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Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting Qiu Na Li Zhengxiang Zhou Ru Ye Liyan Zhong Yashuang Xu Junhui Ren Yi Liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community health service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

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Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria Jiménez Carretero IrisÁlvarez-Merz Jorge Hernández-Campano Sergei A.Kirov Jesús M.Hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for health Research(IRYCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative Medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

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Effects of different plasma expanders on rats subjected to severe acute normovolemic hemodilution

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Military Medical Research 2021年第2期8卷 183-195页

作者： Guo-Xing You Bing-Ting Li Zhen Wang Quan Wang Ying Wang Jing-Xiang Zhao Lian Zhao Hong Zhou Institute of health service and Transfusion Medicine Beijing 100850China

Background:Plasma expanders are widely used for acute normovolemic hemodilution(ANH).However,existing studies have not focused on large-volume infusion with colloidal plasma expanders,and there is a lack of studies that compare the effects of different plasma ***:The viscosity,hydrodynamic radius(Rh)and colloid osmotic pressure(COP)of plasma expanders were determined by a cone-plate viscometer,Zetasizer and cut-off membrane,*** male rats were randomized into five groups with Gelofusine(Gel),Hydroxyethyl Starch 200/0.5(HES200),Hydroxyethyl Starch 130/0.4(HES130),Hydroxyethyl Starch 40(HES40),and Dextran 40(Dex40),with 12 rats used in each group to build the ANH *** was performed by the withdrawal of blood and simultaneous infusion of plasma ***-base,lactate,blood gas and physiological parameters were ***:Gel had a lower intrinsic viscosity than HES200 and HES130(P<0.01),but at a low shear rate in a mixture of colloids,red cells and plasma,Gel had a higher viscosity(P<0.05 or P<0.01,respectively).For hydroxyethyl starch plasma expanders,the COP at a certain concentration decreases from 11.1 mmHg to 6.1 mmHg with the increase of Rh from 10.7 nm to 20.2 nm.A severe ANH model,with the hematocrit of 40%of the baseline level,was established and accompanied by disturbances in acid-base,lactate and blood gas *** the end of ANH and 60 min afterward,the Dex40 group showed a worse outcome in maintaining the acid-base balance and systemic oxygenation compared to the other *** systolic blood pressure(SBP),diastolic blood pressure(DBP),and mean arterial pressure(MAP)decreased significantly in all groups at the end of *** DBP and MAP in the Dex40 group further decreased 60 min after the end of *** the process of ANH,the Dex40 group showed a drop and recovery in SBP,DBP and *** DBP and MAP in the HES200 group were significantly higher than those in the other groups at some time points(P<0.05 o

关键词： Acute normovolemic hemodilution Plasma expander Acid-base Lactate Blood gas Physiological arameters

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Management of dog bites by frontline service providers in primary healthcare facilities in the Greater Accra Region of Ghana,2014-2015

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Infectious Diseases of Poverty 2018年第1期7卷 189-198页

作者： Ernest Kenu Vincent Ganu Charles Lwanga Noora Richard Adanu Margaret Lartey Department of Medicine School of Medicine and DentistryCollege of Health SciencesUniversity of GhanaKorle BuAccraGhana Department of Epidemiology and Disease Control School of Public HealthCollege of Health SciencesUniversity of GhanaLegonAccraGhana Department of Medicine and Therapeutics Korle Bu Teaching HospitalAccraGhana Sunyani Regional Hospital Ghana Health ServiceSunyaniGhana Department of Population Family and Reproductive health School of Public HealthCollege of Health SciencesUniversity of GhanaLegonAccraGhana.

