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Context-dependent role of sirtuin 2 in inflammation

Neural Regeneration Research 2025年第3期20卷 682-694页

作者： NoemíSola-Sevilla Maider Garmendia-Berges MCarmen Mera-Delgado Elena Puerta Department of Pharmaceutical sciences Division of PharmacologySchool of Pharmacy and NutritionUniversity of NavarraPamplonaSpain Navarra Institute for Health Research(IdiSNA) PamplonaSpain

Sirtuin 2 is a member of the sirtuin family nicotinamide adenine dinucleotide(NAD~+)-dependent deacetylases, known for its regulatory role in different processes, including inflammation. In this context, sirtuin 2 has been involved in the modulation of key inflammatory signaling pathways and transcription factors by deacetylating specific targets, such as nuclear factor κB and nucleotide-binding oligomerization domain-leucine-rich-repeat and pyrin domain-containing protein 3(NLRP3). However, whether sirtuin 2-mediated pathways induce a pro-or an anti-inflammatory response remains controversial. Sirtuin 2 has been implicated in promoting inflammation in conditions such as asthma and neurodegenerative diseases, suggesting that its inhibition in these conditions could be a potential therapeutic strategy. Conversely, arthritis and type 2 diabetes mellitus studies suggest that sirtuin 2 is essential at the peripheral level and, thus, its inhibition in these pathologies would not be recommended. Overall, the precise role of sirtuin 2 in inflammation appears to be context-dependent, and further investigation is needed to determine the specific molecular mechanisms and downstream targets through which sirtuin 2 influences inflammatory processes in various tissues and pathological conditions. The present review explores the involvement of sirtuin 2 in the inflammation associated with different pathologies to elucidate whether its pharmacological modulation could serve as an effective strategy for treating this prevalent symptom across various diseases.

关键词： interferon inflammation lipopolysaccharide neuroinflammation NLRP3 nuclear factorκB sirtuin 2

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Capn3b-deficient zebrafish model reveals a key role of autoimmune response in LGMDR1

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Journal of Genetics and Genomics 2024年第12期51卷 1375-1388页

作者： Yayue Chen Delai Huang Aixuan Xie Ying Shan Shuyi Zhao Ce Gao Jun Chen Hui Shi Weihuan Fang Jinrong Peng MOE Key laboratory for Molecular Animal nutrition College of Animal SciencesZhejiang University College of life sciences Zhejiang University

Mutations in calcium-dependent papain-like protease CALPAIN3 (CAPN3) cause Limb-Girdle Muscular Dystrophy Recessive Type 1 (LGMDR1),the most common limb-girdle muscular dystrophy in *** addition to progressive muscle weakness,persistent inflammatory infiltration is also a feature of *** the underlying mechanism remaining poorly understood,we consider that it may relate to the newly defined role of CAPN3/Capn3b in the ***,we report that the loss of function of zebrafish capn3b,the counterpart of human CAPN3,induces an autoimmune response akin to that in LGMDR1 ***3b mutant larvae are more susceptible to Listeria monocytogenes injection,characterized by recruiting more *** germ-free conditions,transcriptome analysis of the capn3b mutant muscle reveals a significant upregulation of the chemokine-production-related ***,more neutrophils are recruited to the injury site imposed by either muscle stabbing or tail fin *** proteomic analysis and enzymatic assays reveal NKAP,an activating factor of the NF-k B pathway,to be a target of *** conclude that the accumulation of Nkap and other factors in the capn3b mutant may be involved in the over-activation of innate *** studies indicate that the zebrafish capn3b mutant is a powerful model for studying the immunity-related progression of human LGMDR1.

关键词： Autoimmunity LGMDR1 Neutrophil Nkap Zebrafish capn3b

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Xylanase improves the intestinal barrier function of Nile tilapia(Oreochromis niloticus)fed with soybean(Glycine max)meal

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Journal of Animal Science and Biotechnology 2023年第5期14卷 2224-2238页

作者： Tong Wang Nannan Zhou Junyi He Zhenzhen Hao Chentao Zhou Yidi Du Zhenyu Du Xiaoyun Su Meiling Zhang laboratory of Aquaculture nutrition and Environmental Health(LANEH) School of Life SciencesEast China Normal UniversityShanghai 200241China State Key laboratory of Animal nutrition Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijing 100193China

