Protective effects of lupeol and mango extract against androgen induced oxidative stress in Swiss albino mice
Protective effects of lupeol and mango extract against androgen induced oxidative stress in Swiss albino mice作者机构：Environmental Carcinogenesis Division Industrial Toxicology Research Centre Lucknow 226001 India
出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)
年 卷 期：2008年第10卷第2期
页 面：313-318页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：mango pulp extract lupeol testosterone oxidative stress antioxidant enzymes prostate cancer
摘 要：Aim： To investigate antioxidant potential of lupeol/mango pulp extract （MPE） in testosterone induced oxidative stress in prostate of male Swiss albino mice. Methods： Oral treatment of lupeol （1 mg/animal） and MPE （1 mL [20% w/v]/ animal） was given separately to animals along with subcutaneous injection of testosterone （5 mg/kg body weight） consecutively for 15 days. At the end of the study period, the prostate was dissected out for the determination of reactive oxygen species （ROS） levels, lipid peroxidation and antioxidant enzymes status （catalase, superoxide dismutase, glutathione reductase, glutathione-S-transferase）. Results： In testosterone treated animals, increased ROS resulted in depletion of antioxidant enzymes and increase in lipid peroxidation in mouse prostate. However, lupeol/MPE treatment resulted in a decrease in ROS levels with restoration in the levels of lipid peroxidation and antioxidant enzymes. Conclusion： The results of the present study demonstrate that lupeol/MPE are effective in combating oxidative stress-induced cellular injury of mouse prostate. Mango and its constituents, therefore, deserve study as a potential chemopreventive agent against prostate cancer. （Asian J Androl 2008 Mar; 10： 313-318）
维普期刊数据库