Background:Dog bites are common in developing countries including Ghana,with the victims often being *** some breeds of dogs have been identified as being more aggressive than others,all dog bites carry a risk of *** and initial assessment of the risk for tetanus and rabies infection with appropriate interventions such as wound management and subsequent selection of prophylactic antibiotics are essential in the management of dog *** study examined the management of patients with dog bites by frontline service providers at primary healthcare facilities in the Greater Accra Region,***:We conducted a cross-sectional study in 66 public health facilities in the Greater Accra Region from July 2014 to April *** to four frontline service providers were randomly selected to participate from each facility.A structured questionnaire was administered to all consenting *** variables were presented as means and standard *** frontline service providers’knowledge was assessed as a discrete variable and values obtained presented as percentages and *** chi-square test of proportions was used to determine any significant associations between the various categories of the frontline service providers and their knowledge about the management of ***:Regarding the frontline service providers’knowledge about rabies,57.8%(134/232)were correct in that the rabies virus is the causative agent of rabies,39.2%(91/232)attributed it to a dog bite,2.6%(6/232)did not know the cause,and one person(0.4%)attributed it to the herpes *** 15.5%(36/232)knew the incubation period in dogs and the period required to observe for signs of a rabies *** respect to the administration of rabies immunoglobulin,42.2%(98/232)of the frontline service providers did not know how to administer *** the facilities visited,76%(50/66)did not have the rabies vaccines and 44%(102/232)of frontline service p

关键词： Dog bites Rabies Frontline service providers healthcare facilities Greater Accra Region Ghana

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Success of intravenous immunoglobulin and steroids in managing severe COVID-19 following lung transplantation:A case report

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World Journal of Transplantation 2025年第1期15卷 178-184页

作者： Yen-Shou Kuo Kuan-Hsun Lin Ying-Yi Chen Yuan-Ming Tsai Ti-Hui Wu Hsu-Kai Huang Tsai-Wang Huang Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114202Taiwan

BACKGROUND Coronavirus disease 2019(COVID-19)pneumonia with severe septic shock and acute respiratory distress syndrome(ARDS)are critical illnesses for patients following *** immunoglobulin(IVIG)plays a role in both immune support and inflammation control,especially in immunocompromised *** case report describes the first successful experience using IVIG and pulse steroids to manage this critical condition following lung *** SUMMARY A 65-year-old male patient reported a history of chronic obstructive pulmonary disease and poor lung function and received bilateral sequential lung ***,he developed COVID-19 pneumonia,severe septic shock,and *** recovered from this critical condition after empirical antibiotics administration and veno-venous extracorporeal membrane oxygenation,in addition to IVIG and pulse *** IVIG is a valuable adjunct in managing severe sepsis in lung transplant recipients after COVID-19 *** aim,for the first time,to report the success of such a management approach for COVID-19 ARDS and sepsis in the post-lung transplant *** further investigations,this is a starting point for wider analysis of such an approach in this setting and consequently helps guide clinical practice for such a challenging patient population moving forward.

关键词： COVID-19 Septic shock Intravenous immunoglobulin Lung transplantation Post-transplant complications Case report

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AN ANALYSIS OF MULTIPLE CONGENITAL ANOMALY SYNDROMES IN A CHINESE POPULATION

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中华医学杂志(英文版) 1991年第7期104卷 577-580页

作者：林德深周潘纯娴 Clinical Genetic service Department of Health Hong Kong.

During an eight-year period, 4 890 index patients and their families were referred to the Clinical Genetic service. Of the probands, 2 096 were diagnosed as suffering from multiple congenital anomaly syndromes. These represented 42.9% of the total. Ten commonest conditions accounted for 50% of patients suffering from this category of genetic diseases. A multidisciplinary approach was emphasized in the diagnosis and management.

