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Flexible Graphene Field‑Effect Transistors and Their Application in Flexible Biomedical Sensing

Nano-Micro Letters 2025年第2期17卷 252-313页

作者： Mingyuan Sun Shuai Wang Yanbo Liang Chao Wang Yunhong Zhang Hong Liu Yu Zhang Lin Han institute of marine science and Technology Shandong UniversityQingdao 266237ShandongPeople’s Republic of China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongPeople’s Republic of China School of Integrated Circuits Shandong UniversityJinan 250100ShandongPeople’s Republic of China shandong Engineering research center of Biomarker and Artificial Intelligence Application Jinan250100ShandongPeople’s Republic of China

Flexible electronics are transforming our lives by making daily activities more *** to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabrication,low-power consumption,fast response times,and ***,known for its exceptional mechanical properties,high electron mobility,and biocompatibility,is an ideal material for FET channels and *** combination of graphene and FETs has given rise to flexible graphene field-effect transistors(FGFETs),driving significant advances in flexible electronics and sparked a strong interest in flexible biomedical ***,we first provide a brief overview of the basic structure,operating mechanism,and evaluation parameters of FGFETs,and delve into their material selection and patterning *** ability of FGFETs to sense strains and biomolecular charges opens up diverse application *** specifically analyze the latest strategies for integrating FGFETs into wearable and implantable flexible biomedical sensors,focusing on the key aspects of constructing high-quality flexible biomedical ***,we discuss the current challenges and prospects of FGFETs and their applications in biomedical *** review will provide valuable insights and inspiration for ongoing research to improve the quality of FGFETs and broaden their application prospects in flexible biomedical sensing.

关键词： Flexible Graphene Field-effect transistor Wearable Implantable Biosensor

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Genes and proteins expressed at different life cycle stages in the model protist Euplotes vannus revealed by both transcriptomic and proteomic approaches

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science China Life sciences 2025年第1期 232-248页

作者： Yaohan Jiang Xiao Chen Chundi Wang Liping Lyu Saleh A.Al-Farraj Naomi A.Stover Feng Gao Key Laboratory of Evolution & marine Biodiversity (Ministry of Education) and institute of Evolution & marine Biodiversity Ocean University of China marine College Shandong University Zoology Department College of ScienceKing Saud University Department of Biology Bradley University Laboratory for marine Biology and Biotechnology Qingdao Marine Science and Technology Center

Sexual reproduction first appeared in unicellular protists and has continued to be an essential biological process in almost all *** protists, which contain both germline and somatic genomes within a single cell, have evolved a special form of sexual reproduction called conjugation that involves mitosis, meiosis, fertilization, nuclear differentiation, genome rearrangement, and the development of unique cellular structures. The molecular basis and mechanisms of conjugation vary dramatically among ciliates, and many details of the process and its regulation are still largely unknown. In order to better comprehend these processes and mechanisms from an evolutionary perspective, this study provides the first comprehensive overview of the transcriptome and proteome profiles during the entire life cycle of the newly-established marine model ciliate Euplotes vannus. Transcriptome analyses from 14 life cycle stages(three vegetative stages and 11 sexual stages) revealed over 26,000 genes that are specifically expressed at different stages, many of which are related to DNA replication,transcription, translation, mitosis, meiosis, nuclear differentiation, and/or genome rearrangement. Quantitative proteomic analyses identified 338 proteins with homologs associated with conjugation and/or somatic nuclear development in other ciliates, including dicer-like proteins, Hsp90 proteins, RNA polymerase Ⅱ and transcription elongation factors, ribosomal-associated proteins, and ubiquitin-related proteins. Four of these homologs belong to the PIWI family, each with different expression patterns identified and confirmed by RT-qPCR,which may function in small RNA-mediated genome rearrangement. Proteins involved in the nonhomologous end-joining pathway are induced early during meiosis and accumulate in the developing new somatic nucleus, where more than 80% of the germline sequences are eliminated from the somatic genome. A number of new candidate genes and proteins likely t

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Distribution and pollution assessment of trace metals in seawater and sediment in Laizhou Bay

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Chinese Journal of Oceanology and Limnology 2015年第4期33卷 1053-1061页

作者：吕冬伟郑冰房燕申格刘惠军 Yantai research institute ChinaAgricultural University Key Laboratory of marine Ecological Restoration Shandong Marine Fisheries Research Institute national oceanographic center

