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Navigating emotional challenges:A journey with patients undergoing chemotherapy

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World Journal of Clinical Oncology 2024年第9期15卷 1132-1135页

作者： Nisha Mani Pandey Pooja Ramakant Department of Geriatric Mental Health King George's Medical UniversityLucknow 226003India Department of Endocrine Surgery King Georges Medical UniversityLucknow 226003India

A recent article reported that cancer patients with subthreshold depression are more likely to develop major depression within a *** regression analysis revealed that regular exercise was a protective factor against cancerrelated fatigue,whereas advanced age,radiotherapy,pain,and low hemoglobin were risk factors for cancer-related fatigue.A limitation of this study was the lack of methodological details about leukemia patients receiving depressive treatment at a specific *** assessment,behavioral modification plans,communication,destressing techniques,and educational plans may help chemotherapy patients manage emotional issues and reduce ***,these strategies can inspire patients to create,facilitate their treatment,and help them to remain healthy.

关键词： Leukemia patients Cancer patients Emotional distress Subthreshold depression Chemotherapy

Chelation in Metal Intoxication XLIV: Efficacy of α-Mercapto β-(5-Substituted, 2-Furyl) Acrylic Acids in Mobilizing Intracellularly Bound Cadmium in Rat

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Biomedical and Environmental Sciences 2000年第3期13卷 205-212页

作者： SUSHIL K. TANDON\+1, SATGUR PRASAD, AND SURENDRA SINGH Industrial Toxicology Research Centre, lucknow_226001, India Indust. Toxicology Research Centre Lucknow 226001 India Indust. Toxicology Research Centre M. G. Marg Lucknow-226001 India

The efficacy of α mercapto β (2_furyl) acrylic acid (MFA), α mercapto β (5_sodiumsulfonate, 2_furyl) acrylic acid (MSFA) and α mercapto β (5_acetoxymethyl, 2_furyl) acrylic acid (MAFA) to mobilize intracellularly bound cadmium in liver and kidney was investigated in rats pre_exposed to cadmium. MFA was effective in reducing cadmium levels of hepatic and renal supernatant cytosolic fraction (SCF) while MSFA and MAFA were effective in lowering cadmium levels of renal SCF and hepatic SCF respectively. All the chelating agents also enhanced the excretion of cadmium more in feces than in urine. However, substitution on the furan ring lowered cadmium mobilizing efficacy of the parent compound, MFA. The treatment with MFA did not affect the status of endogenous zinc and copper while the treatment with MSFA and MAFA enhanced their excretion. MSFA increased hepatic and renal zinc and renal copper while MAFA increased their copper levels.

关键词： Mercapto Substituted Chelation in Metal Intoxication XLIV Furyl Intracellularly Bound Cadmium in Rat Efficacy of Acrylic Acids in Mobilizing

Effect of Nicotinamide on 12-O-tetradecanoyl-phorbol-13-acetate Exposed Mouse Skin Endonuclease Activity and DNA Synthesis

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Biomedical and Environmental Sciences 2000年第2期13卷 122-130页

作者： KRISINAP．GUPTA REENARANI CorrespondingAuthor：industrialToxicologyResearchCentre PostBOxNo.80MahatmaGandhiMargLucknow－226001India. EnvironmentalCarcinogenesisDivision IndustrialToxicologyResearchCentreLucknow

Nicotinamide (NA), a relatively nontoxic compound, has been shown to inhibit tumor development, induce differentiation, increase the sensitization of the anticancer drug resistant cancer cells and is being used in different skin ailments. But there are not many reports on its mechanism of action. Here we report that NA induced endonuclease activity. This endonuclease induction by NA appeared to be dose dependent and a function of time. As evident by the use of modifiers of DNase I, this endonuclease appeared to be like DNase type I. Increased [3H] thymidine incorporation in DNA in the presence of NA is possibly a consequence of increased 3_OH'nicks due to increased DNA fragmentation by increased endonuclease activity. The present results would be of help in the better understanding of the mechanism of NA action and its improved use in cancer control.