Background Soybean(Glycine max)meal is one of the important protein sources for fish,but the non-starch polysaccharides(NSP)in soybean meal impair the intestinal barrier *** we aimed to investigate whether xylanase can alleviate the adverse effects on the gut barrier induced by soybean meal in Nile tilapia and to explore the possible *** Nile tilapia(Oreochromis niloticus)(4.09±0.02 g)were fed with two diets including SM(soybean meal)and SMC(soybean meal+3,000 U/kg xylanase)for 8 *** characterized the effects of xylanase on the gut barrier,and the transcriptome analysis was performed to investigate the underlying *** xylanase improved intestinal morphology and decreased the concentration of lipopolysaccharide(LPS)in *** results of transcriptome and Western blotting showed that dietary xylanase up-regulated the expression level of mucin2(MUC2)which may be related to the inhibition of protein kinase RNA-like endoplasmic reticulum kinase(perk)/activating transcription factor 4(atf4)signaling *** analysis showed that addition of xylanase in soybean meal altered the intestinal microbiota composition and increased the concentration of butyric acid in the ***,dietary sodium butyrate was supplemented into the soybean meal diet to feed Nile tilapia,and the data verified that sodium butyrate mirrored the beneficial effects of *** Collectively,supplementation of xylanase in soybean meal altered the intestinal microbiota composition and increased the content of butyric acid which can repress the perk/atf4 signaling pathway and increase the expression of muc2 to enhance the gut barrier function of Nile *** present study reveals the mechanism by which xylanase improves the intestinal barrier,and it also provides a theoretical basis for the application of xylanase in aquaculture.

关键词： Butyrate Exogenous enzymes Intestinal health Intestinal microbiota Mucin Xylanase

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Double-edged effect of sodium citrate in Nile tilapia(Oreochromis niloticus):Promoting lipid and protein deposition *** hyperglycemia and insulin resistance

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Animal nutrition 2023年第3期14卷 303-314页

作者： Jun-Xian Wang Fang Qiao Mei-Ling Zhang Li-Qiao Chen Zhen-Yu Du Yuan Luo laboratory of Aquaculture nutrition and Environmental Health(LANEH) School of Life SciencesEast China Normal UniversityShanghaiChina

Citrate is an essential substrate for energy metabolism that plays critical roles in regulating glucose and lipid metabolic ***,the action of citrate in regulating nutrient metabolism in fish remains poorly ***,we investigated the effects of dietary sodium citrate on growth performance and systematic energy metabolism in juvenile Nile tilapia(Oreochromis niloticus).A total of 270Nile tilapia(2.81±0.01 g)were randomly divided into three groups(3 replicates per group,30 fish per replicate)and fed with control diet(35%protein and 6%lipid),2%and 4%sodium citrate diets,respectively,for 8 *** results showed that sodium citrate exhibited no effect on growth performance(P>0.05).The whole-body crude protein,serum triglyceride and hepatic glycogen contents were significantly increased in the 4%sodium citrate group(P0.05).The 4%sodium citrate treatment significantly increased the serum glucose and insulin levels at the end of feeding trial and also in the glucose tolerance test(P<0.05).The 4%sodium citrate significantly enhanced the hepatic phosphofructokinase activity and inhibited the expression of pyruvate dehydrogenase kinase isozyme 2 and phosphor-pyruvate dehydrogenase E1 component subunit alpha proteins(P<0.05).Additionally,the 4%sodium citrate significantly increased hepatic triglyceride and acetyl-Co A levels,while the expressions of carnitine palmitoyl transferase 1a protein were significantly down-regulated by the 4%sodium citrate(P<0.05).Besides,the 4%sodium citrate induced crude protein deposition in muscle by activating m TOR signaling and inhibiting AMPK signaling(P<0.05).Furthermore,the 4%sodium citrate significantly suppressed serum aspartate aminotransferase and alanine aminotransferase activities,along with the lowered expression of pro-inflammatory genes,such as nfκb,tnfa and il8(P<0.05).Although the 4%sodium citrate significantly increased phosphor-nuclear factor-k B p65 prote

关键词： Sodium citrate Lipid and protein deposition Insulin resistance Nile tilapia

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Probiotic Pediococcus pentosaceus restored gossypol-induced intestinal barrier injury by increasing propionate content in Nile tilapia

