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Tunable Dendritic Ligands of Chiral 1,2-Diamine and Their Application in asymmetric Transfer Hydrogenation

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有机化学 2004年第Z1期24卷 49-50页

作者： LIU,Wei-Guo CUI,Xin CUN,Lin-Feng WU,Jun ZHU,Jin DENG,Jin-Gen key laboratory of asymmetric synthesis & chirotechnology of sichuan province and union laboratory of asymmetric synthesis Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041

　　Dendrimers are perfect monodisperse macromolecules with a regular and highly branched three-dimensional architecture, so their unique physical and chemical properties are noticed and utilized more and more.[1] The dendrimer architecture can offer a means of better controlling the disposition of the catalytic species in soluble polymer-based catalysts and such novel catalysts of nano-scale size may aid the recycling of catalysts simply by supra-filtration or solvent precipitation methods.……

关键词： precipitation methods chemical properties

Copper-Catalyzed Enantioselective synthesis of α-Hydroxyamine Using Monodentate Phosphoramidites

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有机化学 2004年第Z1期24卷 43-44页

作者： DONG,Lin CUN,Lin-Feng GONG,Liu-Zhu MI,Ai-Qiao JIANG,Yao-Zhong key laboratory of asymmetric synthesis and chirotechnology of sichuan province and union laboratory of asymmetric synthesis Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041

　　Development of new methods for the introduction of a nitrogen atom to a carbonyl group is still the most important synthetic target. Cu-catalyzed addition of organozinc reagents to α,β-unsaturated carbonyl compounds has been the subject of intensive investigation.[1] Moreover, trapping of the intermediate Zn-enolates has been achieved using nitrosobenzene. To demonstrate the feasibility of developing enantioselective variants of these tandem C-C bond formations,α,β-unsaturated substrates a～d was subjected to standard reaction conditions using Feringa's (L1*, L2*) and our own phosphoramidite ligands (L3*, L4*). In this reaction, medium to high levels of enantioselectivities were observed.……

关键词： carbonyl compounds methods for

synthesis and preliminary cytotoxic evaluation of substituted indoles as potential anticancer agents

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Chinese Chemical Letters 2007年第8期18卷 899-901页

作者： Chang Qing Shi Zhang Qin Liu Wen Qing Lin Yuan Wei Chen key laboratory of asymmetric synthesis ＆ chirotechnology of sichuan province and union laboratory of asymmetric synthesis Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 China Graduate School of Chinese Academy of Sciences Beijing 100049 China

A variety of indole derivatives were designed, synthesized and preliminarily evaluated for their in vitro cytotoxic activity in the A431 and H460 cell lines. All the compounds examined conferred unusual potency in a tumor cell cytotoxicity assay. The findings showed the indole derivatives would be a promising candidate for the development of new anticancer agents.

关键词： Indoles synthesis Kinesin spindle protein inhibitor Cytotoxicity Cancer treatment

synthesis of urea acetates as potential PPARα/γ dual agonists

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Chinese Chemical Letters 2008年第2期19卷 166-168页

作者： Chang Yan Zhao Chang Qing Shi Yuan Wei Chen key laboratory of asymmetric synthesis ＆ chirotechnology of sichuan province and union laboratory of asymmetric synthesis Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 China Graduate School of Chinese Academy of Sciences Beijing 100049 China

In the quest for novel PPARα/γ dual agonists as putative drugs for the treatment of type 2 diabetes and dyslipidemia, we designed and synthesized a series of urea acetates as potential PPARα/γ dual agonists. The s... 详细信息

关键词： Oxazolc PPAR agonist Type 2 diabetes Urea Ammonolysis synthesis

Small Peptides Catalyzed Direct Aldol Reactions of Aldehydes with Hydroxyacetone with Regiocontrol in Aqueous Media

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有机化学 2004年第Z1期24卷 41-42页

作者： TANG,Zhuo YANG,Zhi-Hua CUN,Lin-Feng GONG,Liu-Zhu MI,Ai-Qiao JIANG,Yao-Zhong key laboratory of asymmetric synthesis and chirotechnology of sichuan province and union laboratory of asymmetric synthesis Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041

