Electrochemical protein biosensors for disease marker detection:progress and opportunities

作     者：Lanpeng Guo Yunong Zhao Qing Huang Jing Huang Yanbing Tao Jianjun Chen Hua-Yao Li Huan Liu 

作者机构：School of Integrated CircuitsWuhan National Laboratory for OptoelectronicsOptics Valley LaboratoryHuazhong University of Science and TechnologyWuhan 430074China Key Laboratory of Intelligent Computing and Signal Processing of Ministry of EducationSchool of Integrated CircuitsAnhui UniversityHefei 230601China School of Optoelectronic Materials and TechnologyJianghan UniversityWuhan 430056China Department of OtorhinolaryngologyUnion HospitalTongji Medical CollegeHuazhong University of Science and Technology1277 Jiefang AvenueWuhan 430022China Wenzhou Institute of Advanced Manufacturing TechnologyHuazhong University of Science and TechnologyWenzhou 325000China 

出 版 物：《Microsystems & Nanoengineering》 (微系统与纳米工程（英文）)

年 卷 期：2024年第10卷第3期

页      面：1-20页

核心收录：

学科分类：080202[工学-机械电子工程] 08[工学] 0802[工学-机械工程] 

基　　金：supported by the Hubei Provincial Natural Science Foundation of China(Grant No.2022CFA035) the Zhejiang Provincial Natural Science Foundation of China(Grant No.Y23F040019) 

主　　题：diagnosis specificity Electrochemical 

摘      要：The development of artificial intelligence-enabled medical health care has created both opportunities and challenges for next-generation biosensor *** are extensively used as biological macromolecular markers in disease diagnosis and the analysis of therapeutic *** protein biosensors have achieved desirable specificity by using the specific antibody–antigen binding principle in ***,the active centers of protein biomarkers are surrounded by a peptide matrix,which hinders charge transfer and results in insufficient sensor ***,electrode-modified materials and transducer devices have been designed to increase the sensitivity and improve the practical application prospects of electrochemical protein *** this review,we summarize recent reports of electrochemical biosensors for protein biomarker *** highlight the latest research on electrochemical protein biosensors for the detection of cancer,viral infectious diseases,inflammation,and other *** corresponding sensitive materials,transducer structures,and detection principles associated with such biosensors are also addressed ***,we present an outlook on the use of electrochemical protein biosensors for disease marker detection for the next few years.