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1688-1703页

作者： Feifei Ding Nannan Zhou Yuan Luo Tong Wang Weijie Li Fang Qiao Zhenyu Du Meiling Zhang laboratory of Aquaculture nutrition and Environmental Health(LANEH) School of Life SciencesEast China Normal UniversityShanghai 200241China

Background Intestinal barrier is a dynamic interface between the body and the ingested food components, however, dietary components or xenobiotics could compromise intestinal integrity, causing health risks to the host. Gossypol, a toxic component in cottonseed meal(CSM), caused intestinal injury in fish or other monogastric animals. It has been demonstrated that probiotics administration benefits the intestinal barrier integrity, but the efficacy of probiotics in maintaining intestinal health when the host is exposed to gossypol remains unclear. Here, a strain(YC) affiliated to Pediococcus pentosaceus was isolated from the gut of Nile tilapia(Oreochromis niloticus) and its potential to repair gossypol-induced intestinal damage was *** A total of 270 Nile tilapia(2.20 ± 0.02 g) were allotted in 3 groups with 3 tanks each and fed with 3 diets including CON(control diet), GOS(control diet containing 300 mg/kg gossypol) and GP(control diet containing 300 mg/kg gossypol and 10^(8) colony-forming unit(CFU)/g P. pentosaceus YC), respectively. After 10 weeks, addition of P. pentosaceus YC restored growth retardation and intestinal injury induced by gossypol in Nile tilapia. Transcriptome analysis and si RNA interference experiments demonstrated that NOD-like receptors(NLR) family caspase recruitment domain(CARD) domain containing 3(Nlrc3) inhibition might promote intestinal stem cell(ISC) proliferation, as well as maintaining gut barrier integrity. 16S r RNA sequencing and gas chromatography-mass spectrometry(GC-MS) revealed that addition of P. pentosaceus YC altered the composition of gut microbiota and increased the content of propionate in fish gut. In vitro studies on propionate's function demonstrated that it suppressed nlrc3 expression and promoted wound healing in Caco-2 cell *** The present study reveals that P. pentosaceus YC has the capacity to ameliorate intestinal barrier injury by modulating gut microbiota composition and elevating

关键词： Gut barrier injury Gossypol ISCs proliferation Nlrc3 Propionate

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Uridine alleviates high-carbohydrate diet-induced metabolic syndromes by activating sirt1/AMPK signaling pathway and promoting glycogen synthesis in Nile tilapia(Oreochromis niloticus)

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Animal nutrition 2023年第3期14卷 56-66页

作者： Nan-Nan Zhou Tong Wang Yu-Xin Lin Rong Xu Hong-Xia Wu Fei-Fei Ding Fang Qiao Zhen-Yu Du Mei-Ling Zhang laboratory of Aquaculture nutrition and Environmental Health(LANEH) School of Life SciencesEast China Normal UniversityShanghai 200241China

Carbohydrates have a protein sparing effect,but long-term feeding of a high-carbohydrate diet(HCD)leads to metabolic disorders due to the limited utilization efficiency of carbohydrates in *** to mitigate the negative effects induced by HCD is crucial for the rapid development of *** is a pyrimidine nucleoside that plays a vital role in regulating lipid and glucose metabolism,but whether uridine can alleviate metabolic syndromes induced by HCD remains *** this study,a total of480 Nile tilapia(Oreochromis niloticus)(average initial weight 5.02±0.03 g)were fed with 4 diets,including a control diet(CON),HCD,HCD+500 mg/kg uridine(HCUL)and HCD+5,000 mg/kg uridine(HCUH),for 8 *** results showed that addition of uridine decreased hepatic lipid,serum glucose,triglyceride and cholesterol(P<0.05).Further analysis indicated that higher concentration of uridine activated the sirtuin1(sirt1)/adenosine 5-monophosphate-activated protein kinase(AMPK)signaling pathway to increase lipid catabolism and glycolysis while decreasing lipogenesis(P<0.05).Besides,uridine increased the activity of glycogen synthesis-related enzymes(P<0.05).This study suggested that uridine could alleviate HCD-induced metabolic syndrome by activating the sirt1/AMPK signaling pathway and promoting glycogen *** finding reveals the function of uridine in fish metabolism and facilitates the development of new additives in aquatic feeds.

