检索结果-南通市图书馆

Mobile mini-fluorimeter for antibiotic aptasensing based on surface-plasmonic effect of burlike nanogolds enhanced by digitized imaging diagnosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第5期35卷 418-422页

作者： Tiantian Man Fulin Zhu Yaqi Huang Yuhao Piao Yan Su Shengyuan Deng Ying Wan School of Mechanical engineering Nanjing University of Science and TechnologyNanjing 210094China Key Laboratory of metabolic engineering and Biosynthesis Technology Ministry of Industry and Information TechnologySchool of Environmental and Biological EngineeringNanjing University of Science and TechnologyNanjing 210094China

Antibiotic abuse now poses a grave threat to global ecology and bestirs public concerns about the residue issue in daily *** traceability measurements along supply chain or logistic circulation have become increasingly essential given the labile nature of diverse synthetic residuals on *** an attempt to answer this urgency,here a miniaturized fluorometric aptasensor prototype was contrived that catered to the point-of-care screening norm for two typical additives:chloramphenicol and *** key target-indicating module worked in vitro based on the competitive binding-induced fluorescence recovery of fluorescein-labeled aptamers,which were photobleached beforehand in the format of double helix on burlike nanogold ***“prickly”geometry of the latter not just enriched the capture probes at preferentially substrate-accessible spires;but also contributed to a tip-enhanced surface plasmon effect,sensitizing the signal-on during the duplex dissociation even at nanomolar threshold of the *** the other hand,to encompass a full portable,a set of optical devices were mounted within a 3D-printed cartridge(adaptor)to converge the light beam and route it towards the detector,for which the smartphone camera came up in handy with a home-developed App for calibrating the emissive *** by the high-dynamic-range compression,an imaging diagnostic algorithm was built in to grid and digitize each slide in the album for augmented detection ***,a novel bio-to-silico integration was invented that capable of in situ rapid reporting on the antibiotic presence with high sensitivity and *** field practices in spiked milk on sales proved the precision and rudimentary feasibility of the well-assembled model of appliance,thus holding nice prospects in nonexpert(e.g.,family and local community)utilities for foodborne antibiotic identification.

关键词： Chloramphenicol and enrofloxacin Aptasensor Gold nanoburs Smartphone fluorimetric suite Digitized image postprocessing

Experimental investigation of spectral evolution in flash radiation by hypervelocity impact on aluminum plates

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第7期37卷 96-110页

作者： Xing Chen Yonggang Lu Zhiwen Li Zhonghua Cui Institute of Systems engineering China Academy of Engineering PhysicsMianyang 621900SichuanChina Chongqing Qianwei Technology group Co. LtdChongqing 401121China

In this study,a series of hypervelocity impact tests were carried out based on a two-stage light gas gun,and the sequence spectrum and radiation evolution data of the impact products under different impact conditions were *** diameter of the projectile is 3-5 mm,the impact velocity is 3.13-6.58 km/s,and the chamber pressure is 0.56-990 *** spectrum of ejected debris cloud in the 250-310 nm band were obtained using a transient spectral measurement system and a multi-channel radiometer measurement *** test results reveal that the flash radiation intensity increases as a power function with the kinetic energy of the ***,the peak value of the line spectrum decreases as the chamber vacuum degree increases,while the radiation width gradually *** line spectrum in the spectral characterization curve corresponds to the ejected debris clouds splitting phase,which does not produce significant line spectrum during material fragmentation and is dominated by the continuum spectrum produced by blackbody *** will appear one or three characteristic peaks in the flash radiation time curve,the first and second peaks correspond to the penetration phase and the third peak corresponds to the expansion phase of the ejected debris clouds on the time scale,the first and second peaks are more sensitive to the chamber vacuum degree,and when the pressure is higher than 99 Pa,the first and second characteristic peaks will *** radiant heat attenuation of the flash under different impact conditions is significantly different,the attenuation exponent has a power function relationship with the impact velocity and the chamber vacuum degree,while the attenuation exponent has a linear relationship with the diameter of the projectile,the specific expression of the attenuation exponent is obtained by *** findings from this research can serve as a valuable reference for remote diagnostic technologies based on flash radiation characte

关键词： Hypervelocity impact Flash radiation Evolution Spectral characteristics Damage evaluation

Early-life famine exposure,adulthood obesity patterns,and risk of low-energy fracture

