Stem cells and pain

作     者：Matheus Deroco Veloso da Silva Maiara Piva Geovana Martelossi-Cebinelli Mariana Stinglin Rosa Ribas Beatriz Hoffmann Salles Bianchini Olivia K Heintz Rubia Casagrande Waldiceu A Verri Jr 

作者机构：Department of PathologyLaboratory of PainInflammationNeuropathy and CancerState University of LondrinaLondrina 86057-970ParanáBrazil Morningside Graduate School of Biomedical SciencesUniversity of Massachusetts Chan Medical SchoolWorcesterMA 01655United States Department of Pharmaceutical SciencesCenter of Health ScienceState University of LondrinaLondrina 86038-440ParanáBrazil Department of PathologyLaboratory of PainInflammationNeuropathy and CancerCenter of Biological SciencesState University of LondrinaLondrina 86057-970ParanáBrazil 

出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)

年 卷 期：2023年第15卷第12期

页      面：1035-1062页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Conselho Nacional de Desenvolvimento Científico e Tecnológico,CNPq #203112/2020-2,#307852/2019-9,#309633/2021-4,#405027/2021-4,and#427946/2018-2 PRONEX grant supported by SETI/Fundação Araucária and MCTI/CNPq,and Governo do Estado do Paraná(agreement#014/2017) Fundação Araucária(PBA/PROPPG 13/2021 agreements#276/2022-PBA and#250/2022-PBA) Financiadora de Estudos e Projetos-FINEP and CAPES(finance code#001) 

主　　题：Inflammation Neuropathy Nociceptive Pain Pain treatment Stem cells 

摘      要：ain can be defined as an unpleasant sensory and emotional experience caused by either actual or potential tissue damage or even resemble that unpleasant *** years,science has sought to find treatment alternatives,with minimal side effects,to relieve ***,the currently available pharmacological options on the market show significant adverse ***,the search for a safer and highly efficient analgesic treatment has become a *** cells(SCs)are non-specialized cells with a high capacity for replication,self-renewal,and a wide range of differentiation *** this review,we provide evidence that the immune and neuromodulatory properties of SCs can be a valuable tool in the search for ideal treatment strategies for different types of *** the advantage of multiple administration routes and dosages,therapies based on SCs for pain relief have demonstrated meaningful results with few ***,there are still more questions than answers when it comes to the mechanisms and pathways of pain targeted by ***,this is an evolving field that merits further investigation towards the development of SCbased analgesic therapies,and this review will approach all of these aspects.