检索结果-南通市图书馆

Science China Chemistry 2018年第5期61卷 627-634页

作者： Xiangchun Zhang Li Liu Ru Liu Jing Wang Xuhu Hu Qing Yuan Juanjuan Guo Gengmei Xing Yuliang Zhao Xueyun Gao CAS Key laboratory for biomedical effects of nanomaterials and nanosafety Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China Department of Chemistry and Chemical Engineering Beijing University of Technology Beijing 100124 China University of Chinese Academy of Sciences Beijing 100049 China

Increasingly serious microbial infections call for the development of new simpler methods for the precise diagnosis and specific inhibition of such pathogens. In this work, a peptide mineralized Au cluster probe was applied as a new simplified strategy to both recognize and inhibit a single bacteria species of Staphylococcus aureus(S. aureus) simultaneously. The probes are composed of peptides and Au clusters. Moreover, the peptides specifically target S. aureus cells and the Au clusters provide fluorescent imaging and have an antibacterial effect. These new probes enable the simultaneous specific detection and effective destruction S. aureus cells in situ.

关键词： Au cluster probes single bacteria species S aureus specific detection effective inhibition

Preparation and characterization of doxorubicin functionalized tiopronin-capped gold nanorods for cancer therapy

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2013年第33期58卷 4072-4076页

作者： HUO ShuaiDong JIN ShuBin ZHENG KaiYuan HE ShengTai WANG DongLiang LIANG XingJie CAS Key laboratory for Biological effects of nanomaterials and nanosafety National Center for Nanoscience and Technology School of Materials Science and Engineering Tianjin Polytechnic University

Gold nanomaterials are immerging candidates in medical diagnosis and *** them,gold nanorods(Au NRs)are widely used for cancer *** as a novel thiol drug was used to stabilize Au NRs in this ***(DOX),a chemotherapeutic drug which works by interacting with DNA to arrest the cell cycle and induce apoptosis,was linked to Au NRs through electrostatic reaction with tiopronin,to obtain Au-TIOP-DOX *** NRs are also regarded as hyperthermia agents for photothermal cancer *** delivery system(Au-TIOP-DOX NRs)was designed for passively targeting tumor cells in cancer *** importantly,the carboxyl groups of tiopronin can be modified with some biological molecules(DNA/RNA,peptides,or drugs)to make Au NRs as a novel drug-delivery system for cancer treatment.

关键词：癌症治疗硫普罗宁纳米棒黄金阿霉素功能化自然保护区化疗药物

Intracellular and extracellular enzymatic responsive micelle for intelligent therapy of cancer

在线全文

学校读者我要写书评

暂无评论

Nano Research 2023年第2期16卷 2851-2858页

作者： Dong Wan Qinan Zhu Jianxin Zhang Xi Chen Fangzhou Li Yi Liu Jie Pan School of Chemical Engineering and Technology Tiangong UniversityTianjin 300387China School of Chemistry Tiangong UniversityTianjin 300387China CAS Key laboratory for biomedical effects of nanomaterials and nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China

Recently,the incidence of cancer keeps increasing,seriously endangers human health,and has evolved into the main culprit of human *** chemotherapeutic drugs,such as paclitaxel and doxorubicin(DOX),have some disadvantages,including low therapeutic effect,poor water solubility,high toxic side effects,short blood circulation time in the body,and so *** improve the anti-tumor effect of the drug in vivo and reduce its side effects on the body,researchers have designed and developed a variety of responsive *** this work,we synthesized D-α-tocopherol polyethylene glycol 3350 succinate(TPGS3350)-Gly-Pro-Leu-Gly-Val-Arg(GPLGVR)-DOX(TPD)prodrugs in response to extracellular enzymes of matrix metalloproteinase(MMP-9)in the tumor microenvironment and FA-Asp-Glu-Val-Asp(DEVD)-DOX(FPD)prodrugs responsive to intracellular enzymes of ***,intracellular and extracellular enzyme-responsive TPD&FPD micelles with DOX(TPD&FPD&D)were successfully prepared through dialysis *** outer layer of TPGS3350 can prolong the blood circulation time of micelles in vivo,followed by accumulation of micelles at tumor tissue through enhanced permeability and retention(EPR)*** peptide of GPLGVR can be cleaved by MMP-9 enzymes to remove the outer layer of TPGS3350,exposing the targeting molecule of folate,and then the micelles are engulfed by tumor cells through folate receptor-mediated *** entering the tumor cells,the free DOX loaded in the micelles is released,which induces tumor cell apoptosis to activate caspase-3 in the cells,cutting the peptide DEVD to accelerate the intracellular release of the DOX,which further enhances cytotoxicity to improve antitumor effect.

