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A simplified noncryogenic strategy to transport mesenchymal stem cells: Potential applications in cell therapy and regenerative medicine

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Genes & Diseases 2024年第3期11卷 26-29页

作者： Xiangyu Dong Yannian Gou Meichun Guo Jiamin Zhong Aohua Li Ailing Hao Wei Zeng Rex C.Haydon Hue H.Luu Russell R.Reid Tongchuan He Yan Xu Jiaming Fan Ministry of Education Key laboratory of Diagnostic Medicine And Department of Clinical BiochemistryCollege of Laboratory MedicineChongqing Medical UniversityChongqing 400016China molecular Oncology laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Department of Interventional Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China laboratory of Craniofacial Suture Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Institute of Sports Medicine Beijing Key Laboratory of Sports InjuriesPeking University Third HospitalBejing 100191China

With the rapid advances in stem cell research and po-tential cell-based therapies,there is an urgent need to develop safe and reliable cell transport *** for autologous stem cell-based therapies,allogeneic stem cell therapies and ex vivo genetically engineered cell therapies would require safe,efficient,and reliable cell preservation and transport methods.

关键词： transport methods simplified

A stable metal-covalent-supramolecular organic framework hybrid: enrichment of catalysts for visible light-induced hydrogen production

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Science China chemistry 2018年第7期61卷 830-835页

作者： Xiong-Fei Li Shang-Bo Yu Bo Yang Jia Tian Hui Wang Dan-Wei Zhang Yi Liu Zhan-Ting Li Department of chemistry Collaborative Innovation Centre of Chemistry for Energy Materials(iChEM) Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan University The molecular Foundry Lawrence Berkeley National Laboratory

Cubic metal-covalent-supramolecular organic framework(MCSOF-1)hybrid has been created from the reaction of two molecular components and subsequent co-assembly with cucurbit[8]uril(CB[8])in *** the presence of CB[8],[Ru(bpy)_3]^(2+)-based acylhydrazine 1·2Cl reacted with aldehyde 2·Cl to quantitatively yield six-armed precursor 3·8Cl through the generation of ***-1 combines the structural features of metal-,covalent-and supramolecular organic *** periodicity in water and in the solid state was confirmed by synchrotron X-ray scattering and diffraction ***-1could enrich discrete anionic polyoxometalates(POMs),maintain periodicity in acidic medium,and remarkably facilitate visible light-induced electron transfer from its[Ru(bpy)_3]^(2+)units to enriched POMs,leading to enhanced catalysis of the POMs for the reduction of proton to H_2in both aqueous(homogeneous)and organic(heterogeneous)media.

关键词： supramolecular organic framework self-assembly cucurbituril photocatalysis hydrogen production

Design and modification of metal sulfide-based catalysts for lithiumsulfur batteries

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Particuology 2024年第3期86卷 86-100页

作者： Yufei Zhao Chuannan Geng Li Wang Haotian Yang Wei Lv Quan-Hong Yang Nanoyang Group State Key Laboratory of Chemical EngineeringSchool of Chemical Engineering and TechnologyNational Industry-Education Integration Platform of Energy Storageand Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)Tianjin UniversityTianjin300072China Shenzhen Geim Graphene Center Engineering Laboratory for Functionalized Carbon MaterialsTsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen518055China Haihe laboratory of Sustainable Chemical Transformations Tianjin300192China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou350207China

Metal sulfide(MS)have good conductivity,strong adsorption ability,and excellent catalytic activity for the conversion of sulfur species,and thus,show great promise as the catalysts in LieS ***,the relationship between their properties and electrochemical performance is still ***,further in-depth discussions are required to improve their design in Li-S *** review systematically summarizes the basic structural and electrochemical properties of MSs and highlights the advantages that guarantee them as high-performance catalysts in Li-S ***,various modification strategies for MSs to enhance the catalytic activity,efficiency,and stability are also *** last,future opportunities for MS catalysts in Li-S batteries are proposed.

关键词： Lithium-sulfur battery Metal sulfide Catalysis

Single-cell mass spectrometry studies of drug metabolism heterogeneity and primary resistance to gefitinib in non-small cell lung cancer cells

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Chinese Chemical Letters 2024年第2期35卷 436-440页

作者： Guizhen Zhu Yaoyao Zhao Wenmei Zhang Yuanyuan Wu Yuanxing Liu Guangsheng Guo Xiayan Wang Zhihong Liu Center of Excellence for Environmental Safety and Biological Effects Beijing Key Laboratory for Green Catalysis and SeparationDepartment of ChemistryBeijing University of TechnologyBeijing 100124China Minzu University of China Beijing 100081China Key laboratory for the Synthesis and Application of Organic Functional Molecules College of Health Science and EngineeringHubei UniversityWuhan 430062China

