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甲状腺癌手术——memorial sloan-kettering cancer Center经验（一）

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中华耳鼻咽喉头颈外科杂志 2011年第9期46卷 787-791页

作者： Ziv Gil Snehal G. Patel 李平栋(译) 于振坤(译) Head and Neck Service Memorial Slomi-Kettering Cancer Center New York New York 10021 首都医科大学附属北京同仁医院耳鼻咽喉头颈外科中心耳鼻咽喉头颈科学教育部重点实验室(首都医科大学) 100730

甲状腺切除术是甲状腺癌的标准治疗方式，可由普外科、耳鼻咽喉头颈外科、内分泌外科或肿瘤外科医生来完成。对肿瘤外科来讲，甲状腺外科主要有三个目的：完整切除单侧或双侧甲状腺腺叶，保留保护好甲状旁腺及其血供，避免喉上神经和喉... 详细信息

甲状腺切除术是甲状腺癌的标准治疗方式，可由普外科、耳鼻咽喉头颈外科、内分泌外科或肿瘤外科医生来完成。对肿瘤外科来讲，甲状腺外科主要有三个目的：完整切除单侧或双侧甲状腺腺叶，保留保护好甲状旁腺及其血供，避免喉上神经和喉返神经的损伤。

关键词：甲状腺癌手术耳鼻咽喉头颈外科肿瘤外科医生甲状腺切除术内分泌外科甲状腺腺叶甲状腺外科治疗方式

Nasal metastases from renal cell carcinoma are associated with memorial sloan-kettering cancer Center poor-prognosis classification

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Chinese Journal of cancer 2011年第2期30卷 144-148页

作者： Caroline Victoria Choong Tiffany Tang Wen Yee Chay Christopher Goh Miah Hiang Tay Nor Azhari Mohd Zam Puay Hoon Tan Min-Han Tan Department of Medical Oncology National Cancer Centre Singapore Singapore 169610 Republic of Singapore Department of Otolaryngology Singapore General Hospital Singapore Singapore 169608 Republic of Singapore Department of Urology Singapore General Hospital Singapore Singapore 169608 Republic of Singapore Department of Pathology Singapore General Hospital Singapore Singapore 169608 Republic of Singapore.

Unusual sites of metastases are recognized in patients with renal cell carcinoma (RCC). However, the prognostic implications of these sites are not well understood. We used the memorial sloan-kettering cancer Center (MSKCC) risk classification for metastatic RCC to evaluate 912 consecutive patients with RCC managed at the Singapore General Hospital between 1990 and 2009. Among these patients, 301 had metastases either at diagnosis or during the course of illness. Nasal metastases, all arising from clear cell RCC, were identified histologically in 4 patients (1.3% of those with metastasis). All 4 patients were classified as MSKCC poor prognosis by current risk criteria. Nasal metastases were significantly associated with lung and bone metastases. The frequency of nasal metastases in patients with metastatic RCC is about 1%, occurring predominantly in patients with clear cell RCC. Nasal metastases are associated with poor prognosis as estimated by the MSKCC risk classification, with attendant implications for selection of targeted therapy, and are usually associated with multi-organ dissemination, including concurrent lung and bone involvement.

关键词：风险分类肾细胞癌症预后鼻医院管理 CC标准治疗方案

Chemotherapy of ovarian cancer in elderly patients

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cancer Biology & Medicine 2015年第4期12卷 292-301页

作者： Tiffany A.Troso-Sandoval Stuart M.Lichtman Department of Medicine Memorial Sloan Kettering Cancer CenterNew York

Epithelial ovarian cancer is primarily a disease of older women. Advanced age is risk factor for decreased survival. Optimal surgery and the safe and effective administration of chemotherapy are essential for prolonged progression-free and overall survival(OS). In this article, the available regimens in both the primary treatment and relapsed setting are reviewed.

