Propolis inspired sunscreens for efficient UV-protection and skin barrier maintenance
作者机构：College of Polymer Science and EngineeringState Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China Cosmetics Safety and Efficacy Evaluation CenterDepartment of DermatologyWest China HospitalSichuan UniversityChengdu 610041China NMPA Key Laboratory for Human Evaluation and Big Data of CosmeticsChengdu 610041China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2022年第15卷第9期
页 面：8237-8246页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：the National Natural Science Foundation of China(Nos.52173132 and 81673084) 1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University,the Research Fund from Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application,Soochow University(No.KJS2116) the Fundamental Research Funds for Central Universities
主 题：bioinspired sunscreen composite hydrogel ultraviolet protection
摘 要：The direct use of naturally occurring,small molecular ingredients in bioinspired sunscreens has raised several concerns due to the instability,photocytotoxicity,and potential blood toxicity of those *** this work,we have employed natural ultraviolet(UV)-blocking molecule caffeic acid phenethyl ester(CAPE)from propolis to prepare poly(CAPE)nanoparticles(NPs)as the main bioactive ingredient to fabricate propolis-inspired hydrogel *** with small molecular CAPE,poly(CAPE)NPs exhibited better dispersion and stability in water,as well as lower physiological toxicity and skin *** the resulting composite hydrogels demonstrated promising properties including water-resistant whereas can be easily erased by warm water as well as safety when interacting with *** importantly,the hydrogel sunscreens showed excellent UV protection properties both in vitro and in vivo,and the positive effects in maintaining skin barrier *** work provides new strategies towards the facile construction of nature-inspired robust sunscreens in the future.
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