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TRDMT1 exhibited protective effects against LPS-induced inflammation in rats through TLR4-NF-κB/MAPK-TNF-αpathway

Animal Models and Experimental Medicine 2022年第2期5卷 172-182页

作者： Zhengguang Li Xiaolong Qi Xu Zhang Lei Yu Lijuan Gao Weining Kong Wei Chen Wei Dong Lijun Luo Dan Lu Lianfeng Zhang Yuanwu Ma Key Laboratory of human Disease Comparative Medicine National Health Commission of China(NHC)Institute of Laboratory Animal ScienceChinese Academy of Medical SciencesPeking Union Medicine CollegeBeijingChina National human Diseases Animal Model resource Center and Beijing Engineering Research Center for Experimental Animal Models of human Critical Diseases Institute of Laboratory Animal SciencePeking Union Medicine CollegeChinese Academy of Medical SciencesBeijingChina Neuroscience Center Chinese Academy of Medical SciencesBeijingChina

Background:Inflammation is a complex physiological and pathological *** many types of inflammation are well characterized,their physiological func-tions are largely *** aspartic acid methyltransferase 1(TRDMT1)has been implicated as a stress-related protein,but its intrinsic biological role is ***:We constructed a Trdmt1 knockout rat and adopted the LPS-induced sepsis *** curve,histopathological examination,expression of inflammatory fac-tors,and protein level of TLR4 pathway were ***:Trdmt1 deletion had no obvious impact on development and ***1 de-letion slightly increased the mortality during *** data showed that Trdmt1 strongly responded in LPS-treated rats,and Trdmt1 knockout rats were vulnerable to LPS treat-ment with declined survival *** also observed more aggravated tissue damage and more cumulative functional cell degeneration in LPS-treated knockout rats compared with control *** studies showed upregulated TNF-αlevel in liver,spleen,lung,and serum tissues,which may be explained by enhanced p65 and p38 ***:Our data demonstrated that Trdmt1 plays a protective role in inflamma-tion by regulating the TLR4-NF-κB/MAPK-TNF-α*** work provides useful information to understand the TRDMT1 function in inflammation.

关键词： inflammation knockout rat TLR4 pathway TNF-α Trdmt1

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Generation and measurement of arbitrary four-dimensional spatial entanglement between photons in multicore fibers

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Photonics Research 2019年第1期7卷 19-27页

作者： HEE JUNG LEE HEE SU PARK korea Research institute of Standards and Science(KRISS) Agency for Defense development

High-dimensional entanglement is a valuable resource for secure and efficient quantum information processing.A major challenge for practical use of multidimensional quantum systems is the establishment of controls over arbitrary superposition states in realistic conditions. This work demonstrates spatially entangled photon pairs propagating through two separate four-core optical fibers with the amplitudes and phases of the superposition being independently controllable. Using quantum state analyzers that can detect arbitrary multicore superposition states, Bell-type CGLMP inequalities in two, three, and four dimensions are directly tested. Enhanced violation of the inequality by slight nonmaximality of entanglement is also demonstrated.

关键词： High-dimensional entanglement efficient quantum demonstrates spatially

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Anethole improves the developmental competence of porcine embryos by reducing oxidative stress via the sonic hedgehog signaling pathway

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Journal of Animal Science and Biotechnology 2023年第4期14卷 1395-1407页

作者： Ye Eun Joo Pil-Soo Jeong Sanghoon Lee Se-Been Jeon Min-Ah Gwon Min Ju Kim Hyo-Gu Kang Bong-Seok Song Sun-Uk Kim Seong-Keun Cho Bo-Woong Sim Futuristic Animal resource and Research Center Korea Research Institute of Bioscience and BiotechnologyCheongjuSouth Korea Department of Animal Science College of Natural Resources and Life SciencePusan National UniversityMiryangSouth Korea Laboratory of Theriogenology College of Veterinary MedicineChungnam National UniversityDaejeonSouth Korea Department of Biotechnology College of EngineeringDaegu UniversityGyeongsanSouth Korea Department of Animal Science and Biotechnology College of Agriculture and Life ScienceChungnam National UniversityDaejeonSouth Korea Department of Functional Genomics University of Science and TechnologyDaejeonSouth Korea Department of Animal Science College of Natural Resources and Life ScienceLife and Industry Convergence Research InstitutePusan National UniversityMiryangSouth Korea

