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Lactobacillus rhamnosus rL-H3-005 ameliorates allergic airway inflammation by modulating the gut microbiota in asthmatic mice

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Food Science and Human Wellness 2024年

作者： Shugang Li Mingxin Li Guopeng Li Huanhuan Liu Wenxiu Zhu donglin Sui Yixuan Li Xiaomeng ren Collaborative Innovation center of Seafood deep processing， national Engineering research center of Seafood， School of Food Science and technology， dalian Polytechnic University dalian Jinshiwan Laboratory

The symptoms of allergic airway disease are impacted by the interplay of gut microbiota， which may be modulated by probiotics. This study aimed to investigate the potential anti-inflammatory effects of three lactic acid bacteria (LAB) on allergic asthma through modulation of the gut microbiota. Ovalbumin (OVA)-induced asthmatic mice were treated with three LAB strains， and their gut microbiota profiles were analyzed using 16S rrNA sequencing. Fecal microbiota transplantation (FMT) from mice fed with Lactobacillus rhamnosus rL-H3-005 was administered to OVA-induced asthmatic mice. The results demonstrated that rL-H3-005 effectively reduced inflammatory infiltrates in the lung and colon， as well as suppressed cytokine levels associated with allergic asthma compared to other strains. In addition， the supplementation of rL-H3-005 modulated the composition of gut microbiota in mice with allergic asthma. FMT results further supported the notion that modulating the gut microbiota with rL-H3-005 plays a crucial role in attenuating airway inflammatory symptoms in allergic asthma.

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New structure transistors for advanced technology node CMOS ICs

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national Science review 2024年第3期11卷 24-41页

作者： Qingzhu Zhang Yongkui Zhang Yanna Luo Huaxiang Yin Integrated Circuit Advanced Process r&d center Institute of Microelectronics of Chinese Academy of Sciences(IMECAS) State key Lab of Fabrication Technologies for Integrated Circuits Institute of Microelectronics of Chinese Academy of Sciences School of Integrated Circuits University of Chinese Academy of Sciences

Over recent decades, advancements in complementary metal-oxide-semiconductor integrated circuits(ICs)have mainly relied on structural innovations in transistors. From planar transistors to the fin field-effect transistor(FinFET) and gate-all-around FET(GAAFET), more gate electrodes have been added to three-dimensional(3d) channels with enhanced control and carrier conductance to provide higher electrostatic integrity and higher operating currents within the same device footprint. Beyond the 1-nm node, Moore's law scaling is no longer expected to be applicable to geometrical shrinkage. Vertical transistor stacking, e.g. in complementary FETs(CFET), 3d stack(3dS) FETs and vertical-channel transistors(VFET), for enhanced density and variable circuit or system design represents a revolutionary scaling approach for sustained IC development. Herein, innovative works on specific structures, key process breakthroughs, shrinking cell sizes and design methodologies for transistor structure research and development are reviewed. Perspectives on future innovations in advanced transistors with new channel materials and operating theories are also discussed.

关键词： transistor CMOS GAAFET CFET 3dS FET

Variation of microbiological and small molecule metabolite profiles of Nuodeng ham during ripening by high-throughput sequencing and GC-TOF-MS

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Food Science and Human Wellness 2024年第4期13卷 2187-2196页

作者： Cong Li Yingling Zou Guozhou Liao Zijiang Yang dahai Gu Yuehong Pu Changrong Ge Guiying Wang Livestock Product processing and Engineering technology research center of Yunnan Province Yunnan Agricultural UniversityKunming 650201China College of Food Science and technology Yunnan Agricultural UniversityKunming 650201China

The internal microbial diversity and small molecular metabolites of Nuodeng ham in different processing years(the first,second and third year sample)were analyzed by high-throughput sequencing technology and gas chromatography-time of flight mass spectrography(GC-TOF-MS)to study the effects of microorganisms and small molecular metabolites on the quality of ham in different processing *** results showed that the dominant bacteria phyla of Nuodeng ham in different processing years were Proteobacteria and Firmicutes,the dominant fungi phyla were Ascomycota and Basidiomycota,while Staphylococcus and Aspergillus were the dominant bacteria and fungi of Nuodeng ham,***,252 kinds of small molecular metabolites were identified from Nuodeng ham in different processing years,and 12 different metabolites were screened through multivariate statistical *** metabolic pathway analysis showed that 23 metabolic pathways were related to ham fermentation,of which 8 metabolic pathways had significant effects on ham fermentation(Impact>0.01,Proline,phenyllactic acid,L-lysine,carnosine,taurine,d-proline,betaine and creatine were significantly positively correlated with the relative abundance of Staphylococcus and Serratia,but negatively correlated with the relative abundance of Halomonas,Aspergillus and Yamadazyma.