关键词： Ovarian cancer chemotherapy paclitaxel carboplatin intraperitoneal elderly geriatrics

Systemic therapy of non-colorectal gastrointestinal malignancies in the elderly

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cancer Biology & Medicine 2015年第4期12卷 284-291页

作者： Avni M.Desai Stuart M.Lichtman Department of Medicine Memorial Sloan Kettering Cancer CenterNew York

In the coming years life expectancy is expected to increase and with this the percentage of the population above age 65 will grow. Patients above 65 make up more than two thirds of those currently diagnosed with gastrointestinal malignancies. Available evidence based medicine does not focus on the average patient, above the age 70, encountered in every day practice. Most guidelines and clinical trials are not designed to take into account the special considerations needed when treating the elderly such as functional status, comorbidities, polypharmacy, life expectancy, and social support. The majority of available data is based on retrospective reviews or subset analyses of larger studies where the elderly represent a fraction of the studied population. This review focuses on the toxicities and tolerability of current standard therapies for noncolorectal gastrointestinal malignancies, including gastroesophageal, pancreatic, bile duct and hepatocellular cancers in the elderly. With careful patient selection and geriatric assessment the elderly can safely benefit from standard therapies offered to younger patients.

关键词： Pancreatic cancer esophageal cancer biliary cancer hepatocellular carcinoma(HCC) chemotherapy elderly geriatrics gastric cancer

Innate lymphocytes-lineage,localizationandtimingof differentiation

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Cellular & Molecular Immunology 2019年第7期16卷 627-633页

作者： Emily R.Kansler Ming O.Li Immunology Program Sloan Kettering InstituteMemorial Sloan Kettering Cancer CenterNew YorkNY10065USA Louis V.Gerstner Jr.Graduate School of Biomedical Sciences Memorial Sloan Kettering Cancer CenterNew YorkNY10065USA

Innate lymphocytes are a diverse population of cells that carry out specialized functions in steady-state homeostasis and during immune *** circulating cytotoxic natural killer(NK)cells have been studied for decades,tissue-resident innate lymphoid cells(ILCs)have only been characterized and studied over the past few *** ILCs have been largely viewed in the context of helper T-cell biology,models of ILC lineage and function have been founded within this ***,tissue-resident innate lymphocytes with cytotoxic potential have been described in an array of tissues,yet whether they are derived from the NK or ILC lineage is only beginning to be *** this review,we aim to shed light on the identities of innate lymphocytes through the lenses of cell lineage,localization,and timing of differentiation.

关键词： lymphocytes lineage homeostasis

Identification of cancer gene fusions based on advanced analysis of the human genome or transcriptome

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Frontiers of Medicine 2013年第3期7卷 280-289页

作者： Lu Wang Department of Pathology Memorial Sloan-Kettering Cancer CenterNew YorkNY 10065USA

Many gene fusions have been recognized as important diagnostic and/or prognostic markers in human *** recent years,novel gene fusions have been identified in cases without prior knowledge of the genetic *** by a powerful computational data analysis method,new genome-wide screening approaches were used to detect cryptic genomic *** review focused on advanced genome-wide screening approaches in fusion gene identification,such as microarray-based approaches,next-generation sequencing,and NanoString nCounter gene expression *** fundamental rationale and strategy for fusion gene identification using each biotech platform are also discussed.

关键词： gene fusion cancer microarray next-generation sequencing NanoString nCounter system

Novel translational strategies in colorectal cancer research

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World Journal of Gastroenterology 2007年第44期13卷 5902-5910页

作者： Ignacio Gil-Bazo cancer Biology & Genetics Program Memorial Sloan-Kettering Cancer Center New York NY 10021 United States

Defining translational research is still a complex task. In oncology, translational research implies using our basic knowledge learnt from in vitro and in vivo experiments to directly improve diagnostic tools and therapeutic approaches in cancer patients. Moreover, the better understanding of human cancer and its use to design more reliable tumor models and more accurate experimental systems also has to be considered a good example of translational research. The identification and characterization of new molecular markers and the discovery of novel targeted therapies are two main goals in colorectal cancer translational research. However, the straightforward translation of basic research findings, specifically into colorectal cancer treatment and vice versa is still underway. In the present paper, a summarized view of some of the new available approaches on colorectal cancer translational research is provided. Pros and cons are discussed for every approach exposed.

