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Effects of Tanreqing Injection on ICU Mortality among ICU Patients Receiving Mechanical Ventilation: Time-Dependent Cox Regression Analysis of A Large Registry

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Chinese Journal of Integrative Medicine 2023年第9期29卷 782-790页

作者： WANG Wen HE Qiao WANG Ming-qi XU Jia-yue JI Peng ZHANG Rui ZOU Kang SUN Xin Chinese Evidence-Based Medicine Center West China HospitalSichuan UniversityChengdu610041China nmpa key laboratory for real world data research and evaluation in hainan Chengdu610041China Sichuan Center of Technology Innovation for real world data Chengdu610041China Intensive Care Unit West China HospitalSichuan UniversityChengdu610041China Information Center West China HospitalSichuan UniversityChengdu610041China

Objective To assess whether the use of Tanreqing(TRQ)Injection could show improvements in time to extubation,intensive care unit(ICU)mortality,ventilator-associated events(VAEs)and infection-related ventilator associated complication(IVAC)among patients receiving mechanical ventilation(MV).Methods A time-dependent cox-regression analysis was conducted using data from a well-established registry of healthcare-associated infections at ICUs in *** receiving continuous MV for 3 days or more were included.A time-varying exposure definition was used for TRQ Injection,which were recorded on daily *** outcomes included time to extubation,ICU mortality,VAEs and ***-dependent Cox models were used to compare the clinical outcomes between TRQ Injection and non-use,after controlling for the influence of comorbidities/conditions and other medications with both fixed and time-varying *** the analyses of time to extubation and ICU mortality,Fine-Gray competing risk models were also used to measure competing risks and outcomes of *** Overall,7,685 patients were included for the analyses of MV duration,and 7,273 patients for the analysis of ICU *** to non-use,patients with TRQ Injection had a lower risk of ICU mortality(Hazards ratios(HR)0.761,95%CI,0.581–0.997),and was associated with a higher hazard for time to extubation(HR 1.105,95%CI,1.005–1.216),suggesting a beneficial effect on shortened time to *** significant differences were observed between TRQ Injection and non-use regarding VAEs(HR 1.057,95%CI,0.912–1.225)and IVAC(HR 1.177,95%CI,0.929–1.491).The effect estimates were robust when using alternative statistic models,applying alternative inclusion and exclusion criteria,and handling missing data by alternative *** Our findings suggested that the use of TRQ Injection might lower mortality and improve time to extubation among patients receiving MV,even after controlling for the factor tha

关键词： Tanreqing critical care mechanical ventilation mortality ventilator-associated events

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Propolis inspired sunscreens for efficient UV-protection and skin barrier maintenance

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Nano research 2022年第9期15卷 8237-8246页

作者： Yu Fu Ruoyu Wan Lei Yang Lidan Xiong Junfei Hu Jie Tang Hailun He Zhipeng Gu Li Li Yiwen Li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China Cosmetics Safety and Efficacy evaluation Center Department of DermatologyWest China HospitalSichuan UniversityChengdu 610041China nmpa key laboratory for Human evaluation and Big data of Cosmetics Chengdu 610041China

The direct use of naturally occurring,small molecular ingredients in bioinspired sunscreens has raised several concerns due to the instability,photocytotoxicity,and potential blood toxicity of those *** this work,we have employed natural ultraviolet(UV)-blocking molecule caffeic acid phenethyl ester(CAPE)from propolis to prepare poly(CAPE)nanoparticles(NPs)as the main bioactive ingredient to fabricate propolis-inspired hydrogel *** with small molecular CAPE,poly(CAPE)NPs exhibited better dispersion and stability in water,as well as lower physiological toxicity and skin *** the resulting composite hydrogels demonstrated promising properties including water-resistant whereas can be easily erased by warm water as well as safety when interacting with *** importantly,the hydrogel sunscreens showed excellent UV protection properties both in vitro and in vivo,and the positive effects in maintaining skin barrier *** work provides new strategies towards the facile construction of nature-inspired robust sunscreens in the future.

