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Comparison Between Early and Late 21stC Phytoplankton Biomass and Dimethylsulfide Flux in the Subantarctic Southern Ocean

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Journal of Ocean University of China 2020年第1期19卷 151-160页

作者： QU Bo Albert JGABRIC JIANG Limei LI Chunyue school of Science Nantong UniversityNantong 226019China school of Environment and Science Griffith UniversityNathan Qld 4111Australia nantong chong chuan school Nantong 226000China Marketing Thermo Fisher ScientificShanghai 201206China

Time-series of chlorophyll-a(CHL),a proxy for phytoplankton biomass,and various satellite-derived climate indicators are compared in a region of the Subantarctic Southern Ocean(40°-60°S,110°-140°E)for years *** reached a minimum in winter(June)and a maximum in late summer(early February).Zonal mean CHL decreased towards the *** sea surface temperature(SST)ranged between 8℃and 15℃and peaked in late *** and SST were positively correlated from March to June,negatively correlated from July to *** and wind speed(WIND)were negatively correlated with peak WIND occurred in *** direction(WIRD)was mostly in the southwest to westerly *** Antarctic Oscillation index(AAO)and CHL were negatively correlated(R=−0.58),indicating that as synoptic wind systems move southwards,CHL increases,and conversely when wind systems move northwards,CHL decreases.A genetic algorithm is used to calibrate the biogeochemical DMS model’s key *** 4×CO2(after year 2100)Regional mean SST increases 12%-17%,WIND increases 1.2ms−1,Cloud Cover increases 4.8%and mixed layer depth(MLD)decreases *** annual CHL increases 6.3%.The annual mean DMS flux increase 25.2%,increases 37%from day 1 to day 280 and decrease 3%from day 288 to day *** general increase of DMS flux under 4×CO2 conditions indicates the Subantarctic regional climate would be affected by changes in the DMS flux,with the potential for a cooling effect in the austral summer and autumn.

关键词： wind speed phytoplankton dimethylsulfide flux climate change subantarctic Southern Ocean

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PPARγ2 functions as a tumor suppressor in a translational mouse model of human prostate cancer

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Asian Journal of Andrology 2022年第1期24卷 90-96页

作者： Fu-Lu Dong Dong-Mei Liu Ting-Ting Lu Feng Li chong Zhang Qun E Yong-Hui Zhang Laboratory of Nuclear Receptors and Cancer Research Department of PathologyMedical SchoolNantong UniversityNantong 226001China

Peroxisome proliferator-activated receptorsγ(PPARγ)is a master regulator that controls energy metabolism and cell ***γ2,a PPARγisoform,is highly expressed in the normal prostate but expressed at lower levels in prostate cancer *** the present study,PC3 and LNCaP cells were used to examine the benefits of restoring PPARγ2 ***γ2 was overexpressed in PC3 and LNCaP cells,and cell proliferation and migration were *** and eosin(H&E)staining was used to detect pathological *** genes regulated by PPARγ2 overexpression were detected by microarray *** restoration of PPARγ2 in PC3 and LNCaP cells inhibited cell proliferation and ***3-PPARγ2 tissue recombinants showed necrosis in cancerous regions and leukocyte infiltration in the surrounding stroma by H&E *** found higher mixed lineage kinase domain-like(MLKL)and lower microtubule-associated protein 1 light chain 3(LC3)expression in cancer tissues compared to controls by immunohistochemistry(IHC)*** analysis showed that PPARγ2 gain of function in PC3 cells resulted in the reprogramming of lipid-and energy metabolism-associated signaling *** data indicate that PPARγ2 exerts a crucial tumor-suppressive effect by triggering necrosis and an inflammatory reaction in human prostate cancer.

关键词： inflammatory reaction necrosis PPARγ prostate cancer tissue recombination-xenografting

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Peroxisome proliferator-activated receptor gamma signaling in human sperm physiology

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Asian Journal of Andrology 2015年第6期17卷 942-947,I0008页

作者： Li-Li Liu Hua Xian Jing-Chen Cao chong Zhang Yong-Hui Zhang Miao-Miao Chen Yi Qian Ming Jiang Laboratory of Nuclear Receptors and Cancer Research Basic Medical Research Center Nantong University School of Medicine Nantong Jiangsu China Department of Surgery Affiliated Hospital of Nantong University Nantong Jiangsu China Division of Epidemiology Department of Medicine Vanderbilt lngram Cancer CenterVanderbilt University Medical Center Nashville TN USA .