Background Anethole(AN)is an organic antioxidant compound with a benzene ring and is expected to have a positive impact on early embryogenesis in ***,no study has examined the effect of AN on porcine embryonic ***,we investigated the effect of AN on the development of porcine embryos and the underlying *** We cultured porcine in vitro-fertilized embryos in medium with AN(0,0.3,0.5,and 1 mg/mL)for 6 *** at 0.5 mg/mL significantly increased the blastocyst formation rate,trophectoderm cell number,and cellular survival rate compared to the ***-supplemented embryos exhibited significantly lower reactive oxygen species levels and higher glutathione levels than the ***,AN significantly improved the quantity of mitochondria and mitochondrial membrane potential,and increased the lipid droplet,fatty acid,and ATP ***,the levels of proteins and genes related to the sonic hedgehog(SHH)signaling pathway were significantly increased by *** These results revealed that AN improved the developmental competence of porcine preimplantation embryos by activating SHH signaling against oxidative stress and could be used for large-scale production of high-quality porcine embryos.

关键词： Anethole Lipid metabolism Mitochondrial function Porcine embryo development Sonic hedgehog signaling pathway

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Investigating environmental quality among G20 nations: The impacts of environmental goods and low-carbon technologies in mitigating environmental degradation

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Geoscience Frontiers 2024年第1期15卷 84-96页

作者： Ernest Baba Ali Samira Shayanmehr Riza Radmehr Richard Bayitse Ebenezer Agbozo Department of Economics University for Development StudiesTamale P.O.Box TL1350Ghana Department of Agricultural Economics Ferdowsi University of MashhadIran Council for Scientific and Industrial Research Institute of Industrial ResearchAccra P.O.Box LG 576Ghana Department of Big Data Analytics and Methods of Video Analysis Ural Federal University19 Mira Str60002 EkaterinburgRussia

Environmental goods and low-carbon technologies have long been identified as having the potential to drive long-term economic progress without compromising environmental quality. However, their exact role in mitigating environmental degradation are yet to be unravelled. In addressing this shortfall, the extant literature relied on research funding and patent application as proxies for green technologies. Having established the weaknesses in the use of these variables as proxies for green technologies, this study explored the role of trade in environmental goods and low-carbon technologies in boosting environmental quality among G20 nation using a panel dataset from 1994 to 2018. The study employed the Method of Moment quantile regression for the model estimation and the Ridge regression, Discroll-Kraay standard error, and the Newey-West standard error estimators to test the robustness of our findings. Our findings indicate that whereas environmental goods promote environmental quality, low-carbon technologies decrease same. Also, the study found economic growth to exert an aggravating effect on environmental quality, while foreign direct investments, natural resource rents, human capital development, and renewable energy consumption exert positive influence on environmental quality. Based on the findings of the study, G20 nations are encouraged to improve green market structures to improve the trade in environmental goods and low-carbon technologies. Also the share of renewable energy sources in the overall energy basket must be improved to help improve environmental quality.