关键词： bioinspired sunscreen composite hydrogel ultraviolet protection

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A comparative analysis of differentially expressed genes in rostral and caudal regions after spinal cord injury in rats

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Neural Regeneration research 2022年第10期17卷 2267-2271页

作者： Xue-Min Cao Sheng-Long Li Yu-Qi Cao Ye-Hua Lv Ya-Xian Wang Bin Yu Chun Yao key laboratory of Neuroregeneration of Jiangsu and Ministry of Education NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsCo-innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina

The initial mechanical damage of a spinal cord injury(SCI)triggers a progressive secondary injury cascade,which is a complicated process integrating multiple systems and *** is crucial to explore the molecular and biological process alterations that occur after SCI for therapy *** differences between the rostral and caudal regions around an SCI lesion have received little ***,we analyzed the differentially expressed genes between rostral and caudal sites after injury to determine the biological processes in these two segments after *** identified a set of differentially expressed genes,including Col3a1,Col1a1,Dcn,Fn1,Kcnk3,and Nrg1,between rostral and caudal regions at different time points following *** enrichment analysis indicated that these genes were involved in response to mechanical stimulus,blood vessel development,and brain *** then chose Col3a1,Col1a1,Dcn,Fn1,Kcnk3,and Nrg1 for quantitative real-time PCR and Fn1 for immunostaining *** results indicate alterations in different biological events enriched in the rostral and caudal lesion areas,providing new insights into the pathology of SCI.

关键词： biological process caudal differentially expressed genes Gene Ontology hemisection immunostaining Rattus norvegicus RNA-sequencing rostral spinal cord injury

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Projected burden of stroke in China through 2050

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Chinese Medical Journal 2023年第13期136卷 1598-1605页

作者： Minghong Yao Yan Ren Yulong Jia Jiayue Xu Yuning Wang Kang Zou Xin Sun Institute of Integrated Traditional Chinese and Western Medicine and Chinese Evidence-Based Medicine Center and Cochrane China Center West China HospitalSichuan UniversityChengdu 610041China nmpa key laboratory for real world data research and evaluation in hainan ChengduSichuan 610041China Sichuan Center of Technology Innovation for real world data ChengduSichuan 610041China

Background:Stroke is the leading cause of death in China,and predicting the stroke burden could provide essential information guiding the setting of medium-and long-term health policies and *** study aimed to project trends associated with stroke burden in China through 2050,not only in terms of incidence and mortality but also for prevalence and disability-adjusted life years(DALYs).Methods:data on stroke rates in incidence,prevalence,deaths,and DALYs in China between 1990 and 2019 were obtained from a recent Global Burden of Disease ***-specific trends in rates over time were estimated using three models:the loglinear model,the Lee-Carter model,and a functional time series *** mean absolute percentage error and the root mean squared error were used for model *** up to 2050 were estimated using the best fitting *** Nations population data were used to project the absolute numbers through ***:From 2019 to 2050,the crude rates for all measures of the stroke burden are projected to increase continuously among both men and *** project that compared with those in 2019,the incidence,prevalence,deaths,and DALYs because of stroke in China in 2050 will increase by 55.58%,119.16%,72.15%,and 20.04%,respectively;the corresponding increases in number were 2.19,34.27,1.58,and 9.21 *** age-standardized rate is projected to substantially decline for incidence(8.94%),death(40.37%),and DALYs(43.47%),but the age-standardized prevalence rate is predicted to increase by 10.82%.By 2050,the burden of stroke among the population aged≥65 years will increase significantly:by 104.70%for incidence,by 218.48%for prevalence,by 100.00%for death,and by 58.93%for ***:With the aging population in China increasing over the next three decades,the burden of stroke will be markedly *** efforts are needed to improve stroke health care and secondary prevention,especially for older adults.

关键词： Projections Incidence Prevalence Mortality Disability-adjusted life years Stroke

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Structure based release kinetics analysis of doxazosin mesylate sustained-release tablets using micro-computed tomography

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Asian Journal of Pharmaceutical Sciences 2024年第6期19卷 154-162页

作者： Qian Liu Mengqing Zan Hanhan Huang Hai Su Wenjing Zhang Lingyun Ma Guangchao Zhang Zunjian Zhang Jiwen Zhang Jianzhao Niu Mingdi Xu nmpa key laboratory for Quality research and evaluation of Chemical Drugs National Institutes for Food and Drug ControlBeijing 100050China China Pharmaceutical University Nanjing 210009China nmpa key laboratory for Quality research and evaluation of Pharmaceutical Excipients National Institutes for Food and Drug ControlBeijing 100050China Center for Drug Delivery System Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