关键词： Nuodeng ham Microbial diversity Small molecule metabolites High-throughput sequencing Gas chromatography-time of flight mass spectrography

Model prediction of inactivation of Aeromonas salmonicida grown on poultry in situ by intense pulsed light

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Food Science and Human Wellness 2024年第2期13卷 1011-1017页

作者： Jingwen Wang Zhenzhen Ning Yifan Chen Xinglian Xu Huhu Wang Jiangsu Collaborative Innovation center of Meat Production and processing Quality and Safety ControlCollege of Food Science and TechnologyNanjing Agricultural UniversityNanjing 210095China

The aim of this study was to evaluate the factors influencing the inactivation effect of intense pulsed light(IPL)on Aeromonas salmonicida grown on chicken meat and skin,and to further develop prediction models of *** this work,chicken meat and skin inoculated with meat-borne *** isolates were subjected to IPL treatments under different *** results showed that IPL had obvious bactericidal effect in the chicken skin and thickness groups when the treatment voltage and time were 7 V combined with 5 *** addition,the lethality curves of *** were fitted under IPL conditions of 3.5-7.5 *** comparison of statistical parameters revealed that the Weibull model could best fit the mortality curves and could accurately predict the mortality dynamic of *** grown on chicken *** further a secondary model between the scale factor b and the treatment voltage in Weibull model was established using linear equations,which determined that the secondary model could accurately predict the inactivation of *** study provides a theoretical basis for future prediction models of Aeromonas,and also provides new ideas for sterilization approaches of meat-borne Aeromonas.

关键词： Aeromonas salmonicida Intense pulsed light Inactivation Chicken meat Model

A comprehensive review on the resynthesis of ternary cathode active materials from the leachate of Li-ion batteries

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Journal of Energy Chemistry 2024年第8期95卷 446-463,I0010页

作者： dongwoo Kim Hyeoncheol Joo Chanmin Kim Seoa Kim Wan-Yi Kim Sangwoo Han Joongkil Park Soyeon Park Heechul Jung Sanghyuk Park Kyungjung Kwon department of Energy and Mineral resources Engineering Sejong UniversitySeoul 05006Republic of Korea LIB recycling research Group LIB Materials R&D CenterPOSCO HoldingsPohang 37859Republic of Korea department of Future Energy Convergence Seoul National University of Science&Technology232 Gongreung-roNowon-guSeoul 01811Republic of Korea Autonomous Intelligent Unmanned Flying Vehicles Institute Sejong UniversitySeoul 05006Republic of Korea

This review highlights the importance of recovering valuable metals from spent Li-ion battery(LIB)cathodes through the resynthesis of cathode active materials(CAMs).The resynthesis process of CAMs,a promising recycling method that directly produces CAM precursors from LIB leachate,is *** process encompasses six key steps,including pretreatment,leaching,purification,adjustment of metal concentrations,precursor synthesis,and *** review also investigates the potential introduction of impurity elements during CAM resynthesis and provides tolerance levels for these impurities based on thorough reference ***,it addresses challenges related to the commercialization of the resynthesis ***,this review represents the first comprehensive assessment of CAM resynthesis,including the systematic evaluation of 12 impurity elements(Fe,Li,Al,Cu,C,P,F,Na,Cl,S,Mg,and Zn).Overall,this comprehensive review is poised to support the commercial development of resynthesized CAMs by offering valuable guidelines for managing impurities and streamlining the purification process.

关键词： Li-ion battery recycling resynthesis Leachate Impurity

Two-dimensional semiconductor heterostructures for photocatalytic CO_(2)conversion

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Science China Chemistry 2024年第8期67卷 2434-2447页

作者： Yang Wu Mingyu Wu Yongfu Sun Yi Xie Hefei national research center for Physical Sciences at Microscale University of Science and Technology of ChinaHefei 230026China

The CO_(2)reduction into carbon-contained fuel via solar energy offers the powerful tools to realize the zero-emission carbon *** to the intriguing features of the two-dimensional(2d)heterostructures,it is susceptible to modulate the electronic structure as well as the surface geometry for optimizing the photocatalytic CO_(2)*** this perspective,we surveyed the fundamental insights of 2d semiconductor heterostructures,involving the fabrication strategies and classification of the 2d semiconductor ***,we have detailly discussed the overview of 2d semiconductor heterostructure for optimizing CO_(2)photocatalytic influenced factors,including the solar energy utilization,photogenerated carriers separation,and redox reaction ***,we showed the significant advantages of 2d heterostructures in elevating CO_(2)photoreduction performance,focusing on activity,selectivity and *** analyzing the limitations and developments,we ended by putting forward insights into the further researches about the CO_(2)photocatalysts and reactor design,even industrial applications.