关键词： Environmental quality Environmental goods Low-carbon technology G20 nations

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Time lag effect of vegetation response to seasonal precipitation in the Mara River Basin

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Ecological Processes 2023年 665-679页

作者： Shouming Feng Zhenke Zhang Shuhe Zhao Xinya Guo Wanyi Zhu Priyanko Das School of Geography and Oceanography Sciences Nanjing University institute of African Studies Nanjing University Jiangsu Center for Collaborative Innovation in Geographical Information resource development and Application

Background Mara River Basin is an ecologically fragile area in East Africa, with a pattern of alternating wet and dry seasons shaped by periodic precipitation. Considering the regional biological traits and climatic change, the vegetation's response to seasonal variation is complicated and frequently characterized by time lags. This study analyzed the variation of the Normalized Difference Vegetation Index(NDVI) and investigated its time lag to precipitation at the monthly scale. NDVI characteristic peaks were proposed from the perspective of seasonal mechanisms and were quantified to assess the lag *** The results showed that the Anomaly Vegetation Index could identify low precipitation in 2006, 2009,and 2017. The NDVI showed an increasing trend in 75% of areas of the basin, while showed a decreased significance in 3.5% of areas, mainly in savannas. As to the time lag, the 1-month lag effect dominated most months, and the spatiotemporal disparities were noticeable. Another method considering the alternations of wet and dry seasons found that the time lag was approximately 30 days. Based on the time distribution of NDVI characteristic peaks, the average time lag was 35.5 days and increased with the range of *** The findings confirmed an increasing trend of NDVI in most regions from 2001 to 2020, while the trends were most obvious in the downstream related to human activities. The results could reflect the time lag of NDVI response to precipitation, and the 1-month lag effect dominated in most months with spatial heterogeneity. Four NDVI characteristic peaks were found to be efficient indicators to assess the seasonal characteristics and had a great potential to quantify vegetation variation.

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Metformin booster adipocyte-targeted gene therapy for the treatment of obesity and related metabolic syndromes

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Science China Chemistry 2022年第4期65卷 796-809页

作者： Jie Chen Jee Young Chung Huapan Fang Lin Lin Yong-Hee Kim Huayu Tian Xuesi Chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Department of Bioengineering Institute for Bioengineering and Biopharmaceutical ResearchBK 21 Plus Future Biopharmaceutical Human Resources Training and Research TeamHanyang University133-791 SeoulRepublic of Korea

Obesity has become an important public problem that endangers human conditions and urgently needs to be solved. However,most weight-loss drugs on the market have little effect and are accompanied by adverse effects such as strokes and heart ***, we construct an adipocyte-targeting polypeptide-based gene carrier consisting of an adipocyte-targeting peptide and ptoluylsulfonyl arginine-modified polylysine(ATS-PLL-RT), which can specifically bind to the prohibitin of mature *** further construct a short hairpin RNA(shRNA) to simultaneously silence fatty acid binding proteins 4 and 5(shFABP4/5).FABPs are molecular chaperones for fatty acid metabolism and storage in cells. Moreover, we introduce metformin for combined therapy. First, the metformin combination can effectively improve the efficiency of gene transfection. In addition, metformin itself has an alleviating effect on diet-induced obesity and relevant metabolic diseases. The combination treatment of obese mice with ATS-PLL-RT/shFABP4/5 and metformin achieves body weight reduction and metabolic recovery. This study provides a potentially effective strategy for the clinical treatment of obesity as well as mitigating obesity-induced metabolic syndromes.

关键词： FABP4/5 gene therapy insulin resistance metformin obesity

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3D engineered tissue models for studying human-specific infectious viral diseases

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Bioactive Materials 2023年第3期21卷 576-594页

作者： Kyeong Seob Hwang Eun U Seo Nakwon Choi Jongbaeg Kim Hong Nam Kim Brain Science institute Korea Institute of Science and Technology(KIST)Seoul02792Republic of Korea School of Mechanical Engineering Yonsei UniversitySeoul03722Republic of Korea Yonsei-KIST Convergence Research institute Yonsei UniversitySeoul03722Republic of Korea Division of Bio-Medical Science&Technology KIST SchoolKorea University of Science and Technology(UST)Seoul02792Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul02841Republic of Korea