关键词： Uridine High-carbohydrate diet Metabolism AMPK Nile tilapia

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Partial replacement of soybean meal by yellow mealworm(Tenebrio molitor)meal influences the flesh quality of Nile tilapia(Oreochromis niloticus)

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Animal nutrition 2023年第1期12卷 108-115页

作者： Le Zhang Hong-Xia Wu Wei-Jie Li Fang Qiao Wen-Bing Zhang Zhen-Yu Du Mei-Ling Zhang laboratory of Aquaculture nutrition and Environmental Health School of Life SciencesEast China Normal UniversityShanghai 200241China The Key laboratory of Mariculture Ministry of EducationThe Key Laboratory of Aquaculture Nutrition and FeedsMinistry of AgricultureOcean University of ChinaQingdao 266003China

This study investigated the effects of yellow mealworm meal(YM)replacing soybean meal(SBM)at different proportions(0%,15%,30%and 45%,referred as YM0,YM15,YM30 and YM45,respectively)on the flesh quality of Nile tilapia.A total of 360 fish(70.0±0.12 g)were randomly divided into 4 groups(3 tanks per group).Fish were fed the experimental diet twice daily for 10 *** results showed that muscle protein content significantly decreased in YM30 and YM45,while the lipid content significantly decreased in YM45(P<0.05).The essential amino acids and flavor amino acids of the muscle were not affected by the YM substitution,while saturated fatty acid content decreased in YM30 and YM45 compared with YM0(P<0.05).Fillets in YM45 had higher hardness,gumminess,and a higher proportion of thin myofibers(≤100μm,P<0.05)than those in other *** analysis revealed that apoptosis and atrophy related genes were up-regulated,while the muscle antioxidant capacity decreased significantly in YM45(P<0.05),which may be related to the high acid value in YM45 *** findings indicated that YM could replace up to 30%SBM without substantially altering the flesh *** the replacement ratio increased to 45%,the flesh quality would *** attention should be paid to avoid feed rancidity which may affect the flesh quality of fish.

关键词： Yellow mealworm meal Novel feed protein source Nile tilapia Flesh quality Texture property

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The OsAMT1.1 gene functions in ammonium uptake and ammoniumepotassium homeostasis over low and high ammonium concentration ranges

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Journal of Genetics and Genomics 2016年第11期43卷 639-649页

作者： Chang Li Zhong Tang Jia Wei Hongye Qu Yanjie Xie Guohua Xu State Key laboratory of Crop Genetics and Germpiasm Enhancement and MOA Key laboratory of Plant nutrition and Fertilization in Lower-Middle Reaches of the Yangtze River College of Resources and Environmental Sciences Nanjing Agricultural University Nanjing 210095 China laboratory Center of life sciences College of Life Sciences Nanjing Agricultural University Nanjing 210095 China

Rice （Oryza sativa） grown in paddy fields is an ammonium （NH4^＋）-preferring crop; however, its AMT-type NH4^＋ transporters that mediate root N acquisition have not been well characterized yet. In this study, we analyzed the expression pattern and physiological function of the OsAMT1.1 gene of the AMT1 subfamily in rice. OsAMT1.1 is located in the plasma membrane and is mainly expressed in the root epidermis, stele and mesophyll cells. Disruption of the OsAMTI.1 gene decreased the uptake of NH4^＋, and the growth of roots and shoots under both low NH4^＋ and high NH4^＋ conditions. OsAMT1.1 contributed to the short-term （5 min） ^15NH4^＋ influx rate by approximately one-quarter, irrespective of the NH4^＋ concentration. Knockout of OsAMTI.I significantly decreased the total N transport from roots to shoots under low NH4^＋ conditions. Moreover, compared with the wild type, the osamt1.1 mutant showed an increase in the potassium （K） absorption rate under high NH4^＋ conditions and a decrease under low NH4^＋ conditions. The mutants contained a significantly high concentration of K in both the roots and shoots at a limited K （0.1 mmol/L） supply when NH4^＋ was replete. Taken together, the results indicated that OsAMT1.1 significantly contributes to the NH4^＋ uptake under both low and high NH4^＋ conditions and plays an important role in N-K homeostasis in rice.

