Cydodextrin conjugated ferritin nanocages reduce intracellular cholesterol level in foam cells

作     者：Samyukta Ravishankar Sierin Lim 

作者机构：School of Chemical and Biomedical EngineeringNanyang Technological University70 Nanyang DriveBlk N1.3Singapore 637457Singapore NTU-Northwestem Institute for NanomedicineNanyang Technological University50 Nanyang DriveBlk N3.1Singapore 637553Singapore 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2019年第12卷第12期

页      面：2925-2932页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：support by NTU-Northwestern Institute for Nanomedicine grant 

主　　题：cyclodextrin ferritin protein nanocages cholesterol sequestration foam cells 

摘      要：Accumulation of lipid-laden macrophages(foam cells)is characteristic of atherosclerosis developme nt in the arterial *** nano cages have been found to passively accumulate in the atherosclerotic *** has been actively investigated as a carrier for contrast agents in atherosclerosis diag no *** dem on strate the pote ntial of ferritin as a carrier for therapeutic molecules to mediate cholesterol reducti on from foam *** molecules are chemically conjugated to the ferritin anocages surface or encapsulated within the nanocages using metal co-loadi ng *** cyclodextrin-conjugated ferriti n has nano molar affinity to cholesterol *** of foam cells with the conjugates shows decreased levels of intracellular accumulated *** preferential localization of ferritin to foam cells is due to transferrin receptor-mediated endocytosis *** findings show that ferritin nanocages as carriers localize cyclodextrin molecules to foam cells which mediate intracellular cholesterol reductio n,thus highlight!ng its potential use as a therapeutic agent.