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Evolutionary trend analysis and knowledge structure mapping of endothelial dysfunction in sepsis:a bibliometrics study

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World Journal of Emergency Medicine 2024年第5期15卷 386-396页

作者： Juexian Wei Hengzong Mo Yuting Zhang Wenmin Deng Siqing Zheng Haifeng Mao Yang Ji Huilin Jiang Yongcheng Zhu Department of Emergency the Second Affi liated HospitalGuangzhou Medical UniversityGuangzhou 510260China Department of clinical Medicine the Second Clinical Medicine School of Guangzhou Medical UniversityGuangzhou 511436China School of Basic Medical Sciences Guangzhou Medical UniversityGuangzhou 511436China Department of Pharmacy Central People's Hospital of ZhanjiangZhanjiang 524045China

BACKGROUND:A pathophysiological feature of septic organ failure is endothelial dysfunction in sepsis(EDS).The physiological and pathological mechanism of sepsis is considered to be vascular leakage caused by endothelial *** pathological changes lead to systemic organ ***,an analysis using bibliometric methods has not yet been conducted in the field of *** study was conducted to provide an overview of knowledge structure and research trends in the fi eld of ***:Based on previous research,a literature search was performed in the Web of Science Core Collection(WoSCC)for publications associated with EDS published between the year 2003 and *** types of data from the publications,such as citation frequency,authorship,keywords and highly cited articles,were ***"Create Citation Report"feature in the WoSCC was employed to calculate the Hirsch index(h-index)and average citations per item(ACI)of authors,institutions,and *** conduct bibliometric and visualization analyses,three bibliometric tools were used,including R-bibliometrix,CiteSpace(co-citation analysis of references),and VOSviewer(co-authorship analysis of institutions,co-authorship analysis of authors,co-occurrence analysis of keywords).RESULTS:After excluding invalid records,the study finaly included 4,536 publications with 135,386 *** of these publications originated in the USA,China,Germany,Canada,and *** University emerged as the most prolifi c institution,while professor Jong-Sup Bae and his research team at Kyungpook National University emerged as authors with the greatest infl ***"protein C","tissue factor","thrombin","glycocalyx",“acute kidney injury”,“syndecan-1”and“biomarker”were identifi ed as prominent areas of *** research may focus on molecular mechanisms(such as as vascular endothelial[VE]-cadherin regulation)and therapeutic interventions to enhance endothelial repair and ***:Our find

关键词： Sepsis Endothelium Bibliometrics CiteSpace VOSviewer

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Rapid characterization of non-volatile phenolic compounds reveals the reliable chemical markers for authentication of traditional Chinese medicine Xiang-ru among confusing Elsholtzia species

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Chinese Journal of Natural Medicines 2024年第4期22卷 375-384页

作者： ZENG Zhen ZHANG Chen HU Jiadong WANG Feiyan WU Ziding WANG Jing ZHANG Jun YANG Shuda CHEN Junfeng LI Mingming TONG Qi QIU Shi CHEN Wansheng The SATCM Key laboratory for New Resources&Quality Evaluation of Chinese Medicine Institute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai 201203China Department of Pharmacy Second Affiliated Hospital of Navy Medical UniversityShanghai 200003China Kunming Plant Classification Biotechnology Co. Ltd.Kunming 650500China School of Pharmaceutical Sciences and Yunnan Key laboratory of Pharmacology for Natural Products Kunming Medical UniversityKunming 650500China State Key laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Beijing100700China

The aerial parts of Mosla chinensis *** Mosla chinensis cv.'Jiangxiangru'(MCJ)are widely utilized in traditional Chinese medicine(TCM),known collectively as ***,due to clinical effectiveness concerns and frequent misidentification,the original plants have increasingly been substituted by various species within the genera Elsholtzia and *** challenge in distinguishing between these genera arises from their similar morphological and metabolic *** address this issue,our study introduced a rapid method for metabolic characterization,employing high-resolution mass spectrometry-based *** detailed biosynthetic and chemometric analyses,we pinpointed five phenolic compounds—salviaflaside,cynaroside,scutellarein-7-O-D-glucoside,rutin,and vicenin-2—among 203 identified compounds,as reliable chemical markers for distinguishing Xiang-ru from closely related Elsholtzia *** methodology holds promise for broad application in the analysis of plant aerial parts,especially in verifying the authenticity of aromatic traditional medicinal *** findings underscore the importance of non-volatile compounds as dependable chemical markers in the authentication process of aromatic traditional medicinal plants.

