Gold-based nanomaterials for the treatment of brain cancer

作     者：Li Tu Zheng Luo Yun-Long Wu Shuaidong Huo Xing-Jie Liang Li Tu;Zheng Luo;Yun-Long Wu;Shuaidong Huo;Xing-Jie Liang

作者机构：Fujian Provincial Key Laboratory of Innovative Drug Target ResearchSchool of Pharmaceutical SciencesXiamen UniversityXiamen 361102China CAS Center for Excellence in NanoscienceCAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and TechnologyBeijing 100190China 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2021年第18卷第2期

页      面：372-387页

核心收录：

学科分类：1002[医学-临床医学] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(NSFC)(Grant Nos.82001959 and 31630027) NSFC-German Research Foundation(DFG)project(Grant No.31761133013) appreciate support from the“Ten Thousand Elite Plan”(Grant No.Y9E21Z11) CAS International Collaboration Plan(Grant No.E0632911ZX) the National Key Research&Development Program of China(Grant No.2018YFE0117800) the Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety CAS(Grant No.NSKF202003) Fujian Provincial Key Laboratory of Innovative Drug Target Research(Grant No.FJ-YW-2021KF04) financial support from the Nanqiang Outstanding Young Talents Program from Xiamen University 

主　　题：Gold-based nanomaterials BBB penetration brain cancer therapy 

摘      要：Brain cancer,also known as intracranial cancer,is one of the most invasive and fatal cancers affecting people of all *** the great advances in medical technology,improvements in transporting drugs into brain tissue have been limited by the challenge of crossing the blood-brain barrier(BBB).Fortunately,recent endeavors using gold-based nanomaterials(GBNs)have indicated the potential of these materials to cross the ***,GBNs might be an attractive therapeutic strategy against brain ***,we aim to present a comprehensive summary of current understanding of the critical effects of the physicochemical properties and surface modifications of GBNs on BBB penetration for applications in brain cancer ***,the most recent GBNs and their impressive performance in precise bioimaging and efficient inhibition of brain tumors are also summarized,with an emphasis on the mechanism of their effective BBB ***,the challenges and future outlook in using GBNs for brain cancer treatment are *** hope that this review will spark researchers interest in constructing more powerful nanoplatforms for brain disease treatment.