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Cancer-macrophage hybrid membrane-camouflaged photochlor for enhanced sonodynamic therapy against triple-negative breast cancer

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Nano Research 2022年第5期15卷 4224-4232页

作者： Lishan Zhang Ting Yin Baozhen Zhang Chong Yan Chengyu Lu Lanlan Liu Ze Chen Hui Ran Qingxia Shi Hong Pan Aiqing Ma Lintao Cai Guangdong Key Laboratory for Research and Development of Natural Drugs Key Laboratory for NanomedicineGuangdong Medical UniversityDongguan 523808China Guangdong Key Laboratory of nanomedicine CAS-HK Joint Lab of BiomaterialsShenzhen Engineering Laboratory of Nanomedicine and NanoformulationsInstitute of Biomedicine and BiotechnologyShenzhen Institute of Advanced Technology(SIAT)Chinese Academy of SciencesShenzhen 518055China

Sonodynamic therapy(SDT)has aroused considerable momentum in cancer therapy due to its abilities of deep penetration,low toxicity,and noninvasion,while insufficient tumor accumulation of sonosensitizers is a major obstacle for SDT ***,we developed a 4T1 cancer cell-macrophage hybrid membrane(HM)-camouflaged sonosensitizer nanoplatform by encapsulating photochlor(HPPH)-loaded albumin nanoparticles(PHNPs).The experimental results proved that the HM-coated biomimetic NPs(PHNPs@HM)could express the characteristic membrane proteins of both cancer cells and macrophages,remarkedly enhancing the effective targeting and endocytosis to 4T1 cells through homologous adhesion recognition and immune ***,as a novel sonosensitizer,HPPH could generate amount of reactive oxygen species(ROS)under ultrasound(US)irradiation and exhibit obvious SDT efficiency to inhibit 4T1 tumor growth through ROS-induced cell *** study provides a novel and multifunctional biomimetic sonosensitizer system to enhance SDT efficiency.

关键词： biomimetic materials sonodynamic therapy hybrid cell membrane photochlor sonosensitizer noninvasive treatment

Advances in cancer nanomedicine

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Cancer Biology & Medicine 2015年第3期12卷 141-142页

作者： Lin-Tao Cai Zong-Hai Sheng Center for nanomedicine and Nanobiotechnology Institute of Biomedicine and Biotechnology Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences

Cancer has become the leading cause of *** progress in diagnosis and treatment is still *** the past three decades,emergence and rapid development of nanotechnology have brought new hopes for cancer therapy.A repertoi... 详细信息

关键词：癌症治疗纳米医学纳米技术

Programmable pyrrole-imidazole polyamides:A potent tool for DNA targeting

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Chinese Chemical Letters 2018年第7期29卷 1105-1112页

作者： Chunlei Wu Wei Wang Lijing Fang Wu Su Guangdong Key Laboratory of nanomedicine Institute of Biomedicine and BiotechnologyShenzhen Institutes of Advanced TechnologyChinese Academy of Sciences

Hairpin pyrrole-imidazole(Py-Im) polyamides are a class of programmable minor-groove binders that recognize pre-determined DNA double helixes with high affinity and specificity. They are capable of regulating gene expression by modulating the activity of transcription factors. To date, Py-Im polyamides have been successfully applied as a potent tool to disturb DNA functions and considered as a group of promising candidates for the clinical applications. Herein, this review will focus on summarizing the recent advances of Py-Im polyamides from their synthesis to applications via various modifications at the molecular level.

关键词： Py-Im polyamides DNA binding Gene modulation Targeting ligands

Multifunctional to multistage delivery systems: The evolution of nanoparticles for biomedical applications

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Chinese Science Bulletin 2012年第31期57卷 3961-3971页

作者： MARTINEZ Jonathan O BROWN Brandon S QUATTROCCHI Nicoletta EVANGELOPOULOS Michael FERRARI Mauro TASCIOTTI Ennio Department of nanomedicine The Methodist Hospital Research Institute Graduate School of Biomedical Sciences The University of Texas at Houston

Nanomaterials are advancing in several directions with significant progress being achieved with respect to their synthesis, functionalization and biomedical application. In this review, we will describe several classes of prototypical nanocarriers, such as liposomes, silicon particles, and gold nanoshells, in terms of their individual function as well as their synergistic use. Active and passive targeting, photothermal ablation, and drug controlled release constitute some of the crucial functions identified to achieve a medical purpose. Current limitations in targeting, slow clearance, and systemic as well as local toxicity are addressed in reference to the recent studies that attempted to comprehend and solve these issues. The demand for a more sophisticated understanding of the impact of nanomaterials on the body and of their potential immune response underlies this discussion. Combined components are then discussed in the setting of multifunctional nanocarriers, a class of drug delivery systems we envisioned, proposed, and evolved in the last 5 years. In particular, our third generation of nanocarriers, the multistage vectors, usher in the new field of nanomedicine by combining several components onto multifunctional nanocarriers characterized by emerging properties and able to achieve synergistic effects.

