Multifaceted function of YAP/TEAD on chromatin:prospects of‘A non-canonical role of YAP/TEAD is required for activation of estrogen-regulated enhancers in breast cancer’

作     者：Lizhen Chen Zhijie Liu 

作者机构：Barshop Institute for Longevity and Aging StudiesDepartment of Cell Systems and AnatomyThe University of Texas Health Science Center at San AntonioSan AntonioTX 78229USA Department of Molecular MedicineMays Cancer CenterThe University of Texas Health Science Center at San AntonioSan AntonioTX 78229USA 

出 版 物：《Journal of Molecular Cell Biology》 (分子细胞生物学报（英文版）)

年 卷 期：2019年第11卷第12期

页      面：1101-1103页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by funds from CPRIT RR160017,V Foundation V2016-017,V Foundation DVP2019- 018 the San Antonio Nathan Shock Center(NIA grant) Voelcker Fund Young Investigator Award UT Rising STARs Award Susan G.Komen CCR Award CCR17483391 NCI U54 CA217297/PRJ001 

主　　题：activation function instance 

摘      要：Cellular function and behavior are controlled by various signals during development and disease progression in *** is important to understand how signals ultimately alter the function and structure of DNA regulatory elements,especially enhancers,causing the changes of gene expression *** average,each mature human cell harbors at least^100000 enhancers,but only a small percent of them have the function to activate gene *** instance,only^12%–18%of ERα-bound enhancers are active *** enhancers become functionally active is critical for our overall understanding of enhancer biology and gene *** are recognized by signaling-dependent DNA binding transcription factors(TFs),resulting in the recruitment of different enhancer activation components that allow distal enhancers to interact with their target promoters through chromatin looping(Plank and Dean,2014).Increasing evidence indicates that the recruitment and switching of enhancer components underlie enhancer activation and the deregulation in enhancer component or architecture profoundly alters signal-regulated transcriptional machineries,leading to developmental defects or diseases.