Early-life famine exposure,adulthood obesity patterns,and risk of low-energy fracture

作     者：Hongyan Qi Chunyan Hu Jie Zhang Lin Lin Shuangyuan Wang Hong Lin Xiaojing Jia Yuanyue Zhu Yi Zhang Xueyan Wu Mian Li Min Xu Yu Xu Tiange Wang Zhiyun Zhao Weiqing Wang Yufang Bi Meng Dai Yuhong Chen Jieli Lu Hongyan Qi;Chunyan Hu;Jie Zhang;Lin Lin;Shuangyuan Wang;Hong Lin;Xiaojing Jia;Yuanyue Zhu;Yi Zhang;Xueyan Wu;Mian Li;Min Xu;Yu Xu;Tiange Wang;Zhiyun Zhao;Weiqing Wang;Yufang Bi;Meng Dai;Yuhong Chen;Jieli Lu

作者机构：Department of Endocrine and Metabolic DiseasesShanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Shanghai National Clinical Research Center for Endocrine and Metabolic DiseasesKey Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the People’s Republic of ChinaShanghai National Center for Translational MedicineRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China 

出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)

年 卷 期：2024年第18卷第1期

页      面：192-203页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the Ministry of Science and Technology of China(No.2022YFC2505202) the National Natural Science Foundation of China(Nos.81970691 and 82170819) Shanghai Outstanding Academic Leaders Plan(No.20XD1422800) Shanghai Medical and Health Development Foundation(No.DMRFP_I_01) Clinical Research Plan of SHDC(No.SHDC2020CR3064B) Science and Technology Committee of Shanghai(No.20Y11905100) Key Medical Subject of Jiading District,Shanghai(No.2020-jdyxzdzk-01) 

主　　题：famine obesity body mass index waist-to-hip ratio low-energy fracture 

摘      要：Malnutrition in early life increases the risk of osteoporosis,but the association of early-life undernutrition combined with adulthood obesity patterns with low-energy fracture remains *** study included 5323 community-dwelling subjects aged⩾40 years from ***-life famine exposure was identified based on the participants’birth *** obesity was assessed using the body mass index(BMI),and abdominal obesity was evaluated with the waist-to-hip ratio(WHR).Low-energy fracture was defined as fracture occurring after the age of⩾40 typically caused by falls from standing height or *** to the nonexposed group,the group with fetal,childhood,and adolescence famine exposure was associated with an increased risk of fracture in women with odds ratios(ORs)and 95%confidence intervals(CIs)of 3.55(1.57–8.05),3.90(1.57–9.71),and 3.53(1.05–11.88),respectively,but not in *** interactions were observed between fetal famine exposure and general obesity with fracture among women(P for interaction=0.0008).Furthermore,compared with the groups with normal BMI and WHR,the group of women who underwent fetal famine exposure and had both general and abdominal obesity had the highest risk of fracture(OR,95%CI:3.32,1.17–9.40).These results indicate that early-life famine exposure interacts with adulthood general obesity and significantly increases the risk of low-energy fracture later in life in women.