关键词： Genus Elsholtzia Genus Mosla Traditional Chinese medicine Xiang-ru Non-volatile phenolic compounds Liquid chromatography-mass spectrometry

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Noteworthy impacts of COVID-19 pandemic on cancer screening:A systematic review

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Fundamental Research 2024年第3期4卷 484-494页

作者： Huilin Wang Min Yang Wei Xiong Quan Wang Bobo Zheng Yang Bai Kaiyong Zou Jibin Li Jiansong Ren Wanqing Chen Jingbo Zhai Jiang Li Office for Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Comprehensive Intervention National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Gynecology Endocrine&Reproductive Center National Clinical Research Center for Obstetric&Gynecologic Diseases Department of Obstetrics and GynecologyPeking Union Medical College HospitalPeking Union Medical College/Chinese Academy of Medical SciencesBeijing 100005China Ambulatory Surgery Center of Xijing Hospital Fourth Military Medical UniversityXi'an 710068China Department of General Surgery Shaanxi Provincial People’s HospitalXi'an 710068China College of clinical Medicine Capital Medical UniversityBeijing 100069China School of Public Health Tianjin University of Traditional Chinese MedicineTianjin 301617China

The sudden onset of the coronavirus disease 2019(COVID-19)in January 2020 has affected essential global health ***-screening services that can reduce cancer mortality are strongly ***,the specific role of COVID-19 in cancer screening is not fully *** study aimed to assess the efficiency of global cancer screening programs before and during the COVID-19 pandemic and to promote potential cancer-screening strategies for the next *** searches in PubMed,Embase,and Web of Science,and manual searches were performed between January 1,2020 and March 1,*** studies that reported the number of participants who underwent cancer screening before and during the COVID-19 pandemic were *** methodological quality of the included studies was assessed using the Newcastle-Ottawa *** in cancer-screening rates were estimated using the incidence rate ratio(IRR).Fifty-five cohort studies were included in this *** screening rates of colorectal cancer using invasive screening methods(Pooled IRR=0.52,95%CI:0.42 to 0.65,panalyses revealed that the reduction in cancer-screening rates varied across *** results suggest that the COVID-19 pandemic has had a noteworthy impact on colorectal,cervical,breast,and prostate cancer *** innovative cancer-screening technologies is important to promote the efficiency of cancer-screening services in the post-COVID-19 era and prepare fo

关键词： Cancer screening COVID-19 pandemic Cohort study Incidence rate ratio Meta-analysis

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Perioperative complication incidence and risk factors for retroperitoneal neuroblastoma in children:analysis of 571 patients

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World Journal of Pediatrics 2024年第3期20卷 250-258页

作者： Min He Jia-Bin Cai Xuan Wu Yin-Bing Tang Jin-Yan Wang Jun-Qin Mao Ji-Jun Chen Li-Feng Zhang Zhong-Hai Guan Jie-Ni Xiong Wan-Xin Peng Jin-Hu Wang Ting Tao Pediatric Cancer Research Center National Clinical Research Center for Child HealthHangzhouChina Department of Surgical Oncology Children's HospitalZhejiang University School of MedicineHangzhouChina Cancer Center Zhejiang UniversityNo.3333 Binsheng RodeHangzhouChina

Background Surgery plays an important role in the treatment of *** complications may impact the course of neuroblastoma *** date,comprehensive analyses of complications and risk factors have been *** Patients with retroperitoneal neuroblastoma undergoing tumor resection were retrospectively analyzed between 2014 and *** data collected included clinical characteristics,operative details,operative complications and postopera-tive *** factors for perioperative complications of retroperitoneal neuroblastoma were *** A total of 571 patients were enrolled in this *** complications were observed in 255(44.7%)*** leakage(28.4%),diarrhea(13.5%),and injury(vascular,nerve and organ;7.5%)were the most frequent *** were three operation-related deaths(0.53%):massive hemorrhage(n=1),biliary tract perforation(n=1)and intestinal necrosis(n=1).The presence of image-defined risk factors(IDRFs)[odds ratio(OR)=2.09,P<0.01],high stage of the International Neuroblastoma Risk Group staging system(INRGSS)(OR=0.454,P=0.04),retroperitoneal lymph node metastasis(OR=2.433,P=0.026),superior mesenteric artery encasement(OR=3.346,P=0.003),and inferior mesenteric artery encasement(OR=2.218,P=0.019)were identified as independent risk factors for perioperative *** Despite the high incidence of perioperative complications,the associated mortality rate was quite ***-perative complications of retroperitoneal neuroblastoma were associated with IDRFs,INRGSS,retroperitoneal lymph node metastasis and vascular *** with high-risk factors should receive more serious attention during surgery but should not discourage the determination to pursue total resection of neuroblastoma.