关键词： cancer micelle peptide enzyme-responsive folate

A nanoplatform self-assembled by coordination delivers siRNA for lung cancer therapy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2023年第5期42卷 1483-1493页

作者： Zi-Yao Wang Jie Mei Dong-Qi Ni Sheng-Mei Li Jin-Min Ye Shi-Lin Li Ya-Ling Wang Ying Liu CAS Key laboratory for biomedical effects of nanomaterials and nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaBeijing100190China University of Chinese Academy of Sciences Beijing100049China GBA National Institute for Nanotechnology Innovation Guangzhou510700China

The high incidence and mortality of lung cancer have present threaten in front of people all over the *** in clinical trials find that mutations of some genes influence progress of lung cancer directly or indirectly,therefore,some kinds of molecular inhibitors benefit patients in clinical therapy,which helpfully prolong survival time of patients and show great potential in lung cancer *** is a kind of nucleic acid molecules which can silence targeted gene translation through binding to mRNA completely to cure *** delivery of siRNA for cancer therapy mostly can be classified into loading through electrostatic interaction,physical surrounding,and chemically *** delivering siRNA by coordination has not been *** study unprecedently utilizes the coordination between siRNA and Fe^(2+)to form a self-assembly structure in which doxorobicin(DOX) and human serum albumin(HSA) were used to stabilize the whole nanoplatform followed polyethylenimine(PEI) *** the heat incubation strategy,highly loading efficiency for siRNA and DOX was *** nanoplatform with stability and sustain release of drugs exhibited good lysosome escape,gene silencing effect and cytotoxicity which provided new horizon for co-deli very of siRNA and other molecular or protein drugs.

关键词： Lung cancer siRNA Coordination Nanoparticles Drug delivery

Take precautions against potential threats that carbon nanotubes may bring to you

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2020年第2期63卷 141-142页

作者： Min Luo Ziying Xiang Zhanjun Gu CAS Key laboratory for biomedical effects of nanomaterials and nanosafety Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China College of Materials Science and Optoelectronic Technology University of Chinese Academy of SciencesBeijing 100049China

Long-term pulmonary exposure to multi-walled carbon nanotubes (MWCNTs) may promote breast cancer metastasis and rapid colonization in the lungs and other organs according to recent research conducted by *** Chen,*** Z... 详细信息

关键词： carbon potential organs

Gold-based nanomaterials for the treatment of brain cancer

在线全文

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2021年第2期18卷 372-387页

作者： Li Tu Zheng Luo Yun-Long Wu Shuaidong Huo Xing-Jie Liang Fujian Provincial Key laboratory of Innovative Drug Target Research School of Pharmaceutical SciencesXiamen UniversityXiamen 361102China CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and TechnologyBeijing 100190China

Brain cancer,also known as intracranial cancer,is one of the most invasive and fatal cancers affecting people of all *** the great advances in medical technology,improvements in transporting drugs into brain tissue have been limited by the challenge of crossing the blood-brain barrier(BBB).Fortunately,recent endeavors using gold-based nanomaterials(GBNs)have indicated the potential of these materials to cross the ***,GBNs might be an attractive therapeutic strategy against brain ***,we aim to present a comprehensive summary of current understanding of the critical effects of the physicochemical properties and surface modifications of GBNs on BBB penetration for applications in brain cancer ***,the most recent GBNs and their impressive performance in precise bioimaging and efficient inhibition of brain tumors are also summarized,with an emphasis on the mechanism of their effective BBB ***,the challenges and future outlook in using GBNs for brain cancer treatment are *** hope that this review will spark researchers'interest in constructing more powerful nanoplatforms for brain disease treatment.

关键词： Gold-based nanomaterials BBB penetration brain cancer therapy

Apoptosis induced by NaYF_4:Eu^(3+) nanoparticles in liver cells via mitochondria damage dependent pathway

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2017年第1期60卷 122-129页

作者： Shaohan Zhang Shizhu Chen Chunyue Gao Yi Jin Guang Jia Zhenhua Li Dandan Liu Xingjie Liang Xinjian Yang Jinchao Zhang College of Chemistry & Environmental Science Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of EducationChemical Biology Key Laboratory of Hebei ProvinceHebei University CAS Key laboratory for Biological effects of nanomaterials and nanosafety National Center for Nanoscience and Technology

As lanthanide-doped sodium yttrium flouride(NaYF_4)nanoparticles have great potential inbiomedical applications,their biosafety is important and has attracted significant *** the present work,three different sized NaYF_4:Eu^(3+)nanoparticles have been *** BRL 3 A cell was used as a cell model to evaluate their biological *** viability and apoptosis assays were used to confirm the cytotoxicity induced by NaYF_4:Eu^(3+)*** from the elevated malondialdehyde(MDA),the decrease of superoxide dismutase(SOD),glutathione peroxidase(GSH-PX)and catalase(CAT)activity indicated reactive oxygen species(ROS)generation,which were associated with oxidative *** decrease of mitochondrial membrane potential(MMP)value demonstrated the occurrence of mitochondria ***,release of cytochrome c from mitochondria and activation of caspase-3 confirmed that NaYF_4:Eu^(3+)NPs induced apoptosis was mitochondria damage-dependent.