Peroxisome proliferator-activated receptor gamma （PPARy） is a member of the PPARs, which are transcription factors of the steroid receptor superfamily. PPARy acts as an important molecule for regulating energy homeostasis, modulates the hypothalamic-pituitary-gonadal （HPG） axis, and is reciprocally regulated by HPG. In the human, PPARγprotein is highly expressed in ejaculated spermatozoa, implying a possible role of PPARγ signaling in regulating sperm energy dissipation. PPARγ protein is also expressed in Sertoli cells and germ cells （spermatocytes）. Its activation can be induced during capacitation and the acrosome reaction. This mini-review will focus on how PPARy signaling may affect fertility and sperm quality and the potential reversibility of these adverse effects.

关键词： fertilization hypothalamic-pituitary-gonadal axis insulin resistance leptin peroxisome proliferator-activated receptor gamma sperm physiology spermatogenesis spermatozoa

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A Novel ***129His Variant in SIX1 Leads to Dominant,Delayed-onset Hearing Loss with Possible Association with Congenital Anosmia

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Biomedical and Environmental Sciences 2021年第4期34卷 314-318页

作者： PANG Xiu Hong ZHENG Xiao Yong LIN Yun ZHENG Hao XU Jun LIU Dong JIN Chun Yan ZHANG Lu Ping ZHANG Yu Ting CHU Jiu Sheng CHAI Yong chuan YANG Tao Department of Otolaryngology-Head and Neck Surgery Taizhou People's Hospitalthe Fifth Affiliated Hospital of Nantong University&Clinical Hospital of Dalian Medical UniversityTaizhou 225300JiangsuChina Department of Dermatology Taizhou People's Hospitalthe Fifth Affiliated Hospital of Nantong UniversityTaizhou 225300JiangsuChina Department of Otolaryngology-Head and Neck Surgery the Ninth People's HospitalShanghai Jiaotong University School of MedicineShanghai 200011China Ear Institute Shanghai Jiaotong University School of MedicineShanghai 200011China Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases Shanghai 200011China Department of Clinical Medicine Medical School of Nantong UniversityNantong 226000JiangsuChina Life scientific school Neuroregenerative Key Laboratory of Jiangsu and Ministry of EducationNeuroregenerative Co-innovation CenterNantong UniversityNantong 226000JiangsuChina Department of Medical Genetics Taizhou People's Hospitalthe Fifth Affiliated Hospital of Nantong UniversityTaizhou 225300JiangsuChina Department of Otolaryngology-Head and Neck Surgery Affiliated Hospital of Nantong UniversityNantong 226000JiangsuChina

SIX1(OMIM 601205),as a member of the SIX homeobox transcription factor family,belongs to homologs of the Drosophila‘sine oculis’gene that expresses primarily in the developing visual system of the *** SIX family includes six members(SIX1–SIX6),which share a homologous DNA-binding homeodomain(HD)and a highly conserved protein–protein interacting SIX domain(SD)[1].

关键词： SIX1 homeobox belongs

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Experimental Optimization of Jet Self-Priming Centrifugal Pump Based on Orthogonal Design and Grey-Correlational Method

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Journal of Thermal Science 2020年第1期29卷 241-250页

作者： CHANG Hao SHI Weidong LI Wei WANG chuan ZHOU Ling LIU Jianrui YANG Yongfei RAMESH KAgarwal Research Center of Fluid Machinery Engineering and Technology Jiangsu UniversityZhenjiang 212013China Department of Mechanical Engineering&Materials Science Washington University in St.LouisSt.Louis 63130USA school of Mechanical Engineering Nantong UniversityNantong 226019China school of Hydraulic Energy and Power Engineering Yangzhou UniversityYangzhou 225002China

The novel jet self-priming centrifugal pump,as important modern irrigation equipment,is widely used in large-scale irrigation,mine drainage and so *** order to improve the profile streamline of blade,the inlet shape of impeller was designed as distorted and the outlet shape as cylindrical,which can not only improve the pump efficiency,but also shorten the self-priming ***,the novel jet self-priming system was proposed,by employing the jet nozzle and check valve to improve the velocity of ***,nine different structure jet nozzles were designed based on the orthogonal design method,and the relevant self-priming experiments were performed on I level accuracy test bench in Jiangsu *** to the greycorrelational analysis,the influence of the nozzle geometry parameters on the self-priming performance was *** relationship between self-priming time and self-priming height was *** test results showed that the hydraulic design of jet self-priming centrifugal pump was reasonable;all indicators met the Chinese national standard;the head reached 21.04 m and efficiency was 72.8%under the design flow *** is more,the self-priming performance was obviously improved by adjusting the geometrical parameters of *** the height of the self-priming process was 5.3 m,the self-priming time reached 62 s,which was much shorter than the national ***,this research could provide reference for designing the structure of jet self-priming centrifugal pump.