Patients with epidermal growth factor receptor(EGFR)wild-type non-small cell lung cancer(NSCLC)often show primary resistance to gefitinib *** is thus necessary to study the metabolism of gefitinib in NSCLC cells to comprehensively reveal the reasons for the primary resistance of ***,we develop a platform for studying drug metabolism heterogeneity based on single-cell mass spectrometry(sDMH-scMS)by integrating living-cell electrolaunching ionization MS(ILCEI-MS)and high-performance liquid chromatography-MS(HPLC-MS)analysis,and the primary resistance of NSCLC cells to gefitinib was studied using this *** ILCEI-MS analysis showed that approximately 11.9%of NSCLC single cells contained the gefitinib metabolite M11;HPLC-MS detection diluted the intensity of M11 in subpopulations and concealed the heterogeneity of drug metabolism in tumor single *** intensity of gefitinib in EGFR wild-type A549 cells was markedly lower than in mutant PC9 cells,and the intensity of gefitinib metabolites was significantly higher than in PC9 cells,suggesting that the primary resistance of NSCLC cells is related to gefitinib ***,the combination of gefitinib and the drug-metabolizing enzyme inhibitorα-naphthoflavone was shown to overcome the primary resistance of the NSCLC ***,the results of this study are expected to be applicable for clinical drug resistance diagnosis and treatment at the single-cell level.

关键词： Single-cell mass spectrometry Drug metabolism Non-small cell lung cancer Gefitinib Primary resistance

Electrochemical protein biosensors for disease marker detection:progress and opportunities

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Microsystems & Nanoengineering 2024年第3期10卷 1-20页

作者： Lanpeng Guo Yunong Zhao Qing Huang Jing Huang Yanbing Tao Jianjun Chen Hua-Yao Li Huan Liu School of Integrated Circuits Wuhan National Laboratory for OptoelectronicsOptics Valley LaboratoryHuazhong University of Science and TechnologyWuhan 430074China Key laboratory of Intelligent Computing and Signal Processing of Ministry of Education School of Integrated CircuitsAnhui UniversityHefei 230601China School of Optoelectronic materials and Technology Jianghan UniversityWuhan 430056China Department of Otorhinolaryngology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology1277 Jiefang AvenueWuhan 430022China Wenzhou Institute of Advanced Manufacturing Technology Huazhong University of Science and TechnologyWenzhou 325000China

The development of artificial intelligence-enabled medical health care has created both opportunities and challenges for next-generation biosensor *** are extensively used as biological macromolecular markers in disease diagnosis and the analysis of therapeutic *** protein biosensors have achieved desirable specificity by using the specific antibody–antigen binding principle in ***,the active centers of protein biomarkers are surrounded by a peptide matrix,which hinders charge transfer and results in insufficient sensor ***,electrode-modified materials and transducer devices have been designed to increase the sensitivity and improve the practical application prospects of electrochemical protein *** this review,we summarize recent reports of electrochemical biosensors for protein biomarker *** highlight the latest research on electrochemical protein biosensors for the detection of cancer,viral infectious diseases,inflammation,and other *** corresponding sensitive materials,transducer structures,and detection principles associated with such biosensors are also addressed ***,we present an outlook on the use of electrochemical protein biosensors for disease marker detection for the next few years.

关键词： diagnosis specificity Electrochemical

A high-resolution dataset for lower atmospheric process studies over the Tibetan Plateau from 1981 to 2020

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Big Earth Data 2024年第3期8卷 540-565页

作者： Fei Li Shupo Ma Jinhuan Zhu Han Zou Peng Li Libo Zhou Department of Lower Atmospheric Observation Research Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina State Key laboratory of Atmospheric Boundary Layer Physics and Atmospheric chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina

ABSTRACT A high-resolution meteorological dataset(≤10 km)over the Tibetan Plateau(TP)is the foundation for investigating and predicting the weather and climate over *** TP Subregional Dynamical Downscaling(TPSDD)dataset is a newly developed high-spatial-temporal resolution gridded dataset for land‒air exchange pro-cesses and lower atmospheric structure studies over the whole TP region,taking the climate characteristics of each TP subregion into *** dataset spans from 1981 to 2020,covering the TP with a temporal resolution of 2 hr and spatial resolution of 10 *** elements of the dataset include near-surface land-air exchange parameters,such as downward/upward long-wave/shortwave radiation flux,sensible heat flux,latent heat flux,*** addition,the vertical distributions of 3-dimensional wind,temperature,humidity,and pressure from the surface to the lower stratosphere are also *** evaluations were con-ducted to verify the performance of the TPSDD dataset by compar-ing TPSDD/reanalysis with surface and vertical observations through the calculation of statistical *** results demonstrate the accuracy and superiority of this dataset against reanalysis data,which provides great potential for future climate change research.