Selected trace metals （Pb, Cd, Cu, Hg） and arsenic in seawater and surface sediments of Laizhou Bay were determined, to evaluate their spatial distribution, pollution risk and potential ecological risk. Concentrations of the elements were 0.56-2.07, 0.14-0.38, 12.70-18.40, 0.014-0.094, and 1.13- 2.37 μg/L in the seawater and 8.94-32.2, 0.18-0.67, 4.51-30.5, 0.006-0.058, and 5.75-15.3 mg/kg in sediments for Pb, Cd, Cu, Hg and As, respectively. High concentrations of the trace metals and arsenic in seawater and surface sediments were generally observed near the fiver estuary. The pollution risk result of the elements showed that Cu was the prominent trace metal pollutant in seawater, followed by Hg, Pb, Cd and As. The metal complex pollution index in seawater was at a medium level. The most important trace metal pollutant in sediments was Cd, followed by As, Cu, Pb, and Hg. Our pollution assessment suggests that trace metal pollution in Laizhou Bay sediments was at a low level. The potential ecological risk was also low in surface sediment.

关键词： Laizhou Bay trace metals arsenic sediments seawater

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Transcriptome Analysis Reveals the Regulation Role of miR-144-5p in Intestinal Immunity of Japanese Flounder(Paralichthys olivaceus)

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Journal of Ocean University of China 2023年第3期22卷 801-812页

作者： LI Yingrui SU Lin GUO Baoshan XU Kefeng ZHOU Shun XIU Yunji School of marine science and Engineering Qingdao Agricultural UniversityQingdao 266109China College of marine science and Engineering Nanjing Normal UniversityNanjing 210023China marine science research institute of shandong province(national oceanographic center Qingdao)Qingdao 266104China

MicroRNAs(miRNAs),22-nucleotide-long micromanagers that guide the post-transcriptional regulation of a wide range of target genes,can theoretically be used as a diagnostic or therapeutic target for inflammatory *** fish,miR-144-5p expression varies dramatically in response to the different bacterial infections and can regulate immunity-related genes to reduce the occurrence of *** this research,the regulation function of miR-144-5p to the intestinal innate immunity was udied in flounder Paralichthys *** flounders were interfered by 2μg g^(-1) miR-144-5p antagomir and their tissues(intestine,liver and spleen)were harvested from the fish at 12 h *** than 60 million high-quality reads were *** 24 hours after miR-144-5p or miR-NC interference,a total of 2704 and 1823 different-expresion genes(DEGs)were identified in comparison with control group,*** DEGs were enriched in a variety of immunity-related signaling pathways,including NOD-like receptor,Wnt and Toll-like receptor signaling pathways,according to GO and KEGG analyses.A total of 503 highly interacting DEGs engaged in 33 immunity-related signaling pathways were discovered using KEGG ***,5 hub genes were found by protein-protein interaction networks,which formed an intricate immune regulation ***,these hub genes were mostly involved in focal adhesion,Wnt signaling pathway,as well as the Intestinal Immune Network for IgT(IgA)Production *** conclusion,the loss of miR-144-5p can affect immunity-related genes and downstream signaling *** findings suggest that miR-144-5p is a modulator of gene networks and signaling pathways associated with intestinal innate immunity.

关键词： miR-144-5p intestinal inflammation innate immunity Paralichthys olivaceus

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Observation and analysis of morphology abnormalities in development of Oryzias melastigma embryos

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Journal of Oceanology and Limnology 2021年第4期39卷 1485-1499页

作者： Jingjing SONG Haiyi WU Kaikai LIU Wendan CHI Shanshan GE Zhipeng ZHANG Mingqi WANG Yi YU Daode YU Healthy Mariculture Engineering research center of shandong province Marine Science Research Institute of Shandong ProvinceQingdao 266104China Tianjin research institute for Water Transport Engineering Ministry of TransportTianjin 300456China Ocean University of China Qingdao 266100China