The structures of solid dosage forms determine their release behaviors and are critical attributes for the design and evaluation of the solid dosage ***,the 3D structures of doxazosin mesylate sustained-release tablets were parallelly assessed by micro-computed tomography(micro-CT).There were no significant differences observed in the release profiles between the RLD and the generic formulation in the conventional dissolution,but the generic preparation released slightly faster in media with ethanol during an alcohol-induced dose-dumping *** their 3D structures obtained via micro-CT determination,the unique release behaviors of both RLD and the generic were investigated to reveal the effects of internal fine structure on the release *** structural parameters for both preparations were similar in conventional dissolution test,while the dissolutions in ethanol media showed some distinctions between RLD and generic preparations due to their static and dynamic ***,the findings revealed that the presence of ethanol accelerated dissolution and induced changes in internal structure of both RLD and generic ***,structure parameters like volume and area of outer contour,remaining solid volume and cavity volumewere not equivalent between the two formulations in 40%*** conclusion,the structure data obtained from this study provided valuable insights into the diverse release behaviors observed in various modified-release formulations in drug development and quality control.

关键词： Doxazosin mesylate sustained-release tablets Osmotic pump tablets Micro-computed tomography Three-dimensional structures Ethanol

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Oridonin restores hepatic lipid homeostasis in an LXRa-ATGL/EPT1 axis-dependent manner

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Journal of Pharmaceutical Analysis 2023年第11期13卷 1281-1295页

作者： Yulian Chen Huanguo Jiang Zhikun Zhan Jindi Lu Tanwei Gu Ping Yu Weimin Liang Xi Zhang Shilong Zhong Lan Tang nmpa key laboratory for research and evaluation of Drug Metabolism Guangdong Provincial Key Laboratory of New Drug ScreeningSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou510515China Department of Pharmacy Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou510515China

Hepatosteatosis is characterized by abnormal accumulation of triglycerides(TG),leading to prolonged and chronic inflammatory *** date,there is still a lack of effective and economical therapies for ***(ORI)is a major bioactive component extracted from the traditional Chinese medicinal herb Rabdosia *** this paper,we showed that ORI exerted significant protective effects against hepatic steatosis,inflammation and fibrosis,which was dependent on LXRa *** is reported that LXRa regulated lipid homeostasis between triglyceride(TG)and phosphatidylethanolamine(PE)by promoting ATGL and EPT1 ***,we implemented the lipidomic strategy and luciferase reporter assay to verify that ORI contributed to the homeostasis of lipids via the regulation of the ATGL gene associated with TG hydrolysis and the EPT1 gene related to PE synthesis in a LXRadependent manner,and the results showed the TG reduction and PE *** detail,hepatic TG overload and lipotoxicity were reversed after ORI treatment by modulating the ATGL and EPT1 genes,*** together,the data provide mechanistic insights to explain the bioactivity of ORI in attenuating TG accumulation and cytotoxicity and introduce exciting opportunities for developing novel natural activators of the LXRa-ATGL/EPT1 axis for pharmacologically treating hepatosteatosis and metabolic disorders.

关键词： Oridonin Lipid homeostasis TG reduction PE elevation LXRa-ATGL/EPT1 axis

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Fibroblast exosomal TFAP2C induced by chitosan oligosaccharides promotes peripheral axon regeneration via the miR-132-5p/CAMKK1 axis

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Bioactive Materials 2023年第8期26卷 249-263页

作者： Yahong Zhao Jina Liu Sha Liu Panpan Yang Yunyun Liang Jinyu Ma Susu Mao Cheng Sun Yumin Yang key laboratory of Neuroregeneration of Jiangsu Province and Ministry of Education Co-Innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong University19 Qixiu RoadNantongJiangsu226001China School of Medicine Nantong University19 Qixiu RoadNantongJiangsu226001China

Chitosan and its degradation product,oligosaccharides,have been shown to facilitate peripheral nerve ***,the underlying mechanisms are not well *** this study,we analyzed the protein expression profiles in sciatic nerves after injury using proteomics.A group of proteins related to exosome packaging and transport is up-regulated by chitosan oligosaccharides(COS),implying that exosomes are involved in COS-induced peripheral nerve *** fact,exosomes derived from fibroblasts(f-EXOs)treated with COS significantly promoted axon extension and *** protein identification and functional studies,revealed that TFAP2C is a key factor in neurite outgrowth induced by ***,we showed that TFAP2C targets the pri-miRNA-132 gene and represses miR-132-5p expression in dorsal root ganglion ***1 is a downstream substrate of miR-132-5p that positively affects axon *** rats,miR-132-5p antagomir stimulates CAMKK1 expression and improves axon regeneration and functional recovery in sciatic nerves after *** data reveal the mechanism for COS in axon regeneration,that is COS induce fibroblasts to produce TFAP2C-enriched EXOs,which are then transferred into axons to promote axon regeneration via miR-132-5p/***,these results show a new facet of fibroblasts in axon regeneration in peripheral nerves.