关键词： Tibetan Plateau WRF model dynamical downscaling land‒air interaction the lower atmosphere

单原子在铝合金中的扩散迁移行为:可解释机器学习加速第一原理计算方法

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Science China materials 2024年第4期67卷 1140-1149页

作者：黄敬涛薛景腾李明伟程源来忠红胡津周飞曲囡刘勇朱景川 School of materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China National Key laboratory for Precision Hot Processing of Metals Harbin Institute of TechnologyHarbin 150001China National Key laboratory of Science and Technology on Advanced Composites in SpecialEnvironments Harbin Institute of TechnologyHarbin 150001 China Center for Analysis Measurement and ComputingHarbin Institute of TechnologyHarbin 150001China State Key laboratory for Environment-friendly Energy materials School of Materials Science and EngineringSouthwest University of Science and TechnologyMianyang 621010China

本文采用机器学习加速第一原理计算的方法,研究了铝基体中单原子的扩散迁移行为.建立铝基体中三十多种单原子扩散迁移行为的小样本数据集,以原子半径、离子半径和第一电离能等固有参数作为输入特征值,合金原子与空位之间的相互作用能以... 详细信息

本文采用机器学习加速第一原理计算的方法,研究了铝基体中单原子的扩散迁移行为.建立铝基体中三十多种单原子扩散迁移行为的小样本数据集,以原子半径、离子半径和第一电离能等固有参数作为输入特征值,合金原子与空位之间的相互作用能以及合金原子在铝基体中的扩散势垒作为输出参数.通过相关性分析初步确定描述符与预测目标之间的关系,并利用递归特征消除法确定不同目标的输入特征和描述符数量.通过交叉验证证明所选模型的先进性,并进行微调以优化其性能.为了验证其效率和准确性,CatBoost模型经过了传统算法的严格测试.利用训练有素的模型预测周期表中其他单原子在铝基体中的扩散迁移行为.机器学习加速第一原理计算的结果可为进一步开发新型铝合金提供理论依据.

关键词：机器学习扩散迁移交叉验证输出参数单原子第一原理计算原子半径小样本数据

Adsorption and separation technologies based on supramolecular macrocycles for water treatment

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Eco-Environment & Health 2024年第3期3卷 381-391页

作者： Qian Lin Xiaolong Ding Yuansheng Hou Wajahat Ali Zichen Li Xinya Han Zhen Meng Yue Sun Yi Liu School of chemistry and Chemical Engineering Anhui University of TechnologyMaanshan 243002China State Key laboratory of Separation Membrane and Membrane Process School of ChemistryTiangong UniversityTianjin 300387China QingHai Salt Lake Industry Co.Ltd. Golmud 816099China Department of chemistry University of BaltistanSkardu 16100Pakistan School of chemistry and Chemical Engineering Nanjing UniversityNanjing 210023China

The escalating challenges in water treatment,exacerbated by climate change,have catalyzed the emergence of innovative *** adsorption separation and membrane filtration methodologies,achieved through molecular structure manipulation,are gaining traction in the environmental and energy *** technologies,integral to both the chemical industry and everyday life,encompass concentration and purification ***,recognized as porous materials,have been prevalent in water treatment due to their inherent benefits:stability,adaptability,and facile *** structures typically exhibit high selectivity and reversibility for specific ions or molecules,enhancing their efficacy in water purification *** progression of purification methods utilizing macrocyclic frameworks holds promise for improved adsorption separations,membrane filtrations,resource utilization,and broader water treatment *** review encapsulates the latest breakthroughs in macrocyclic host-guest chemistry,with a focus on adsorptive and membrane *** aim is to spotlight strategies for optimizing macrocycle designs and their subsequent implementation in environmental and energy endeavors,including desalination,elemental extraction,seawater energy harnessing,and sustainable ***,this review can guide the design and functionality of macrocycles,offering a significantly promising pathway for pollutant removal and resource utilization.

关键词： Environmental pollution Water treatment Supramolecular macrocycles Membrane separation

Spectral Selectivity of CdTe Cells with Substrate Configuration for Photovoltaic/Thermal Applications

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Journal of Thermal Science 2024年第4期33卷 1542-1553页

作者： CHEN Ken HU Kongfu ZHAO Bin CHEN Tao HAO Yong PEI Gang Department of Thermal Science and Energy Engineering University of Science and Technology of ChinaHefei230027China Key laboratory of Solar Thermal Conversion of Anhui Province Hefei230027China Hefei National laboratory for Physical Sciences at Microscale Department of Materials Science and EngineeringUniversity of Science and Technology of ChinaHefei230026China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China

Existing photovoltaic cells with high infrared emissivity generate huge radiative heat loss in photovoltaic/thermal applications and degrade the photothermal *** purpose of this work is to evaluate the full spectral absorptivity of CdTe cells to find a spectrally selective photovoltaic cell for photovoltaic/thermal *** this end,the solar absorptivity and mid-infrared thermal emissivity of CdTe cells were tested by ellipsometry,UV-Vis-NIR spectrophotometer,and Fourier transform infrared *** experimental results show that the AM 1.5 solar spectrum weighted absorptivity of the substrate configuration CdTe cell reaches 0.91,and the mid-infrared emissivity is only 0.29,while the superstrate configuration cell emissivity is as high as *** research shows that substrate configuration with a transparent conductive layer on top can be flexibly grown on metal foils and has spectral selectivity with high solar absorptivity and low mid-infrared emissivity should be considered in the future for photovoltaic/thermal applications.

关键词： photovoltaic/thermal spectral selectivity substrate configuration CdTe cell ITO