关键词： NaYF4 nanoparticles liver cells apoptosis oxidative stress mitochondria damage

Utilization of unmodified gold nanoparticles in colorimetric detection

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2011年第10期54卷 1757-1765页

作者： HE Sha LIU DingBin WANG Zhuo CAI KaiYong JIANG XingYu College of Bioengineering Chongqing University Chongqing 400044 China Chinese Academy of Sciences Key laboratory for Biological effects of nanomaterials and nanosafety National Center for NanoScience and Technology Beijing 100190 China

This review begins with an overview of the appealing properties and various applications of gold nanoparticles, and briefly summarizes recent advances in using unmodified gold nanoparticles to detect different kinds of targets including nucleic acids, proteins, metal ions and small organic molecules. The key point to the unmodified gold nanoparticle-based visual detection assay is to control dispersion and aggregation of colloidal nanoparticles by targets of interest, which usually relies on affinities between gold nanoparticles and targets. The degree of dispersion or aggregation can be visualized through the change of the solution color or the precipitation of nanoparticles from the solution. Thus, the existence of the target molecules can be trans-lated into optical signals and monitored by the naked eye conveniently. Finally, some future prospects of this research field are given.

关键词： gold nanoparticles colorimetric detection biosensor

Stable isotope labeling of nanomaterials for biosafety evaluation and drug development

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2022年第7期33卷 3303-3314页

作者： Xue-Ling Chang Lingyun Chen Boning Liu Sheng-Tao Yang Haifang Wang Aoneng Cao Chunying Chen CAS Key laboratory for biomedical effects of nanomaterials and nanosafety Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Key laboratory of Pollution Control Chemistry and Environmental Functional Materials for Qinghai-Tibet Plateau of the National Ethnic Affairs Commission School of Chemistry and EnvironmentSouthwest Minzu UniversityChengdu 610041China Institute of Nanochemistry and Nanobiology Shanghai UniversityShanghai 200444China CAS Key laboratory for biomedical effects of nanomaterials and nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of Chinaand University of Chinese Academy of SciencesBeijing 100190China

Quantitative information,such as environmental migration,absorption,biodistribution,biotransformation,and elimination,is fundamental and essential for the nanosafety evaluations of *** to the complexity of biological and environmental systems,it is challenging to develop quantitative approaches and tools that could characterize intrinsic behaviors of nanomaterials in the *** isotopic tracers are ideal candidates to tune the physical properties of nanomaterials while preserving their chemical *** this review article,we summarized the stable isotope labeling methods of nanomaterials for evaluating their environmental and biological *** skeleton labeling protocols of carbon nanomaterials and metal/metal oxide nanoparticles were *** advantages and disadvantages of stable isotope labeling were discussed in comparison with other quantitative methods for *** quantitative information of nanomaterials in environmental and biological systems was summarized along with the biosafety *** benefits for drug development of nanomedicine were analyzed based on the targeting effects,persistent accumulation,and ***,the challenges and future perspectives of stable isotope labeling in nanoscience and nanotechnology were discussed.

关键词： Stable isotope labeling Quantification Carbon nanomaterials Metal oxide nanoparticles Nanotoxicity biomedical effects

Targeted peptide-Au cluster binds to epidermal growth factor receptor (EGFR) in both active and inactive states： a clue for cancer inhibition through dual pathways

在线全文

学校读者我要写书评

暂无评论

Science Bulletin 2018年第6期63卷 349-355页

作者： Peng Zhang Jiao Zhai Xueyun Gao Hongkang Zhao Wenyong Su Lina Zhao School of Physics Beijing Institute of Technology Beijing 100081 China Key laboratory for biomedical effects of nanomaterials and nanosafety Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China Department of Chemistry and Chemical Engineering. Beijing University of Technology Beijing 100124 China

The epidermal growth factor receptor （EGFR） has become an important target protein in anticancer drug development. Meanwhile, peptide-Au cluster has been proposed as potential targeted nano-drug assembled by targeting peptide. Here, we designed and synthesized a novel peptide-Au cluster as AuloPeptides to target to EGFR. We found AumPeptides could target to the natural binding sites of all EGFRs at mem- brane in both active and inactive states by molecular simulations. Its targeted ability was further verified by the co-localization and blocking experiments. We also study the configuration modifications of both active and inactive EGFRs after binding by AumPeptides. For active EGFR, the absorbed AuloPeptide5 might replace the natural ligand in EGFR endocytosis process. Then, the peptide-Au cluster in endochylema could inhibit the cancer relating enzyme activity including thioredoxin reductasel （TrxR1） and induce the oxidative stress mediated apoptosis in tumor cells. For inactive EGFR, it was retained in inactive state by Au10 Peptides binding to inhibit dimerization of EGFR for anticancer. Both pathways might be applied in anticancer drug development based on the theoretical and experimental study here.

关键词： peptide-Au cluster EGFR Targeted binding Anticancer