Fabrication of Dex-Loaded Shape Memory Polymer Based Composite Nanofibers for Potential Bone Tissue Engineering

作     者：王先流 谢静 杨亮亮 娄向新 张彦中 

作者机构：Laboratory of Biomimetic Biomaterials for Regenerative Medicine Department of BioengineeringCollege of ChemistryChemical Engineering & BiotechnologyDonghua University 

出 版 物：《Journal of Donghua University(English Edition)》 (东华大学学报（英文版）)

年 卷 期：2014年第31卷第5期

页      面：709-713页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the Fundamental Research Funds for the Central Universities,China(No.14D110519) Pujiang Talent Program Funded by the Science and Technology Commission of Shanghai Municipality,China(No.10PJ1400200) National Natural Science Foundation of China(No.51073032) 

主　　题：dexamethasone (Dex) shape memory polymer (SMP) ultrasound bone tissue engineering( BTE) electrospinning 

摘      要：Biodegradable shape memory polymers( SMPs) are a class of intelligent materials with great potential for imparting biomaterial scaffolds multifunctionality in the field of tissue engineering and regenerative *** this study,the biodegradable SMP poly( D,L-lactide-co-trimethylene carbonate)( PLMC) incorporated with the dexamethasone( Dex),which was a kind of synthetic bone-formation inducing factor,was fabricated into nanofibers via *** morphology,constituent,thermal and mechanical properties of the produced Dex / PLMC composite nanofibers were characterized by scanning electron microscopy( SEM), Fourier transform infrared spectroscopy( FTIR), differential scanning calorimetry( DSC),and tensile testing,***,ultrasound was employed as a remote stimulus to regulate the Dex releasing behavior from the composite *** was found that the generated Dex /PLMC composite nanofibers had a uniform and smooth morphology with a diameter of ca.564 *** testing results showed that incorporation of the Dex gave rise to improved mechanical performance with the tensile strength,Young s modulus and strainat-break increased by 18.2%,20.0% and 64.4%,*** data revealed that the glass transition temperature( Tg) of the composite nanofibers, i.e., the thermal transition temperature( Ttrans) for activating shape memory effect, was 39.7 ℃.Moreover, the release kinetics of the encapsulated Dex in the nanofibers could be manipulated by varying the acoustic power and insonation *** results suggested that the newly developed Dex / PLMC nanofibers could be a promising drug delivery system for applications in bone tissue engineering( BTE).