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Journal of Molecular Cell Biology 2019年第12期11卷 1101-1103页

作者： Lizhen Chen Zhijie Liu Barshop Institute for Longevity and Aging Studies Department of Cell Systems and AnatomyThe University of Texas Health Science Center at San AntonioSan AntonioTX 78229USA Department of Molecular Medicine Mays Cancer CenterThe University of Texas Health Science Center at San AntonioSan AntonioTX 78229USA

Cellular function and behavior are controlled by various signals during development and disease progression in *** is important to understand how signals ultimately alter the function and structure of DNA regulatory elements,especially enhancers,causing the changes of gene expression *** average,each mature human cell harbors at least^100000 enhancers,but only a small percent of them have the function to activate gene *** instance,only^12%–18%of ERα-bound enhancers are active *** enhancers become functionally active is critical for our overall understanding of enhancer biology and gene *** are recognized by signaling-dependent DNA binding transcription factors(TFs),resulting in the recruitment of different enhancer activation components that allow distal enhancers to interact with their target promoters through chromatin looping(Plank and Dean,2014).Increasing evidence indicates that the recruitment and switching of enhancer components underlie enhancer activation and the deregulation in enhancer component or architecture profoundly alters signal-regulated transcriptional machineries,leading to developmental defects or diseases.

关键词： activation function instance

Targeting LIF/LIFR signaling in cancer

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Genes & Diseases 2022年第4期9卷 973-980页

作者： Suryavathi Viswanadhapalli Kalarickal V.Dileep Kam Y.J.Zhang Hareesh B.Nair Ratna K.Vadlamudi Department of Obstetrics and Gynecology University of Texas Health San AntonioSan AntonioTX 78229USA Laboratory for Structural Bioinformatics Center for Biosystems Dynamics ResearchRIKENYokohamaKanagawa 230-0045Japan Evestra Inc.San AntonioTX 78245USA mays cancer center University of Texas Health San AntonioSan AntonioTX 78229USA

Leukemia inhibitory factor (LIF), and its receptor (LIFR), are commonly over-expressed in many solid cancers and recent studies have implicated LIF/LIFR axis as a promising clinical target for cancer therapy. LIF/LIFR activate oncogenic signaling pathways including JAK/STAT3 as immediate effectors and MAPK, AKT, mTOR further downstream. LIF/LIFR signaling plays a key role in tumor growth, progression, metastasis, stemness and therapy resistance. Many solid cancers show overexpression of LIF and autocrine stimulation of the LIF/LIFR axis;these are associated with a poorer relapse-free survival. LIF/LIFR signaling also plays a role in modulating multiple immune cell types present in tumor micro environment (TME). Recently, two targeted agents that target LIF (humanized anti-LIF antibody, MSC-1) and LIFR inhibitor (EC359) were under development. Both agents showed effectivity in preclinical models and clinical trials using MSC-1 antibody are in progress. This article reviews the significance of LIF/LIFR pathways and inhibitors that disrupt this process for the treatment of cancer.

关键词： LIF LIFR LIFR inhibitor STAT3 Targeted therapy

Long-term survival of patients with stage Ⅱ and Ⅲgastric cancer who underwent gastrectomy with inadequate nodal assessment

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World Journal of Gastrointestinal Surgery 2021年第11期13卷 1463-1483页

作者： Jacopo Desiderio Andrea Sagnotta Irene Terrenato Eleonora Garofoli Claudia Mosillo Stefano Trastulli Federica Arteritano Federico Tozzi Vito D'Andrea Yuman Fong Yanghee Woo Sergio Bracarda Amilcare Parisi Department of Digestive Surgery St.Mary’s HospitalTerni 05100Italy Department of Surgical Sciences Sapienza University of RomeRome 00161Italy Department of General Surgery and Surgical Oncology San Filippo Neri HospitalRome 00135Italy Biostatistics and Bioinformatic Unit Scientific DirectionIRCCS Regina Elena National Cancer InstituteRome 00144Italy Department of Medical Oncology St.Mary’s HospitalTerni 05100Italy Division of Surgical Oncology and Endocrine Surgery Mays Cancer CenterUniversity of Texas Health Science Center San AntonioSan AntonioTX 78229United States Division of Surgical Oncology Department of SurgeryCity of Hope National Medical CenterDuarteLA91010United States

