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Concomitant extrahepatic autoimmune diseases do not compromise the long-term outcomes of primary biliary cholangitis

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Hepatobiliary & Pancreatic Diseases International 2022年第6期21卷 577-582页

作者： Sha Chen Meng-Qi Li Wei-Jia Duan Bu-Er Li Shu-Xiang Li Ting-Ting Lv Lin Ma Ji-Dong Jia liver Research center Beijing Friendship HospitalCapital Medical UniversityBeijing Key Laboratory of Translational Medicine on Liver CirrhosisNational Clinical Research Center for Digestive Diseases95 Yong’an RoadBeijing 100050China

Background:Primary biliary cholangitis(PBC)patients often have concomitant extrahepatic autoimmune(EHA)diseases including Sjögren’s syndrome(SS),systemic sclerosis(SSc),rheumatoid arthritis(RA),and autoimmune thyroid *** present study aimed to describe the prevalence of EHA diseases in PBC and explore the impact of EHA diseases on the long-term outcomes of PBC in Chinese ***:Medical records of PBC patients diagnosed in our institute were retrospectively ***-tients were followed up by a standardized telephone *** endpoints were defined as liver-related death and/or liver ***:Totally 247 of the 985(25.1%)PBC patients enrolled in the study had at least one concomi-tant EHA ***ögren’s syndrome(n=140,14.2%)was the most frequent one,followed by rheuma-toid arthritis(RA)(n=56,5.7%)and Hashimoto’s thyroiditis(n=45,4.6%).Patients with EHA dis-eases were more common in females(P<0.001)and in those with a family history of autoimmune disease(P=0.017).Overall,no differences were found between PBC patients with and without EHA dis-eases in terms of biochemical response rates to ursodeoxycholic acid,the incidence of hepatic events,or transplant-free *** and EHA≥2 were protective factors for hepatic events in univariate Cox analysis,but the results became insignificant in multivariate ***:Concomitant EHA diseases were common in PBC patients but did not compromise the long-term outcomes of PBC.

关键词： Primary biliary cholangitis Extrahepatic autoimmune diseases Sjögren’s syndrome Rheumatoid arthritis Prognosis

Control of Chronic Hepatitis B in China:Perspective of diagnosis and Treatment

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China CDC weekly 2020年第31期2卷 596-600页

作者： Yu Wang Min Wang Guanhua Zhang Xiaojuan Ou Hong Ma Hong You Jidong Jia liver Research center Beijing Friendship HospitalCapital Medical University/Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis/National Clinical Research Center for Digestive DiseasesBeijingChina

In the last three decades,China has made extraordinary effort and achieved great progress in the control of hepatitis *** to the adoption of universal administering of HBV vaccinations for newborns since 1992,the prevalence of hepatitis B surface antigen(HBsAg)in the population born after 1992 decreased significantly resulting in a decline in the general population from 9.75%to about 6%(1).

关键词： Chronic vaccination prevalence

A case of COVID-19 complicated by massive gastrointestinal bleeding

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Gastroenterology Report 2021年第1期9卷 85-87,I0003页

作者： Yan-Ling Wang Jin-Song Mu Xiao-Bao Qi Wen-Hui Zhang liver cirrhosis diagnosis and Treatment center 5th Medical Center of PLA General Hospital of ChinaBeijingP.R.China Intensive Care Unit 5th Medical Center of PLA General Hospital of ChinaBeijingP.R.China

The coronavirus disease 2019(COVID-19)outbreak that was first reported in Wuhan,China has spread globally,causing unprecedented health and economic damage[1].Although its clinical manifestations are mainly fever and respiratory symptoms,in some cases,gastrointestinal(GI)symptoms were the first manifestations[2].Here we present a case of an elderly patient with COVID-19 who developed massive GI bleeding during treatment.

关键词：胃肠道出血 respiratory clinical

Adenovirus and severe acute hepatitis of unknown etiology in children:Offender or bystander?

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Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 354-355页

作者： Shan Shan Ji-Dong Jia liver Research center Beijing Friendship HospitalCapital Medical University/Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis/National Clinical Research Center for Digestive DiseasesBeijing 100050China

On April 6,2022,the United Kingdom Health Security Agency(UKHSA)released an alert on cases of hepatitis of unknown etiology in children[1].On April 15,2022,World Health Organization(WHO)published the first notice of this condition[2].Later on,similar cases were reported from the UK,other European countries,and other parts of the world.