关键词： self-priming centrifugal pump design optimization orthogonal experiment grey-correlational

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Advances in prostate cancer research models:From transgenic mice to tumor xenografting models

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Asian Journal of Urology 2016年第2期3卷 64-74页

作者： Yuejiao Huang Chun Cheng chong Zhang Yonghui Zhang Miaomiao Chen Douglas W.Strand Ming Jiang Department of Oncology Affiliated Cancer Hospital of Nantong UniversityNantongJiangsuChina Department of Immunology Nantong University School of MedicineNantongJiangsuChina Laboratory of Nuclear Receptors and Cancer Research Center for Basic Medical ResearchNantong University School of MedicineNantongJiangsuChina Department of Urology UT Southernwestern Medical CenterDallasTXUSA Institute of Medicine and Public Health Division of EpidemiologyDepartment of MedicineVanderbilt-Ingram Cancer CenterVanderbilt University Medical CenterNashvilleTNUSA

The identification of the origin and molecular characteristics of prostate cancer(PCa)has crucial implications for personalized *** development of effective treatments for PCa has been limited;however,the recent establishment of several transgenicmouse lines and/or xenografting models is better reflecting the disease in *** appropriate models,valuable tools for elucidating the functions of specific genes have gone deep into prostate development and *** the present review,we summarize a number of important PCa research models established in our laboratories(PSA-Cre-ERT2/PTEN transgenic mouse models,AP-OX model,tissue recombination-xenografting models and PDX models),which represent advances of translational models from transgenic mouse lines to human tumor *** understanding of the developments of these models will offer new insights into tumor progression and may help explain the functional significance of genetic variations in ***,this understanding could lead to new modes for curing PCa based on their particular biological phenotypes.

关键词： Prostate cancer Transgenic mouse lines Tumor xenografting models Translational medical systems

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Effect of fatigue load on the bending tribo-corrosion-fatigue behaviors between the main cable wires

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Friction 2024年第7期12卷 1512-1531页

作者： Bo WANG Dagang WANG Jihong YE Liang TANG Hailang chong Wei XU Xinxin ZHANG Jianhao CHEN Haiyan DENG Jie ZHANG Guowen YAO Magd Abdel WAHAB school of Mechatronic Engineering China University of Mining and TechnologyXuzhou 221116China Xuzhou Key Laboratory for Fire Safety of Engineering Structures China University of Mining and TechnologyXuzhou 221116China National Wire Rope Quality Inspection Center Nantong Product Quality Supervision and Inspection InstituteNantong 226011China Jiangsu Langshan Wire Rope Co. Ltd.Nantong 226003China school of Mechatronic Engineering Southwest Petroleum UniversityChengdu 610500China school of Civil Engineering Chongqing Jiaotong UniversityChongqing 400074China Soete Laboratory Faculty of Engineering and ArchitectureGhent UniversityZwijnaarde B-9052Belgium

The main cable bent around the saddle of the suspension bridge is subjected to the wind,the vehicle,the bridge’s own weight and the corrosive *** coupling of the three loads and the environments causes the friction,the corrosion,and the fatigue(tribo-corrosion-fatigue)among the wires inside the main *** this paper,a wire bending tribo-corrosion-fatigue test rig was designed and *** effect of fatigue load on the bending friction behaviors between the cable wires in ultrapure water and 3.5%NaCl solution was *** tribological properties and electrochemical corrosion behaviors under different fatigue loading ranges were *** tribo-corrosion-fatigue interaction between the cable wires was quantitatively characterized,and the mechanism of the interaction was *** results demonstrate that the increasing fatigue load exacerbates the coupling damage of the cable wires attributed to the enhanced *** findings carry theoretical importance when assessing the main cable’s deterioration and the load-bearing safety of a suspension bridge.

