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Neurotrophins differentially stimulate the growth of cochlear neurites on collagen surfaces and in gels

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Neural Regeneration research 2013年第17期8卷 1541-1550页

作者： Joanna Xie Kwang Pak Amaretta Evans Andy Kamgar-Parsi Stephen Fausti Lina Mullen Allen Frederic Ryan Department of Surgery/Otolaryngology School of Medicine and Veterans Administration Medical Center University of California national center for research on auditory Rehabilitation Portland VA Medical Center Department of Neurosciences School of Medicine and Veterans Administration Medical Center University of California

The electrodes of a cochlear implant are located far from the surviving neurons of the spiral ganglion, which results in decreased precision of neural activation compared to the normal ear. If the neurons could be induced to extend neurites toward the implant, it might be possible to stimulate more discrete subpopulations of neurons, and to increase the resolution of the device. However, a major barrier to neurite growth toward a cochlear implant is the fluid filling the scala tympani, which separates the neurons from the electrodes. The goal of this study was to evaluate the growth of cochlear neurites in three-dimensional extracellular matrix molecule gels, and to increase biocompatibility by using fibroblasts stably transfected to produce neurotrophin-3 and brain-derived neurotrophic factor. Spiral ganglion explants from neonatal rats were evaluated in cultures. They were exposed to soluble neurotrophins, cells transfected to secrete neurotrophins, and/or collagen gels. We found that cochlear neurites grew readily on collagen surfaces and in three-dimensional collagen gels. Co-culture with cells producing neurotrophin-3 resulted in increased numbers of neurites, and neurites that were longer than when explants were cultured with control fibroblasts stably transfected with green fluorescent protein. Brain-derived neurotrophic factor-producing cells resulted in a more dramatic increase in the number of neurites, but there was no significant effect on neurite length. It is suggested that extracellular matrix molecule gels and cells transfected to produce neurotrophins offer an opportunity to attract spiral ganglion neurites toward a cochlear implant.

关键词： neural regeneration peripheral nerve injury cochlear implant inner ear neuron neurite guidance neurotrophin extracellular matrix collagen gel grants-supported paper neuroregeneration

Patent foramen ovale in an old patient with ischemic stroke following carotid surgery

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Journal of Geriatric Cardiology 2018年第8期15卷 551-553页

作者： Elpidio Santillo Monica Migale Luciano Marini Raffaele Antonelli-Incalzi Geriatric-rehabilitative Department Italian National Research Center oll Aging IRCCS-INRCA Fermo. Italy Chair of Geriatrics Biomedic Campus Univeerity Via Alvaro del Portillo 21 Rome Italy

Post-procedural strokes have been observed in 0.5-2.7% of patients after carotid endarterectomy （CEA）. They are frequently due to carotid embolism or thrombosis of the operated artery. lntracerebral haemorrhages and... 详细信息

关键词： Carotid surgery Ischemic stroke Patent foramen ovale The elderly

Application of the Kurtosis Metric to the Assessment of Hearing Loss Associated with Occupational Noise Exposure

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China CDC weekly 2021年第18期3卷 390-393页

作者： Wei Qiu Meibian Zhang Weijiang Hu Xin Sun auditory research Laboratory State University of New York at PlattsburghNew YorkUSA Zhejiang Provincial center for Disease Control and Prevention HangzhouZhejiangChina national Institute of Occupational Health and Poison Control BeijingChina.

It is well known that high-level noise exposure can lead to hearing ***-induced hearing loss(NIHL)continues to be one of the major occupational health *** underlying assumption in current noise standards,e.g.,ISO 1999:2013(1),is that hearing loss is related to the total energy of the ***,the risk of NIHL can be predicted according to the ISO 1999 prediction ***,the validity of the prediction model to correctly predict the NIHL for all types of noise exposure is still under question,especially for complex noise of impulsive character.

关键词： prediction occupational hearing

The Role of the Kurtosis Metric in Evaluating the Risk of Occupational Hearing Loss Associated with Complex Noise—Zhejiang Province,China,2010−2019

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China CDC weekly 2021年第18期3卷 378-382页

作者： Meibian Zhang Xiangjing Gao Wei Qiu Xin Sun Weijiang Hu Occupational Health and Radiation Protection Institute Zhejiang Provincial Center for Disease Control and PreventionHangzhouZhejiangChina auditory research Laboratory State University of New York at PlattsburghPlattsburghNew YorkUSA national Institute of Occupational Health and Poisoning Control China Center for Disease Control and PreventionBeijingChina.

Summary What is already known about this topic?Occupational noise-induced hearing loss(NIHL)has been the second most common occupational disease in *** energy is the main risk factor for occupational *** shows the temporal structure of noise(as indicated by kurtosis metric)contribute to the development of ***,the role of the kurtosis metric in evaluating the risk of occupational NIHL associated with complex noise has been rarely reported.