BACKGROUND Gastric cancer is an aggressive disease with frequent lymph node(LN)*** NCCN recommends a D2 lymphadenectomy and the harvesting of at least 16 *** threshold has been the subject of great debate,not only for the extent of surgery but also for more appropriate *** reclassification of stage IIB through IIIC based on N3b nodal staging in the eighth edition of the American Joint Committee on cancer(AJCC)staging system highlights the efforts to more accurately discriminate survival expectancy based on nodal ***,studies have suggested that pathologic assessment of 30 or more LNs improve prognostic accuracy and is required for proper staging of *** To evaluate the long-term survival of advanced gastric cancer patients who deviated from expected survival curves because of inadequate nodal *** Eligible patients were identified from the Surveillance,Epidemiology,and End Results *** with stage II-III gastric cancer were considered for *** groups were compared based on the number of analyzed *** were inadequate LN assessment(ILA,cancer-specific *** were analyzed by the Kaplan-Meier product-limit method,log-rank test,hazard risk,and Cox proportional univariate and multivariate *** score matching(PSM)was used to compare the ALA and OLA *** The analysis included 11607 *** had advanced T stages(T3=48%;T4=42%).The pathological AJCC stage distribution was IIA=22%,IIB=18%,IIIA=26%,IIIB=22%,and IIIC=12%.The overall sample divided by the study objective included ILA(50%),ALA(35%),and OLA(15%).Median OS was 24 mo for the ILA group,29 mo for the ALA group,and 34 mo for the OLA group(P<0.001).Univariate analysis showed that the ALA and OLA groups had better OS than the ILA group[ALA hazard ratio(HR)=0.84,95%co

关键词： Gastric cancer Lymphadenectomy Gastrectomy Staging N stage Surveillance,Epidemiology,and End Results

Mental Health Impacts of the COVID-19 Pandemic: Reflecting on Lockdowns and Social Isolations

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Advances in Infectious Diseases 2022年第2期12卷 193-202页

作者： Ali Cheshmehzangi Zhaohui Su Tong Zou Hengcai Chen Tian Tang Ayotunde Dawodu Network for Education and Research on Peace and Sustainability (NERPS) Hiroshima University Hiroshima Japan Department of Architecture and Built Environment University of Nottingham Ningbo China Ningbo China center on Smart and Connected Health Technologies Mays Cancer Center School of Nursing UT Health San Antonio San Antonio USA Department of Science and Technology AVA Engineering Consultants Ltd. Chongqing China

This brief study explores the diverse and long-term mental impacts of the COVID-19 pandemic on societies worldwide. Based on the recent existing literature, six primary categories of mental effects are identified to verify how people are affected by reoccurring lockdowns and social isolations. The study urges holistic research in this field, suggesting that researchers must not neglect the diversity of mental health impacts and context-specific factors. While long-term mental and psychological impacts are mostly hidden for now, we anticipate them to fuel other health issues already experienced by the vulnerable groups, healthcare units, and those fighting the pandemic at the front line. The paper aims to highlight primary mental health impacts of the COVID-19 pandemic due to reoccurring lockdowns and social isolations. This is an opinion paper reflecting on ongoing research related to mental health issues of the ongoing pandemic, some of that could be looked at through case study research or extended research and comparative studies. This brief study suggests further case study-based analysis to evaluate the impacts of lockdowns and social isolations on societal wellbeing and mental health. Globally, the ongoing pandemic has made public health unstable and is expected to continue with its long-term consequences on societies. Research studies should help make governments and policymakers more aware of such long-term consequences to ensure they can respond more effectively to foreseeing public health issues.