Viral infections cause damage to various organ systems by inducing organ-specific symptoms or systemic multi-organ *** on the infection route and virus type,infectious diseases are classified as respiratory,nervous,immune,digestive,or skin *** these infectious diseases can widely spread in the com-munity and their catastrophic effects are severe,identification of their causative agent and mechanisms un-derlying their pathogenesis is an urgent *** infection-associated mechanisms have been studied in two-dimensional(2D)cell culture models and animal models,they have shown limitations in organ-specific or human-associated pathogenesis,and the development of a human-organ-mimetic system is ***,three-dimensional(3D)engineered tissue models,which can present human organ-like physiology in terms of the 3D structure,utilization of human-originated cells,recapitulation of physiological stimuli,and tight cell–cell interactions,were ***,recent studies have shown that these models can recapitulate infection-associated *** this review,we summarized the recent advances in 3D engineered tissue models that mimic organ-specific viral ***,we briefly described the limitations of the current 2D and animal models in recapitulating human-specific viral infection ***,we provided an overview of recently reported viral infection models,focusing particularly on organ-specific infection ***,a future perspective that must be pursued to reconstitute more human-specific infectious diseases is presented.

关键词： 3D engineered tissue model Infectious viral disease Infection route Pathology In vivo-mimicking

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Deep Convolutional Neural Networks for Accurate Classification of Gastrointestinal Tract Syndromes

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Computers, Materials & Continua 2024年第1期78卷 1207-1225页

作者： Zahid Farooq Khan Muhammad Ramzan Mudassar Raza Muhammad Attique Khan Khalid Iqbal Taerang Kim Jae-Hyuk Cha Department of Computer Science COMSATS University IslamabadWah CampusWah47040Pakistan Department of Computer Science and Mathematics Lebanese American UniversityBeirut13-5053Lebanon Department of Computer Science HITEC UniversityTaxila47080Pakistan Department of Computer Science COMSATS University IslamabadAttock CampusAttock43600Pakistan Department of Computer Science Hanyang UniversitySeoul04763Korea

Accurate detection and classification of artifacts within the gastrointestinal(GI)tract frames remain a significant challenge in medical image *** science combined with artificial intelligence is advancing to automate the diagnosis and treatment of numerous *** to this is the development of robust algorithms for image classification and detection,crucial in designing sophisticated systems for diagnosis and *** study makes a small contribution to endoscopic image *** proposed approach involves multiple operations,including extracting deep features from endoscopy images using pre-trained neural networks such as Darknet-53 and ***,feature optimization utilizes the binary dragonfly algorithm(BDA),with the fusion of the obtained feature *** fused feature set is input into the ensemble subspace k nearest neighbors(ESKNN)*** Kvasir-V2 benchmark dataset,and the COMSATS University Islamabad(CUI)Wah private dataset,featuring three classes of endoscopic stomach images were *** assessments considered various feature selection techniques,including genetic algorithm(GA),particle swarm optimization(PSO),salp swarm algorithm(SSA),sine cosine algorithm(SCA),and grey wolf optimizer(GWO).The proposed model excels,achieving an overall classification accuracy of 98.25% on the Kvasir-V2 benchmark and 99.90% on the CUI Wah private *** approach holds promise for developing an automated computer-aided system for classifying GI tract syndromes through endoscopy images.

关键词： Feature fusion Darknet-53 Xception binary dragonfly algorithm ensemble

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Designed fabrication of active tumor targeting covalent organic framework nanotherapeutics via a simple post-synthetic strategy

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Nano Research 2023年第5期16卷 7085-7094页