关键词： EPITHELIAL-CELLS APOPTOSIS RADIOSENSITIZATION INHIBITION PROMOTERS CLEAVAGE ABSENCE

Fecal microbiota transplantation in the treatment of hepatic encephalopathy:A perspective

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World Journal of Hepatology 2024年第5期16卷 678-683页

作者： Arghya Samanta Moinak Sen Sarma Department of Pediatric Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical SciencesLucknow 226014India

Due to its complex pathogenesis,treatment of hepatic encephalopathy(HE)continues to be a therapeutic *** late,gut microbiome has garnered much attention for its role in the pathogenesis of various gastrointestinal and liver diseases and its potential therapeutic *** evidence suggests that gut micro-biota plays a significant role in cerebral *** in the gut microbiota has been documented in patients with HE in a number of clinical and experimental *** on gut dysbiosis in patients with HE has opened newer therapeutic avenues in the form of probiotics,prebiotics and the latest fecal microbiota transplantation(FMT).Recent studies have shown that FMT is safe and could be effective in improving outcomes in advanced liver disease patients presenting with ***,questions over the appropriate dose,duration and route of administration for best treatment outcome remains unsettled.

关键词： Fecal microbiota Dysbiosis Hepatic encephalopathy Cirrhosis

Metabolic dysfunction-associated steatotic liver disease:A silent pandemic

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World Journal of Hepatology 2024年第4期16卷 511-516页

作者： Arghya Samanta Moinak Sen Sarma Department of Pediatric Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical SciencesLucknow 226014India

The worldwide epidemiology of non-alcoholic fatty liver disease(NAFLD)is showing an upward trend,parallel to the rising trend of metabolic syndrome,owing to lifestyle *** pathogenesis of NAFLD has not been fully understood ***,NAFLD has emerged as a public health concern in the field of hepatology and metabolisms *** changes in the nomenclature from NAFLD to metabolic dysfunction-associated steatotic liver disease have brought a positive outlook changes in the understanding of the disease process and doctor-patient *** changes are the main treatment ***,clinical trial using drugs that target‘insulin resistance’which is the driving force behind NAFLD,have shown promising *** translational research is needed to better understand the underlying pathophysiological mechanism of NAFLD which may open newer avenues of therapeutic *** role of gut dysbiosis in etiopathogenesis and use of fecal microbiota modification in the treatment should be studied *** of this silent epidemic by spreading awareness and early intervention should be our priority.

关键词： Metabolic dysfunction Fatty liver Obesity Insulin resistance

A comprehensive review of rectangular duct solar air heaters featuring artificial roughness

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Clean Energy 2024年第5期8卷 186-217页

作者： Ravi Shankar Rajeev Kumar Arun Kumar Pandey Deep Singh Thakur Department of Mechanical Engineering Rajkiya Engineering College BandaUttar Pradesh 210201India Department of Mechanical Engineering Institute of Engineering&TechnologyLucknowUttar Pradesh 226021India Department of Mechanical Engineering Bundelkhand Institute of Engineering&TechnologyJhansiUttar Pradesh 284128India

Solar air heaters(SAHs)are widely used solar thermal systems with applications in diverse ***,its effectiveness is re-strained by low convective heat transfer(HT)coefficients at the absorber plate,leading to inefficient HT,and the elevated temperature of the absorber plate causes significant heat losses,reducing thermal *** study addresses these challenges by introducing ribs or roughness on the absorber plate creating turbulence in the airflow,resulting in significant *** research inves-tigates various rib configurations,the influence of rib parameters,performance methods,and arrangements to evaluate their HT and friction *** these rib configurations,a comparative analysis is done on various factors such as the Nusselt number ratio,thermal enhancement factor,friction factor ratio,and thermal efficiency to optimize distinct roughness parameters and rib ar-rangement *** study also provides valuable recommendations from existing literature,offering insights into the effective design,prospects,and implementation of SAH systems.

