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Fabrication of Dex-Loaded Shape Memory Polymer Based Composite Nanofibers for Potential Bone Tissue Engineering

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Journal of Donghua University(English Edition) 2014年第5期31卷 709-713页

作者：王先流谢静杨亮亮娄向新张彦中 laboratory of Biomimetic biomaterials for Regenerative Medicine Department of BioengineeringCollege of ChemistryChemical Engineering & BiotechnologyDonghua University

Biodegradable shape memory polymers( SMPs) are a class of intelligent materials with great potential for imparting biomaterial scaffolds multifunctionality in the field of tissue engineering and regenerative *** this study,the biodegradable SMP poly( D,L-lactide-co-trimethylene carbonate)( PLMC) incorporated with the dexamethasone( Dex),which was a kind of synthetic bone-formation inducing factor,was fabricated into nanofibers via *** morphology,constituent,thermal and mechanical properties of the produced Dex / PLMC composite nanofibers were characterized by scanning electron microscopy( SEM), Fourier transform infrared spectroscopy( FTIR), differential scanning calorimetry( DSC),and tensile testing,***,ultrasound was employed as a remote stimulus to regulate the Dex releasing behavior from the composite *** was found that the generated Dex /PLMC composite nanofibers had a uniform and smooth morphology with a diameter of ca.564 *** testing results showed that incorporation of the Dex gave rise to improved mechanical performance with the tensile strength,Young's modulus and strainat-break increased by 18.2%,20.0% and 64.4%,*** data revealed that the glass transition temperature( Tg) of the composite nanofibers, i.e., the thermal transition temperature( Ttrans) for activating shape memory effect, was 39.7 ℃.Moreover, the release kinetics of the encapsulated Dex in the nanofibers could be manipulated by varying the acoustic power and insonation *** results suggested that the newly developed Dex / PLMC nanofibers could be a promising drug delivery system for applications in bone tissue engineering( BTE).

关键词： dexamethasone (Dex) shape memory polymer (SMP) ultrasound bone tissue engineering( BTE) electrospinning

Fabrication and Characterization of Dual-layer Multichannel Nerve Guidance Conduit

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Journal of Donghua University(English Edition) 2017年第1期34卷 167-170页

作者：孙彬彬吴桐王娟布托阿齐袁柳李丹丹莫秀梅 biomaterials and Tissue Engineering laboratory College of Chemistry Chemical Engineering & Bioengineering Donghua University Shanghai 201620 China

Nowadays, muifichannel nerve guidance conduit （NGC） was designed by mimicking the architecture of nerve fascicles, and it was used to reduce dispersion of regenerating axons within the NGC lumen. In this paper, gelatin was used to prepare multichannel inner layer of NGC by freeze-drying, and poly （ L-lactic add-co-ε- caprolactone）（P（LLA-CL）） was used to fabricate nanofiber outer layer of NGC by electrospinning. The morphology of dual-layer mtlltichannel NGC was observed by scanning electron microscopy （SEM）. In vitro degradation experiment of the NGC demonstrated that the inner layer of NGC had the faster degradation rate than the outer layer of NGC. tell viability assay indicated that Schwann cells （SCs） showed better proliferation on dual-layer multichannel NGC than hollow NGC, because the multichannel structure introduced contact guidance for direct cell migration. Therefore, it was suggested that the dual-layer multichannel NGC had the potential for nerve lissue regeneration.

关键词： poly(L-lactic acid-co-ε-caprolactone) (P(LLA-CL)) gelatin electrospinniag multichannel nerve tissue engineering

A pore way to heal and regenerate:21st century thinking on biocompatibility

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Regenerative biomaterials 2016年第2期3卷 107-110页

作者： Buddy D.Ratner Department of bioengineering and Chemical Engineering University of Washington Engineered BiomaterialsUniversity of WashingtonSeattleWA 98195USA

This article raises central questions about the definition of biocompatibility,and also about how we assess *** start with the observation that a porous polymer where every pore is spherical,40 microns in diameter and interconnected,can heal into vascularized tissues with little or no fibrosis and good restoration of vascularity(i.e.,little or no foreign body reaction).The same polymer in solid form will trigger the classic foreign body reaction characterized by a dense,collagenous foreign body capsule and low vascularity.A widely used definition of biocompatibility is‘the ability of a material to perform with an appropriate host response in a specific application’.With precision-porous polymers,in direct comparison with the same polymer in solid form,we have the same material,in the same application,with two entirely different biological *** both reactions be‘biocompatible?’This conundrum will be elaborated upon and proposals will be made for future considerations and measurement of biocompatibility.

