Implications of the immunoregulatory functions of mesenchymal stem cells in the treatment of human liver diseases

作     者：Hu Lin Ruonan Xu Zheng Zhang Liming Chen Ming Shi Fu-Sheng Wang 

作者机构：Liver Disease Research Center for Biological TherapyBeijing 302 HospitalBeijingChina 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2011年第8卷第1期

页      面：19-22页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This work was supported by grants from the National Grand Program on Key Infectious Disease(No.2009ZX10004-309,No.2008ZX10002-007 and No.2008ZX10002-005-6) the National Key Basic Research Program of China(No.2007CB512805 and No.2007CB512804) 

主　　题：immunomodulation liver diseases mesenchymal stem cells transplantation 

摘      要：Transplantation of mesenchymal stem cells(MSCs)has been recently studied in animal models,and in clinical trials of patients with fulminant hepatic failure,end-stage liver diseases and inherited metabolic *** cytokines produced by MSCs can inhibit immunocyte proliferation and migration to the liver,thereby attenuating inflammatory injury and reducing hepatocyte *** addition,MSCs play an important role in regressing liver fibrosis and in supporting the function,proliferation and differentiation of endogenous hepatocytes under appropriate *** remarkable progress has been achieved in basic and clinical MSC studies,optimal therapeutic regimens for the clinical application of MSCs,such as optimal doses,transplantation routine and interval period for transplantation,need to be elucidated in ***,the long-term safety and therapeutic efficacy of MSC transplantation should be evaluated in future clinical *** review summarizes our current understanding of the immunomodulatory effects of MSC therapies on human liver diseases.