关键词： Translational research Colorectal cancer Genomics Proteomics Targeted therapies

Modern management of rectal cancer: A 2006 update

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World Journal of Gastroenterology 2006年第20期12卷 3186-3195页

作者： Glen C Balch Alex De Meo Jose G Guillem Colorectal Service at memorial sloan-kettering cancer Center New York New York 10021 United States

The goal of this review is to outline some of the important surgical issues surrounding the management of patients with early (T1/T2 and NO), as well as locally advanced (T3/T4 and/or N1) rectal cancer. Surgery for rectal cancer continues to develop towards the ultimate goals of improved local control and overall survival, maintaining quality of life, and preserving sphincter, genitourinary, and sexual function. Information concerning the depth of tumor penetration through the rectal wall, lymph node involvement, and presence of distant metastatic disease is of crucial importance when planning a curative rectal cancer resection. Preoperative staging is used to determine the indication for neoadjuvant therapy as well as the indication for local excision versus radical cancer resection. Local excision is likely to be curative in most patients with a primary tumor which is limited to the submucosa (T1N0M0), without high-risk features and in the absence of metastatic disease. In appropriate patients, minimally invasive procedures, such as local excision, TEM, and laparoscopic resection allow for improved patient comfort, shorter hospital stays, and earlier return to preoperative activity level. Once the tumor invades the muscularis propria (T2), radical rectal resection in acceptable operative candidates is recommended. In patients with transmural and/or node positive disease (T3/T4 and/or N1) with no distant metastases, preoperative chemoradiation followed by radical resection according to the principles of TME has become widely accepted. During the planning and conduct of a radical operation for a locally advanced rectal cancer, a number of surgical management issues are considered, including: (1) total mesorectal excision (TME); (2) autonomic nerve preservation (ANP); (3) circumferential resection margin (CRM); (4) distal resection margin; (5) sphincter preservation and options for restoration of bowel continuity; (6) laparoscopic approaches; and (7) postoperative qu

关键词： Rectal cancer Surgery Local surgery Total mesorectal excision Review

Prospective evaluation of ^(18)F-FDG positron emission tomography in the preoperative staging of patients with hepatic colorectal metastases

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Hepatobiliary Surgery and Nutrition 2022年第4期11卷 539-554页

作者： Tim Akhurst Mithat Gönen Raymond E.Baser Lawrence H.Schwartz Scott Tuorto Lynn A.Brody Anne Covey Karen T.Brown Steven M.Larson Yuman Fong Department of Radiology Memorial Sloan-Kettering Cancer CenterNew YorkNYUSA Peter MacCallum cancer Centre VictoriaAustralia Department of Epidemiology and Biostatistics Memorial Sloan-Kettering Cancer CenterNew YorkNYUSA Department of Surgery Memorial Sloan-Kettering Cancer CenterNew YorkNYUSA

Background:Despite considerable advances in preoperative imaging,up to one-third of patients operatively explored for hepatic colorectal metastases are unexpectedly found to harbor unresectable intrahepatic or extrahepatic ***:The current study is a prospective,blinded study comparing utility of[18F]2-fluoro-2-deoxyglucose positron emission tomography(18F-FDG-PET)to computed tomography(CT)and CT arterial portography(CTAP)as preoperative ***:The 125 planned subjects were *** seen on FDG-PET alone changed therapy for 23 of 125 patients(18%).FDG-PET confirmed other radiologic findings in 16 cases(13%),for an overall influence on therapy in 39 cases(31%).FDG-PET was the most sensitive diagnostic imaging test for extrahepatic cancer;it was 80-90%sensitive for extrahepatic cancer and 70-90%*** the 28 cases of unresectable disease due to extrahepatic disease,FDG-PET findings solely changed therapies in 16 cases(57%)and influenced therapy in seven other cases(25%).Of the 21 unresectable cases due to extent of intrahepatic disease,FDG-PET did not solely change therapy in ***,FDG-PET had the lowest sensitivity for hepatic sites compared with CT or *** particular,small(cancer or those with high risk for extrahepatic *** is not a good test for identification of small tumors in the liver.

关键词： Positron emission tomography(PET) computed tomography(CT) colorectal hepatic metastases surgery