在线全文

学校读者我要写书评

暂无评论

Frontiers of Medicine 2024年第1期18卷 192-203页

作者： Hongyan Qi Chunyan Hu Jie Zhang Lin Lin Shuangyuan Wang Hong Lin Xiaojing Jia Yuanyue Zhu Yi Zhang Xueyan Wu Mian Li Min Xu Yu Xu Tiange Wang Zhiyun Zhao Weiqing Wang Yufang Bi Meng Dai Yuhong Chen Jieli Lu Department of Endocrine and metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Shanghai National Clinical Research Center for Endocrine and metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the People’s Republic of ChinaShanghai National Center for Translational MedicineRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China

Malnutrition in early life increases the risk of osteoporosis,but the association of early-life undernutrition combined with adulthood obesity patterns with low-energy fracture remains *** study included 5323 community-dwelling subjects aged⩾40 years from ***-life famine exposure was identified based on the participants’birth *** obesity was assessed using the body mass index(BMI),and abdominal obesity was evaluated with the waist-to-hip ratio(WHR).Low-energy fracture was defined as fracture occurring after the age of⩾40 typically caused by falls from standing height or *** to the nonexposed group,the group with fetal,childhood,and adolescence famine exposure was associated with an increased risk of fracture in women with odds ratios(ORs)and 95%confidence intervals(CIs)of 3.55(1.57–8.05),3.90(1.57–9.71),and 3.53(1.05–11.88),respectively,but not in *** interactions were observed between fetal famine exposure and general obesity with fracture among women(P for interaction=0.0008).Furthermore,compared with the groups with normal BMI and WHR,the group of women who underwent fetal famine exposure and had both general and abdominal obesity had the highest risk of fracture(OR,95%CI:3.32,1.17–9.40).These results indicate that early-life famine exposure interacts with adulthood general obesity and significantly increases the risk of low-energy fracture later in life in women.

关键词： famine obesity body mass index waist-to-hip ratio low-energy fracture

Exhaust hood performance and its improvement technologies in industrial buildings:A literatu rereview

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Building Simulation 2024年第1期17卷 23-40页

作者： Jing Zhang Jian Wang Jun Gao Weimin Zhang Architectural engineering Institute Jinhua PolytechnicJinhua 321017China Institute of HVAC engineering Schoolof Mechanical EngineeringTongji UniversityShanghai 200092China Tongji Architectural Design(group)Co .LtdShanghai 200092China

The pollutant control performance of exhaust hoods plays a crucial role in the indoor air quality and energy consumption of ventilation systems in industrial *** better understand the impact of local ventilation on the industrial indoor environment,this paper presents a literature review of exhaust hood performance and its improvement *** create an index for evaluating the performance of exhaust hoods,the capture velocity,capture efficiency,flow ratio of pollutant emissions and exhaust airflow and energy consumption are first introduced.A number of factors affecting exhaust hood performance are assessed such as hood type,hood opening size,exhaust rate,installation distance,pollution source emission and environmental *** to structural improvement methods,the use of active airflow is a more effective way to improve the exhaust hood *** most commonly used methods for determining the exhaust rate are the controlled speed method and the flow ratio *** use of an exhaust hood with an appropriate exhaust rate and jet parameters(for an active air-assisted hood)can effectively improve the pollutant control performance and reduce the energy consumption that would be wasted on the redundant exhaust *** more information focused on exhaust hood performance,this work suggests more effective strategies for improving indoor air quality and reducing energy consumption in industrial buildings.

关键词： industrial ventilation exhaust hood capture efficiency exhaust rate performance improvement

Experimental study on the dynamic response of a 3-D wedge under asymmetric impact

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2024年第2期36卷 263-274页

作者： Saeed Hosseinzadeh Kristjan Tabri Maritime engineering Research group School of EngineeringUniversity of SouthamptonSouthamptonUK Department of Civil engineering and Architecture Tallinn University of TechnologyTallinnEstonia Marine Technology Competence Center Tallinn University of TechnologyKuressaareEstonia

Water entry problems represent complex multiphase flows involving air,water,and structure interaction,occurring rapidly in rough seas,and potentially effecting structural integrity of floating *** paper experimentally investigates asymmetric slamming loads acting on a 3-D elastic wedge *** specimen,featuring two different bottom plates(stiffened and unstiffened),each 4 mm thick,aims to assess the effect of structural stiffness on dynamic *** experiments are conducted at different drop heights of 25 cm and 50 cm and varying heel angles from 5°to 25°.The paper describes the experimental conditions,including wedge geometry,material properties,and the test *** study explores the influence of heel angle on impact acceleration,revealing an increase in peak acceleration with a higher inclination angle,particularly in the vertical ***,the hydrodynamic pressure resulting from asymmetric slamming is *** pressure results analyzed and compared at different locations along the length of the *** experimental findings indicate that,despite the leeward side(stiffened)experiencing a smaller hydrodynamic load,the heel angle significantly affects pressure results on the windward side(unstiffened),leading to a more pronounced dynamic *** time history of pressure results emphasizes the effect of elastic vibrations,particularly noticeable on the unstiffened bottom *** study contributes to a deeper understanding of asymmetric slamming on aluminum structures,facilitating the enhancement of mathematical models and the validation of numerical simulations.