关键词： peripheral nerves chitosan oligosaccharides fibroblast exosomes TFAP2C axon regeneration

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Standardized neutralization antibody analytical procedure for clinical samples based on the AQbD concept

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2078-2080页

作者： Jianyang Liu Yu Bai Mingchen Liu Dejiang Tan Jing Li Zhongfang Wang Zhenglun Liang Miao Xu Junzhi Wang Qunying Mao National Institutes for Food and Drug Control BeijingChina NHC key laboratory of research on Quality and Standardization of Biotech Products BeijingChina nmpa key laboratory for Quality research and evaluation of Biological Products BeijingChina Sinovac Life Science Co. Ltd.BeijingChina Guangzhou laboratory GuangzhouGuangdong ProvinceChina

Dear Editor,Vaccination is an effective strategy for controlling the COVID-19 pandemic and reducing the number of cases of hospitalization and deaths.1 Neutralizing antibody(Ntab)is one of the key indicators for evaluating the effectiveness of COVID-19 vaccines.2 Over 40 COVID-19 vaccines have been approved for emergency use,marketing,or marketing with conditions,and the available Ntab data from clinical trials have been published.

关键词： clinical QbD cases

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Promise of spatially resolved omics for tumor research

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Journal of Pharmaceutical Analysis 2023年第8期13卷 851-861页

作者： Yanhe Zhou Xinyi Jiang Xiangyi Wang Jianpeng Huang Tong Li Hongtao Jin Jiuming He State key laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100050China New Drug Safety evaluation Center Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100050China nmpa key laboratory for Safety research and evaluation of Innovative Drug Beijing10050China

Tumors are spatially heterogeneous tissues that comprise numerous cell types with intricate *** interacting with the microenvironment,tumor cells undergo dynamic changes in gene expression and metabolism,resulting in spatiotemporal variations in their capacity for proliferation and *** recent years,the rapid development of histological techniques has enabled efficient and high-throughput biomolecule *** preserving location information while obtaining a large number of gene and molecular data,spatially resolved metabolomics(SRM)and spatially resolved transcriptomics(SRT)approaches can offer new ideas and reliable tools for the in-depth study of *** review provides a comprehensive introduction and summary of the fundamental principles and research methods used for SRM and SRT techniques,as well as a review of their applications in cancer-related fields.

关键词： Tumor Spatially resolved transcriptomics Spatially resolved metabolomics

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A novel method for evaluating the dynamic biocompatibility of degradable biomaterials based on real-time cell analysis

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Regenerative Biomaterials 2020年第3期7卷 321-329页

作者： Xiaoxiao Gai Chenghu Liu Guowei Wang Yang Qin Chunguang Fan Jia Liu Yanping Shi Department of Biological evaluation Shandong Quality Inspection Center for Medical DevicesNO.15166 Century AvenueH-T Industrial Development ZoneJinan 250101China Shandong key laboratory of Biological evaluation for Medical Devices NO.15166 Century AvenueH-T Industrial Development ZoneJinan 250101China Department of Biological evaluation NMPA Key Laboratory for Safety Evaluation of Biomaterials and Medical DevicesNO.15166 Century AvenueH-T Industrial Development ZoneJinan 250101China

Degradable biomaterials have emerged as a promising type of medical materials because of their unique advantages of biocompatibility,biodegradability and *** to their bioabsorbable and biocompatible properties,magnesium-based biomaterials are considered as ideal degradable medical ***,the rapid corrosion of magnesium-based materials not only limits their clinical application but also necessitates a more specific biological evaluation system and biosafety *** this study,extracts of pure Mg and its calcium alloy were prepared using different media based on ISO 10993:12;the Mg^2+ concentration and osmolality of each extract were *** biocompatibility was investigated using the MTT assay and xCELLigence real-time cell analysis(RTCA).Cytotoxicity tests were conducted with L929,MG-63 and human umbilical vein endothelial cell *** results of the RTCA highly matched with those of the MTT assay and revealed the different dynamic modes of the cytotoxic process,which are related to the differences in the tested cell lines,Mg-based materials and dilution rates of *** study provides an insight on the biocompatibility of biodegradable materials from the perspective of cytotoxic dynamics and suggests the applicability of RTCA for the cytotoxic evaluation of degradable biomaterials.

关键词： degradable biomaterials biocompatibility real-time cell analysis magnesium-based biomaterials

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