Fish embryos are widely used as models in toxicology,drug development,and human disease research because of their high sensitivity,observability,and operability,providing the basis for an in-depth understanding of the *** studies have indicated that birth defects are *** this study,we used Oryzias melastigma as a model to conduct a study of 185-day embryogenesis and observed self-induced non-pathological abnormal *** experienced pre-puberty stage,adolescence stage,and senescence stage,and individuals produced up to 102 eggs per ***,the fecundity was markedly reduced during the senescent *** the active egg and blastodisc stages,pseudo-fertilization and pseudo-blastocysts were *** cleavage at the 4-to 32-cell stages,we observed blastomeres separation or *** separated blastomeres formed double blastoderms,eventually resulting in conjoined *** the blastula stage,we observed abnormally increased cell volume,narrowed and elongated blastocysts,and abnormally coated *** the organogenesis stage,we observed abnormal numbers of Kupff er’s vesicles and conjoined *** in the location and number of oil droplets were observed in various development *** development was more commonly observed in fertilized eggs produced by broodstock in pre-puberty or senescence stages,which is probably related to the age of fish and the egg *** study can provide the materials for comparative analysis in toxicological and molecular studies of ***,and may provide evidence for other economic fish that produce sticky eggs.

关键词： marine fish model abnormal embryogenesis blastomeres separation Kupffer’s vesicle conjoined twins

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Superhydrophobic diamond-coated Si nanowires for application of anti-biofouling

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Journal of Materials science & Technology 2020年第13期47卷 1-8页

作者： Wenjing Long Haining Li Bing Yang Nan Huang Lusheng Liu Zhigang Gai Xin Jiang Shenyang national Laboratory for Materials science Institute of Metal ResearchChinese Academy of SciencesShenyang110016China Department of Materials science and Engineering University of Science and Technology of ChinaHefei230026China institute of oceanographic Instrumentation Qilu University of Technology(Shandong Academy of Sciences)Shandong Provincial Key Laboratory of Marine Monitoring Instrument Equipment TechnologyNational Engineering and Technological Research Center of Marine Monitoring EquipmentQingdao266100China

The effect of the surface wettability of plasma-modified vertical Si nanowire array on the bio-fouling performance has been *** Si nanowires prepared by a metal-assisted chemical etching technique exhibit a super-hydrophilic *** treatment in CH4/H2 gas plasma environment leads to the decoration of graphite and diamond nanoparticles around Si *** detailed interface between graphite/diamond and Si nanowire was characterized by HRTEM *** surface-modified nanowire samples show an increased water contact angle with ultrananocrystalline diamond decorated ones being *** immersion test in chlorella solution reveals that the diamond-coated Si nanowires possess the least attachment of chlorella in comparison with other Si *** result confirms that the coating of Si nanowires with diamond nanoparticles shows the best behavior in ***,this work provides a method fabricated super-hydrophobic surface for the application of biofouling prevention.

关键词： Silicon nanowires Plasma treatment Super-hydrophobic Diamond

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GPU Accelerated marine Data Visualization Method

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Journal of Ocean University of China 2014年第6期13卷 964-970页

作者： LI Bo CHEN Ge TIAN Fenglin SHAO Baomin JI Pengbo Department of marine Technology Ocean University of ChinaEngineering Research Center of Marine Information TechnologyMinistry of Education shandong Provincial Key Laboratory of Optical Astronomy and Solar Environment Institute of Space SciencesShandong University institute of oceanographic Instrumentation Shandong Academy of Science

The study of marine data visualization is of great value. marine data, due to its large scale, random variation and multiresolution in nature, are hard to be visualized and analyzed. Nowadays, constructing an ocean model and visualizing model results have become some of the most important research topics of ‘Digital Ocean'. In this paper, a spherical ray casting method is developed to improve the traditional ray-casting algorithm and to make efficient use of GPUs. Aiming at the ocean current data, a 3D view-dependent line integral convolution method is used, in which the spatial frequency is adapted according to the distance from a camera. The study is based on a 3D virtual reality and visualization engine, namely the VV-Ocean. Some interactive operations are also provided to highlight the interesting structures and the characteristics of volumetric data. Finally, the marine data gathered in the East China Sea are displayed and analyzed. The results show that the method meets the requirements of real-time and interactive rendering.

关键词： marine data visualization techniques and methodologies spherical ray casting line integral convolution multiquadric method VV-Ocean

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Comparative study of responses in the brown algae Sargassum thunbergii to zinc and cadmium stress

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Journal of Oceanology and Limnology 2018年第3期36卷 933-941页

作者： LU Fang DIND Gang LIU Wei ZHAN Dongmei WU Haiyi GUO We marine Biology institute of shandong province Qingdao 266104China Qingdao Macroalgae Engineering Technology research center Qingdao 266104China