关键词： COVID-19 Mental Health Lockdown Response Public Health Social Isolation

Piriformospora indica confers drought tolerance on Zea mays *** enhancement of antioxidant activity and expression of drought-related genes

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The Crop Journal 2017年第3期5卷 251-258页

作者： Le Xu Aiai Wang Jun Wang Qiao Wei Wenying Zhang Hubei Collaborative Innovation center for Grain Industry/Research center of Crop Stresses Resistance Technologies Yangtze UniversityJingzhou 434025China

Drought stress is one of the most severe environmental constraints to plant growth and crop productivity. Plant growth is greatly affected by drought stress, and plants, to survive,adapt to this stress by invoking different pathways. Piriformospora indica, a root-colonizing endophytic fungus of Sebacinales, promotes plant growth and confers resistance to biotic and abiotic stresses, including drought stress, by affecting the physiological properties of the host plant. The fungus strongly colonizes the roots of maize(Zea mays L.) and promotes shoot and root growth under both normal growth conditions and drought stress. We used polyethylene glycol(PEG-6000) to mimic drought stress and found that root fresh and dry weight, leaf area, SPAD value, and leaf number were increased in P. indica-colonized *** antioxidative activities of catalases and superoxide dismutases were upregulated within 24h in the leaves of P. indica-colonized plants. Drought-related genes DREB2A, CBL1,ANAC072, and RD29A were upregulated in drought-stressed leaves of P. indica-colonized plants. Furthermore, after drought treatment, proline content increased, whereas accumulation of malondialdehyde(MDA), an indicator of membrane damage, decreased in P. indica-colonized maize. We conclude that P. indica-mediated plant protection against the detrimental effects of drought may result from enhanced antioxidant enzyme activity,proline accumulation, and expression of drought-related genes and lower membrane damage in maize plants.

关键词： Antioxidants Drought-related genes Drought tolerance Piriformospora indica Maize

ZmGns,a maize class I β-1,3-glucanase,is induced by biotic stresses and possesses strong antimicrobial activity

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Journal of Integrative Plant Biology 2015年第3期57卷 271-283页

作者： Yu-Rong Xie Yenjit Raruang Zhi-Yuan Chen Robert L.Brown Thomas E.Cleveland Department of Plant Pathology and Crop Physiology Louisiana State University Agricultural Center Biotechnology Research Institute the Chinese Academy of Agricultural Sciences Southern Regional Research center USDA-ARS

Plant b-1,3-glucanases are members of the pathogenesis-related protein 2（PR-2） family,which is one of the 17 PR protein families and plays important roles in biotic and abiotic stress *** of the differentially expressed proteins（spot 842） identified in a recent proteomic comparison between five pairs of closely related maize（Zea mays L.） lines differing in aflatoxin resistance was further investigated in the present ***,the corresponding cDNA was cloned from maize and designated as *** encodes a protein of338 amino acids containing a potential signal *** expression of Zm Gns was detectible in all tissues studied with the highest level in *** was significantly induced by biotic stresses including three bacteria and the fungus Aspergillus *** was also induced by most abiotic stresses tested and growth hormones including salicylic *** vivo,ZmGns showed a significant inhibitory activity against thebacterial pathogen Pseudomonas syringae *** DC3000 and fungal pathogen Botrytis cinerea when it overexpressed in *** high level of expression in the silk tissue and its induced expression by phytohormone treatment,as well as by bacterial and fungal infections,suggest it plays a complex role in maize growth,development,and defense.