Very recently, we[1] found that L-proline amides and dipeptides acted as efficient catalysts for the asymmetric direct aldol reaction. We report here that L-proline-based peptides 1~5 can catalyze the aldol reactions of hydroxyacetone with aldehydes 6 in aqueous media, to give 1,4-diols (7), the disfavored products with either aldolase or L-proline. Both peptides 3 and 4 give good results.……

关键词： aldol reaction aqueous media

A Cell Solid Structure of cis-1,3-Cyclohexanedicarboxylic Acid and Its Complex Crystal with 4,4'-Dipyridine

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有机化学 2004年第Z1期24卷 51-52页

作者： GAO,Wei YU,Kai-Bei ZHU,Jin DENG,Jin-Gen key laboratory of asymmetric synthesis & chirotechnology of sichuan province and union laboratory of asymmetric synthesis Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041

Carboxylic acids are important in crystal engineering because they can form strong and directional O-H…O hydrogen bonds as dimmer and catmer.[1] The dicarboxylic acids (not containing other hydrogen bonding groups) generally form the extended line structure interlinked through dimmer,[2] except that oxalic acid forms both the β-oxalic acid linked by dimmer (finite synthon) and the a-oxalic acid by catmer[3] (infinite synthon). A new molecular packing structure of cis-1,3-cyclohexanedicarboxylic acid (CHDA), which is different from line structure,[4] was gotten (P1/2, Figure 1). The novel structure has dimmer and catmer hydrogen bond pairs in the crystal and the hydrogen bond length of O-H…O is 0.268 nm in catmer and 0.264 nm in dimmer. The bond angles of O=C-O vary from 123.1° to 123.8° in catmer and from 123.1° to 122.0° in dimmer comparing with the ones in line structure.……

关键词： oxalic acid hydrogen bonding crystal engineering molecular packing novel structure hydrogen bonds bond length

synthesis of Stereoisomers of 3-Aminocyclohexanecarboxylic Acid and cis-3-Aminocyclohexene-5-carboxylic Acid

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Chinese Journal of Chemistry 2006年第6期24卷 795-799页

作者：胡昱余盛良杨玉金朱槿邓金根 key laboratory of asymmetric synthesis and chirotechnology of sichuan province at Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu Sichuan 610041 China Graduate School of Chinese Academy of Sciences Beijing 100039 China

A practical synthesis of stereoisomers of 3-aminocyclohexanecarboxylic acid and cis-3-aminocyclohexene-5- carboxylic acid was achieved from cyclohexene-4-carboxylic acid via a key resolving approach with chiral 1-phen... 详细信息

关键词： resolution enantiopure γ-aminobutyric acid 3-aminocyclohexanecarboxylic acid 3-aminocyclohexene-5-carboxylic acid

asymmetric Double Michael Reaction Catalyzed by Simple Primary Amine Catalysts： A Straightforward Approach to Construct Spirocyclic Oxindoles

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Chinese Journal of Chemistry 2012年第5期30卷 1185-1188页

作者：罗西娅汪亮亮彭林摆建飞贾利娜贺光云田芳徐小英王立新 key laboratory of asymmetric synthesis and chirotechnology of sichuan province Chengdu Institute of Organic ChemistryChinese Academy of SciencesChengduSichuan 610041China Graduate University of Chinese Academy of Sciences Beijing 10039China

The enantioselective double Michael reaction of N-Boc-3-nonsubstitued oxindoles with dienones catalyzed by chiral monoimide protected cyclohexane-1,2-diamines was developed. A wide range of optically active spirocycli... 详细信息

关键词： double Michael reaction spirocyclic oxindole amine catalyst organocatalysis

Organocatalytic asymmetric Double Michael Reaction of Benzofuranone with Dienones to Construct Spirocyclic Benzofuranones

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Chinese Journal of Chemistry 2012年第11期30卷 2703-2706页

作者：罗西娅汪亮完彭林摆建飞贾利娜田芳徐小英王立新 key laboratory of asymmetric synthesis and chirotechnology of sichuan province Chengdu Institute of Organic ChemistryChinese Academy of SciencesChengduSichuan 610041China Graduate University of Chinese Academy of Sciences Beijing 10039China

The enantioselective double Michael reaction of benzofuranone with dienones catalyzed by Cinchona-based primary amines was developed. A number of optically active spirocyclic benzofuranones were obtained in up to 89% ... 详细信息

关键词： double Michael reaction spirocyclic compounds benzofuranone organocatalysis