关键词： biocompatibility foreign body reaction pore healing regeneration

Surface Modification of Polycarbonate Urethane by Covalent Linkage of Heparin with a PEG Spacer

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Transactions of Tianjin University 2013年第1期19卷 58-65页

作者：冯亚凯田鸿谭明奇张鹏飞陈庆良刘建实 School of Chemical Engineering and Technology Tianjin University Tianjin University-Helmholtz-Zentrum Geesthacht Joint Laboratory for Biomaterials and Regenerative Medicine Key laboratory of Systems bioengineering Ministry of Education Tianjin University Tianjin Chest Hospital

Heparin was grafted onto polycarbonate urethane (PCU) surface via a three-step procedure utilizing α, ωdiamino-poly(ethylene glycol) (APEG, M n =2 000) as a spacer. In the first step, isocyanate functional groups were introduced onto PCU surface by the treatment of hexamethylene diisocyanate (HDI) in the presence of di-n-butyltin dilaurate (DBTDL) as a catalyst. In the second step, APEG was linked to the PCU surface to obtain the APEG conjugated PCU surface (PCU-APEG). In the third step, heparin was covalently coupled with PCU-APEG in the presence of N-hydroxysuccinimide (NHS) and 1-ethyl-3-(3-dimethylamidopropyl) carbodiimide (EDAC). The amount of heparin (1.639 μg/cm 2 ) covalently immobilized on the PCU-APEG surface was determined by the toluidine blue method. The modified surface was characterized by water contact angle, attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), and atomic force microscopy (AFM). The hemocompatibility was preliminarily studied by platelet adhesion test. The results indicated that heparin was successfully grafted onto the PCU surface, and meanwhile the hydrophilicity and hemocompatibility of the modified PCU surface were improved significantly compared with the blank PCU surface.

关键词： polycarbonate urethane surface modification heparin hemocompatibility poly(ethylene glycol)

Surface Modification of NiTi Alloy via Cathodic Plasma Electrolytic Deposition and its Effect on Ni Ion Release and Osteoblast Behaviors

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Plasma Science and Technology 2013年第7期15卷 648-653页

作者：燕颖蔡开勇杨维虎刘鹏 Key laboratory of Biorheological Science and Technology of Ministry of Education College of Bioengineering Chongqing University

To reduce Ni ion release and improve biocompatibility of NiTi alloy, the cathodic plasma electrolytic deposition （CPED） technique was used to fabricate ceramic coating onto a NiTi alloy surface. The formation of a coating with a rough and micro-textured surface was confirmed by X-ray diffraction, scanning electron microscopy, and energy-dispersive X-ray spectroscopy, re- spectively. An inductively coupled plasma mass spectrometry test showed that the formed coating significantly reduced the release of Ni ions from the NiTi alloy in simulated body fluid. The in- fluence of CPED treated NiTi substrates on the biological behaviors of osteoblasts, including cell adhesion, cell viability, and osteogenic differentiation function （alkaline phosphatase）, was inves- tigated in vitro. Immunofluorescence staining of nuclei revealed that the CPED treated NiTi alloy was favorable for cell growth. Osteoblasts on CPED modified NiTi alloy showed greater cell viability than those for the native NiTi substrate after 4 and 7 days cultures. More importantly, osteoblasts cultured onto a modified NiTi sample displayed significantly higher differentiation lev-els of alkaline phosphatase. The results suggested that surface functionalization of NiTi alloy with ceramic coating via the CPED technique was beneficial for cell proliferation and differentiation. The approach presented here is useful for NiTi implants to enhance bone osseointegration and reduce Ni ion release in vitro.