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Assessment of the usefulness of integrated disease surveillance and response on suspected ebola cases in the Brong Ahafo Region, Ghana

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Infectious Diseases of Poverty 2015年第1期4卷 168-175页

作者： Kofi Issah Kennedy Nartey Richard Amoah Emmanuel George Bachan Jacob Aleeba Enuamah Yeetey Timothy Letsa Ghana health service Regional Health DirectorateP.O.Box 145SunyaniBrong Ahafo RegionGhana Kintampo health Centre Ghana Health ServiceKintampoBrong Ahafo RegionGhana

Background:This study assessed the quality,core and support functions of the integrated disease surveillance and response(IDSR)system relating to 18 suspected cases of Ebola virus disease(EVD)in the Brong Ahafo Region,***:Data was collected on selected indicators of the surveillance system relating to 18 suspected cases of EVD,from epidemiological week 19 to 45 of *** conducted in-depth interviews with seven medical directors and two district directors of health services,and also reviewed documentation on the implementation of the core,support and quality functions of the IDSR *** also monitored news in the media and rumours about EVD within the community as well as in health facility surveillance ***:The study identified gaps in the implementation of IDSR relating to 18 suspected cases of *** staff heavily relied on haemorrhage as the only symptom for detection of suspected EVD *** blood samples and a swab of secretions from the mouth of the thirteenth patient(who died)tested negative for EVD using PCR assay in laboratory *** blood samples of three patients were discarded,as they did not fit the case definition for suspected cases,whilst two refused for their blood samples to be *** community-based surveillance(CBS)system has not been given a prominent role in EVD surveillance and response,as demonstrated by CBS volunteers and health staff not receiving any training in these *** was intense public interest in EVD in August and September *** interest has since waned for reasons that have to be formally *** fear of and anxiety about EVD still remain challenges due to a lack of in-depth knowledge about the disease in ***:Ghana has been one of the pioneers in the implementation of IDSR in *** this,gaps have been identified in the implementation of IDSR relating to EVD in the Brong Ahafo *** address these gaps,the CBS system has to activ

关键词： Ebola Disease surveillance Brong Ahafo Ghana

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Deep brain stimulation for autism spectrum disorder

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World Journal of Psychiatry 2023年第5期13卷 174-181页

作者： Stefano Marini Lucia D'Agostino Carla Ciamarra Alessandro Gentile Department of Mental health National Health ServiceTermoli 86039Italy

Deep brain stimulation(DBS)is a medical treatment that aims to obtain therapeutic effects by applying chronic electrical impulses in specific brain structures and neurological *** the years,DBS has been studied for the treatment of many psychiatric *** research on the use of DBS in people with autism has focused this interest mainly on treatment-resistant obsessive-compulsive disorder,drug-resistant epilepsy,self-injurious behaviors(SIB),and aggressive behaviors toward the *** spectrum disorder(ASD)includes a group of developmental disabilities characterized by patterns of delay and deviance in the development of social,communicative,and cognitive skills and the presence of repetitive and stereotyped behaviors as well as restricted *** with autism often have numerous medical and psychiatric comorbidities that worsen the quality of life of patients and their ***-compulsive symptoms can be found in up to 81.3%of people with *** are often severe,refractory to treatment,and particularly difficult to *** has a high prevalence in severely retarded individuals and is often associated with *** treatment of both autism and SIB presents a therapeutic *** describe the current state of the art regarding the efficacy of DBS in people with ASD,a literature search was conducted for relevant studies using the PubMed *** studies have been considered in this *** to date,DBS has been used for the stimulation of the nucleus accumbens,globus pallidus internus,anterior limb of the internal capsule,ventral anterior limb of the internal capsule,basolateral amygdala,ventral capsule and ventral striatum,medial forebrain bundle,and posterior *** the total sample of 16 patients,4 were adolescents,and 12 were *** patients had symptoms resistant to multiple drug *** patients taken into consideration by the studies showed clinical improvements as evidenced

关键词： stimulation capsule epilepsy

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Impact of community public health care on treatment effect,health cognition,and self-management in patients with type 2 diabetes

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World Journal of Clinical Cases 2025年第5期13卷 22-29页

作者： Hong Shi Chun Liu Hong-Yan Luo Department of Infrastructure Operation West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Public health Minzu Street Community Health Service CenterWuhan 430000Hubei ProvinceChina Caotang Community health service Center Chengdu 610031Sichuan ProvinceChina