关键词：生物医学应用纳米粒子多功能传递系统演变多级药物控制释放纳米载体

Recent advances in exploring new blood-based biomarkers for the early diagnosis of gastric cancer

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Science China Chemistry 2025年第1期 35-45页

作者： Xinyu Peng Qian Ma Da Han School of Life Science Shanghai University institute of Molecular Medicine Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine State Key Laboratory of Oncogenes and Related Genes Renji Hospital School of Medicine Shanghai Jiao Tong University Department of Research and Development Intellinosis Biotechnologies Co.Ltd.

Gastric cancer(GC) is a prevalent and lethal malignancy worldwide, and the 5-year survival rate is less than 30%. The absence of distinctive symptoms often leads to late-stage diagnosis, contributing to a grim prognosis. Early detection is pivotal for improving the survival rates and outcomes of GC patients. Traditional diagnostic methods, including gastroscopy and histopathological examination, are restricted in the early diagnosis of GC. Conventional protein biomarkers, such as carcinoembryonic antigen(CEA), carbohydrate antigen 19-9(CA19-9), and carbohydrate antigen 72-4(CA72-4), exhibit insufficient sensitivity and specificity for GC screening, which diminishes their clinical value. Recently, novel circulating biomarkers, such as circulating tumor cells(CTCs), circulating tumor cell DNA(ct DNA), and circulating free RNA(cf RNA), have emerged as promising candidates in the burgeoning field of liquid biopsy due to their superior sensitivity and specificity. This review focuses on the latest research on blood-based biomarkers for GC diagnosis and examines the clinical potentials and challenges associated with these emerging biomarkers.

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Targeting stem cell signaling pathways for drug discovery:advances in the Notch and Wnt pathways

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Science China(Life Sciences) 2014年第6期57卷 575-580页

作者： AN Songzhu Michael DING Qiang ZHANG Jie XIE JingYi LI LingSong Curegenix Inc. Center for Stem Cell and nanomedicine Shanghai Advanced Research InstituteChinese Academy of Sciences

Signaling pathways transduce extracellular stimuli into cells through molecular cascades to regulate cellular *** stem cells,a small number of pathways,notably those of TGF-?/BMP,Hedgehog,Notch,and Wnt,are responsible for the regulation of pluripotency and *** embryonic development,these pathways govern cell fate specifications as well as the formation of tissues and *** adulthood,their normal functions are important for tissue homeostasis and regeneration,whereas aberrations result in diseases,such as cancer and degenerative *** complex biological systems,stem cell signaling pathways work in concert as a network and exhibit crosstalk,such as the negative crosstalk between Wnt and *** the past decade,genetic and genomic studies have identified a number of potential drug targets that are involved in stem cell signaling ***,discovery of new targets and drugs for these pathways has become one of the most active areas in both the research community and pharmaceutical *** progress has been made and several promising drug candidates have entered into clinical *** review focuses on recent advances in the discovery of novel drugs which target the Notch and Wnt pathways.

关键词： stem cell drug discovery signaling pathways Notch Wnt cancer

Genome editing and animal models

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Chinese Science Bulletin 2014年第1期59卷 1-6页

作者： Ruby Yanru Chen-Tsai Ruhong Jiang Luping Zhuang Junfeng Wu Lingsong Li Jiarui Wu Department of Animal Disease Modeling Center for Stem Cell and NanoMedicine Shanghai Advanced Research InstituteChinese Academy of Sciences

Transgenic technology allows a gene of interest to be introduced into the genome of a laboratory animal,and provides an extremely powerful tool to dissect the molecular mechanisms of *** mouse models made by microinjection of DNA into zygotic pronuclei in particular have been widely used by the genetics community for 30 ***,it remains a rather crude approach:injected sequences randomly insert in multiple copies as concatamers,they can be mutagenic,and they have variable or silenced expression depending on the site of integration,a phenomenon called position *** a result,multiple lines are required in order to confirm appropriate transgene *** can be partially overcome by flanking transgenes with insulator sequences to protect the transgene from the influence of the surrounding regulatory ***(\300 kb)BACbased transgenic vectors have also been shown to be more resistant to position ***,animals carrying extra copies of fairly large regions of the genome could have unpredictable *** most effective method used to control for position effects is to target transgene insertion to specific genomic loci,the so-called targeted transgenesis;for instance,the fast,site-specific transgenic technology Targatt *** purpose of this review is to provide an overview on the current existing methods for making targeted transgenic mouse models.

