Stable isotope labeling of nanomaterials for biosafety evaluation and drug development

作     者：Xue-Ling Chang Lingyun Chen Boning Liu Sheng-Tao Yang Haifang Wang Aoneng Cao Chunying Chen Xue-Ling Chang;Lingyun Chen;Boning Liu;Sheng-Tao Yang;Haifang Wang;Aoneng Cao;Chunying Chen

作者机构：CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyInstitute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Key Laboratory of Pollution Control Chemistry and Environmental Functional Materials for Qinghai-Tibet Plateau of the National Ethnic Affairs CommissionSchool of Chemistry and EnvironmentSouthwest Minzu UniversityChengdu 610041China Institute of Nanochemistry and NanobiologyShanghai UniversityShanghai 200444China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of Chinaand University of Chinese Academy of SciencesBeijing 100190China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2022年第33卷第7期

页      面：3303-3314页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 10[医学] 0702[理学-物理学] 

基　　金：financial support from the National Key Research and Development Program of China(No.2021YFA1200904) the Beijing Natural Science Foundation(No.2202065) the Fundamental Research Funds for the Central Universities,Southwest Minzu University(No.2021PTJS36) Major instrument project of National Natural Science Foundation of China(No.22027810) 

主　　题：Stable isotope labeling Quantification Carbon nanomaterials Metal oxide nanoparticles Nanotoxicity Biomedical effects 

摘      要：Quantitative information,such as environmental migration,absorption,biodistribution,biotransformation,and elimination,is fundamental and essential for the nanosafety evaluations of *** to the complexity of biological and environmental systems,it is challenging to develop quantitative approaches and tools that could characterize intrinsic behaviors of nanomaterials in the *** isotopic tracers are ideal candidates to tune the physical properties of nanomaterials while preserving their chemical *** this review article,we summarized the stable isotope labeling methods of nanomaterials for evaluating their environmental and biological *** skeleton labeling protocols of carbon nanomaterials and metal/metal oxide nanoparticles were *** advantages and disadvantages of stable isotope labeling were discussed in comparison with other quantitative methods for *** quantitative information of nanomaterials in environmental and biological systems was summarized along with the biosafety *** benefits for drug development of nanomedicine were analyzed based on the targeting effects,persistent accumulation,and ***,the challenges and future perspectives of stable isotope labeling in nanoscience and nanotechnology were discussed.