关键词： Complication Neuroblastoma Risk factors Surgery

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Validation and performance of three scoring systems for predicting primary non-function and early allograft failure after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 463-471页

作者： Yu Nie Jin-Bo Huang Shu-Jiao He Hua-Di Chen Jun-Jun Jia Jing-Jing Li Xiao-Shun He Qiang Zhao General Surgery Center Department of Hepatobiliary Surgery IIResearch Center for Artificial Organ and Tissue EngineeringGuangzhou Clinical Research and Transformation Center for Artificial LiverInstitute of Regenerative MedicineZhujiang HospitalSouthern Medical UniversityGuangzhou 510515China Organ Transplant Center the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong Provincial Key laboratory of Organ Donation and Transplant Immunology Guangzhou 510080China Guangdong Provincial International Cooperation Base of Science and Technology Guangzhou 510080China Division of Hepatobiliary Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Background: Primary non-function(PNF) and early allograft failure(EAF) after liver transplantation(LT) seriously affect patient outcomes. In clinical practice, effective prognostic tools for early identifying recipients at high risk of PNF and EAF were urgently needed. Recently, the Model for Early Allograft Function(MEAF), PNF score by King's College(King-PNF) and Balance-and-Risk-Lactate(BAR-Lac) score were developed to assess the risks of PNF and EAF. This study aimed to externally validate and compare the prognostic performance of these three scores for predicting PNF and EAF. Methods: A retrospective study included 720 patients with primary LT between January 2015 and December 2020. MEAF, King-PNF and BAR-Lac scores were compared using receiver operating characteristic(ROC) and the net reclassification improvement(NRI) and integrated discrimination improvement(IDI) analyses. Results: Of all 720 patients, 28(3.9%) developed PNF and 67(9.3%) developed EAF in 3 months. The overall early allograft dysfunction(EAD) rate was 39.0%. The 3-month patient mortality was 8.6% while 1-year graft-failure-free survival was 89.2%. The median MEAF, King-PNF and BAR-Lac scores were 5.0(3.5–6.3),-2.1(-2.6 to-1.2), and 5.0(2.0–11.0), respectively. For predicting PNF, MEAF and King-PNF scores had excellent area under curves(AUCs) of 0.872 and 0.891, superior to BAR-Lac(AUC = 0.830). The NRI and IDI analyses confirmed that King-PNF score had the best performance in predicting PNF while MEAF served as a better predictor of EAD. The EAF risk curve and 1-year graft-failure-free survival curve showed that King-PNF was superior to MEAF and BAR-Lac scores for stratifying the risk of EAF. Conclusions: MEAF, King-PNF and BAR-Lac were validated as practical and effective risk assessment tools of PNF. King-PNF score outperformed MEAF and BAR-Lac in predicting PNF and EAF within 6 months. BAR-Lac score had a huge advantage in the prediction for PNF without post-transplant variables. Proper use

关键词： Primary non-function Early allograft failure Risk predicting model Liver transplantation

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Prognostic implications of overt congestion in heart failure with preserved ejection fraction and the interaction with spironolactone:Insights from TOPCAT

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Chinese Medical Journal 2024年第10期137卷 1249-1251页

作者： Yingwen Lin Hengli Zhao Dongtu Hu Jia Huang You Peng Juncong Li Dingli Xu Qingchun Zeng State Key laboratory of Organ Failure Research Department of CardiologyNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Guangdong Provincial Key laboratory of clinical Pharmacology Medical Research InstituteGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510515China Department of Radiology The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510150China Department of Obstetrics and Gynecology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

To the Editor:Heart failure with preserved ejection fraction(HFpEF)is a clinical entity characterized by impaired diastolic *** recently,there have been few studies directly evaluating how volume status impacts future cardiac events for patients with *** supporting the application of spironolactone in HFpEF is mainly derived from the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist(TOPCAT)*** though primary analysis of the trial reached a neutral result,subgroup and subsequent post hoc analyses have confirmed its efficacy in selected groups of patients,suggesting that identifying the potential subgroups of patients who would benefit from spironolactone treatment is important.[1]Data regarding the impact of congestion status on the efficacy of spironolactone in HFpEF are lacking.

关键词： function. fraction impaired

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Relationship between dietary niacin intake and erectile dysfunction:a population-based study

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Asian Journal of Andrology 2024年第4期26卷 382-388页

作者： Wei-Long Lin Cheng Zheng Hao-Xu Wang Wei Zhang Ming-En Lin Department of Urology The First Affiliated Hospital of Shantou University Medical CollegeMedical College of Shantou UniversityShantou 515041China The Second School of clinical Medicine Southern Medical UniversityGuangzhou 510260China.

