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Utility of linked color imaging for endoscopic diagnosis of early gastric cancer

World Journal of Gastroenterology 2019年第10期25卷 1248-1257页

作者： Toshihisa Fujiyoshi Ryoji Miyahara Kohei Funasaka Kazuhiro Furukawa Tsunaki Sawada Keiko Maeda Takeshi Yamamura Takuya Ishikawa Eizaburo Ohno Masanao Nakamura Hiroki Kawashima Masato Nakaguro Masahiro Nakatochi Yoshiki Hirooka Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine Department of Endoscopy Nagoya University Hospital Department of Pathology and Laboratory Medicine Nagoya University Hospital Division of Data Science Data Coordinating CenterDepartment of Advanced MedicineNagoya University Hospital

BACKGROUND Linked color imaging(LCI) is a method of endoscopic imaging that emphasizes slight differences in red mucosal *** To evaluate LCI in diagnostic endoscopy of early gastric cancer and to compare LCI and pathological *** Endoscopic images were obtained for 39 patients(43 lesions) with early gastric cancer. Three endoscopists evaluated lesion recognition with white light imaging(WLI) and LCI. Color values in Commission Internationale de l'Eclairage(CIE)1976 L*a*b* color space were used to calculate the color difference(ΔE) between cancer lesions and non-cancer areas. After endoscopic submucosal dissection,blood vessel density in the surface layer of the gastric epithelium was evaluated pathologically. The identical region of interest was selected for analyses of endoscopic images(WLI and LCI) and pathological *** LCI was superior for lesion recognition(P < 0.0001), and ΔE between cancer and non-cancer areas was significantly greater with LCI than WLI(29.4 vs 18.6, P <0.0001). Blood vessel density was significantly higher in cancer lesions(5.96% vs4.15%, P = 0.0004). An a* cut-off of ≥ 24 in CIE 1976 L*a*b* color space identified a cancer lesion using LCI with sensitivity of 76.7%, specificity of 93.0%, and accuracy of 84.9%.CONCLUSION LCI is more effective for recognition of early gastric cancer compared to WLI as a result of improved visualization of changes in redness. Surface blood vessel density was significantly higher in cancer lesions, and this result is consistent with LCI image analysis.

关键词： Linked color imaging Early gastric cancer Endoscopic submucosal dissection Vessel density Color difference

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Role of microRNAs in gastric cancer

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World Journal of Gastroenterology 2014年第19期20卷 5694-5699页

作者： Hideyuki Ishiguro Masahiro Kimura Hiromitsu Takeyama Department of Gastroenterological Surgery Nagoya City University Graduate School of Medical SciencesNagoya 467-8601Japan

Although gastric cancer(GC)is one of the leading causes of cancer-related death,major therapeutic advances have not been made,and patients with GC still face poor *** prognosis of GC also remains poor because the molecular mechanisms of GC progression are incompletely ***(miRNAs)are noncoding RNAs that are associated with gastric *** investigating the regulation of gene expression by miRNAs have made considerable progress in recent years,and abnormalities in miRNA expression have been shown to be associated with the occurrence and progression of *** contribute to gastric carcinogenesis by altering the expression of oncogenes and tumor suppressors,affecting cell proliferation,apoptosis,motility,and ***,a number of miRNAs have been shown to be associated with tumor type,tumor stage,and patient survival and therefore may be developed as novel diagnostic or prognostic *** this review,we discuss the involvement of miRNAs in GC and the mechanisms through which they regulate gene expression and biological ***,we review recent research on the involvement of miRNAs in GC prognosis,their potential use in chemotherapy,and their effects on Helicobacter pylori infections in GC.A greater understanding of the roles of miRNAs in gastric carcinogenesis could provide insights into the mechanisms of tumor development and could help to identify novel therapeutic targets.

关键词： MicroRNA Gastric cancer Reverse transcription-polymerase chain reaction Chemosensitivity Helicobacter pylori Circulating MicroRNA

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Novel electrodeposition process for preparinghydroxyapatite coating on titanium substrate

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中国有色金属学会会刊：英文版 2005年第6期15卷 1367-1372页

作者：赵中伟李洪桂孙培梅陈星宇 Okido Masazumi School of Metallurgical Science and Engineering Central South University Changsha 410083 Hunan Department of Materials Science School of Engineering Nagoya University Nagoya 464-8603 Japan

A novel process for electrodeposition of hydroxyapatite coating on titanium substrate was developed. The mechanism of the electrochemical reaction on the cathode was changed by adding H2O2 into the electrolyte. The evolution of H2 gas was erased. And owing to the fact that H2O2 posesses high tendency of being reduced, a fairly high cathodic current can be gained at a more positive potential than -1.0V. During the electrodeposition, 6%H2O2 is added, the temperature of deposition is fixed at 55℃ and pH of electrolyte is adjusted to 5.5. Dense and homogeneous film is crystallized at high rate. The mechanism of crystallize process was discussed.