关键词： solar air heater artificial roughness low heat transfer heating solar energy

Protective effects of lupeol and mango extract against androgen induced oxidative stress in Swiss albino mice

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Asian Journal of Andrology 2008年第2期10卷 313-318页

作者： Sahdeo Prasad Neetu Kalra Madhulika Singh Yogeshwer Shukla Environmental Carcinogenesis Division Industrial Toxicology Research Centre Lucknow 226001 India

Aim： To investigate antioxidant potential of lupeol/mango pulp extract （MPE） in testosterone induced oxidative stress in prostate of male Swiss albino mice. Methods： Oral treatment of lupeol （1 mg/animal） and MPE （1 mL [20% w/v]/ animal） was given separately to animals along with subcutaneous injection of testosterone （5 mg/kg body weight） consecutively for 15 days. At the end of the study period, the prostate was dissected out for the determination of reactive oxygen species （ROS） levels, lipid peroxidation and antioxidant enzymes status （catalase, superoxide dismutase, glutathione reductase, glutathione-S-transferase）. Results： In testosterone treated animals, increased ROS resulted in depletion of antioxidant enzymes and increase in lipid peroxidation in mouse prostate. However, lupeol/MPE treatment resulted in a decrease in ROS levels with restoration in the levels of lipid peroxidation and antioxidant enzymes. Conclusion： The results of the present study demonstrate that lupeol/MPE are effective in combating oxidative stress-induced cellular injury of mouse prostate. Mango and its constituents, therefore, deserve study as a potential chemopreventive agent against prostate cancer. （Asian J Androl 2008 Mar; 10： 313-318）

关键词： mango pulp extract lupeol testosterone oxidative stress antioxidant enzymes prostate cancer

Hepatic pseudotumor:A diagnostic challenge

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World Journal of Hepatology 2024年第5期16卷 667-670页

作者： Arghya Samanta Moinak Sen Sarma Department of Pediatric Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical SciencesLucknow 226014India

Hepatic pseudotumors are rare lesions of unknown origin,characterized by the proliferation of fibrous connective tissue and inflammatory cell *** mimic malignant lesions clinically,and radiologically,given their non-specific clinical and imaging *** pathophysiology of hepatic pseudotumor is incompletely understood and there are no standardized criteria for *** have been reported to develop in various organs in the body with the lung and liver being the most common *** pseudotumors develop in patients with underlying triggers of liver inflammation and injury,including infections,autoimmune liver diseases,bile duct injury,or *** pse-udotumors respond well to conservative treatment with antibiotics,and steroids and some may regress spontaneously,thus avoiding unnecessary *** condition is rewarding to *** is important to recognize pseudotumor as a distinct clinical entity and include it in the differential of liver masses with atypical imaging features.

关键词： Hepatic pseudotumor Infection Stroglyloides Hepatic resection

Predictors of permanent pacemaker implantation following transcatheter aortic valve replacement-the search is still on!

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World Journal of Cardiology 2024年第3期16卷 104-108页

作者： Sudesh Prajapathi Akshyaya Pradhan Department of Cardiology King George's Medical UniversityLucknow 226003Uttar PradeshIndia

Several anatomical,demographic,clinical,electrocardiographic,procedural,and valve-related variables can be used to predict the probability of developing con-duction abnormalities after transcatheter aortic valve replacement(TAVR)that necessitate permanent pacemaker(PPM)*** variables include calcifications around the device landing zone and in the mitral annulus;pre-existing electrocardiographic abnormalities such as left and right bundle branch blocks(BBB),first-and second-degree atrioventricular blocks,as well as bifas-cicular and trifascicular blocks;male sex;diabetes mellitus(DM);hypertension;history of atrial fibrillation;renal failure;dementia;and use of self-expanding *** current study supports existing literature by demonstrating that type 2 DM and baseline right BBB are significant predictors of PPM implantation *** of the side of the BBB,this study demonstrated,for the first time,a linear association between the incidence of PPM implantation post-TAVR and every 20 ms increase in baseline QRS duration(above 100 ms).After a 1-year follow-up,patients who received PPM post-TAVR had a higher rate of hospital-ization for heart failure and nonfatal myocardial infarction.

关键词： Bundle branch block Self expanding aortic valve Atrioventricular node Diabetes mellitus QRS duration