关键词： Flexible fluid structure interactions(FFSI) experimental study asymmetric impact hydrodynamic pressure slamming loads

Mechanism of action of the bile acid receptor TGR5 in obesity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第2期14卷 468-491页

作者： Weijun Lun Qihao Yan Xinghua Guo Minchuan Zhou Yan Bai Jincan He Hua Cao Qishi Che Jiao Guo Zhengquan Su Guangdong engineering Research Center of Natural Products and New Drugs Guangdong Provincial University Engineering Technology Research Center of Natural Products and DrugsGuangdong Pharmaceutical UniversityGuangzhou 510006China Guangdong metabolic Disease Research Center of Integrated Chinese and Western Medicine Key Laboratory of Glucolipid Metabolic DisorderMinistry of Education of ChinaGuangdong TCM Key Laboratory for Metabolic DiseasesGuangdong Pharmaceutical UniversityGuangzhou 510006China School of Public Health Guangdong Pharmaceutical UniversityGuangzhou 510310China School of Chemistry and Chemical engineering Guangdong Pharmaceutical UniversityZhongshan 528458China Guangzhou Rainhome Pharm&Tech Co. Ltd.Science CityGuangzhou 510663China

G protein-coupled receptors(GPCRs)are a large family of membrane protein receptors,and Takeda G protein-coupled receptor 5(TGR5)is a member of this *** a membrane receptor,TGR5 is widely distributed in different parts of the human body and plays a vital role in regulating metabolism,including the processes of energy consumption,weight loss and blood glucose *** studies have shown that TGR5 plays an important role in glucose and lipid metabolism disorders such as fatty liver,obesity and *** the global obesity situation becoming more and more serious,a comprehensive explanation of the mechanism of TGR5 and filling the gaps in knowledge concerning clinical ligand drugs are urgently *** this review,we mainly explain the anti-obesity mechanism of TGR5 to promote the further study of this target,and show the electron microscope structure of TGR5 and review recent studies on TGR5 ligands to illustrate the specific binding between TGR5 receptor binding sites and ligands,which can effectively provide new ideas for ligand research and promote drug research.

关键词： Obesity TGR5 Bile acids Ligand Appetite Metabolism GLP-1 Inflammation

Effect of Co on Solidification Characteristics and Microstructural Transformation of Non-equilibrium Solidified Cu-Ni Alloys

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2024年第2期39卷 444-453页

作者：安红恩 Bih-Lii Chua Ismail Saad Willey Yun Hsien Liew Materials engineering Research group Faculty of EngineeringUniversity Malaysia Sabah88400 Kota KinabaluSabahMalaysia College of Mechanical and Electronic engineering Huanghe Jiaotong UniversityJiaozuo 454950China Henan engineering Technology Research Center on Intelligent Manufacturing Technology and Equipment Jiaozuo 454950China Centre of Research in Energy and Advanced Materials Faculty of EngineeringUniversiti Malaysia SabahJalan UMS88400 Kota KinabaluSabahMalaysia Nano engineering and Materials Research group Faculty of EngineeringUniversity Malaysia Sabah88400 Kota KinabaluSabahMalaysia

Non-equilibrium solidification structures of Cu55Ni45 and Cu55Ni43Co2 alloys were prepared by the molten glass purification cycle superheating *** variation of the recalescence phenomenon with the degree of undercooling in the rapid solidification process was investigated using an infrared *** addition of the Co element affected the evolution of the recalescence phenomenon in Cu-Ni *** images of the solid-liquid interface migration during the rapid solidification of supercooled melts were captured by using a high-speed *** solidification rate of Cu-Ni alloys,with the addition of Co elements,was ***,the grain refinement structure with low supercooling was characterised using electron backscatter diffraction(EBSD).The effect of Co on the microstructural evolution during nonequilibrium solidification of Cu-Ni alloys under conditions of small supercooling is investigated by comparing the microstructures of Cu55Ni45 and Cu55Ni43Co2 *** experimental results show that the addition of a small amount of Co weakens the recalescence behaviour of the Cu55Ni45 alloy and significantly reduces the thermal strain in the rapid solidification *** the rapid solidification phase,the thermal strain is greatly reduced,and there is a significant increase in the characteristic undercooling ***,the addition of Co and the reduction of Cu not only result in a lower solidification rate of the alloy,but also contribute to the homogenisation of the grain size.