关键词：电解沉积钛合金生物材料羟基磷灰石生物陶瓷极化

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On Learning Adaptive Service Compositions

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Journal of Systems Science and Systems Engineering 2021年第4期30卷 465-481页

作者： Ahmed Moustafa Department of Computer Science Nagoya Institute of TechnologyGokiso-choShowa-kuNagoyaAichi466-8555Japan Faculty of Informatics Zagazig UniversityZagazigEgypt

Service composition is an important and effective technique that enables atomic services to be combined together to forma more powerful service,i.e.,a composite *** the pervasiveness of the Internet and the proliferation of interconnected computing devices,it is essential that service composition embraces an adaptive service provisioning *** learning has emerged as a powerful tool to compose and adapt Web services in open and dynamic ***,the most common applications of reinforcement learning algorithms are relatively inefficient in their use of the interaction experience data,whichmay affect the stability of the learning process when deployed to cloud *** particular,they make just one learning update for each interaction *** paper introduces a novel approach that aims to achieve greater data efficiency by saving the experience data and using it in aggregate to make updates to the learned *** proposed approach devises an offline learning scheme for cloud service composition where the online learning task is transformed into a series of supervised learning tasks.A set of algorithms is proposed under this scheme in order to facilitate and empower efficient service composition in the cloud under various policies and different *** results of our experiments show the effectiveness of the proposed approach for composing and adapting cloud services,especially under dynamic environment settings,compared to their online learning counterparts.

关键词： Service composition reinforcement learning cloud services offline learning

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Micronization of curcumin with biodegradable polymer by supercritical anti-solvent using micro swirl mixer

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Frontiers of Chemical Science and Engineering 2018年第1期12卷 184-193页

作者： Kimthet Chhouk Wahyudiono Hideki Kanda Shin-Ichro Kawasaki Motonobu Goto Department of Chemical Engineering Nagoya University Nagoya 464-8603 Japan Department of Chemical Engineering and Food Technology Institute of Technology of Cambodia Phnom Penh Cambodia Department of Materials Process Engineering Nagoya University Nagoya 464-8603 Japan Research Institute for Chemical Engineering Process Technology National Institute of Advanced Industrial Science and Technology Sendai 983-8551 Japan

Curcumin is a hydrophobic polyphenol compound exhibiting a wide range of biological activities such as anti-inflammatory, anti-bacterial, anti-fungal, anti-carcinogenic, anti-human immunodeficiency virus, and antimicrobial activity. In this employed to produce the work, a swirl mixer was micronized curcumin with polyvinylpyrrolidone （PVP） by the supercritical antisolvent process to improve the bioavailability of curcumin. The effects of operating parameters such as curcumin/PVP ratio, feed concentration, temperature, pressure, and CO2 flow rate were investigated. The characterization and solubility of particles were determined by using scanning electron microscopy, Fourier Transform Infrared spectroscopy, and ultra-violet-visible spectroscopy. The result shows that the optimal condition for the production of curcumin/PVP particles is at curcumin/PVP ratio of 1：30, feed concentration of 5 mg·mL^-1, temperature of 40 ℃, pressure of 15 MPa, and CO2 flow rate of 15 mL·min^-1. Moreover, the dissolution of curcumin/PVP particles is faster than that of raw curcumin.

关键词： micronization curcumin polyvinylpyrrolidone supercritical anti-solvent swirl mixer

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Laser-Surface Interaction of Compound Semiconductors-Desorption Induced by Electronic Excitation of Surface States

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原子与分子物理学报 1990年第4期7卷 1598-1599页

作者： Noriaki Itoh Yasuo Nakai Ken Hattori Akiko Okano Hidehiko Yamashita Jun-ichi kanasaki Department of Physics Faculty ScienceNagoya University FurochoNagoya 464-01JapanDepartment of PhysicsFaculty ScienceNagoya University FurochoNagoya 464-01JapanDepartment of PhysicsFaculty ScienceNagoya University FurochoNagoya 464-01JapanDepartment of PhysicsFaculty ScienceNagoya University FurochoNagoya 464-01JapanDepartment of PhysicsFaculty ScienceNagoya University FurochoNagoya 464-01JapanDepartment of PhysicsFaculty ScienceNagoya University FurochoNagoya 464-01Japan

In this talk a review is given of currently carricd out studies on laser-induced desorption from surfaces of compound *** reviewincludes only the non-thermal *** can be detected by eitherirradiation with laser of subgap photon energies or with extremely low-intensity pulsed *** is emphasized also that laser induced non-thermaldesorption is a powerful technique for surface characterization and surfacecleaning.

