PPARγ2 functions as a tumor suppressor in a translational mouse model of human prostate cancer

作     者：Fu-Lu Dong Dong-Mei Liu Ting-Ting Lu Feng Li Chong Zhang Qun E Yong-Hui Zhang Fu-Lu Dong;Dong-Mei Liu;Ting-Ting Lu;Feng Li;Chong Zhang;Qun E;Yong-Hui Zhang

作者机构：Laboratory of Nuclear Receptors and Cancer ResearchDepartment of PathologyMedical SchoolNantong UniversityNantong 226001China 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2022年第24卷第1期

页      面：90-96页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：The work was supported by the National Natural Science Foundation of China(NSFC No.81874171 and 81703259) 

主　　题：inflammatory reaction necrosis PPARγ prostate cancer tissue recombination-xenografting 

摘      要：Peroxisome proliferator-activated receptorsγ(PPARγ)is a master regulator that controls energy metabolism and cell ***γ2,a PPARγisoform,is highly expressed in the normal prostate but expressed at lower levels in prostate cancer *** the present study,PC3 and LNCaP cells were used to examine the benefits of restoring PPARγ2 ***γ2 was overexpressed in PC3 and LNCaP cells,and cell proliferation and migration were *** and eosin(H&E)staining was used to detect pathological *** genes regulated by PPARγ2 overexpression were detected by microarray *** restoration of PPARγ2 in PC3 and LNCaP cells inhibited cell proliferation and ***3-PPARγ2 tissue recombinants showed necrosis in cancerous regions and leukocyte infiltration in the surrounding stroma by H&E *** found higher mixed lineage kinase domain-like(MLKL)and lower microtubule-associated protein 1 light chain 3(LC3)expression in cancer tissues compared to controls by immunohistochemistry(IHC)*** analysis showed that PPARγ2 gain of function in PC3 cells resulted in the reprogramming of lipid-and energy metabolism-associated signaling *** data indicate that PPARγ2 exerts a crucial tumor-suppressive effect by triggering necrosis and an inflammatory reaction in human prostate cancer.