Effects of Tanreqing Injection on ICU Mortality among ICU Patients Receiving Mechanical Ventilation: Time-Dependent Cox Regression Analysis of A Large Registry

作     者：WANG Wen HE Qiao WANG Ming-qi XU Jia-yue JI Peng ZHANG Rui ZOU Kang SUN Xin WANG Wen;HE Qiao;WANG Ming-qi;XU Jia-yue;Ji Peng;ZHANG Rui;ZOU Kang;SUN Xin

作者机构：Chinese Evidence-Based Medicine CenterWest China HospitalSichuan UniversityChengdu610041China NMPA Key Laboratory for Real World Data Research and Evaluation in HainanChengdu610041China Sichuan Center of Technology Innovation for Real World DataChengdu610041China Intensive Care UnitWest China HospitalSichuan UniversityChengdu610041China Information CenterWest China HospitalSichuan UniversityChengdu610041China 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2023年第29卷第9期

页      面：782-790页

核心收录：

学科分类：100218[医学-急诊医学] 1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 10[医学] 

基　　金：Supported by the National Natural Science Foundation of China(No.72104155) Postdoctoral Research Project,West China Hospital,Sichuan University(No.2020HXBH148) the 1•3•5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(No.ZYYC08003) 

主　　题：Tanreqing critical care mechanical ventilation mortality ventilator-associated events 

摘      要：Objective To assess whether the use of Tanreqing(TRQ)Injection could show improvements in time to extubation,intensive care unit(ICU)mortality,ventilator-associated events(VAEs)and infection-related ventilator associated complication(IVAC)among patients receiving mechanical ventilation(MV).Methods A time-dependent cox-regression analysis was conducted using data from a well-established registry of healthcare-associated infections at ICUs in *** receiving continuous MV for 3 days or more were included.A time-varying exposure definition was used for TRQ Injection,which were recorded on daily *** outcomes included time to extubation,ICU mortality,VAEs and ***-dependent Cox models were used to compare the clinical outcomes between TRQ Injection and non-use,after controlling for the influence of comorbidities/conditions and other medications with both fixed and time-varying *** the analyses of time to extubation and ICU mortality,Fine-Gray competing risk models were also used to measure competing risks and outcomes of *** Overall,7,685 patients were included for the analyses of MV duration,and 7,273 patients for the analysis of ICU *** to non-use,patients with TRQ Injection had a lower risk of ICU mortality(Hazards ratios(HR)0.761,95%CI,0.581–0.997),and was associated with a higher hazard for time to extubation(HR 1.105,95%CI,1.005–1.216),suggesting a beneficial effect on shortened time to *** significant differences were observed between TRQ Injection and non-use regarding VAEs(HR 1.057,95%CI,0.912–1.225)and IVAC(HR 1.177,95%CI,0.929–1.491).The effect estimates were robust when using alternative statistic models,applying alternative inclusion and exclusion criteria,and handling missing data by alternative *** Our findings suggested that the use of TRQ Injection might lower mortality and improve time to extubation among patients receiving MV,even after controlling for the factor tha