Change of strategies and future perspectives against hepatitis B virus recurrence after liver transplantation

作     者：Masatoshi Ishigami Yasuhiro Ogura Yoshiki Hirooka Hidemi Goto 

作者机构：Department of Gastroenterology and HepatologyNagoya University School of Medicine Department of Transplant SurgeryNagoya University School of Medicine 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2015年第21卷第36期

页      面：10290-10298页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：Liver transplantation Hepatitis B virus Prophylaxi 

摘      要：A few decades ago,liver transplantation in patients with chronic hepatitis B virus(HBV) infection was considered a relative contraindication because of the high rate of graft infections and poor prognosis. Since then,remarkable progress was introduced by using nucleos(t)ide analogues and/or hepatitis B immunoglobulin(HBIg) and liver transplantation for HBV-related disease is now becoming one of the good indication. However,high cost burden is the main problem for this combination prophylaxis for a long time use,and this issue should be emerged to be resolved. In this review,we show the progress of post antiHBV strategies showing the history from introduction of HBIg and nucleos(t)ide analogues to recent new strategies with hepatitis B vaccine or saving or stopping protocols of HBIg,and clarify and discuss how to do for further improvement of prevention strategies with better quality.