Existing research on the precise link between dietary niacin intake and erectile dysfunction(ED)is ***,this study aimed to investigate the potential association between dietary niacin intake and the risk of *** logistic regression and restricted cubic splines(RCSs)were used to examine the relationship between dietary niacin intake and *** interaction analysis was performed to assess the impact of different subgroups on the study *** addition,1:1 propensity score matching(PSM)was employed to adjust for potential confounding factors,ensuring the reliability of the *** analyzed data were collected from the 2001–2004 National Health and Nutrition Examination Survey(NHANES)in the *** study encompassed 3184 adults,among whom 863 participants were identified as having *** adjustments for potential confounders,the findings revealed that higher niacin intake,specifically in the highest tertile,was associated with a decreased risk of ED compared to that in the lowest tertile,showing an odds ratio(OR)of 0.56(95%confidence interval[CI]:0.37–0.85).Analysis of dose–response curves illustrated a negative correlation between dietary niacin intake and the risk of *** and interaction analyses fortified the consistency of these ***,PSM corroborated the validity of the *** study suggests an inverse association between dietary niacin intake and the risk of ***,establishing a cause-and-effect relationship remains elusive,and defining the safe threshold of niacin intake to prevent ED requires further investigation.

关键词： dietary niacin erectile dysfunction National Health and Nutrition Examination Survey propensity score matching

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Associations between the use of red yeast rice preparations and adverse health outcomes:An umbrella review of meta-analyses of randomized controlled trials

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Journal of Integrative Medicine 2024年第2期22卷 126-136页

作者： Zhen-yu Ma Shu-ping Yang Ying Li Tian-tian Xu Ya-lin Yang Hui-yong Yang Heng-bing Li Le-jin Zhou Yong Diao Su-yun Li School of Medicine Huaqiao UniversityQuanzhou 362021Fujian ProvinceChina College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan 250355Shandong ProvinceChina Second clinical Medical College Nanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina

Background:Red yeast rice(RYR),a natural lipid-lowering agent,is widely used in clinical ***,the existing meta-analyses concerning the safety of RYR preparations have yielded inconsistent results,and the credibility of the evidence has not been ***:This study was designed to evaluate the existing evidence and offer a comprehensive understanding of the associations between the use of RYR preparations and various adverse health *** strategy:Seven literature databases were searched from inception to May 5,2023,using medical subject headings and free-text terms(e.g.,“red yeast rice,”“Xuezhikang,”and“Zhibitai”).Inclusion criteria:Meta-analyses that investigated and quantitatively estimated associations between the use of RYR preparations and adverse health outcomes were included in this *** extraction and analysis:Two researchers independently extracted data using a standardized data collection table;any disagreements were resolved by consulting a third *** on the participant,intervention,comparator and outcome(PICO)framework in each eligible meta-analysis,a series of unique associations between the use of RYR preparations and adverse health outcomes were *** associations’effect estimates were re-evaluated using random-effect ***:Fifteen meta-analyses,comprising 186(164 unique)randomized controlled trials,were *** on A Mea Surement Tool to Assess Systematic Reviews version 2,3(20%)and 12(80%)of these meta-analyses had low and critically low confidence,respectively.A total of 61 unique associations between the use of RYR preparations and adverse health outcomes were extracted from eligible *** on the random-effect models,10(16.4%)associations indicated a significant protective effect of RYR preparations against adverse health outcomes,while 5(8.2%)indicated an increased risk of adverse health outcomes related to uric acid,alanine transaminase and aspartate trans

关键词： Red yeast rice Safety Adverse health outcomes Umbrella review Meta-analysis Systematic review

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Microrna-1224-5p Is a Potential Prognostic and Therapeutic Biomarker in Glioblastoma:Integrating Bioinformatics and clinical analyses

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Current Medical Science 2022年第3期42卷 584-596页

作者： Xing WEI Qing-mei ZHANG Chang LIU Song WU Wei-xia NONG Ying-ying GE Li-na LIN Feng LI Xiao-xun XIE Bin LUO Department of Histology and Embryology School of Pre-clinical MedicineGuangxi Medical UniversityNanning 530021China Department of Neurology the First Affiliated HospitalGuangxi Medical UniversityNanning 530021China Central laboratory of Pre-clinical Medicine(Key laboratory of Guangxi Colleges and Universities) Guangxi Medical UniversityNanning 530021China Department of Neurosurgery the First Affiliated HospitalGuangxi Medical UniversityNanning 530021China Key laboratory of Early Prevention and Treatment of Regional High Frequency Tumor(Guangxi Medical University) Ministry of EducationNanning 530021China