关键词： etiology hepatitis cases

Implications of the immunoregulatory functions of mesenchymal stem cells in the treatment of human liver diseases

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Cellular & Molecular Immunology 2011年第1期8卷 19-22页

作者： Hu Lin Ruonan Xu Zheng Zhang Liming Chen Ming Shi Fu-Sheng Wang liver Disease Research center for Biological therapy Beijing 302 HospitalBeijingChina

Transplantation of mesenchymal stem cells(MSCs)has been recently studied in animal models,and in clinical trials of patients with fulminant hepatic failure,end-stage liver diseases and inherited metabolic *** cytokines produced by MSCs can inhibit immunocyte proliferation and migration to the liver,thereby attenuating inflammatory injury and reducing hepatocyte *** addition,MSCs play an important role in regressing liver fibrosis and in supporting the function,proliferation and differentiation of endogenous hepatocytes under appropriate *** remarkable progress has been achieved in basic and clinical MSC studies,optimal therapeutic regimens for the clinical application of MSCs,such as optimal doses,transplantation routine and interval period for transplantation,need to be elucidated in ***,the long-term safety and therapeutic efficacy of MSC transplantation should be evaluated in future clinical *** review summarizes our current understanding of the immunomodulatory effects of MSC therapies on human liver diseases.

关键词： immunomodulation liver diseases mesenchymal stem cells transplantation

Clinical application of liver stiffness measurement using transient elastography in chronic liver disease from longitudinal perspectives

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World Journal of Gastroenterology 2013年第12期19卷 1890-1900页

作者： Beom Kyung Kim James Fung Man-Fung Yuen Seung Up Kim Department of Internal Medicine Institute of Gastroenterology Yonsei University College of Medicine liver cirrhosis Clinical Research center Department of Medicine State Key Laboratory for Liver Research the University of Hong Kong

Accurate determination of the presence and degree of fibrosis in liver is of great importance, because the prognosis and management strategies for chronic liver disease depend mainly on these factors. To date, liver biopsy (LB) remains the "gold standard" for assessing the severity of liver fibrosis; however, LB is often limited by its invasiveness, sampling error, and intra/ inter-observer variability in histological interpretation. Furthermore, repeated LB examinations within a short time interval are indeed ineligible in a real clinical practice. Thus, due to the pressing need for non-invasive surrogates for liver fibrosis, transient elastography (TE),as a novel ultrasound based technology, has allowed a noninvasive measurement of liver stiffness and has gained in popularity over recent years. In the past few years, additional roles for transient TE beyond the initial purpose of a non-invasive surrogate for LB have included the prediction of the most two critical consequences of fibrosis progression: the development of portal hypertension-related complications and hepatocellular carcinoma. This indicates that the role of transient TE is not merely limited to reducing the need for LB, but transient TE can enable the establishment of tailored management strategies by providing more detailed prognostic information. In particular, under the concept in which the clinical course of liver fibrosis is dynamic and bidirectional, especially when appropriate intervention is commenced, transient TE can be used to track the dynamic changes in fibrotic burden during antiviral or antifibrotic treatment. This review discussed extended applications of transient TE in prediction of the development of real clinical endpoints from a longitudinal perspective.

关键词： liver stiffness Transient elastography Fibroscan Fibrosis Longitudinal Outcome

Exploring the potential of extrachromosomal DNA as a novel oncogenic driver

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Science China Life Sciences 2025年第1期 144-157页

作者： Huanbo Zhu Longtao Huangfu Junbing Chen Jiafu Ji Xiaofang Xing Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Division of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute Department of Gastrointestinal Cancer center Peking University Cancer Hospital & Institute Department of liver Surgery & Transplantation Liver Cancer InstituteZhongshan HospitalFudan University Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDivision of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute

Extrachromosomal DNA(ecDNA) is a form of circular DNA mostly found in tumor cells. Unlike the typical chromosomal DNA, ecDNA is circular, self-replicating, and carries complete or partial gene fragments. Although ecDNA occurrence remains a rare event in cancer, recent studies have shown that oncogene amplification on ecDNA is widespread throughout many types of cancer, implying that ecDNA plays a central role in accelerating tumor evolution. ecDNA has also been associated with increased tumor mutation burden, chromosomal instability, and even tumor microenvironment remodeling. ecDNA may be crucial in influencing tumor heterogeneity, drug sensitivity,oncogenic senescence, and tumor immunogenicity, leading to a worsening prognosis for tumor patients. In this way, several clinical trials have been conducted to investigate the importance of ecDNA in clinical treatment. In this review, we summarize the biogenesis, characteristics, and current research methods of ecDNA, discuss the vital role of ecDNA-caused tumor heterogeneity in cancers, and highlight the potential role of ecDNA in cancer therapy.