关键词： two-dimensional semiconductor heterostructures photocatalysis CO_(2)conversion

Geometry characteristics and wide temperature behavior of silicon-based GaN surface acoustic wave resonators with ultrahigh quality factor

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Science China(Information Sciences) 2024年第2期67卷 267-278页

作者： Guofang YU renrong LIANG Haiming ZHAO Lei XIAO Jie CUI Yue ZHAO Wenpu CUI Jing WANG Jun XU Jun FU Tianling rEN School of Integrated Circuits Tsinghua University Beijing national research center for Information Science technology Tsinghua University

Surface acoustic wave(SAW) resonators with an ultrahigh Q-factor are designed and fabricated on silicon-based gallium nitride(GaN/Si). The temperature-dependent performance is characterized over a wide range, from 10 to 500 K. Finite element analysis is employed to guide the design of the SAW resonator from indications of the rayleigh mode and weak propagation direction dependence of SAW in the c-plane of GaN/Si. The SAW resonator with 100 pairs of interdigital transducers(IdT), 100 pairs of grating reflectors(Gr) for each side, aperture size of 80 μm, metallization ratio of 0.5, and electrode width of 500 nm resonates at 1.9133 GHz accordingly with an ultrahigh Q-factor of 7622 at room temperature, which contributes the fr× Qr, up to 14.583×1012Hz. A resonator operating over 10 to 500 K indicates an approximately linear decreasing temperature dependence above 280 K while being approximately constant below 40 K. The fitting to resonator characteristics using the modified Butterworth Van dyke(m BVd) model reveals a reduction in both the electrode and mechanical losses while worsening the dielectric loss with cooling down.

关键词： GaN/Si SAW resonator ultrahigh Q-factor temperature-dependent performance mBVd losses

Fecal microbiota transplantation:whole grain highland barley improves glucose metabolism by changing gut microbiota

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Food Science and Human Wellness 2024年第4期13卷 2014-2024页

作者： Xin ren Fulong Zhang Min Zhang Yuan Fang Zenglong Chen Meili Huan Beijing Advanced Innovation center for Food Nutrition and Human Health Beijing Engineering and Technology Research Center of Food AdditivesNational Grain Industry Highland Barley Deep Processing Technology Innovation CenterBeijing Technology and Business UniversityBeijing 100048China State Key Laboratory of Integrated Management of Pest Insects and rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China COFCO Nutrition and Health research Institute Beijing 102209China

Highland barley(HB)is a high-altitude cereal with rich nutritional components and potential health *** clarify its hypoglycemic effect and mechanism,we investigated the effect of whole grain HB and fecal microbiota transplantation(FMT)on glucose metabolism and gut microbiota in high-fat diet and streptozotocin(HFd/STZ)-induced diabetic *** results showed that HB(40%)significantly decreased fasting blood glucose and the area under the glucose tolerance curve,significantly increased insulin secretion and improved insulin resistance in HFd/STZ-induced diabetic mice(Pry factors and blood lipid indices were also significantly alleviated after 12 weeks of 40%HB intervention(Pdditionally,beneficial bacteria,such as Bifidobacterium and Akkermansia,were significantly enriched in the gut of diabetic mice after whole grain HB ***,the results of further FMT experiments verified that the fecal microbiota after the 40%HB intervention not only significantly increased the relative abundance of Bifidobacterium and Akkermansia but also effectively improved glucose metabolism and alleviated the inflammatory state in HFd/STZ-induced diabetic ***,our study confirmed the bridge role of gut microbiota in improving glucose metabolism of whole grain HB,which could promote the development of precision nutrition.

关键词： Highland barley diabetes Glucose metabolism Gut microbiota Fecal bacteria transplantation

The quality control and hypoglycemic effect of Cinnamomi Cortex aqueous extract

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Journal of Future Foods 2024年第2期4卷 167-172页

作者： Xuting Hao Ziheng Jin ruiyu Gao Shiming Li Changqin Li Lijun Liu Jinmei Wang national r&d center for Edible Fungus processing technology Henan UniversityKaifeng 475004China Key Laboratory of Natural Pigment Preparation of Henan Province Luohe 462600China department of Food Science rutgers University New BrunswickNJ 08901USA Joint International research Laboratory of Food&Medicine resource Function of Henan Province Kaifeng 475004China Huaihe Hospital of Henan University Kaifeng 475000China

Cinnamomi Cortex was a material as medicinal and edible resources and it has been demonstrated that Cinnamomi Cortex aqueous extract(CCAE)possess hypoglycemic effect,but there were no active compounds identified as quality standard of CCAE to be used in the investigate of hypoglycemic ***,in this study,the quality standard and the hypoglycemic effect of CCAE were *** and coumarin as the quality control in CCAE were analyzed by high performance liquid chromatography(HPLC)*** results showed that the average yield of extraction was 10.06%.The concentration of coumarin was linear with peak area ranging from 0.02–1.00μg/mL(r=0.9996,n=6)and that of cinnamaldehyde also demonstrated a good linear relationship with peak area in the range of 1.05–52.50μg/mL(r=0.9997,n=6).The average recovery rate of coumarin and cinnamaldehyde was 99.42%and 100.11%,*** investigation of hypoglycemic effect revealed that CCAE could improve weight loss,lower liver and pancreas indices,improve organ damage caused by diabetes,and lower fasting blood glucose,glycosylated serum protein(GSP)and total cholesterol(TC)*** results showed that CCAE can reduce fasting blood glucose and blood lipid levels in diabetic mice.

关键词： Cinnamomi Cortex Cinnamaldehyde Coumarin Hypoglycemic effect