Objective Glioblastoma(GBM)is the most common,invasive,and malignant primary brain tumor with a poor prognosis and high recurrence ***’s known that some microRNAs(miRNAs)which are associated with tumorigenesis and progression can be considered as prognostic and therapeutic targets in tumors including *** study aims to highlight the potential role of the core miRNAs in GBM and their potential use as a prognostic and therapeutic *** Differentially expressed miRNAs(DEmiRNAs)were identified in GBM by integrating miRNA-sequencing results and a GBM microarray dataset from the Gene Expression Omnibus(GEO)database through bioinformatics *** dysregulated miRNAs were identified by survival analysis through Chinese Glioma Genome Atlas(CGGA).Target genes of the dysregulated miRNAs were predicted on MiRWalk and miRTarBase ***2.0 database,Gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways analysis were used to analyze the function of the dysregulated ***,protein-protein interaction(PPI)network analysis was used to identify the top 20 hub targets of the up-regulated and down-regulated miRNAs,***,core miRNAs in GBM were identified by constructing dysregulated miRNA-differentially expressed hub gene *** of the core miRNAs expression was detected in 41 GBM tissues compared to 8 normal brain ***,the potential biomarkers were identified by clinical correlation analysis and survival *** Totally,68 intersecting DEmiRNAs were identified,40 of which were upregulated and the other 28 miRNAs were *** upregulated and 4 downregulated miRNAs showed prognostic *** differentially expressed hub genes were regulated by the miR-28-5p and miR-1224-5p,which were respectively upregulated and downregulated in *** correlation between miR-1224-5p level and recurrence was statistically significant(P=0.011).Survival analysis showed that high

关键词： glioblastoma microRNAs microRNA-1224-5p bioinformatics

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Effects of postoperative treatment with chemotherapy and cellular immunotherapy on patients with colorectal cancer

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3202-3210页

作者： Zhen-Yu Ding Ying Piao Tong Jiang Juan Chen Yi-Nuo Wang Hui-Ying Yu Zhen-Dong Zheng Department of Oncology General Hospital of Northern Theater CommandShenyang 110016Liaoning ProvinceChina laboratory of Military Health in Cold Region Center for Disease Control and Prevention of Northern Theater CommandShenyang 110034Liaoning ProvinceChina Department of clinical Medicine Shenyang Pharmaceutical UniversityShenyang 110016Liaoning ProvinceChina Basic Medicine laboratory General Hospital of Northern Theater CommandShenyang 110016Liaoning ProvinceChina

BACKGROUND The outcome of surgical treatment for colorectal cancer(CRC)remains unsatis-factory and warrants further exploration and *** To clarify the impact of chemotherapy plus cellular immunotherapy[dendritic cell-cytokine-induced killer(DC-CIK)cell immunotherapy]on patients after CRC surgery and to explore the mediating *** A total cohort of 121 patients who underwent CRC surgery between January 2019 and April 2022 were *** sample comprised a control group of 55 pa-tients who received the XELOX chemotherapy regimen and a research group of 66 patients who received XELOX+DC-CIK *** performed compa-rative analyses of the clinical and pathological data of the two groups,including efficacy(2-year disease-free survival[DFS]rate),the incidence of adverse events(diarrhea,myelosuppression,gastrointestinal reactions,and peripheral neuritis),serum levels of tumor markers[carcinoembryonic antigens and carbohydrate an-tigens(CA)19-9 and CA242],and T-cell subsets[cluster of differentiation(CD)3+,CD3+CD4+,CD3+CD8+,natural killer(NK),and NK T cells].We also conducted preliminary univariate and mul-tivariate analyses of the variables that affected the efficacy of the *** We found a significantly higher 2-year DFS rate of treatment efficacy in the research group than in the control group,with a statistically lower incidence of adverse *** groups showed a reduction in serum tumor markers after treatment but there was no marked intergroup *** treatment,the various T-cell subgroup indicators in the control group were significantly lower than those in the research *** indices of T-cell subsets in the research group showed no significant change from preoperative *** analysis revealed a significant correlation between TNM staging,tumor differentiation,and the rates of nonresponse to treatment in CRC patients after *** results indicated that the treatment approach si

关键词： Analysis of variables affecting outcomes Cellular immunotherapy Chemotherapy Colorectal cancer clinical effects

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