner TILLABOEVA Shakhnozakhan BAKHSH Allah Department of Agricutlural Genetic Engineering Faculty of Agricultural Sciences and TechnologiesNigde Omer Halisdemir University51240 NigdeTurkey

Since the advent of transgenic technology,the incorporation of gene(s)encoding traits of economic importance in cotton is being practiced ***,factors like recalcitrant nature of cotton cultivars,in vitro regeneration via tissue culture(especially via somatic embryogenesis),genotype dependency,long and toilsome protocols impede the pace of development of transgenic *** that,types and age of explants,media composition,plant growth regulators and other environmental factors affect in vitro cotton regeneration *** studies of genetic control of in vitro regeneration in plants have elucidated the role of certain transcription factor genes that are induced and expressed during somatic *** these transcription factors,BABY BOOM(BBM)plays a very important role in signal transduction pathway,leading to cell differentiation and somatic embryos *** role of BBM has been established in plant cell proliferation,growth and development even without exogenous growth *** review intends to provide an informative summary of regeneration and transformation problems in cotton and the latest developments in utilization of BBM transcription factors in *** believe that the use of BBM will not only ease cotton genetic improvement but will also accelerate cotton breeding programmes.

关键词： Cotton Genetic manipulations Regeneration and transformation BBM

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