关键词： China Occupational hearing

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Signal Transduction and Targeted Therapy 2022年第7期7卷 2533-2544页

作者： Xi Shi Zihao Wang Wei Ren Long Chen Cong Xu Menghua Li Shiyong Fan Yuru Xu Mengbing Chen Fanjun Zheng Wenyuan Zhang Xinbo Zhou Yue Zhang Shiwei Qiu Liyuan Wu Peng Zhou Xinze Lv Tianyu Cui Yuehua Qiao Hui Zhao Weiwei Guo Wei Chen Song Li Wu Zhong Jian Lin Shiming Yang Department of Pharmacy Peking University Third HospitalBeijingChina Artificial auditory Laboratory of Jiangsu Province Xuzhou Medical UniversityXuzhouChina national Engineering research center for the Emergency Drug Beijing Institute of Pharmacology and ToxicologyBeijingChina College of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalBeijingChina national Clinical research center for Otolaryngologic Diseases BeijingChina Key Lab of Hearing Science Ministry of EducationBeijingChina Beijing Key Lab of Hearing Impairment for Prevention and Treatment BeijingChina Synthetic and Functional Biomolecules center Beijing National Laboratory for Molecular SciencesKey Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of Chemistry and Molecular EngineeringInnovation Center for GenomicsPeking UniversityBeijingChina

Inner ear disorders are a cluster of diseases that cause hearing loss in more than 1.5 billion people ***,the presence of the blood-labyrinth barrier(BLB)on the surface of the inner ear capillaries greatly hinders the effectiveness of systemic drugs for prevention and intervention due to the low permeability,which restricts the entry of most drug compounds from the bloodstream into the inner ear ***,we report the finding of a novel receptor,low-density lipoprotein receptor-related protein 1(LRP1),that is expressed on the BLB,as a potential target for shuttling therapeutics across this *** a proof-ofconcept,we developed an LRP1-binding peptide,IETP2,and covalently conjugated a series of model small-molecule compounds to it,including potential drugs and imaging *** compounds were successfully delivered into the inner ear and inner ear lymph,indicating that targeting the receptor LRP1 is a promising strategy to enhance the permeability of the *** discovery of the receptor LRP1 will illuminate developing strategies for crossing the BLB and for improving systemic drug delivery for inner ear disorders.

关键词： drugs prevention barrier

The impact of hearing impairment and noise-induced hearing injury on quality of life in the active-duty military population:challenges to the study of this issue

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Journal of Medical Colleges of PLA(China) 2016年第3期31卷 153-161页

作者： Hasanat Alamgir Caryn A.Turner Nicole J.Wong Sharon P.Cooper Jose A.Betancourt James Henry Andrew J.Senchak Tanisha L.Hammill Mark D.Packer Deptartment of Health Policy and Management School of Health Sciences and PracticeNew York Medical CollegeValhallaNY 10595USA School of Public Health The University of Texas Health Science Center at Houston7411 John Smith Drive Suite 1100 San AntonioTX 78229USA national center for rehabilitative auditory research 3710 SW US Veteran Hospital RoadPortlandOR 87239USA Walter Reed national Military Medical center 8901 Wisconsin AveBethesdaMD 20814USA Department of Defense Hearing center of Excellence 59MDW/SG02O2200 Bergqiust Drive Suite 1JBSA LacklandTX 78236USA.

The objectives of this review were to 1)summarize the available evidence on the impact of hearing loss on quality of life(QOL)among ***-duty service members,2)describe the QOL instruments that have been used to quantify the impact of hearing loss on quality of life,3)examine national population-level secondary databases and report on their utility for studying the impact of hearing loss on QOL among active-duty service members,and 4)provide recommendations for future studies that seek to quantify the impact of hearing loss in this *** is a lack of literature that addresses the intersection of hearing impairment,the military population,and quality of life *** audiological research,*** personnel offer a unique research population,as they are exposed to noise levels and blast environments that are highly unusual in civilian work settings and can serve as a model population for studying the impact on QOL associated with these *** review recommends conducting a study on the active-duty service member population using a measurement instrument suitable for determining decreases in QOL specifically due to hearing loss.