Heavy metal pollution in aquatic system is becoming a serious problem worldwide. In this study, responses of Sargassum thunbergii to dif ferent concentrations(0, 0.1, 0.5, 1.0 and 5.0 mg/L) of zinc(Zn) and cadmium(Cd) exposure separately were studied for 15 days in laboratory-controlled conditions. The results show that the specifi c growth rates increased slightly under the lower Zn concentration treatment(0.1 mg/L) at the first 5 d and then decreased gradually, which were significantly reduced with the exposure time in higher Zn concentrations and all Cd treatments compared to respective control, especially for 1.0 and 5.0 mg/L Cd. Chlorophyll a contents showed significant increase in 0.1 mg/L Zn treatment, whereas the gradually reduction were observed in the other three Zn treatments and all Cd treatments. The oxygen evolution rate and respiration rate presented distinct behavior in the Zn-treated samples, but both declined steadily with the exposure time in Cd treatments. The P/R value analyses showed similar variation patterns as chlorophyll a contents. Real-time PCR showed that lower Zn concentration(0.1 mg/L) increased mRNA expression of rbcL gene, whereas higher Zn concentrations and Cd reduced the rbcL expression. Taken together, these findings strongly indicate that Zn and Cd had different effects on S. thunbergii both at the physiological and gene transcription levels, the transcript level of photosynthesis-related gene rbcL can be used as an useful molecular marker of algal growth and environment impacts.

关键词： Sargassum thunbergii heavy metal stress chlorophyll photosynthesis rate respiration rate rbcL gene

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Studies on the isolation and culture of protoplasts from Kappaphycus alvarezii

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Acta Oceanologica Sinica 2014年第10期33卷 114-123页

作者： ZHANG Si LIU Cui JIN Yuemei CHI Shan TANG Xianming CHEN Fuxiao FANG Xu LIU Tao national marine Environmental Forecasting center College of marine Life sciences Ocean University of China Hainan Provincial Fisheries research institute School of Life science Shandong University

In this study, protoplasts were successfully isolated from Kappaphycus alvarezii using snail enzymes, abalone enzymes and cellulase. The optimum enzymic ratio was fixed to be 20% of abalone enzyme, 12% of cellulase and the osmotic stabilizer was 2.0 mol/L glucose. The optimum enzymic hydrolysis conditions were found to be dark enzymolysis at 30°C continuing for 4.0 h. The resultant density and yield of protoplasts achieved 32.60×10^4 mL-1, 65.20×10^4 g-1 tissue for Kappaphycus alvarezii. Finally, under the temperature of 20°C, light intensity of 1 500–2 000 lx and photoperiod of 12 h/d, two developmental pathways were investigated：（1） callus-like cell mass and regenerated plantlet occurred on protoplast;（2） young shoots and calluslike cell mass occurred in tissue blocks after enzymolysis.

关键词： Kappaphycus alvarezii protoplast regenerated plantlet callus-like young shoots

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Reduced salinity interacts with ultraviolet radiation to alter photosystem Ⅱ function in diatom Skeletonema costatum

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Journal of Oceanology and Limnology 2022年第4期40卷 1615-1627页

作者： Shasha ZANG Fang YAN Daode YU Jingjing SONG Lei WANG Zhiguang XU Hongyan WU College of Life science Ludong UniversityYantai 264025China marine science research institute of shandong province Qingdao 266104China Key Laboratory of marine Biotechnology in Universities of shandong(Ludong University) Yantai 264025China

To investigate the effect of reduced salinity on diatoms’ capacity to cope with changing ultraviolet radiation(U VR) and photosynthetically active radiation(PAR),Skeletonema costatum was grown in a range of salinity(15,25,and 35).The photo system Ⅱ(PSⅡ) function was analyzed by increasing PAR and UVR to mimic a mixing event in turbulent *** re sults show that high UVR exposure significantly reduced PSII activity,especially in cells grown at low ***,but not salinity,stimulated the ’removal’ rate of PSII protein *** alone,in the range of 15 to 35,did not regulate PSⅡ acceptor region;however,the low salinity+UVR treatment decreased the energy flux for electron transport per PSⅡ reaction center in *** showed that low salinity exacerbated the damaging effect of UVR on PSⅡ function in *** by suppressing Psb A protein synthe sis and modifying the photochemistry of PSⅡ.Although higher catalase(CAT) activity and NPQs were induced,they were unable to prevent the combined damage effect of low salinity+*** findings indicate that reduced salinity and increased UVR potentially affect the abundance and distribution of *** with the escalation of climate disturbances.

关键词： diatom ultraviolet radiation(UVR) photoinactivation photosystem II

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