关键词： surface modification plasma applications biomaterials cathodic plasma elec-trolytic deposition

Polycaprolactone/mesoporous silica MCM-41 composites prepared by in situ polymerization

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Particuology 2017年第1期15卷 135-143页

作者： Laura Lopez-Figueras Nuria Navascues Silvia Irusta Department of Chemical Engineering Nanoscience Institute of Aragon (INA) University of Zaragoza 50018 Zaragoza Spain Networking Research Center on bioengineering Biomaterials and Nanomedicine CIBER-BBN 50018 Zaragoza Spain

Composites of polycaprolactone （PCL） with mesoporous silica MCM-41 and N-[3- （trimethoxysilyl）propyl]-ethylenediamine （EPTES）-functionalized MCM-41 （EPTES/MCM-41） were prepared by in situ polymerization. The thermal properties of the composites were characterized by thermogravimetric analysis. There was an increase in the thermal decomposition temperature of PCL by more than 55 ℃, when the EPTES/MCM-41 loading was higher than 2 wt%. Tensile test results indicated that adding MCM-41 increased the brittleness of the PCL matrix, while adding 8 wt% of EPTES/MCM-41 increased the Young＇s modulus by 26%. Incorporating MCM-41 increased the crystallinity of the resulting PCL composite, compared with that of PCL. Incorporating up to 5 wt% EPTES/MCM-41 slightly reduced the crystallinity of PCL. The different effects of MCM-41 and EPTES/MCM-41 on the composite reflected the degree of interaction and dispersion of the silica filler in the polymer matrix, as evidenced by results from transmission electron microscopy and atomic force microscopy.

关键词： Nanocomposite Mesoporous silica Polycaprolactone

Applications of Nanobiomaterials in the Therapy and Imaging of Acute Liver Failure

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Nano-Micro Letters 2021年第2期13卷 74-109页

作者： Yuanyuan Jin Haixia Wang Ke Yi Shixian Lv Hanze Hu Mingqiang Li Yu Tao laboratory of biomaterials and Translational Medicine The Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630People’s Republic of China Department of bioengineering University of WashingtonSeattleWA 98195USA Department of Biomedical Engineering Columbia UniversityNew YorkNY 10027USA

Acute liver failure(ALF),a fatal clinical disease featured with overwhelming hepatocyte necrosis,is a grand challenge in global ***,a satisfactory therapeutic option for curing ALF is still absent,other than liver *** are currently being developed for the diagnosis and treatment of *** liver can sequester most of nanoparticles from blood circulation,which becomes an intrinsic superiority for nanobiomaterials targeting hepatic *** can enhance the bioavailability of free drugs,thereby significantly improving the therapeutic effects in *** can also increase the liver accumulation of therapeutic agents and enable more effective targeting of the liver or specific liver *** addition,stimuli-responsive,optical,or magnetic nanomaterials exhibit great potential in the therapeutical,diagnostic,and imaging applications in ***,therapeutic agents in combination with nanobiomaterials increase the specificity of ALF therapy,diminish adverse systemic effects,and offer a multifunctional theranostic *** holds excellent significance and prospects in ALF *** this review,we summarize the therapeutic mechanisms and targeting strategies of various nanobiomaterials in *** highlight recent developments of diverse nanomedicines for ALF therapy,diagnosis,and ***,the challenges and future perspectives in the theranostics of ALF are also discussed.