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Knowledge about non-invasive diagnostic tests for varices in liver cirrhosis:A questionnaire survey to the Gastroenterology Branch of the Liaoning Medical Association,China

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Gastroenterology Report 2016年第2期4卷 141-147,I0002,I0003页

作者： Xingshun Qi Xiaozhong Guo Hongyu Li Xu Liu Han Deng liver cirrhosis Study Group Department of GastroenterologyGeneral Hospital of Shenyang Military AreaShenyangLiaoningChina

Background and aims:Due to the invasiveness of upper gastrointestinal endoscopy,non-invasive diagnostic tests for varices in liver cirrhosis have been widely established by numerous studies.A questionnaire survey,which was aimed at understanding the current knowledge about non-invasive diagnostic tests for varices in liver cirrhosis,was distributed among the members of Gastroenterology Branch of the Liaoning Medical ***:A questionnaire assessing the knowledge about non-invasive diagnostic tests for varices was sent to 42 members who participated in the entire ninth *** were from 33 hospitals in 13 cities of Liaoning Province,***:Overall,97.6%(41/42)of participants responded to the questionnaire.A majority of participants were chief physicians(85.4%),had>20 years of experience in clinical work of digestive diseases(80.5%)and worked at tertiary hospitals(97.6%).In 46.3%of participants’departments,there were>200 patients with liver cirrhosis and gastroesophageal varices admitted every *** 90.2%of participants’departments,upper gastrointestinal endoscopy was regularly employed for the diagnosis of gastroesophageal *** six(15%)participants often used non-invasive diagnostic tests for varices in clinical ***(75%)participants knew at least one non-invasive diagnostic test for *** knowledge of at least one non-invasive diagnostic test was significantly associated with the number of cirrhotic patients with varices(P¼0.038)or the regular use of gastrointestinal endoscopy to diagnose varices(P¼0.022).Conclusions:This questionnaire survey suggested that non-invasive diagnostic tests for varices in liver cirrhosis were rarely or never used in clinical practices in Liaoning Province,***,non-invasive indexes should be further explored in a well-designed multi-center observational study.

关键词： liver cirrhosis varices portal hypertension non-invasive diagnostic tests questionnaire survey

Development of a new Cox model for predicting long-term survival in hepatitis cirrhosis patients underwent transjugular intrahepatic portosystemic shunts

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 491-502页

作者： Yi-Fan Lv Bing Zhu Ming-Ming Meng Yi-Fan Wu Cheng-Bin Dong Yu Zhang Bo-Wen Liu Shao-Li You Sa Lv Yong-Ping Yang Fu-Quan Liu liver Disease Minimally Invasive diagnosis and Treatment center Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China liver Vascular Disease diagnosis and Treatment center The Fifth Medical Center of Chinese People's Liberation Army General HospitalBeijing 100039China

BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS)placement is a procedure that can effectively treat complications of portal hypertension,such as variceal bleeding and refractory ***,there have been no specific studies on predicting long-term survival after TIPS *** To establish a model to predict long-term survival in patients with hepatitis cirrhosis after *** A retrospective analysis was conducted on a cohort of 224 patients who un-derwent TIPS *** univariate and multivariate Cox regression analyses,various factors were examined for their ability to predict survival at 6 years after ***,a composite score was formulated,encompassing the indication,shunt reasonability,portal venous pressure gradient(PPG)after TIPS,percentage decrease in portal venous pressure(PVP),indocyanine green retention rate at 15 min(ICGR15)and total bilirubin(Tbil)***,the performance of the newly developed Cox(NDC)model was evaluated in an in-ternal validation cohort and compared with that of a series of existing *** The indication(variceal bleeding or ascites),shunt reasonability(reasonable or unreasonable),ICGR15,post-operative PPG,percentage of PVP decrease and Tbil were found to be independent factors affecting long-term survival after TIPS *** NDC model incorporated these parameters and successfully identified patients at high risk,exhibiting a notably elevated mortality rate following the TIPS procedure,as observed in both the training and validation ***,in terms of predicting the long-term survival rate,the performance of the NDC model was significantly better than that of the other four models[Child-Pugh,model for end-stage liver disease(MELD),MELD-sodium and the Freiburg index of post-TIPS survival].CONCLUSION The NDC model can accurately predict long-term survival after the TIPS procedure in patients with hepatitis cirrhosis,help identify high-risk patients

关键词： Transjugular intrahepatic portosystemic shunt Long-term survival Predictive model