关键词： Ammonium Ammonium transporter Interaction Potassium Rice

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Suitability of Hermetia illucens larvae meal and fat in broiler diets:effects on animal performance,apparent ileal digestibility,gut histology,and microbial metabolites

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Journal of Animal Science and Biotechnology 2022年第5期13卷 1386-1401页

作者： Kristina Hartinger Katharina Froschl Marco Antonio Ebbing Barbara Bruschek-Pfleger Karl Schedle Christiane Schwarz Martin Gierus Department of Agrobiotechnology Institute of Animal NutritionLivestock Productsand Nutrition PhysiologyUniversity of Natural Resources and Life SciencesViennaAustria

Background:The possibility of partially replacing soybean meal(SBM)with Hermetia illucens(HI)defatted larvae meal in broiler nutrition has frequently been *** sustainability reasons,however,the larvae fat produced during defatting should also be used and could be particularly beneficial regarding gut health due to its fatty acid *** evaluate the suitability of HI larvae as protein and fat source,a 2×3 factorial arrangement with two types of protein,***(S)or SBM and 15%of its crude protein replaced by HI larvae meal(L),and three levels of fat sources,namely 0(0 L),50%(50 L)or 100%HI larvae fat(100 L)at the expense of soybean oil was ***:In the starter phase,an interaction showed higher body weight(BW),average daily gain(ADG)and improved feed conversion ratio(FCR)if 50%or 100%HI larvae fat was fed with HI larvae ***,BW,ADG and FCR improved when feeding HI larvae meal as protein ***,we observed an increased average daily feed intake in the grower,finisher,and overall phase in the L groups and an improved FCR in 0 L compared to 50 L groups during the overall *** apparent ileal digestibility,HI larvae meal feeding increased dry matter,organic matter,and fat *** HI larvae meal as protein source decreased the concentrations of agmatine,spermidine,spermine and ammonia in the caecal digesta,whereas fat source affected agmatine with higher concentrations in 50 L compared to 0 L in the colonic *** contrast,caecal ethanolamine concentrations increased in HI larvae meal groups compared to *** butyric acid concentrations decreased with HI larvae meal *** interaction was found for the jejunal villus area,being higher in L+100 L compared to S+100 ***,L groups had greater villus ***:A partial replacement of SBM with HI larvae meal and soybean oil with HI larvae fat in broiler diets without impairing animal performance or gut health seems possible

关键词： Broiler chicken Hermetia illucens Larvae fat Larvae meal Lauric acid Microbial metabolites Performance

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Regulatory effects of dietary L-Arg supplementation on the innate immunity and antioxidant ability in broiler chickens

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Journal of Integrative Agriculture 2016年第11期15卷 2578-2587页

作者： HU Ya-di TAN Jian-zhuang QI Ji ZHANG Hong-fu State Key laboratory of Animal nutrition Institute of Animal SciencesChinese Academy of Agricultural Sciences

Here, we investigated the effect of dietary arginine（Arg） supplementation on innate immunity and the antioxidant ability of broiler chickens. The experiment was designed as a single-factorial arrangement（n=8 cages/treatment, six birds/cage）, and we used four dietary Arg concentrations（10.0, 15.0, 20.0 or 25.0 g kg–1）. On day 21, the birds were killed to obtain spleen, cecal tonsil and liver samples to determine the gene expression and antioxidant characteristics. Increasing the Arg concentration linearly decreased（P0.05） the m RNA expression of splenic interleukin-18（IL-18） and tumor necrosis factor-α（TNF-α）. Dietary Arg supplementation quadratically decreased（P0.05） the expression of interleukin-1b（IL-1b） and interferon-γ（IFN-γ） m RNA in the spleen. Increasing Arg concentrations linearly and quadratically reduced the expression of IL-18 m RNA in the spleen. Meanwhile, increasing dietary Arg supplementation linearly and quadratically increased the lymphotactin m RNA（P0.05） expression, and linearly increased the macrophage inflammatory protein-1β（MIP-1β） and toll-like receptor 15（TLR15） m RNA expression in the cecal tonsils. Dietary Arg supplementation linearly（P0.05） increased the glutathione peroxidase（GSH-Px）, catalase（CAT）, and lysozyme（LZM） activities in the liver. However, the malondialdehyde（MDA） activity in the liver was not influenced by the dietary Arg concentration（P0.05）. No significant（P0.05） effect was found on the activity of superoxide dismutase（SOD） in the liver. Thus high levels of Arg supplementation（20.0 g kg^（–1）） may potentially suppress the innate immunity of broiler chickens, and dietary Arg supplementation enhances the antioxidant activity in broiler chickens.

关键词： arginine innate immunity antioxidant ability broiler

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