关键词：化合物半导体激光-表面相互作用电子激发

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Change of strategies and future perspectives against hepatitis B virus recurrence after liver transplantation

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World Journal of Gastroenterology 2015年第36期21卷 10290-10298页

作者： Masatoshi Ishigami Yasuhiro Ogura Yoshiki Hirooka Hidemi Goto Department of Gastroenterology and Hepatology Nagoya University School of Medicine Department of Transplant Surgery Nagoya University School of Medicine

A few decades ago,liver transplantation in patients with chronic hepatitis B virus(HBV) infection was considered a relative contraindication because of the high rate of graft infections and poor prognosis. Since then,remarkable progress was introduced by using nucleos(t)ide analogues and/or hepatitis B immunoglobulin(HBIg) and liver transplantation for HBV-related disease is now becoming one of the good indication. However,high cost burden is the main problem for this combination prophylaxis for a long time use,and this issue should be emerged to be resolved. In this review,we show the progress of post antiHBV strategies showing the history from introduction of HBIg and nucleos(t)ide analogues to recent new strategies with hepatitis B vaccine or saving or stopping protocols of HBIg,and clarify and discuss how to do for further improvement of prevention strategies with better quality.

关键词： Liver transplantation Hepatitis B virus Prophylaxi

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Diagnosis of IgG4-related sclerosing cholangitis

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World Journal of Gastroenterology 2013年第43期19卷 7661-7670页

作者： Takahiro Nakazawa Itaru Naitoh Kazuki Hayashi Katsuyuki Miyabe Shuya Simizu Takashi Joh Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical SciencesNagoya 467-8601Japan

IgG4-related sclerosing cholangitis(IgG4-SC)is often associated with autoimmune ***,the diffuse cholangiographic abnormalities observed in IgG4-SC may resemble those observed in primary sclerosing cholangitis(PSC),and the presence of segmental stenosis suggests cholangiocarcinoma(CC).IgG4-SC responds well to steroid therapy,whereas PSC is only effectively treated with liver transplantation and CC requires surgical *** IgG4-SC was first described,it has become a third distinct clinical entity of sclerosing *** aim of this review was to introduce the diagnostic methods for ***4-SC should be carefully diagnosed based on a combination of characteristic clinical,serological,morphological,and histopathological features after cholangiographic classification and targeting of a disease for differential *** intrapancreatic stenosis is detected,pancreatic cancer or CC should be ruled *** multiple intrahepatic stenoses are evident,PSC should be distinguished on the basis of cholangiographic findings and liver biopsy with IgG4 *** inflammatory bowel disease is suggestive of *** stenosis is demonstrated in the hepatic hilar region,CC should be discriminated by ultrasonography,intraductal ultrasonography,bile duct biopsy,and a higher cutoff serum IgG4 level of 182 mg/dL.

关键词： IgG4-related sclerosing cholangitis Primary sclerosing cholangitis IgG4 Sclerosing cholangitis

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Reachability of Patterned Conditional Pushdown Systems

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Journal of Computer Science & Technology 2020年第6期35卷 1295-1311页

作者： Xin Li Patrick Gardy Yu-Xin Deng Hiroyuki Seki Shanghai Key Laboratory of Trustworthy Computing East China Normal UniversityShanghai 200062China Graduate School of Informatics Nagoya UniversityNagoya 464-8601Japan

Conditional pushdown systems (CPDSs) extend pushdown systems by associating each transition rule with a regular language over the stack alphabet. The goal is to model program verification problems that need to examine the run-time call stack of programs. Examples include security property checking of programs with stack inspection, compatibility checking of HTML5 parser specifications, etc. Esparza et al. proved that the reachability problem of CPDSs is EXPTIME-complete, which prevents the existence of an algorithm tractable for all instances in general. Driven by the practical applications of CPDSs, we study the reachability of patterned CPDS (pCPDS) that is a practically important subclass of CPDS, in which each transition rule carries a regular expression obeying certain patterns. First, we present new satura-tion algorithms for solving state and configuration reachability of pCPDSs. The algorithms exhibit the exponential-time complexity in the size of atomic patterns in the worst case. Next, we show that the reachability of pCPDSs carrying sim-ple patterns is solvable in fixed-parameter polynomial time and space. This answers the question on whether there exist tractable reachability analysis algorithms of CPDSs tailored for those practical instances that admit efficient solutions such as stack inspection without exception handling. We have evaluated the proposed approach, and our experiments show that the pattern-driven algorithm steadily scales on pCPDSs with simple patterns.

关键词： conditional pushdown system pattern reachability saturation algorithm

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On a conjecture of Chowla and Walum

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Science China Mathematics 2010年第10期53卷 2755-2771页

作者： TANIGAWA Yoshio Graduate School of of Mathematics Nagoya University

We show the asymptotic behaviour of the mean square of the sum n c√x naPk(x/n),where Pk(x) = Bk({x}) and Bk(x) denotes the Bernoulli polynomial of degree k and c > 0 is a real number such that c2 is *** result implie... 详细信息

关键词： the Dirichlet divisor problem error term mean square the Bernoulli polynomial the Vorono formula Chowla and Walum’s conjecture.

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