关键词： non-equilibrium solidification recalescence effect solidification character microstructure

A novel refined dynamic model of high-speed maglev train-bridge coupled system for random vibration and running safety assessment

在线全文

学校读者我要写书评

暂无评论

Journal of Central South University 2024年第7期31卷 2532-2544页

作者： MAO Jian-feng LI Dao-hang YU Zhi-wu CAI Wen-feng GUO Wei ZHANG Guang-wen School of Civil engineering Central South UniversityChangsha 410075China National engineering Research Center of High-speed Railway Construction Technology Changsha 410075China China Railway group Limited Beijing 100039China China Railway Eryuan engineering group Co. Ltd.Chengdu 610031China

Running safety assessment and tracking irregularity parametric sensitivity analysis of high-speed maglev train-bridge system are of great concern,especially need perfect refinement models in which all properties can be well characterized based on various stochastic excitations.A three-dimensional refined spatial random vibration analysis model of high-speed maglev train-bridge coupled system is established in this paper,in which multi-source uncertainty excitation can be considered simultaneously,and the probability density evolution method(PDEM)is adopted to reveal the system-specific uncertainty dynamic *** motion equation of the maglev vehicle model is composed of multi-rigid bodies with a total 210-degrees of freedom for each vehicle,and a refined electromagnetic force-air gap model is used to account for the interaction and coupling effect between the moving train and track beam bridges,which are directly established by using finite element *** model is proven to be applicable by comparing with Monte Carlo *** applying the proposed stochastic framework to the high maglev line,the random dynamic responses of maglev vehicles running on the bridges are studied for running safety and stability ***,the effects of track irregularity wavelength range under different amplitude and running speeds on the coupled system are *** results show that the augmentation of train speed will move backward the sensitive wavelength interval,and track irregularity amplitude influences the response remarkably in the sensitive interval.

关键词： maglev train-bridge interaction electromagnetic force-air gap model stochastic dynamic analysis running safety assessment probability density evolution method

Intelligent solubility estimation of gaseous hydrocarbons in ionic liquids

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum 2024年第1期10卷 109-123页

作者： Behnaz Basirat Fariborz Shaahmadi Seyed Sorosh Mirfasihi Abolfazl Jomekian Bahamin Bazooyar Ahvaz Faculty of Petroleum engineering Petroleum University of Technology (PUT) School of engineering & Physical Sciences Heriot Watt University Department of Fluids & Environment The University of Manchester Department of engineering Chemical Engineering Group Esfarayen University of Technology Mechanical and Aerospace engineering Brunel University London

The research focuses on evaluating how well new solvents attract light hydrocarbons, such as propane,methane, and ethane, in natural gas sweetening units. It is important to accurately determine the solubility of hydrocarbons in these solvents to effectively manage the sweetening process. To address this challenge, the study proposes using advanced empirical models based on artificial intelligence techniques like Multi-Layer Artificial Neural Network(ML-ANN), Support Vector Machines(SVM), and Least Square Support Vector Machine(LSSVM). The parameters for the SVM and LSSVM models are estimated using optimization methods like Genetic Algorithm(GA), Particle Swarm Optimization(PSO), and Shuffled Complex Evolution(SCE). Data on the solubility of propane, methane, and ethane in various ionic liquids are collected from reliable literature sources to create a comprehensive database. The proposed artificial intelligence models show great accuracy in predicting hydrocarbon solubility in ionic liquids. Among these, the hybrid SVM models perform exceptionally well, with the PSO-SVM hybrid model being particularly efficient computationally. To ensure a comprehensive analysis, different examples of hydrocarbons and their order are included. Additionally, a comparative analysis is conducted to compare the AI models with the thermodynamic COSMO-RS model for solubility analysis. The results demonstrate the superiority of the AI models, as they outperform traditional thermodynamic models across a wide range of data. In conclusion, this study introduces advanced artificial intelligence algorithms such as ML-ANN, SVM, and LSSVM in accurately estimating the solubility of hydrocarbons in ionic liquids. The incorporation of optimization techniques and variations in hydrocarbon examples improves the accuracy, precision, and reliability of these intelligent models. These findings highlight the significant potential of AI-based approaches in solubility analysis and emphasize their superiori

关键词： Solubility Gaseous hydrocarbon Intelligent models Ionic liquids