BACKGROUND At present,China has become the country with the largest number of individuals with diabetes mellitus(DM)in the world,with a total of approximately 140 million patients,the majority of whom have type 2 DM(T2DM).Based on conven-tional nursing methods,community home care has important clinical significance in controlling blood sugar and disease *** To explore the impact of community public health nursing on treatment effect,health cognition,and self-management in patients with *** One hundred patients with T2DM were selected as the research *** patients were divided into either a conventional nursing group or community nursing(CN)group using the random number table *** conventional nursing group(50 cases)received routine care,while the CN group(50 cases)received community public health care in addition to routine care as that for the conventional nursing *** rate of excellent and good blood glucose control,fasting blood glucose before and after care,2-h postprandial blood glucose,health cognition,and self-management ability,and patient satisfaction were compared between the two *** The CN group had a higher rate of excellent blood sugar control than the conventional nursing group(88%vs 70%,P0.05).After nursing,fasting blood glucose and 2-h postprandial blood glucose were reduced to varying degrees in both groups,and both blood glucose levels in the CN group were lower than those of the conventional nursing group(P<0.05).Compared with the scores before care,the cognitive level score for diabetes and self-management ability score improved after care in both *** cognitive level and self-management ability of patients in the CN group were higher than those of the conventional nursing group(P<0.05).The overall satisfaction of the CN group was better than

关键词： Community public health care Type 2 diabetes Blood sugar control Self-management ability Cognition level

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Efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine for patients with rheumatic immune diseases

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World Journal of Clinical Cases 2025年第6期13卷 14-23页

作者： Hang Shu Xiao-Yu Chen Jie Zhao Pin Li Zhen Sun Department of Traditional Chinese Medicine Hangzhou Special Service Recuperation Center of Chinese People's Liberation Army Air ForceNanjing 210000Jiangsu ProvinceChina Department of Convalescence Hangzhou Special Service Recuperation Center of Chinese People's Liberation Army Air ForceNanjing 210000Jiangsu ProvinceChina

BACKGROUND Rheumatic immune diseases are a group of chronic inflammatory diseases charac-terized by joint and systemic multi-organ involvement,including rheumatoid arthritis,systemic lupus erythematosus,and Sjogren’s syndrome,among *** pathogenesis of these diseases is related to the abnormal activation and regulatory imbalance of the immune *** prevalence and morbidity of rheumatic immune diseases are high,imposing a significant burden on patients'quality of life and socio-economic ***,the treatment of rheumatic immune diseases mainly relies on Western medicine,such as non-steroidal anti-inflammatory drugs,glucocorticoids,disease-modifying antirheumatic drugs,and ***,the therapeutic effects of Western medicine are not ideal,some patients poorly respond or are resistant to Western medicine,and long-term use often causes various adverse *** To systematically evaluate the efficacy and safety of Tripterygium wilfordii gly-cosides tablets combined with Western medicine in the treatment of patients with rheumatic immune *** This study conducted a meta-analysis to systematically evaluate the efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine for patients with rheumatic immune *** and English databases were searched for randomized controlled trials(RCTs)on the treatment of rheumatic immune diseases with Tripterygium wilfordii glycosides tablets combined with Western *** quality of the included studies was assessed using the Cochrane risk of bias assessment ***-analysis was performed using RevMan 5.4 *** The meta-analysis included 11 RCTs involving 1026 patients with rheumatic immune *** combined treatment significantly reduced the risk of disease recurrence(relative risk=1.07,95%confidence interval:1.01-1.15,P<0.05)and showed no significant heterogeneity(I2=0%,P=0.53),indicating that Tripterygium wilfordii glycosides

关键词： Rheumatic immune diseases Tripterygium wilfordii polyglycosides tablets Western medicine treatment Systematic review Meta-analysis

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