关键词： bending tribo-corrosion-fatigue interaction parallel steel wires fatigue load

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Advances in Drug Therapy for Alzheimer’s Disease

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Current Medical Science 2020年第6期40卷 999-1008页

作者： chuan-cong ZHU Si-yu FU Yu-xin CHEN Ling LI Ruo-lin MAO Jian-zhi WANG Rong LIU Yi LIU Xiao-chuan WANG Department of Pathophysiology School of Basic MedicineKey Laboratory of Education Ministry of China for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Co-innovation Center of Neuroregeneration Nantong UniversityNantong 226001China Department of Pathology and Pathophysiology School of MedicineJianghan UniversityWuhan 430056China

Alzheimer’s disease(AD)is a chronic neurodegenerative disease that mainly causes *** is a serious threat to the health of the global elderly *** money and effort has been invested in the development of drug therapy for AD *** drug therapies are currently under development or in clinical trials,based on two known mechanisms of AD,namely,Aβtoxicity and the abnormal Tau *** drugs are also being developed for other AD associated mechanisms such as neuroinflammation,neurotransmitter imbalance,oxidative damage and mitochondrial dysfunction,neuron loss and *** so,the number of drugs that can successfully improve symptoms or delay the progression of the disease remains very ***,multi-drug combinations may provide a new avenue for drug therapy for *** addition,early diagnosis of AD and timely initiation of treatment may allow drugs that act on the early pathological processes of AD to help improve the symptoms and prevent the progression of the condition.

关键词： Alzheimer’s disease Aβ tau drug therapy

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Glycogen Synthase Kinase-3β,NLRP3 Inflammasome,and Alzheimer's Disease

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Current Medical Science 2023年第5期43卷 847-854页

作者： Yue-ran JIA Zi-qing GUO Qian GUO Xiao-chuan WANG Department of Pathophysiology School of Basic MedicineKey Laboratory of Education Ministry/Hubei Province of China for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Co-innovation Center of Neuroregeneration Nantong UniversityNantong 226001China

Alzheimer’s disease (AD) is the most prevalent cause of dementia worldwide. Because of the progressive neurodegeneration, individual cognitive and behavioral functions are impaired, affecting the quality of life of millions of people. Although the exact pathogenesis of AD has not been fully elucidated, amyloid plaques, neurofibrillary tangles (NFTs), and sustaining neuroinflammation dominate its characteristics. As one of the major tau kinases leading to hyperphosphorylation and aggregation of tau, glycogen synthase kinase-3β (GSK-3β) has been drawing great attention in various AD studies. Another research focus of AD in recent years is the inflammasome, a multiprotein complex acting as a regulator in immunological reactions to exogenous and endogenous danger signals, of which the Nod-like receptor (NLR) family, pyrin domain-containing 3 (NLRP3) inflammasome has been studied mostly in AD and proven to play a significant role in AD development by its activation and downstream effects such as caspase-1 maturation and interleukin (IL)-1β release. Studies have shown that the NLRP3 inflammasome is activated in a GSK-3β-dependent way and that inhibition of the NLRP3 inflammasome downregulates GSK-3β, suggesting that these two important proteins are closely related. This article reviews the respective roles of GSK-3β and the NLRP3 inflammasome in AD as well as their relationship and interaction.

关键词： glycogen synthase kinase-3β NLRP3 inflammasome Alzheimer's disease

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Simultaneous Separation and Detection of Bisphenol A and Dibutyl Phthalate by Paper-Chromatography Electrochemiluminescence Devices

Simultaneous Separation and Detection of Bisphenol A and Dib...

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中国化学会第十四届全国电分析化学学术会议

作者： chuan-Guo Shi Xiao-Lei Huo Hai-Ying Gu Ning Bao school of Chemistry and Chemical Engineering Nantong University school of Public Health Nantong University

Electrochemiluminescence（ECL） is a powerful technique with the advantages of high sensitivity and wide dynamic range,but it is normally difficult to simultaneously detect multicomponent *** this work,a simple paper-chromatography ECL device was developed for simultaneous separation and detection of bisphenol A（BPA） and dibutyl phthalate（DBP）.In our design,a filter paper was used to effectively separate the BPA and DBP.A carbon conductive tape modified with multiwalled carbon nanotube（MWCNTs） and CdSe quantum dot（CdSe QDs） was attached to an ITO glass and used as an ECL detection *** linear relationships between ECL signals and the concentrations of DBP and BPA were obtained as a result of the quenching effect of BPA and DBP on the ECL emission of CdSe *** designed paper-chromatography ECL device provided a quantitative readout proportional to the BPA and DBP concentration both in the range of 1μg/L～10 mg/*** mixture of DBP and BPA was successfully detected by the established paper-chromatography ECL *** to the ease of fabrication and simple operation,the paper-chromatography ECL device has a promising application in multicomponent ECL detection.

关键词： paper-chromatography electrochemiluminescence environmental hormones

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