Innate lymphocytes-lineage,localizationandtimingof differentiation

作     者：Emily R.Kansler Ming O.Li 

作者机构：Immunology ProgramSloan Kettering InstituteMemorial Sloan Kettering Cancer CenterNew YorkNY10065USA Louis V.Gerstner Jr.Graduate School of Biomedical SciencesMemorial Sloan Kettering Cancer CenterNew YorkNY10065USA 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2019年第16卷第7期

页      面：627-633页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：We thank Chun Chou,Briana Nixon,and Efstathios Stamatiades of the Li lab for helpful discussions and critical reading of the manuscript.Work in the Li laboratory was supported by NIAID(R01 CA198280–01 to M.O.L) HHMI(Faculty Scholar Award to M.O.L.) the Ludwig Center for Cancer Immunology(M.O.L.) the Memorial Sloan Kettering Cancer Center Support Grant/Core Grant(P30 CA008748) 

主　　题：lymphocytes lineage homeostasis 

摘      要：Innate lymphocytes are a diverse population of cells that carry out specialized functions in steady-state homeostasis and during immune *** circulating cytotoxic natural killer(NK)cells have been studied for decades,tissue-resident innate lymphoid cells(ILCs)have only been characterized and studied over the past few *** ILCs have been largely viewed in the context of helper T-cell biology,models of ILC lineage and function have been founded within this ***,tissue-resident innate lymphocytes with cytotoxic potential have been described in an array of tissues,yet whether they are derived from the NK or ILC lineage is only beginning to be *** this review,we aim to shed light on the identities of innate lymphocytes through the lenses of cell lineage,localization,and timing of differentiation.