关键词： Acute liver failure Nanomaterials Drug/gene/cytokines delivery Targeted therapy Imaging

Degradation behavior of austenite, ferrite, and martensite present in biodegradable Fe-based alloys in three protein-rich pseudo-physiological solutions

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Bioactive Materials 2024年第11期41卷 96-107页

作者： Abdelhakim Cherqaoui Quang Nguyen Cao Maria Laura Gatto Carlo Paternoster Paolo Mengucci Diego Mantovani laboratory for biomaterials and bioengineering Canada Research Chair I in Biomaterials and Bioengineering for the Innovation in SurgeryDepartment of Min-Met-Materials EngineeringResearch Center of CHU de QuebecDivision of Regenerative MedicineLaval UniversityQuebec CityCanada Department DIISM UniversitàPolitecnica Delle MarcheVia Brecce Bianche 1260131AnconaItaly Department SIMAU&UdR INSTM UniversitàPolitecnica Delle MarcheVia Brecce Bianche 1260131AnconaItaly

This study investigates the degradation behavior of three distinct Fe-based alloys immersed in three pseudo-physiological *** alloys,which have varied Mn and C contents,include a commercially available Fe-0.15C alloy,namely Fe–C,and two newly developed alloys,that is Fe–5Mn-0.2C(namely Fe–5Mn)and Fe–18Mn-0.6C(namely Fe–18Mn).The aim was to understand the effect of alloying elements and the testing solution on the in-vitro degradation behavior of these Fe-based *** immersion degradation and potentiodynamic corrosion tests were carried out using three pseudo-physiological solutions with albumin supply,that is modified Hanks’saline solution(MHSS),phosphate buffered saline solution(PBS),and sodium chloride solution(NaCl).After two weeks of static immersion,the results revealed that Fe–5Mn,characterized by a mixture of ferrite and martensite,showed the highest degradation rate,while Fe–C,composed solely of ferrite,showed the lowest rate of *** predominant degradation products in MHSS and PBS were phosphates and *** PBS,these products formed a remarkably stable protective layer on the surface,contributing to the lowest degradation *** contrast,porous hydroxides appeared as the main degradation products for samples immersed in NaCl solution,leading to the highest degradation *** results provided important insights into the customization of Fe–Mn–C alloys for a range of biomedical applications,meeting a variety of clinical requirements,and highlighting the considerable potential of Fe–Mn–C alloys for biomedical applications.

关键词： Biodegradable metals Fe-based alloys Degradation Albumin Pseudo-physiological solutions

Unleashing the Potential of Electroactive Hybrid biomaterials and Self‑Powered Systems for Bone Therapeutics

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Nano-Micro Letters 2025年第2期17卷 463-497页

作者： Shichang Liu Farid Manshaii Jinmiao Chen Xinfei Wang Shaolei Wang Junyi Yin Ming Yang Xuxu Chen Xinhua Yin Yunlei Zhou Honghui Hospital Xi’an Jiaotong UniversityXi’an 710018People’s Republic of China Department of bioengineering Henry Samueli School of Engineering and Applied ScienceUniversity of California Los AngelesLos Angeles 90095USA Hangzhou Institute of Technology Xidian UniversityHangzhou 311231People’s Republic of China

The incidence of large bone defects caused by traumatic injury is increasing worldwide,and the tissue regeneration process requires a long recovery time due to limited self-healing *** bioelectrical phenomena have been well recognized as critical biophysical factors in bone remodeling and *** by bioelectricity,electrical stimulation has been widely considered an external intervention to induce the osteogenic lineage of cells and enhance the synthesis of the extracellular matrix,thereby accelerating bone *** ongoing advances in biomaterials and energy-harvesting techniques,electroactive biomaterials and self-powered systems have been considered biomimetic approaches to ensure functional recovery by recapitulating the natural electrophysiological microenvironment of healthy bone *** this review,we first introduce the role of bioelectricity and the endogenous electric field in bone tissue and summarize different techniques to electrically stimulate cells and ***,we highlight the latest progress in exploring electroactive hybrid biomaterials as well as self-powered systems such as triboelectric and piezoelectric-based nanogenerators and photovoltaic cell-based devices and their implementation in bone tissue ***,we emphasize the significance of simulating the target tissue’s electrophysiological microenvironment and propose the opportunities and challenges faced by electroactive hybrid biomaterials and self-powered bioelectronics for bone repair strategies.

关键词： Electroactive biomaterials Self-powered bioelectronics Bone regeneration Bone tissue