作者： Yue Yu Guoxin Zhang Zhongping Li Jia Wang Yang Liu Rahul Bhardwaj Renu Wadhwa Yuki Nagao Mototada Shichiri Ran Gao Biomedical Research institute National Institute of Advanced Industrial Science and Technology(AIST)Osaka 563-8577Japan AIST-INDIA DAILAB DBT-AIST International Center for Translational&Environmental Research(DAICENTER)AISTTsukubaIbaraki 305-8565Japan Beijing Engineering Research Center for Experimental Animal Models of human Critical Diseases NHC Key Laboratory of Human Disease Comparative MedicineNational Human Diseases Animal Model Resource CenterInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences(CAMS)&Peking Union Medical CollageBeijing 100021China School of Materials Science Japan Advanced Institute of Science and TechnologyIshikawa 923-1211Japan Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei-roSeodaemun-guSeoul 120-749Republic of Korea Flexible 3D System Integration Laboratory SANKENOsaka UniversityOsaka 567-0047Japan

Developing agents that can accurately differentiate tumors from normal healthy tissues is of utmost importance for safe cancer *** targeting has been considered as an effective technique for tumor *** this work,we demonstrate a folate-functionalized nanoscale covalent organic framework(FATD nCOF)highly specific to cancer cells through active targeting of their enriched folate receptors(FRs).The FATD nCOF prepared by simple post-synthetic modification of the COF surface defeats disperses well in water and exhibits a high loading capacity for various anticancer *** biocompatible FATD nCOF is selectively internalized by FR-harboring cancer cells and consequently augments the efficacy of the loaded drug,Withaferin A(Wi-A),for targeted cancer cell *** biomolecular mechanism studies,Wi-A-loaded FATD(FATD@Wi-A)nanocomposites show remarkably a higher rate of apoptosis in FR-enriched cancer *** analyses of FR-positive and FR-negative tumor xenografts reveal enhanced selective antitumor activity of FATD@Wi-A *** together,the study findings suggest that FATD nCOF holds great promise for active targeting of tumors in *** simple yet effective technology might be valuable for creating new state-of-the-art COFs for chemical and biomedical applications.

关键词： covalent organic framework active targeting folate receptor drug delivery cancer therapy

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Blockade of PD-L1/PD-1 signaling promotes osteo-/odontogenic differentiation through Ras activation

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International Journal of Oral Science 2022年第2期14卷 164-173页

作者： So Mi Jeon Je Sun Lim Su Hwan Park Hyung Joon Kim Hyung-Ryong Kim Jong-Ho Lee Department of health Sciences The Graduate School of Dong-A UniversityBusanRepublic of Korea Department of Oral Physiology Periodontal Diseases Signaling Network Research CenterDental and Life Science InstituteSchool of DentistryPusan National UniversityYangsanRepublic of Korea Department of Pharmacology College of DentistryJeonbuk National UniversityJeonjuRepublic of Korea Department of Biomedical Sciences Dong-A UniversityBusanRepublic of Korea

The programmed cell death ligand 1(PD-L1)and its receptor programmed cell death 1(PD-1)deliver inhibitory signals to regulate immunological tolerance during immune-mediated ***,the role of PD-1 signaling and its blockade effect on human dental pulp stem cells(h DPSCs)differentiation into the osteo-/odontogenic lineage remain *** show here that PD-L1 expression,but not PD-1,is downregulated during osteo-/odontogenic differentiation of h ***,PD-L1/PD-1 signaling has been shown to negatively regulate the osteo-/odontogenic differentiation of h ***,depletion of either PD-L1 or PD-1 expression increased ERK and AKT phosphorylation levels through the upregulation of Ras enzyme activity,which plays a pivotal role during h DPSCs osteo-/odontogenic *** with nivolumab(a human anti-PD-1 monoclonal antibody),which targets PD-1 to prevent PD-L1 binding,successfully enhanced osteo-/odontogenic differentiation of h DPSCs through enhanced Ras activity-mediated phosphorylation of ERK and *** findings underscore that downregulation of PD-L1 expression accompanies during osteo-/odontogenic differentiation,and h DPSCs-intrinsic PD-1 signaling inhibits osteo-/odontogenic *** findings provide a significant basis that PD-1 blockade could be effective immunotherapeutic strategies in h DPSCs-mediated dental pulp regeneration.

关键词： death finding monoclonal

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