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Tailoring Light–Matter Interactions in Overcoupled Resonator for Biomolecule Recognition and Detection

Nano-Micro Letters 2025年第1期17卷 262-280页

作者： Dongxiao Li Hong Zhou Zhihao Ren Cheng Xu Chengkuo Lee Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Center for Intelligent Sensors and mems(CISM) National University of SingaporeSingapore 117608Singapore

Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric Fano resonance ***,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning *** observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric Fano *** characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 *** findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions.

关键词： Plasmonic nanoantennas Light-matter interaction Surface-enhanced infrared absorption Overcoupled Biosensing

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Research on performance of hybrid organic dyes-sensitized solar cell

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Chinese Optics Letters 2006年第6期4卷 357-359页

作者：孙磊苑伟政乔大勇 mems/NEMS laboratory Northwestern Polytechnical University mems/NEMS laboratory Northwestern Polytechnical University

The hybrid sensitizer rhodamine B and coumarin or eosin and coumarin is used to sensitize nanocrystalline porous films. Absorption of the nanoerystalline photovoltaic cell （NPC） is improved in visible light. The performance of these cells is more effective than that of cells sensitized only by sensitizer rhodamine B or eosin. In the simulative solar light, cell sensitized by hybrid sensitizer rhodamine B and coumarin can get open circuit voltage （VOC） of 550 mV and short circuit current （ISC） of 0.1375 mA/cm^2.

关键词： Dyes Electric potential Light absorption Photovoltaic cells Porous materials Short circuit currents

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A novel method for generating a rectangular convex corner compensation structure in an anisotropic etching process

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Journal of Semiconductors 2009年第7期30卷 33-38页

作者：张涵李伟华 Key laboratory of mems of the Ministry of Education Southeast University

Detailed characteristics of three classical rectangular convex corner compensation structures on（100） silicon substrates have been investigated, and their common design steps are *** combining the basic method of a silicon wet anisotropic etching process, a general method of generating compensation structures for a rectangular convex corner is put *** calls for the following two steps：define the topological field and fit some borderlines together into practical compensation *** rules, which must be obeyed during this process, are *** introducing this method, some novel compensation patterns for rectangular convex corner structures are created on both（100） and（110） substrates, and finally simulation results are given to prove this new method＇s validity and applicability.

关键词： rectangular convex corner compensation anisotropic etching general methodology

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A novel compensation method for polygonized mesa structures on(100) silicon substrate

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Journal of Semiconductors 2010年第6期31卷 16-21页

作者：张涵李伟华 Key laboratory of mems of the Ministry of Education Southeast University

A theoretical compensation method for polygonized mesa structures on（100） silicon substrate during the anisotropic etching process has been developed,which contains four stages as follows：prepare the information of the etching condition;predict the structure＇s undercutting profile;construct the topological structure of compensation patterns; and generate practical compensation patterns from the topological *** reasoning process is clearly stated,and detailed steps for the undercutting prediction and topological structure construction are *** are also drawn about the rules which must be obeyed during the pattern generation *** simulation and experimental results of some polygon structures are finally given to prove this method＇s validity and reliability.

关键词： (100) substrate compensation method polygonized mesa structure simulation result experimental result

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Detecting magnetic field direction by a micro beam operating in different vibration modes

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Chinese Physics B 2011年第9期20卷 323-328页

作者：陈洁秦明黄庆安 Key laboratory of mems of Ministry of Education Southeast University

A new method to detect the magnetic field direction by using a silicon structure is presented in this paper. The structure includes a micro beam and an in-plane coil electrode. When the electrode under a magnetic field is applied with an alternating current, the micro beam is actuated under the effect of the Lorentz forces. Magnetic fields of different directions cause different vibration profiles. The direction of the magnetic field is obtained by measuring the vibration amplitudes of the micro beam, which is driven to work at first- and second-order resonant modes. A micro structure has been fabricated using the bulk microma^hined silicon process. A laser Doppler vibrometer system is implemented to measure the vibration amplitudes. The experimental results show that the amplitude of the structure, which depends on the different modes, is a sine or cosine function of the angle of the magnetic field. It agrees well with the simulation result. Currently a resolution of 10~ for the magnetic field direction measurement can be obtained using the detecting principle.

关键词： beam micro-electro-mechanical systems Lorentz force resonance

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Theoretical study of electromechanical property in a p-type silicon nanoplate for mechanical sensors

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Chinese Physics B 2008年第11期17卷 4292-4299页

作者：张加宏黄庆安于虹雷双瑛 Key laboratory of mems of Ministry of Education Southeast University

Electromechanical property of a p-type single-crystal silicon nanoplate is modelled by a microscopic approach where the hole quantization effect and the spin-orbit coupling effect are taken into account. The visible anisotropic subband structures are calculated by solving self-consistently the stress-dependent 6×6 k.p Schrodinger equation with the Poisson equation. The strong mixing among heavy, light, and split-off holes is quantitatively assessed. The influences of the thickness and the temperature on the piezoresistive coefficient are quantitatively investigated by using the hole concentrations and the effective masses from the complex dispersion structure of the valence band with and without stresses. Our results show that the stress determines the extent to which the band is mixed. The hole quantization effect increases as the thickness decreases, and therefore the valence band is strongly reshaped, resulting in the size-dependent piezoresistivity of the silicon nanoplate. The piezoresistive coefficient increases almost 4 times as the thickness reduces from the bulk to 3 nm, exhibiting a promising application in mechanical sensors.