关键词：动物模型基因组转基因小鼠模型转基因技术编辑位置效应显微注射 DNA导入

DNA-directed assembly of copper nanoblocks with inbuilt fluorescent and electrochemical properties： Application in simultaneous amplification-free analysis of multiple RNA species

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Nano Research 2018年第2期11卷 940-952页

作者： Kevin M. Koo Laura G. Carrascosa Matt Trau Centre for Personalized nanomedicine Australian Institute for Bioengineering and Nanotechnology (AIBN) The University of Queensland Brisbane Australia School of Chemistry and Molecular Biosciences The University of Queensland Brisbane Australia

The intrinsic affinity of DNA molecules toward metallic ions can drive the specific formation of copper nanostructures within the nucleic acid helix structure in a sequence-dependent manner. The resultant nanostructures have interesting fluorescent and electrochemical properties, which are attractive for novel biosensing applications. However, the potential of using DNA-templated nano- structures for precision disease diagnosis remains unexplored. Particularly, DNA- templated nanostructures show high potential for the universal amplification-free detection of different RNA biomarker species. Because of their low cellular levels and differing species-dependent length and sequence features, simultaneous detection of different messenger RNAs, microRNAs, and long non-coding RNAs species with a single technique is challenging. Here, we report a contemporary technique for facile in situ assembly of DNA-templated copper nanoblocks （CuNBs） on various RNA species targets after hybridization-based magnetic isolation. Our approach circumvents the typical limitations associated with amplification and labeling procedures of current RNA assays. The synthesized CuNBs enabled amplification-free fM-level RNA detection with flexible fluorescence or electrochemical readouts. Furthermore, our nanosensing technique displays potential for clinical application, as demonstrated by non-invasive analysis of three diagnostic RNA biomarkers from a cohort of 10 prostate cancer patient urinary samples with 100%-concordance （quantitative reverse transcription- polymerase chain reaction （PCR） validation）. The good analytical performance and versatility of our method may be useful in both diagnostics and research fields.

关键词： prostate cancer RNA detection DNA-templated coppernanostTuctures amplification-free fluorescence detection electrochemical detection

Confined thin film wrinkling on shape memory polymer with hybrid surface morphologies

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Acta Mechanica Sinica 2021年第7期37卷 1063-1071,I0001页

作者： Yu Wang Jianliang Xiao Department of Mechanical Engineering University of Colorado BoulderBoulderColorado 80309USA Department of nanomedicine Houston Methodist Research InstituteHoustonTexas 77030USA

With appropriate stimuli,such as heat,humidity,or magnetic field,shape memory polymers(SMPs)can recover to their original shapes from temporary,programmed *** thermal responsive SMPs as substrates,we demonstrate a simple method to realize hybrid surface morphologies through confined thin film wrinkling in localized *** bilayer system was fabricated by depositing a layer of aluminum thin?lm on top of a SMP substrate programmed with a tensile *** the system was heated by a heating wire,hybrid wrinkling patterns were formed in a confined circular area around the heat source,with an inner spoke pattern and an outer ring *** patterns showed good symmetry,and the size of the wrinkling area can be tuned by controlling the heat *** study o?ers a simple but effective approach to fabricate hybrid morphological features in *** appropriate stimuli,such as heat,humidity,or magnetic field,shape memory polymers(SMPs)can recover to their original shapes from temporary,programmed *** thermal responsive SMPs as substrates,we demonstrate a simple method to realize hybrid surface morphologies through confined thin film wrinkling in localized *** bilayer system was fabricated by depositing a layer of aluminum thin?lm on top of a SMP substrate programmed with a tensile *** the system was heated by a heating wire,hybrid wrinkling patterns were formed in a confined circular area around the heat source,with an inner spoke pattern and an outer ring *** patterns showed good symmetry,and the size of the wrinkling area can be tuned by controlling the heat *** study offers a simple but effective approach to fabricate hybrid morphological features in micro-scale.

关键词： Wrinklng Hybrid surface morphologies Shape memory polymers(SMPs)