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Innate lymphocytes-lineage,localizationandtimingof differentiation

Cellular & Molecular Immunology 2019年第7期16卷 627-633页

作者： Emily R.Kansler Ming O.Li Immunology Program Sloan Kettering InstituteMemorial Sloan Kettering Cancer CenterNew YorkNY10065USA louis v.gerstner jr.graduate school of biomedical sciences Memorial Sloan Kettering Cancer CenterNew YorkNY10065USA

Innate lymphocytes are a diverse population of cells that carry out specialized functions in steady-state homeostasis and during immune *** circulating cytotoxic natural killer(NK)cells have been studied for decades,tissue-resident innate lymphoid cells(ILCs)have only been characterized and studied over the past few *** ILCs have been largely viewed in the context of helper T-cell biology,models of ILC lineage and function have been founded within this ***,tissue-resident innate lymphocytes with cytotoxic potential have been described in an array of tissues,yet whether they are derived from the NK or ILC lineage is only beginning to be *** this review,we aim to shed light on the identities of innate lymphocytes through the lenses of cell lineage,localization,and timing of differentiation.

关键词： lymphocytes lineage homeostasis

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Stem cells and pain

引用

World Journal of Stem Cells 2023年第12期15卷 1035-1062页

作者： Matheus Deroco veloso da Silva Maiara Piva Geovana Martelossi-Cebinelli Mariana Stinglin Rosa Ribas Beatriz Hoffmann Salles Bianchini Olivia K Heintz Rubia Casagrande Waldiceu A verri jr Department of Pathology Laboratory of PainInflammationNeuropathy and CancerState University of LondrinaLondrina 86057-970ParanáBrazil Morningside graduate school of biomedical sciences University of Massachusetts Chan Medical SchoolWorcesterMA 01655United States Department of Pharmaceutical sciences Center of Health ScienceState University of LondrinaLondrina 86038-440ParanáBrazil Department of Pathology Laboratory of PainInflammationNeuropathy and CancerCenter of Biological SciencesState University of LondrinaLondrina 86057-970ParanáBrazil

ain can be defined as an unpleasant sensory and emotional experience caused by either actual or potential tissue damage or even resemble that unpleasant *** years,science has sought to find treatment alternatives,with minimal side effects,to relieve ***,the currently available pharmacological options on the market show significant adverse ***,the search for a safer and highly efficient analgesic treatment has become a *** cells(SCs)are non-specialized cells with a high capacity for replication,self-renewal,and a wide range of differentiation *** this review,we provide evidence that the immune and neuromodulatory properties of SCs can be a valuable tool in the search for ideal treatment strategies for different types of *** the advantage of multiple administration routes and dosages,therapies based on SCs for pain relief have demonstrated meaningful results with few ***,there are still more questions than answers when it comes to the mechanisms and pathways of pain targeted by ***,this is an evolving field that merits further investigation towards the development of SCbased analgesic therapies,and this review will approach all of these aspects.

关键词： Inflammation Neuropathy Nociceptive Pain Pain treatment Stem cells

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