关键词： Quality of life(QOL) Hearing impairment Noise-induced hearing injury Hearing loss Tinnitus Hearing impairment and noise-induced hearing injury(HINIHI) Military Service members

Metastatic hepatocellular carcinoma of the external auditory canal

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World Journal of Gastroenterology 2007年第47期13卷 6436-6438页

作者： Ryuji Yasumatsu Kenji Okura Yumiko Sakiyama Makoto Nakamuta Taisei Matsumura Satoru Uehara Tomoya Yamamoto Shizuo Komune Department of Otorhinolaryngology Graduate School of Medical SciencesKyushu University and Department of Otorhinolaryngology and Clinical Research InstituteNational Hospital Organization Kyushu Medical CenterFukuoka 812-8582Japan Department of Otorhino-laryngology and Clinical research Institute National Hospital Organization Kyushu Medical CenterFukuoka 812-8582Japan Department of Gastro-enterology and Clinical research Institute National Hospital Organization Kyushu Medical CenterFukuoka 812-8582Japan Department of Radiology and Clinical research Institute National Hospital Organization Kyushu Medical CenterFukuoka 812-8582Japan Department of Otorhinolaryngology Graduate School of Medical SciencesKyushu UniversityJapan

This report describes a rare case of metastatic hepatocellular carcinoma (HCC) presenting a huge mass in the left external auditory canal (EAC). The patient was a 55-year-old man with hepatitis B virus-related HCC. He presented to our department with a three-month history of increasing left otalgia,and hearing loss with recent fresh aural bleeding. Histopathologic examination indicated that the tumor was secondary to HCC. Although external irradiation was not effective,the tumor was treated with surgical debulking and high dose rate 192 Ir remote afterloading system (RALS) for postoperative intracavitary irradiation. A review of the literature revealed only five other cases of HCC metastasis to the temporal bone,all of which mainly metastasized in the internal acoustic meatus. The present case is the first report of HCC metastasis to the EAC.

关键词： Hepatocellular carcinoma Metastasis External auditory canal

Shrinkage of ipsilateral taste buds and hyperplasia of contralateral taste buds following chorda tympani nerve transection

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Neural Regeneration research 2015年第6期10卷 989-995页

作者： Yi-ke Li Juan-mei Yang Yi-bo Huang Dong-dong Ren Fang-lu Chi Department of Otology and Skull Base Surgery Eye Ear Nose & Throat HospitalFudan University Shanghai auditory Medical center Key Laboratory of Hearing Science Ministry of Health Department of Hearing and Speech Sciences Vanderbilt University

The morphological changes that occur in the taste buds after denervation are not well under- stood in rats, especially in the contralateral tongue epithelium. In this study, we investigated the time course of morphological changes in the taste buds following unilateral nerve transection. The role of the trigeminal component of the lingual nerve in maintaining the structural integrity of the taste buds was also examined. Twenty-four Sprague-Dawley rats were randomly divided into three groups： control, unilateral chorda tympani nerve transection and unilateral chorda tympani nerve transection ＋ lingual nerve transection. Rats were allowed up to 42 days of re- covery before being euthanized. The taste buds were visualized using a cytokeratin 8 antibody. Taste bud counts, volumes and taste receptor cell numbers were quantified and compared among groups. No significant difference was detected between the chorda tympani nerve transection and chorda tympani nerve transection ＋ lingual nerve transection groups. Taste bud counts, volumes and taste receptor cell numbers on the ipsilateral side all decreased significantly compared with control. On the contralateral side, the number of taste buds remained unchanged over time, but they were larger, and taste receptor cells were more numerous postoperatively. There was no evidence for a role of the trigeminal branch of the lingual nerve in maintaining the structural integrity of the anterior taste buds.

关键词： nerve regeneration gustation cytokeratin tongue epithelium immunohistochemistry taste bud trigeminal nerve disorder NSFC grants neural regeneration

Availability and safety assessment of infrared neural stimulation at high repetition rate through an implantable optrode

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Journal of Innovative Optical Health Sciences 2021年第3期4卷 88-102页

作者： Yaqin Wan Meiqun Wang Shaorong Zhang Bingbin Xie Out-Patient Department of the Second Affiliated Hospital of Nanchang University 1 Minde RoadNanchang 330006P.R.China Department of Otolaryngology Head and Neck Surgery The Second Affiliated Hospital of Nanchang University 1 Minde RoadNanchang 330006P.R.China Jiangxi Biomedical Engineering research center for auditory research 1 Minde RoadNanchang 330006P.R.China

An implantable optrode with micro-thermal detectors was designed to investigate the availability and safety of INS using high repetition *** auditory brainstem responses(oABRs)were recorded in normal-hearing guinea pigs,and the energy thresholds,pulse durations,and ampli-tudes evoked by the varied stimulus repetitions were *** oABRs could be evoked through INS even as the repetition rate of stimulation reached 19 *** energy threshold of oABRs was elevated,the amplitudes decreased as pulse durations increased and repetition rates were higher,and the latencies were delayed as the pulse durations *** temperature variation curves on the site of stimulation significantly increased as the pulse duration increased to 400μ*** elevated the temperature around the stimulus site area via thermal accumulation during radiation,especially when higher repetition stimuli were *** results demonstrate that high repetition infrared stimulations can safely evoke stable and available oABRs in normal-hearing guinea pigs.

关键词： Infrared neural stimulation implantable optrode cochlear implant spiral ganglion neuron optical stimulation