关键词： β-1 3-Glucanase biological activity expression profiles Zea mays ZmGns

Genetic variation in a heat shock transcription factor modulates cold tolerance in maize

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Molecular Plant 2024年第9期17卷 1423-1438页

作者： Lei Gao Lingling Pan Yiting Shi Rong Zeng Minze Li Zhuoyang Li Xuan Zhang Xiaoming Zhao Xinru Gong Wei Huang Xiaohong Yang Jinsheng Lai Jianru Zuo Zhizhong Gong Xiqing Wang Weiwei Jin Zhaobin Dong Shuhua Yang State Key Laboratory of Plant Environmental Resilience Frontiers Science Center for Molecular Design BreedingCollege of Biological SciencesCenter for Crop Functional Genomics and Molecular BreedingChina Agricultural UniversityBeijing 100193China State Key Laboratory of Maize Bio-breeding National Maize Improvement CenterFrontiers Science Center for Molecular Design BreedingDepartment of Plant Geneticsand BreedingChinaAgricultural UniversityBeijingChina State Key Laboratory of Plant Genomics and National Plant Gene Research center Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

Understanding how maize(Zea mays)responds to cold stress is crucial for facilitating breeding programs of cold-tolerant *** extensive utilization of the genome-wide association study(GWAs)approach for exploring favorable natural alleles associated with maize cold tolerance,few studies have successfully identified candidate genes that contribute to maize cold *** this study,we used a diverse panel of inbred maize lines collected from different germplasm sources to perform a GWAS on var-iations in the relative injured area of maize true leaves during cold stress-a trait very closely correlated with maize cold *** identified HsF21,which encodes a B-class heat shock transcription factor(HSF)that positively regulates cold tolerance at both the seedling and germination *** varia-tions in the promoter of the cold-tolerant HSF21Hap1 allele led to increased HSF21 expression under cold stress by inhibiting binding of the basic leucine zipper bziP68 transcription factor,a negative regulator of cold *** integrating transcriptome deep sequencing,DNA affinity purification sequencing,and targeted lipidomic analysis,we revealed the function of HsF21 in regulating lipid metabolism homeo-stasis to modulate cold tolerance in *** addition,we found that HsF21 confers maize cold tolerance without incurring yield ***,this study establishes HsF21 as a key regulator that en-hances cold tolerance in maize,providing valuable genetic resources for breeding of cold-tolerant maize varieties.

关键词： heat shock factor HSF21 cold tolerance natural variation bZiP68 lipid metabolism maize

QTL Mapping for Stalk Related Traits in Maize (Zea mays L.) Under Different Densities

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Journal of Integrative Agriculture 2013年第2期12卷 218-228页

作者： ZHU Li-ying CHEN Jing-tang Li Ding ZHANG Jian-hua HUANG Ya-qun ZHAO Yong-feng SONG Zhan-quan LIU Zhi-zeng College of Agronomy Agricultural University of Hebei/Hebei Sub-Center of National Maize Improvement Center Ministry of Agriculture/Northern China Key Laboratory for Crop Germplasm Resources Ministry of Education Baoding University

Stalk related traits, comprising plant height （PH）, ear height （EH）, internode number （IN）, average internode length （ALL）, stalk diameter （SD）, and ear height coefficient （EHC）, are significantly correlated with yield, density tolerance, and lodging resistance in maize. To investigate the genetic basis for stalk related traits, a doubled haploid （DH） population derived from a cross between NX531 and NX110 were evauluated under two densities over 2 yr. The additive quantitative trait loci （QTLs）, epistatic QTLs were detected using inclusive composite interval mapping and QTL-by-environment interaction were detected using mixed linear model. Differences between the two densities were significant for the six traits in the DH population. A linkage map that covered 1 721.19 cM with an average interval of 10.50 cM was constructed with 164 simple sequence repeat （SSR）. Two, two, seven, six, two, and eight additive QTLs for PH, IN, AIL, EH, SD, and EHC, respectively. The extend of their contribution to penotypic variation ranged from 10.10 to 31.93%. Seven QTLs were indentified simultaneously under both densities. One pair, two pairs and one pair of epistatic effects were detected for AIL, SD and EHC, respectively. No epistatic effects were detected for PH, EH, and IN. Nineteen QTLs with environment interactions were detected and their contribution to phenotypic variation ranged from 0.43 to 1.89%. Some QTLs were stably detected under different environments or genetic backgrounds comparing with previous studies. These QTLs could be useful for genetic improvement of stalk related traits in maize breeding.

