Designed fabrication of active tumor targeting covalent organic framework nanotherapeutics via a simple post-synthetic strategy
作者机构：Biomedical Research InstituteNational Institute of Advanced Industrial Science and Technology(AIST)Osaka 563-8577Japan AIST-INDIA DAILABDBT-AIST International Center for Translational&Environmental Research(DAICENTER)AISTTsukubaIbaraki 305-8565Japan Beijing Engineering Research Center for Experimental Animal Models of Human Critical DiseasesNHC Key Laboratory of Human Disease Comparative MedicineNational Human Diseases Animal Model Resource CenterInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences(CAMS)&Peking Union Medical CollageBeijing 100021China School of Materials ScienceJapan Advanced Institute of Science and TechnologyIshikawa 923-1211Japan Department of Chemical and Biomolecular EngineeringYonsei University50 Yonsei-roSeodaemun-guSeoul 120-749Republic of Korea Flexible 3D System Integration LaboratorySANKENOsaka UniversityOsaka 567-0047Japan
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2023年第16卷第5期
页 面：7085-7094页
核心收录：
学科分类：1002[医学-临床医学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 10[医学] 0702[理学-物理学]
基 金：the Japan Society for the Promotion of Science(JSPS)KAKENHI Grant-in-Aid for Early-Career Scientists(No.21K14508) Takeda Science Foundation Advanced Technology Institute Research Grants 2021 Senri Life Science Foundation Murata Science Foundation,JST CREST Grant(No.JPMJCR21B3) grants from AIST(Japan)and the Department of Biotechnology(Govt.of India)under the DAILAB and DAICENTER projects the National Key Research and Development Program of China(No.2022YFF0710705)
主 题：covalent organic framework active targeting folate receptor drug delivery cancer therapy
摘 要：Developing agents that can accurately differentiate tumors from normal healthy tissues is of utmost importance for safe cancer *** targeting has been considered as an effective technique for tumor *** this work,we demonstrate a folate-functionalized nanoscale covalent organic framework(FATD nCOF)highly specific to cancer cells through active targeting of their enriched folate receptors(FRs).The FATD nCOF prepared by simple post-synthetic modification of the COF surface defeats disperses well in water and exhibits a high loading capacity for various anticancer *** biocompatible FATD nCOF is selectively internalized by FR-harboring cancer cells and consequently augments the efficacy of the loaded drug,Withaferin A(Wi-A),for targeted cancer cell *** biomolecular mechanism studies,Wi-A-loaded FATD(FATD@Wi-A)nanocomposites show remarkably a higher rate of apoptosis in FR-enriched cancer *** analyses of FR-positive and FR-negative tumor xenografts reveal enhanced selective antitumor activity of FATD@Wi-A *** together,the study findings suggest that FATD nCOF holds great promise for active targeting of tumors in *** simple yet effective technology might be valuable for creating new state-of-the-art COFs for chemical and biomedical applications.
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