关键词： silicon nanoplate piezoresistive band structure band mixing

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A hybrid model for the charging process of the amorphous SiO_2 film in radio frequency microelectromechanical system capacitive switches

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Chinese Physics B 2011年第3期20卷 426-432页

作者：王立峰黄庆安唐洁影廖小平 Key laboratory of mems of the Ministry of Education Southeast University

Charging is one of the most important reliability issues in radio frequency microelectro- mechanical systems （RF mems） capacitive switches since it makes the actuation voltage unstable. This paper proposes a hybrid model to describe the transient dielectric charging and discharging process in the defect-rich amorphous SiO2 RF mems capacitive switches and verifies experimentally. The hybrid model contains two parts according to two different charging mechanisms of the amorphous SiO2, which are the polarisation and charge injection. The models for polarisation and for charge injection are established, respectively. Analysis and experimental results show that polarisation is always effective, while the charge injection has a threshold electric field to the amorphous SiO2 film. Under different control voltage conditions, the hybrid model can accurately describe the experimental data.

关键词： modeling polarisation charge injection amorphous SiO2

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A novel SOI MOSFET electrostatic field sensor

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Journal of Semiconductors 2010年第4期31卷 68-71页

作者：陈新安黄庆安 Key laboratory of mems of Ministry of Education Southeast University

A novel low temperature solid state electric field sensor is demonstrated as a promising sensor. The sensor is a type of constant voltage Wheatstone bridge whose resistors are four direct gate SOl MOSFET devices. It is demonstrated in theory that the output voltage signal is proportional to the electric field E, the temperature drift is about zero when the temperature is in the range from 200 to 400 K, and the doping concentration is in the range from 1 × 10^14 to 1 × 10^16 cm^-3. The experiment results indicate that the resolution of the sensor is about 3.27 mV for a 1000 V/m electric field at 300 K, and the voltage drift by an amount is about 47 V/m field signal when the degree temperature is in the range from 300 to 370 K, which is much smaller than the current drift of a single MOSFET which is about 10000 V/m field signal.

关键词： electrostatic field sensor low temperature drift Wheatstone bridge

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Copper homeostasis and neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3124-3143页

作者： Yuanyuan Wang Daidi Li Kaifei Xu Guoqing Wang Feng Zhang International Research laboratory of Ethnomedicine of Ministry of Education Key Laboratory of Basic Pharmacology of Ministry of EducationLaboratory Animal Center and Key Laboratory of Basic Pharmacology of Guizhou ProvinceZunyi Medical UniversityZunyiGuizhou ProvinceChina

Copper,one of the most prolific transition metals in the body,is required for normal brain physiological activity and allows various functions to work normally through its range of *** homeostasis is meticulously maintained through a complex network of copper-dependent proteins,including copper transporters(CTR1 and CTR2),the two copper ion transporters the Cu-transporting ATPase 1(ATP7A)and Cu-transporting beta(ATP7B),and the three copper chaperones ATOX1,CCS,and *** in copper homeostasis can lead to either the deficiency or accumulation of copper in brain *** evidence suggests that abnormal copper metabolism or copper binding to various proteins,including ceruloplasmin and metallothionein,is involved in the pathogenesis of neurodegenerative ***,the exact mechanisms underlying these processes are not *** is a potent oxidant that increases reactive oxygen species production and promotes oxidative *** reactive oxygen species levels may further compromise mitochondrial integrity and cause mitochondrial *** oxygen species serve as key signaling molecules in copper-induced neuroinflammation,with elevated levels activating several critical inflammatory ***,copper can bind aberrantly to several neuronal proteins,including alphasynuclein,tau,superoxide dismutase 1,and huntingtin,thereby inducing neurotoxicity and ultimately cell *** study focuses on the latest literature evaluating the role of copper in neurodegenerative diseases,with a particular focus on copper-containing metalloenzymes and copper-binding proteins in the regulation of copper homeostasis and their involvement in neurodegenerative disease *** synthesizing the current findings on the functions of copper in oxidative stress,neuroinflammation,mitochondrial dysfunction,and protein misfolding,we aim to elucidate the mechanisms by which copper contributes to a wide range of heredit

关键词： Alzheimer's disease amyotrophic lateral sclerosis disease copper homeostasis copper toxicity Huntington's disease Menkes'disease multiple sclerosis neurodegenerative disease Parkinson's disease Wilson's disease

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A micromachined inline type microwave power sensor with working state transfer switches

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Journal of Semiconductors 2011年第5期32卷 87-91页

作者：韩磊 Key laboratory of mems of Ministry of Education Southeast University

A wideband 8-12 GHz inline type microwave power sensor, which has both working and non-working states, is presented. The power sensor measures the microwave power coupled from a CPW line by a mems membrane. In order to reduce microwave losses during the non-working state, a new structure of working state transfer switches is proposed to realize the two working states. The fabrication of the power sensor with two working states is compatible with the GaAs MMIC （monolithic microwave integrated circuit） process. The experimental results show that the power sensor has an insertion loss of 0.18 dB during the non-working state and 0.24 dB during the working state at a frequency of 10 GHz. This means that no microwave power has been coupled from the CPW line during the non-working state.

关键词： microwave power sensor micromachined GaAs MMIC transfer switches

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