关键词： maize density stalk related traits quantitative trait loci epistatic effect QTL-by-environment interaction

ZmcrtRB3 Encodes a Carotenoid Hydroxylase that Affects the Accumulation of α-carotene in Maize Kernel

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Journal of Integrative Plant Biology 2012年第4期54卷 260-269页

作者： Yi Zhou Yingjia Han Zhigang Li Yang Fu Zhiyuan Fu Shutu Xu Jiansheng Li Jianbing Yan Xiaohong Yang National Maize Improvement center Key Laboratory of Crop Genomics and Genetic ImprovementChina Agricultural University100193 BeijingChina Zhengzhou Sub-center of Chinese National Maize Improvement center Henan Agricultural UniversityZhengzhou 450002China National Key Laboratory of Crop Improvement Huazhong Agricultural UniversityWuhan 430070China

α-carotene is one of the important components of pro-vitamin A, which is able to be converted into vitamin A in the human body. One maize （Zea mays L.） ortholog of carotenoid hydroxylases in Arabidopsis thaliana, ZmcrtRB3, was cloned and its role in carotenoid hydrolyzations was addressed. ZmcrtRB3 was mapped in a quantitative trait locus （QTL） cluster for carotenoid-related traits on chromosome 2 （bin 2.03） in a recombinant inbred line （RIL） population derived from By804 and B73. Candidate-gene association analysis identified 18 polymorphic sites in ZmcrtRB3 significantly associated with one or more carotenoid-related traits in 126 diverse yellow maize inbred lines. These results indicate that the enzyme ZmcrtRB3 plays a role in hydrolyzing both α- andβ-carotenes, while polymorphisms in ZmcrtRB3 contributed more variation in α-carotene than that inβ-carotene. Two single nucleotide polymorphisms （SNPs）, SNP1343 in 5＇untranslated region and SNP2172 in the second intron, consistently had effects on or-carotene content and composition with explained phenotypic variations ranging from 8.7% to 34.8%. There was 1.7- to 3.7-fold change between the inferior and superior hapiotype for α-carotene content and composition. Thus, SNP1343 and SNP2172 are potential polymorphic sites to develop functional markers for applying marker-assisted selection in the improvement of pro-vitamin A carotenoids in maize kernels.

关键词： α-carotene association analysis maize pro-vitamin A ZmcrtRB3.

Toxic effects of chlortetracycline on maize growth,reactive oxygen species generation and the antioxidant response

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Journal of Environmental Sciences 2012年第6期24卷 1099-1105页

作者： Bei Wen Yu Liu Peng Wang Tong WU Shuzhen Zhang Xiaoquan Shan Jingfen Lu State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Key Laboratory of Natural and Biomimetic Drugs Health Science Center of Peking UniversityBeijing 100191China

The toxicity of chlortetracycline （CTC） on maize （Zea mays L.） growth and reactive oxygen species （ROS） generation was *** root and shoot lengths and fresh weights of maize seedlings were inhibited by CTC treatment （p 〈 0.05）.Root length was more sensitive than other parameters with the EC 10 value of 0.064 mg/*** spin trapping technique followed by electron paramagnetic resonance （EPR） analysis was used to quantify the ROS *** ROS generated in maize roots after exposure to CTC was identified as hydroxyl radical （·OH）.The EPR signal intensity correlated positively with the logarithm of CTC concentrations exposed （p 〈 0.05）.The dynamic changes of malondialdehyde （MDA） contents and the antioxidative enzyme activities in maize roots were also *** compared to the control group,CTC was found to significantly increase MDA *** of maize roots with the ·OH scavenger sodium benzoate （SB） reduced the MDA content and enhanced the antioxidative enzyme *** results demonstrated the harmfulness of CTC at high dose to maize in the early developmental stage,and clarified that the inducement of ·OH is one of the mechanisms of CTC toxicity.

关键词： maize (Zea mays L.) chlortetracycline electron paramagnetic resonance (EPR) spin trapping hydroxyl radical (-OH) antioxidant enzyme